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Items: 1 to 50 of 96

1.

Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1.

Nakagawa S, Serada S, Kakubari R, Hiramatsu K, Sugase T, Matsuzaki S, Matsuzaki S, Ueda Y, Yoshino K, Ohkawara T, Fujimoto M, Kishimoto T, Kimura T, Naka T.

Mol Cancer Ther. 2018 Jun 11. pii: molcanther.0822.2017. doi: 10.1158/1535-7163.MCT-17-0822. [Epub ahead of print]

PMID:
29891489
2.

SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.

Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T.

Gastric Cancer. 2018 Apr 5. doi: 10.1007/s10120-018-0822-1. [Epub ahead of print]

PMID:
29623544
3.

Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury.

Lee H, Fujimoto M, Ohkawara T, Honda H, Serada S, Terada Y, Naka T.

Biochem Biophys Res Commun. 2018 Apr 15;498(4):1045-1051. doi: 10.1016/j.bbrc.2018.03.111. Epub 2018 Mar 17.

PMID:
29550485
4.

Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts.

Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T.

Physiol Rep. 2017 Dec;5(24). pii: e13556. doi: 10.14814/phy2.13556. Epub 2017 Dec 26.

5.

Specific localization of manserin peptide in the rat carotid body.

Ida-Eto M, Ohkawara T, Narita M.

Acta Histochem. 2018 Jan;120(1):11-14. doi: 10.1016/j.acthis.2017.10.006. Epub 2017 Nov 21.

PMID:
29169693
6.

Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1 positive uterine cervical cancer.

Matsuzaki S, Serada S, Hiramatsu K, Nojima S, Matsuzaki S, Ueda Y, Ohkawara T, Mabuchi S, Fujimoto M, Morii E, Yoshino K, Kimura T, Naka T.

Int J Cancer. 2018 Mar 1;142(5):1056-1066. doi: 10.1002/ijc.31124. Epub 2017 Oct 31.

PMID:
29055044
7.

SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma.

Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.

Cancer Res. 2017 Dec 15;77(24):6975-6986. doi: 10.1158/0008-5472.CAN-17-1525. Epub 2017 Oct 17.

PMID:
29042418
8.

Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with l-arginine-induced pancreatitis.

Ohkawara T, Takeda H, Nishihira J.

Life Sci. 2017 Dec 1;190:91-96. doi: 10.1016/j.lfs.2017.09.015. Epub 2017 Sep 15.

PMID:
28919396
9.

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells.

Urushima H, Fujimoto M, Mishima T, Ohkawara T, Honda H, Lee H, Kawahata H, Serada S, Naka T.

Arthritis Res Ther. 2017 Jun 14;19(1):137. doi: 10.1186/s13075-017-1349-2.

10.

Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma.

Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T.

Oncotarget. 2017 Apr 11;8(15):24741-24752. doi: 10.18632/oncotarget.15799.

11.

Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.

Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.

Int J Cancer. 2017 Jun 1;140(11):2608-2621. doi: 10.1002/ijc.30666. Epub 2017 Mar 10.

12.

Mechanism of auditory hypersensitivity in human autism using autism model rats.

Ida-Eto M, Hara N, Ohkawara T, Narita M.

Pediatr Int. 2017 Apr;59(4):404-407. doi: 10.1111/ped.13186. Epub 2016 Dec 12.

PMID:
27706877
13.

Improvement of Triglyceride Levels through the Intake of Enriched-β-Conglycinin Soybean (Nanahomare) Revealed in a Randomized, Double-Blind, Placebo-Controlled Study.

Nishimura M, Ohkawara T, Sato Y, Satoh H, Takahashi Y, Hajika M, Nishihira J.

Nutrients. 2016 Aug 11;8(8). pii: E491. doi: 10.3390/nu8080491.

14.

Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers.

Nishimura M, Ohkawara T, Tetsuka K, Kawasaki Y, Nakagawa R, Satoh H, Sato Y, Nishihira J.

J Tradit Complement Med. 2015 Aug 21;6(3):275-80. doi: 10.1016/j.jtcme.2015.07.003. eCollection 2016 Jul.

15.

The effects of herring-roe lyophilized powder on lipid metabolism.

Nishimura M, Ohkawara T, Kobayashi H, Sato Y, Munekata M, Nishihira J.

J Tradit Complement Med. 2015 May 27;6(3):247-51. doi: 10.1016/j.jtcme.2015.04.002. eCollection 2016 Jul.

16.

Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.

Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.

Br J Cancer. 2016 Jun 28;115(1):66-75. doi: 10.1038/bjc.2016.183. Epub 2016 Jun 16.

17.

Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model.

Watanabe A, Tanaka H, Sakurai Y, Tange K, Nakai Y, Ohkawara T, Takeda H, Harashima H, Akita H.

Int J Pharm. 2016 Jul 25;509(1-2):118-122. doi: 10.1016/j.ijpharm.2016.05.043. Epub 2016 May 24.

PMID:
27231121
18.

Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure.

Nishimura M, Yoshida S, Haramoto M, Mizuno H, Fukuda T, Kagami-Katsuyama H, Tanaka A, Ohkawara T, Sato Y, Nishihira J.

J Tradit Complement Med. 2015 Jan 8;6(1):66-71. doi: 10.1016/j.jtcme.2014.11.022. eCollection 2016 Jan.

19.

Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells.

Tagami-Nagata N, Serada S, Fujimoto M, Tanemura A, Nakatsuka R, Ohkawara T, Murota H, Kishimoto T, Katayama I, Naka T.

Exp Dermatol. 2015 Nov;24(11):864-71. doi: 10.1111/exd.12802. Epub 2015 Sep 3.

PMID:
26173926
20.

Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties.

Nishimura M, Ohkawara T, Kanayama T, Kitagawa K, Nishimura H, Nishihira J.

J Tradit Complement Med. 2015 Jan 20;5(3):161-7. doi: 10.1016/j.jtcme.2014.11.016. eCollection 2015 Jul.

21.

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines.

Takemoto N, Serada S, Fujimoto M, Honda H, Ohkawara T, Takahashi T, Nomura S, Inohara H, Naka T.

Oncotarget. 2015 May 10;6(13):11009-22.

22.

Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice.

Sanosaka M, Fujimoto M, Ohkawara T, Nagatake T, Itoh Y, Kagawa M, Kumagai A, Fuchino H, Kunisawa J, Naka T, Takemori H.

Immunology. 2015 Jun;145(2):268-78. doi: 10.1111/imm.12445.

23.

Facile estimation of catalytic activity and selectivities in copolymerization of propylene oxide with carbon dioxide mediated by metal complexes with planar tetradentate ligand.

Ohkawara T, Suzuki K, Nakano K, Mori S, Nozaki K.

J Am Chem Soc. 2014 Jul 30;136(30):10728-35. doi: 10.1021/ja5046814. Epub 2014 Jul 15.

PMID:
25025746
24.

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder.

Nishimura M, Ohkawara T, Sato H, Takeda H, Nishihira J.

J Tradit Complement Med. 2014 Jan;4(1):72-4. doi: 10.4103/2225-4110.124355.

25.

Maternal viral infection during pregnancy impairs development of fetal serotonergic neurons.

Ohkawara T, Katsuyama T, Ida-Eto M, Narita N, Narita M.

Brain Dev. 2015 Jan;37(1):88-93. doi: 10.1016/j.braindev.2014.03.007. Epub 2014 Apr 26.

PMID:
24780604
26.

Improvement of Blood Pressure, Glucose Metabolism, and Lipid Profile by the Intake of Powdered Asparagus ( Lú Sŭn) Bottom-stems and Cladophylls.

Nishimura M, Ohkawara T, Kagami-Katsuyama H, Sato H, Nishihira J.

J Tradit Complement Med. 2013 Oct;3(4):250-5. doi: 10.4103/2225-4110.119728.

27.

Manganese-corrole complexes as versatile catalysts for the ring-opening homo- and co-polymerization of epoxide.

Robert C, Ohkawara T, Nozaki K.

Chemistry. 2014 Apr 14;20(16):4789-95. doi: 10.1002/chem.201303703. Epub 2014 Mar 11.

PMID:
24616033
28.

Localization of manserin, a secretogranin II-derived neuropeptide, in the oviduct of female rats.

Ida-Eto M, Nomura M, Ohkawara T, Narita N, Narita M.

Acta Histochem. 2014 Apr;116(3):522-6. doi: 10.1016/j.acthis.2013.11.009. Epub 2013 Dec 19.

PMID:
24360019
29.

Copolymerization of epoxides with carbon dioxide catalyzed by iron-corrole complexes: synthesis of a crystalline copolymer.

Nakano K, Kobayashi K, Ohkawara T, Imoto H, Nozaki K.

J Am Chem Soc. 2013 Jun 12;135(23):8456-9. doi: 10.1021/ja4028633. Epub 2013 May 28.

PMID:
23713519
30.

Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes.

Fujii H, Ohnishi N, Shimura K, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Ohkawara Y, Kobata T, Yamaguchi K, Itoh Y.

World J Gastroenterol. 2013 Mar 21;19(11):1834-40. doi: 10.3748/wjg.v19.i11.1834. Review.

31.

Morphology of the facial motor nuclei in a rat model of autism during early development.

Oyabu A, Tashiro Y, Oyama T, Ujihara K, Ohkawara T, Ida-Eto M, Narita M.

Int J Dev Neurosci. 2013 Apr;31(2):138-44. doi: 10.1016/j.ijdevneu.2012.12.002. Epub 2012 Dec 17.

PMID:
23253376
32.

Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein.

Fujii H, Yamaguchi K, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Ohkawara Y, Harada Y, Tanaka H, Takamatsu T, Itoh Y.

Clin J Gastroenterol. 2012 Aug;5(4):261-7. doi: 10.1007/s12328-012-0311-8. Epub 2012 Jun 7.

PMID:
26182391
33.

Subtype-specific parafollicular localization of the neuropeptide manserin in the rat thyroid gland.

Ohkawara T, Oyabu A, Ida-Eto M, Tashiro Y, Narita N, Narita M.

Acta Histochem. 2013 Mar;115(2):190-4. doi: 10.1016/j.acthis.2012.05.003. Epub 2012 Jun 7.

PMID:
22682498
34.

Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: implications for association with developmental disorders.

Ida-Eto M, Oyabu A, Ohkawara T, Tashiro Y, Narita N, Narita M.

Brain Dev. 2013 Mar;35(3):261-4. doi: 10.1016/j.braindev.2012.05.004. Epub 2012 Jun 1.

PMID:
22658806
35.

Factors associated with the overall survival of elderly patients with hepatocellular carcinoma.

Fujii H, Itoh Y, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Ohkawara Y, Yamaguchi K, Minami M, Okanoue T.

World J Gastroenterol. 2012 Apr 28;18(16):1926-32. doi: 10.3748/wjg.v18.i16.1926.

36.

Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis.

Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T.

Inflamm Bowel Dis. 2012 Nov;18(11):2169-79. doi: 10.1002/ibd.22936. Epub 2012 Feb 28.

PMID:
22374925
37.

Existence of manserin, a secretogranin II-derived neuropeptide, in the rat inner ear: relevance to modulation of auditory and vestibular system.

Ida-Eto M, Oyabu A, Ohkawara T, Tashiro Y, Narita N, Narita M.

J Histochem Cytochem. 2012 Jan;60(1):69-75. doi: 10.1369/0022155411425688. Epub 2011 Oct 27.

38.

Manserin as a novel histochemical neuroendocrine marker in prostate cancer.

Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y.

Urol Oncol. 2013 Aug;31(6):787-95. doi: 10.1016/j.urolonc.2011.06.010. Epub 2011 Jul 30.

PMID:
21803620
39.

Embryonic exposure to thimerosal, an organomercury compound, causes abnormal early development of serotonergic neurons.

Ida-Eto M, Oyabu A, Ohkawara T, Tashiro Y, Narita N, Narita M.

Neurosci Lett. 2011 Nov 14;505(2):61-4. doi: 10.1016/j.neulet.2011.05.053. Epub 2011 Jun 6.

PMID:
21669256
40.

γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.

Nakayama K, Nagase H, Koh CS, Ohkawara T.

Cell Mol Neurobiol. 2011 Aug;31(6):887-900. doi: 10.1007/s10571-011-9688-z. Epub 2011 Apr 23. Review.

PMID:
21516353
41.

Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice.

Ohkawara T, Takeda H, Ohnishi S, Kato M, Nishihira J, Asaka M.

Int Immunopharmacol. 2011 Apr;11(4):418-23. doi: 10.1016/j.intimp.2010.12.009. Epub 2010 Dec 24.

PMID:
21185918
42.

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.

Ohkawara T, Nagase H, Koh CS, Nakayama K.

Gene. 2011 Apr 1;475(1):1-9. doi: 10.1016/j.gene.2010.11.014. Epub 2010 Dec 9.

PMID:
21145952
43.

The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells.

Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T.

J Immunol. 2011 Jan 1;186(1):32-40. doi: 10.4049/jimmunol.0903314. Epub 2010 Nov 24.

44.

DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis.

Ohkawara T, Koyama Y, Onodera S, Takeda H, Kato M, Asaka M, Nishihira J.

Clin Exp Immunol. 2011 Jan;163(1):113-22. doi: 10.1111/j.1365-2249.2010.04277.x. Epub 2010 Nov 9.

45.

Relapse of hepatitis C in a pegylated-interferon-alpha-2b plus ribavirin-treated sustained virological responder.

Fujii H, Itoh Y, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Nishimura T, Yamaguchi K, Yasui K, Minami M, Okanoue T, Ohkawara Y, Yoshikawa T.

Hepatol Res. 2010 Jun;40(6):654-60. doi: 10.1111/j.1872-034X.2010.00641.x.

PMID:
20618461
46.

Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression.

Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T.

Int Immunol. 2010 May;22(5):359-66. doi: 10.1093/intimm/dxq015. Epub 2010 Feb 26.

PMID:
20190037
47.

Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition.

Takeda H, Muto S, Hattori T, Sadakane C, Tsuchiya K, Katsurada T, Ohkawara T, Oridate N, Asaka M.

Endocrinology. 2010 Jan;151(1):244-52. doi: 10.1210/en.2009-0633. Epub 2009 Nov 11.

PMID:
19906817
48.

iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases.

Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T.

Ann Rheum Dis. 2010 Apr;69(4):770-4. doi: 10.1136/ard.2009.118919. Epub 2009 Oct 22.

PMID:
19854709
50.

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.

Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H.

Neurosci Lett. 2008 Oct 24;444(2):127-31. doi: 10.1016/j.neulet.2008.08.034. Epub 2008 Aug 15.

PMID:
18722509

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