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Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of NF-κB pathways.

Muraoka H, Yoshimura C, Kawabata R, Tsuji S, Hashimoto A, Ochiiwa H, Nakagawa F, Fujioka Y, Matsuo K, Ohkubo S.

Cancer Sci. 2019 Oct 4. doi: 10.1111/cas.14209. [Epub ahead of print]


Efficacy and safety of TAS-116, an oral inhibitor of heat shock protein 90, in patients with metastatic or unresectable gastrointestinal stromal tumour refractory to imatinib, sunitinib and regorafenib: a phase II, single-arm trial.

Doi T, Kurokawa Y, Sawaki A, Komatsu Y, Ozaka M, Takahashi T, Naito Y, Ohkubo S, Nishida T.

Eur J Cancer. 2019 Nov;121:29-39. doi: 10.1016/j.ejca.2019.08.009. Epub 2019 Sep 16.


Effectiveness of trabeculectomy with mitomycin C for glaucomatous eyes with low intraocular pressure on treatment eye drops.

Yuasa Y, Sugimoto Y, Hirooka K, Ohkubo S, Higashide T, Sugiyama K, Kiuchi Y.

Acta Ophthalmol. 2019 Jul 25. doi: 10.1111/aos.14195. [Epub ahead of print]


PdII catalyzed ligand controlled synthesis of bis(3-furanyl)methanones and methyl 3-furancarboxylates.

Kusakabe T, Mochida T, Ariyama T, Lee D, Ohkubo S, Takahashi K, Kato K.

Org Biomol Chem. 2019 Jul 17;17(28):6860-6865. doi: 10.1039/c9ob01189g.


High-yielding rice Takanari has superior photosynthetic response to a commercial rice Koshihikari under fluctuating light.

Adachi S, Tanaka Y, Miyagi A, Kashima M, Tezuka A, Toya Y, Kobayashi S, Ohkubo S, Shimizu H, Kawai-Yamada M, Sage RF, Nagano AJ, Yamori W.

J Exp Bot. 2019 Oct 15;70(19):5287-5297. doi: 10.1093/jxb/erz304.


TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models.

Yoshimura C, Muraoka H, Ochiiwa H, Tsuji S, Hashimoto A, Kazuno H, Nakagawa F, Komiya Y, Suzuki S, Takenaka T, Kumazaki M, Fujita N, Mizutani T, Ohkubo S.

Mol Cancer Ther. 2019 Jul;18(7):1205-1216. doi: 10.1158/1535-7163.MCT-18-0644. Epub 2019 May 15.


Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells.

Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E.

Int J Oncol. 2019 Jun;54(6):2080-2094. doi: 10.3892/ijo.2019.4780. Epub 2019 Apr 10.


TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models.

Irie H, Ito K, Fujioka Y, Oguchi K, Fujioka A, Hashimoto A, Ohsawa H, Tanaka K, Funabashi K, Araki H, Kawai Y, Shimamura T, Wadhwa R, Ohkubo S, Matsuo K.

Mol Cancer Ther. 2019 Apr;18(4):733-742. doi: 10.1158/1535-7163.MCT-18-1085. Epub 2019 Feb 20.


Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma.

Takeshima S, Higashide T, Kimura M, Udagawa S, Yamada Y, Takemoto D, Ohkubo S, Sugiyama K.

Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):677-684. doi: 10.1167/iovs.18-25694.


First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors.

Shimomura A, Yamamoto N, Kondo S, Fujiwara Y, Suzuki S, Yanagitani N, Horiike A, Kitazono S, Ohyanagi F, Doi T, Kuboki Y, Kawazoe A, Shitara K, Ohno I, Banerji U, Sundar R, Ohkubo S, Calleja EM, Nishio M.

Mol Cancer Ther. 2019 Mar;18(3):531-540. doi: 10.1158/1535-7163.MCT-18-0831. Epub 2019 Jan 24.


Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.

Uno T, Kawai Y, Yamashita S, Oshiumi H, Yoshimura C, Mizutani T, Suzuki T, Chong KT, Shigeno K, Ohkubo M, Kodama Y, Muraoka H, Funabashi K, Takahashi K, Ohkubo S, Kitade M.

J Med Chem. 2019 Jan 24;62(2):531-551. doi: 10.1021/acs.jmedchem.8b01085. Epub 2018 Dec 21.


High-sensitivity sulfur isotopic measurements for Antarctic ice core analyses.

Takahashi K, Nakai Y, Motizuki Y, Ino T, Ito S, Ohkubo SB, Minami T, Takaku Y, Yamaguchi Y, Tanaka M, Motoyama H.

Rapid Commun Mass Spectrom. 2018 Dec 15;32(23):1991-1998. doi: 10.1002/rcm.8275.


The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability.

Ohkubo S, Dalla Via L, Grancara S, Kanamori Y, García-Argáez AN, Canettieri G, Arcari P, Toninello A, Agostinelli E.

Int J Oncol. 2018 Sep;53(3):1257-1268. doi: 10.3892/ijo.2018.4452. Epub 2018 Jun 22.


Blended learning on family planning policy requirements: key findings and implications for health professionals.

Limaye RJ, Ahmed N, Ohkubo S, Ballard A.

BMJ Sex Reprod Health. 2018 Apr;44(2):109-113. doi: 10.1136/bmjsrh-2017-101752. Epub 2018 Jan 24.


The effect of concentric constriction of the visual field to 10 and 15 degrees on simulated motor vehicle accidents.

Udagawa S, Ohkubo S, Iwase A, Susuki Y, Kunimatsu-Sanuki S, Fukuchi T, Matsumoto C, Ohno Y, Ono H, Sugiyama K, Araie M.

PLoS One. 2018 Mar 14;13(3):e0193767. doi: 10.1371/journal.pone.0193767. eCollection 2018.


Seasonal and diurnal patterns of soil respiration in an evergreen coniferous forest: Evidence from six years of observation with automatic chambers.

Makita N, Kosugi Y, Sakabe A, Kanazawa A, Ohkubo S, Tani M.

PLoS One. 2018 Feb 12;13(2):e0192622. doi: 10.1371/journal.pone.0192622. eCollection 2018.


Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer.

Sakaguchi K, Higashide T, Udagawa S, Ohkubo S, Sugiyama K.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5251-5262. doi: 10.1167/iovs.17-21955.


Intraocular pressure and visual field changes in normal-tension glaucoma patients treated using either unoprostone or latanoprost: a prospective comparative study.

Takemoto D, Higashide T, Saito Y, Ohkubo S, Udagawa S, Takeda H, Sugiyama K.

Clin Ophthalmol. 2017 Sep 1;11:1617-1624. doi: 10.2147/OPTH.S144344. eCollection 2017.


A niche for cyanobacteria producing chlorophyll f within a microbial mat.

Ohkubo S, Miyashita H.

ISME J. 2017 Oct;11(10):2368-2378. doi: 10.1038/ismej.2017.98. Epub 2017 Jun 16.


Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.

Adachi R, Okada K, Skene R, Ogawa K, Miwa M, Tsuchinaga K, Ohkubo S, Henta T, Kawamoto T.

Biochem Biophys Res Commun. 2017 Jun 24;488(2):393-399. doi: 10.1016/j.bbrc.2017.05.064. Epub 2017 May 10.


The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma.

Kunimatsu-Sanuki S, Iwase A, Araie M, Aoki Y, Hara T, Fukuchi T, Udagawa S, Ohkubo S, Sugiyama K, Matsumoto C, Nakazawa T, Yamaguchi T, Ono H.

Br J Ophthalmol. 2017 Jul;101(7):896-901. doi: 10.1136/bjophthalmol-2016-308754. Epub 2016 Oct 17.


K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.

Sakamoto K, Kamada Y, Sameshima T, Yaguchi M, Niida A, Sasaki S, Miwa M, Ohkubo S, Sakamoto JI, Kamaura M, Cho N, Tani A.

Biochem Biophys Res Commun. 2017 Mar 11;484(3):605-611. doi: 10.1016/j.bbrc.2017.01.147. Epub 2017 Jan 30.


Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines.

Grancara S, Ohkubo S, Artico M, Ciccariello M, Manente S, Bragadin M, Toninello A, Agostinelli E.

Amino Acids. 2016 Oct;48(10):2313-26. doi: 10.1007/s00726-016-2323-z. Epub 2016 Sep 12. Review.


Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A.

Migliaccio N, Martucci NM, Ruggiero I, Sanges C, Ohkubo S, Lamberti A, Agostinelli E, Arcari P.

Amino Acids. 2016 Oct;48(10):2339-52. doi: 10.1007/s00726-016-2311-3. Epub 2016 Aug 27. Review.


Stability of spermine oxidase to thermal and chemical denaturation: comparison with bovine serum amine oxidase.

Cervelli M, Leonetti A, Cervoni L, Ohkubo S, Xhani M, Stano P, Federico R, Polticelli F, Mariottini P, Agostinelli E.

Amino Acids. 2016 Oct;48(10):2283-91. doi: 10.1007/s00726-016-2273-5. Epub 2016 Jun 13.


Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications.

Grancara S, Dalla Via L, García-Argáez AN, Ohkubo S, Pacella E, Manente S, Bragadin M, Toninello A, Agostinelli E.

Amino Acids. 2016 Oct;48(10):2327-37. doi: 10.1007/s00726-016-2264-6. Epub 2016 Jun 2.


Persistent hypotony after trabeculectomy: incidence and associated factors in the Collaborative Bleb-Related Infection Incidence and Treatment Study.

Higashide T, Ohkubo S, Sugimoto Y, Kiuchi Y, Sugiyama K.

Jpn J Ophthalmol. 2016 Jul;60(4):309-18. doi: 10.1007/s10384-016-0450-4. Epub 2016 May 13.


Temperature change affected groundwater quality in a confined marine aquifer during long-term heating and cooling.

Saito T, Hamamoto S, Ueki T, Ohkubo S, Moldrup P, Kawamoto K, Komatsu T.

Water Res. 2016 May 1;94:120-127. doi: 10.1016/j.watres.2016.01.043. Epub 2016 Jan 21.


Influence of Clinical Factors and Magnification Correction on Normal Thickness Profiles of Macular Retinal Layers Using Optical Coherence Tomography.

Higashide T, Ohkubo S, Hangai M, Ito Y, Shimada N, Ohno-Matsui K, Terasaki H, Sugiyama K, Chew P, Li KK, Yoshimura N.

PLoS One. 2016 Jan 27;11(1):e0147782. doi: 10.1371/journal.pone.0147782. eCollection 2016.


Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma.

Honjo M, Omodaka K, Ishizaki T, Ohkubo S, Araie M, Nakazawa T.

PLoS One. 2015 Oct 27;10(10):e0141293. doi: 10.1371/journal.pone.0141293. eCollection 2015.


Intraocular Pressure Outcomes and Risk Factors for Failure in the Collaborative Bleb-Related Infection Incidence and Treatment Study.

Sugimoto Y, Mochizuki H, Ohkubo S, Higashide T, Sugiyama K, Kiuchi Y.

Ophthalmology. 2015 Nov;122(11):2223-33. doi: 10.1016/j.ophtha.2015.06.038. Epub 2015 Sep 26.


Diagnosis of Early-Stage Glaucoma by Grid-Wise Macular Inner Retinal Layer Thickness Measurement and Effect of Compensation of Disc-Fovea Inclination.

Mayama C, Saito H, Hirasawa H, Tomidokoro A, Araie M, Iwase A, Ohkubo S, Sugiyama K, Hangai M, Yoshimura N.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5681-90. doi: 10.1167/iovs.15-17208.


Long-Term Outcomes and Prognostic Factors of Trabeculectomy following Intraocular Bevacizumab Injection for Neovascular Glaucoma.

Higashide T, Ohkubo S, Sugiyama K.

PLoS One. 2015 Aug 14;10(8):e0135766. doi: 10.1371/journal.pone.0135766. eCollection 2015.


Concomitant Traumatic Macular Hole and Orbital Blowout Fracture with a Baseball Injury.

Takahashi Y, Takahira M, Ohkubo S, Kakizaki H.

Orbit. 2015 Jun;34(3):164-5. doi: 10.3109/01676830.2015.1014511. Epub 2015 Apr 23. No abstract available.


Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation.

Grancara S, Zonta F, Ohkubo S, Brunati AM, Agostinelli E, Toninello A.

Amino Acids. 2015 May;47(5):869-83. doi: 10.1007/s00726-015-1964-7. Epub 2015 Mar 20. Review.


Modulation of sphingosine-1-phosphate and apolipoprotein M levels in the plasma, liver and kidneys in streptozotocin-induced diabetic mice.

Nojiri T, Kurano M, Tokuhara Y, Ohkubo S, Hara M, Ikeda H, Tsukamoto K, Yatomi Y.

J Diabetes Investig. 2014 Nov;5(6):639-48. doi: 10.1111/jdi.12232. Epub 2014 Apr 21.


TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models.

Ohkubo S, Kodama Y, Muraoka H, Hitotsumachi H, Yoshimura C, Kitade M, Hashimoto A, Ito K, Gomori A, Takahashi K, Shibata Y, Kanoh A, Yonekura K.

Mol Cancer Ther. 2015 Jan;14(1):14-22. doi: 10.1158/1535-7163.MCT-14-0219. Epub 2014 Nov 21.


Influences of the inner retinal sublayers and analytical areas in macular scans by spectral-domain OCT on the diagnostic ability of early glaucoma.

Nakatani Y, Higashide T, Ohkubo S, Sugiyama K.

Invest Ophthalmol Vis Sci. 2014 Oct 23;55(11):7479-85. doi: 10.1167/iovs.14-15530.


Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery.

Matsuura K, Mori T, Miyamoto T, Suto C, Saeki Y, Tanaka S, Kawamura H, Ohkubo S, Tanito M, Inoue Y.

Clin Ophthalmol. 2014 Sep 29;8:2013-8. doi: 10.2147/OPTH.S64756. eCollection 2014.


Efficacy of tracheostomy for central alveolar hypoventilation syndrome caused by lateral medullary infarction.

Mishina M, Ohkubo S, Kamiya N, Abe A, Suda S, Sakamaki M, Kominami S, Mizunari T, Kobayashi S, Katayama Y.

J Nippon Med Sch. 2014;81(4):276-84.


Focal relationship between structure and function within the central 10 degrees in glaucoma.

Ohkubo S, Higashide T, Udagawa S, Sugiyama K, Hangai M, Yoshimura N, Mayama C, Tomidokoro A, Araie M, Iwase A, Fujimura T.

Invest Ophthalmol Vis Sci. 2014 Jul 31;55(8):5269-77. doi: 10.1167/iovs.14-14153.


The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach.

Agostinelli E, Condello M, Tempera G, Macone A, Bozzuto G, Ohkubo S, Calcabrini A, Arancia G, Molinari A.

Int J Oncol. 2014 Sep;45(3):1109-22. doi: 10.3892/ijo.2014.2502. Epub 2014 Jun 18.


Association between genetic polymorphisms of the prostaglandin F2α receptor gene, and response to latanoprost in patients with glaucoma and ocular hypertension.

Sakurai M, Higashide T, Ohkubo S, Takeda H, Sugiyama K.

Br J Ophthalmol. 2014 Apr;98(4):469-73. doi: 10.1136/bjophthalmol-2013-304267. Epub 2014 Jan 23.


The 5-year incidence of bleb-related infection and its risk factors after filtering surgeries with adjunctive mitomycin C: collaborative bleb-related infection incidence and treatment study 2.

Yamamoto T, Sawada A, Mayama C, Araie M, Ohkubo S, Sugiyama K, Kuwayama Y; Collaborative Bleb-Related Infection Incidence and Treatment Study Group.

Ophthalmology. 2014 May;121(5):1001-6. doi: 10.1016/j.ophtha.2013.11.025. Epub 2014 Jan 11.


Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma.

Kawaguchi C, Nakatani Y, Ohkubo S, Higashide T, Kawaguchi I, Sugiyama K.

Jpn J Ophthalmol. 2014 Mar;58(2):197-204. doi: 10.1007/s10384-013-0293-1. Epub 2013 Dec 10.


Macular structure parameters as an automated indicator of paracentral scotoma in early glaucoma.

Kimura Y, Hangai M, Matsumoto A, Akagi T, Ikeda HO, Ohkubo S, Sugiyama K, Iwase A, Araie M, Yoshimura N.

Am J Ophthalmol. 2013 Nov;156(5):907-917.e1. doi: 10.1016/j.ajo.2013.06.029. Epub 2013 Aug 21.


Circle- and grid-wise analyses of peripapillary nerve fiber layers by spectral domain optical coherence tomography in early-stage glaucoma.

Mayama C, Saito H, Hirasawa H, Konno S, Tomidokoro A, Araie M, Iwase A, Ohkubo S, Sugiyama K, Otani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N.

Invest Ophthalmol Vis Sci. 2013 Jul 5;54(7):4519-26. doi: 10.1167/iovs.13-11603.


Reproducibility of thickness measurements of macular inner retinal layers using SD-OCT with or without correction of ocular rotation.

Hirasawa H, Araie M, Tomidokoro A, Saito H, Iwase A, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N.

Invest Ophthalmol Vis Sci. 2013 Apr 5;54(4):2562-70. doi: 10.1167/iovs.12-10552.


Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.

Hosokawa H, Tanaka T, Suzuki Y, Iwamura C, Ohkubo S, Endoh K, Kato M, Endo Y, Onodera A, Tumes DJ, Kanai A, Sugano S, Nakayama T.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4691-6. doi: 10.1073/pnas.1220865110. Epub 2013 Mar 7.


Effect of cataract and its removal on ganglion cell complex thickness and peripapillary retinal nerve fiber layer thickness measurements by fourier-domain optical coherence tomography.

Nakatani Y, Higashide T, Ohkubo S, Takeda H, Sugiyama K.

J Glaucoma. 2013 Aug;22(6):447-55. doi: 10.1097/IJG.0b013e3182894a16.


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