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Usefulness of apolipoprotein B-depleted serum in cholesterol efflux capacity assays using immobilized liposome-bound gel beads.

Horiuchi Y, Ohkawa R, Lai SJ, Shimano S, Hagihara M, Tohda S, Kameda T, Tozuka M.

Biosci Rep. 2019 Mar 13. pii: BSR20190213. doi: 10.1042/BSR20190213. [Epub ahead of print]


[Successful readministration of L-asparaginase after development of severe hypertriglyceridemia in a young adult with T-cell acute lymphoblastic leukemia].

Watanabe K, Yoshifuji K, Ohkawa R, Tozuka M, Miura O, Arai A.

Rinsho Ketsueki. 2018;59(12):2555-2560. doi: 10.11406/rinketsu.59.2555. Japanese.


Serum amyloid A does not affect high-density lipoprotein cholesterol measurement by a homogeneous assay.

Sato M, Ohkawa R, Low H, Nishimori M, Okubo S, Yoshimoto A, Yano K, Kameda T, Yatomi Y, Tozuka M.

Clin Biochem. 2019 Jan;63:97-101. doi: 10.1016/j.clinbiochem.2018.10.008. Epub 2018 Oct 17.


Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate.

Mishima Y, Kurano M, Kobayashi T, Nishikawa M, Ohkawa R, Tozuka M, Yatomi Y.

Biosci Rep. 2018 Oct 31;38(5). pii: BSR20181288. doi: 10.1042/BSR20181288. Print 2018 Oct 31.


Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells.

Horiuchi Y, Ohkawa R, Lai SJ, Yamazaki A, Ikoma H, Yano K, Kameda T, Tozuka M.

Biol Chem. 2019 Jan 28;400(2):209-218. doi: 10.1515/hsz-2018-0284.


Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.

Ohkawa R, Kurano M, Sakai N, Kishimoto T, Nojiri T, Igarashi K, Hosogaya S, Ozaki Y, Dohi T, Miyauchi K, Daida H, Aoki J, Okubo S, Ikeda H, Tozuka M, Yatomi Y.

Sci Rep. 2018 Mar 16;8(1):4725. doi: 10.1038/s41598-018-23009-x.


Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells.

Horiuchi Y, Lai SJ, Yamazaki A, Nakamura A, Ohkawa R, Yano K, Kameda T, Okubo S, Shimano S, Hagihara M, Tohda S, Tozuka M.

Biosci Rep. 2018 Apr 13;38(2). pii: BSR20180144. doi: 10.1042/BSR20180144. Print 2018 Apr 27.


Performance of autotaxin as a serum marker for liver fibrosis.

Ikeda H, Kobayashi M, Kumada H, Enooku K, Koike K, Kurano M, Sato M, Nojiri T, Kobayashi T, Ohkawa R, Shimamoto S, Igarashi K, Aoki J, Yatomi Y.

Ann Clin Biochem. 2018 Jul;55(4):469-477. doi: 10.1177/0004563217741509. Epub 2017 Nov 13.


In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes.

Kobayashi S, Terai T, Yoshikawa Y, Ohkawa R, Ebihara M, Hayashi M, Takiguchi K, Nemoto N.

Chem Commun (Camb). 2017 Mar 25;53(24):3458-3461. doi: 10.1039/c7cc00099e. Epub 2017 Mar 8.


Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome.

Kurano M, Kano K, Dohi T, Matsumoto H, Igarashi K, Nishikawa M, Ohkawa R, Ikeda H, Miyauchi K, Daida H, Aoki J, Yatomi Y.

J Lipid Res. 2017 Feb;58(2):433-442. doi: 10.1194/jlr.P071803. Epub 2016 Dec 22.


Cholesterol Efflux Capacity of Apolipoprotein A-I Varies with the Extent of Differentiation and Foam Cell Formation of THP-1 Cells.

Yano K, Ohkawa R, Sato M, Yoshimoto A, Ichimura N, Kameda T, Kubota T, Tozuka M.

J Lipids. 2016;2016:9891316. Epub 2016 Nov 9.


[IgM-Lambda Type Paraproteinemia Interferes with Haptoglobin Measurements].

Nojiri T, Masuda A, Ohkawa R, Okubo S, Kurano M, Ikeda H, Yatomi Y.

Rinsho Byori. 2016 Nov;64(11):1236-1242. Japanese.


Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction.

Nagura Y, Tsuno NH, Kano K, Inoue A, Aoki J, Hirowatari Y, Kaneko M, Kurano M, Matsuhashi M, Ohkawa R, Tozuka M, Yatomi Y, Okazaki H.

Transfus Med. 2016 Oct;26(5):365-372. doi: 10.1111/tme.12326. Epub 2016 Jun 28.


Prognostic impact of homocysteine levels and homocysteine thiolactonase activity on long-term clinical outcomes in patients undergoing percutaneous coronary intervention.

Hassan A, Dohi T, Miyauchi K, Ogita M, Kurano M, Ohkawa R, Nakamura K, Tamura H, Isoda K, Okazaki S, Yatomi Y, Daida H.

J Cardiol. 2017 Jun;69(6):830-835. doi: 10.1016/j.jjcc.2016.08.013. Epub 2016 Sep 28.


High-Density Lipoprotein Binds to Mycobacterium avium and Affects the Infection of THP-1 Macrophages.

Ichimura N, Sato M, Yoshimoto A, Yano K, Ohkawa R, Kasama T, Tozuka M.

J Lipids. 2016;2016:4353620. doi: 10.1155/2016/4353620. Epub 2016 Jul 19.


Effects of serum amyloid A on the structure and antioxidant ability of high-density lipoprotein.

Sato M, Ohkawa R, Yoshimoto A, Yano K, Ichimura N, Nishimori M, Okubo S, Yatomi Y, Tozuka M.

Biosci Rep. 2016 Aug 16;36(4). pii: e00369. doi: 10.1042/BSR20160075. Print 2016 Aug.


Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy.

Shimizu M, Furuichi K, Toyama T, Yamahana J, Ohkawa R, Igarashi K, Aoki J, Kaneko S, Yatomi Y, Wada T.

Intern Med. 2016;55(3):215-21. doi: 10.2169/internalmedicine.55.5473. Epub 2016 Feb 1.


Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein.

Kameda T, Ohkawa R, Yano K, Usami Y, Miyazaki A, Matsuda K, Kawasaki K, Sugano M, Kubota T, Tozuka M.

J Lipids. 2015;2015:592594. doi: 10.1155/2015/592594. Epub 2015 Jul 14.


Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects.

Ohkawa R, Kurano M, Mishima Y, Nojiri T, Tokuhara Y, Kishimoto T, Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Yokota H, Igarashi K, Ikeda H, Tozuka M, Yatomi Y.

Clin Biochem. 2015 Jul;48(10-11):690-7. doi: 10.1016/j.clinbiochem.2015.03.019. Epub 2015 Apr 8.


[Difference in measurements of erythrocyte sedimentation rate obtained using two devices of the same model in a patient with marked leukocytosis].

Nojiri T, Masuda A, Ohkawa R, Koido K, Shimosaka H, Okubo S, Yokota H, Kurano M, Nannya Y, Ikeda H, Kurokawa M, Yatomi Y.

Rinsho Byori. 2014 Jul;62(7):664-7. Japanese.


LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate.

Kurano M, Tsukamoto K, Hara M, Ohkawa R, Ikeda H, Yatomi Y.

J Biol Chem. 2015 Jan 23;290(4):2477-88. doi: 10.1074/jbc.M114.596445. Epub 2014 Dec 12.


Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.

Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y.

Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):463-70. doi: 10.1161/ATVBAHA.114.304748. Epub 2014 Nov 25.


Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells.

Iino J, Osada M, Kurano M, Kaneko M, Ohkawa R, Satoh Y, Okubo S, Ozaki Y, Tozuka M, Tsuno NH, Yatomi Y.

Lipids Health Dis. 2014 Sep 25;13:150. doi: 10.1186/1476-511X-13-150.


ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity.

Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R.

Diabetes. 2014 Dec;63(12):4154-64. doi: 10.2337/db13-1694. Epub 2014 Jun 26.


Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma.

Kondo M, Ishizawa T, Enooku K, Tokuhara Y, Ohkawa R, Uranbileg B, Nakagawa H, Tateishi R, Yoshida H, Kokudo N, Koike K, Yatomi Y, Ikeda H.

Clin Chim Acta. 2014 Jun 10;433:128-34. doi: 10.1016/j.cca.2014.03.006. Epub 2014 Mar 16.


Detection of novel visible-light region absorbance peaks in the urine after alkalization in patients with alkaptonuria.

Tokuhara Y, Shukuya K, Tanaka M, Mouri M, Ohkawa R, Fujishiro M, Takahashi T, Okubo S, Yokota H, Kurano M, Ikeda H, Yamaguchi S, Inagaki S, Ishige-Wada M, Usui H, Yatomi Y, Shimosawa T.

PLoS One. 2014 Jan 23;9(1):e86606. doi: 10.1371/journal.pone.0086606. eCollection 2014.


TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate: implications for inflammation in atherosclerosis.

Ito S, Iwaki S, Kondo R, Satoh M, Iwabuchi K, Ohkawa R, Mishima Y, Yatomi Y, Furumoto T, Tsutsui H, Fujii S.

Coron Artery Dis. 2014 Jun;25(4):311-20. doi: 10.1097/MCA.0000000000000082.


Increased serum mitochondrial creatine kinase activity as a risk for hepatocarcinogenesis in chronic hepatitis C patients.

Enooku K, Nakagawa H, Soroida Y, Ohkawa R, Kageyama Y, Uranbileg B, Watanabe N, Tateishi R, Yoshida H, Koike K, Yatomi Y, Ikeda H.

Int J Cancer. 2014 Aug 15;135(4):871-9. doi: 10.1002/ijc.28720. Epub 2014 Jan 21.


[Sphingolipids, possible biomarkers for atherosclerotic disorders].

Ohkawa R, Kurano M, Nakamura K, Okubo S, Yokota H, Ikeda H, Yatomi Y.

Rinsho Byori. 2013 Sep;61(9):795-802. Review. Japanese.


Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes.

Ito S, Iwaki S, Koike K, Yuda Y, Nagasaki A, Ohkawa R, Yatomi Y, Furumoto T, Tsutsui H, Sobel BE, Fujii S.

Coron Artery Dis. 2013 Dec;24(8):642-50. doi: 10.1097/MCA.0000000000000033.


High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.

Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Kojima S, Matsuura T, Koike K, Yatomi Y, Ikeda H.

Int J Cancer. 2014 May 1;134(9):2189-98. doi: 10.1002/ijc.28547. Epub 2013 Oct 31.


Impact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study.

Kanai R, Iijima T, Hashimoto S, Nakazawa H, Ohnishi H, Yorozu T, Ohkawa R, Nojiri T, Shimizu M, Okazaki H.

Transfus Med. 2013 Oct;23(5):344-50. doi: 10.1111/tme.12056. Epub 2013 Jul 10.


Necessity of lysophosphatidic acid receptor 1 for development of arthritis.

Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.

Arthritis Rheum. 2013 Aug;65(8):2037-47. doi: 10.1002/art.37991.


Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M.

Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y.

Atherosclerosis. 2013 Jul;229(1):102-9. doi: 10.1016/j.atherosclerosis.2013.04.024. Epub 2013 Apr 28.


Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome.

Dohi T, Miyauchi K, Ohkawa R, Nakamura K, Kurano M, Kishimoto T, Yanagisawa N, Ogita M, Miyazaki T, Nishino A, Yaginuma K, Tamura H, Kojima T, Yokoyama K, Kurata T, Shimada K, Daida H, Yatomi Y.

Atherosclerosis. 2013 Jul;229(1):192-7. doi: 10.1016/j.atherosclerosis.2013.03.038. Epub 2013 Apr 22.


Inhibition of lysophosphatidic acid increase by prestorage whole blood leukoreduction in autologous CPDA-1 whole blood.

Nagura Y, Tsuno NH, Ohkawa R, Nojiri T, Tokuhara Y, Matsuhashi M, Yatomi Y, Takahashi K.

Transfusion. 2013 Dec;53(12):3139-48. doi: 10.1111/trf.12152. Epub 2013 Mar 5.


Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration.

Ono Y, Kurano M, Ohkawa R, Yokota H, Igarashi K, Aoki J, Tozuka M, Yatomi Y.

Lipids Health Dis. 2013 Feb 18;12:20. doi: 10.1186/1476-511X-12-20.


Decrease in circulating autotaxin by oral administration of prednisolone.

Sumida H, Nakamura K, Yanagida K, Ohkawa R, Asano Y, Kadono T, Tamaki K, Igarashi K, Aoki J, Sato S, Ishii S, Shimizu T, Yatomi Y.

Clin Chim Acta. 2013 Jan 16;415:74-80. doi: 10.1016/j.cca.2012.10.003. Epub 2012 Oct 9.


Higher lipoprotein-associated phospholipase A2 levels are associated with coronary atherosclerosis documented by coronary angiography.

Dohi T, Miyauchi K, Ohkawa R, Nakamura K, Thuboi S, Ogita M, Miyazaki T, Nishino A, Yokoyama K, Kurata T, Yatomi Y, Daida H.

Ann Clin Biochem. 2012 Nov;49(Pt 6):527-33. doi: 10.1258/acb.2012.011252. Epub 2012 Aug 29.


Development of an enzymatic assay for sphingomyelin with rapid and automatable performances: Analysis in healthy subjects and coronary heart disease patients.

Ohkawa R, Kishimoto T, Kurano M, Dohi T, Miyauchi K, Daida H, Nagasaki M, Uno K, Hayashi N, Sakai N, Matsuyama N, Nojiri T, Nakamura K, Okubo S, Yokota H, Ikeda H, Yatomi Y.

Clin Biochem. 2012 Nov;45(16-17):1463-70. doi: 10.1016/j.clinbiochem.2012.07.093. Epub 2012 Jul 20.


Plasma lysophosphatidic acid levels and hepatocellular carcinoma.

Ikeda H, Enooku K, Ohkawa R, Koike K, Yatomi Y.

Hepatology. 2013 Jan;57(1):417-8. doi: 10.1002/hep.25886. No abstract available.


Serum autotaxin is not a useful biomarker for ovarian cancer.

Nakamura K, Igarashi K, Ohkawa R, Yokota H, Masuda A, Nakagawa S, Yano T, Ikeda H, Aoki J, Yatomi Y.

Lipids. 2012 Sep;47(9):927-30. doi: 10.1007/s11745-012-3691-0. Epub 2012 Jun 15.


Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence.

Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S, Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H.

J Hepatol. 2012 Aug;57(2):330-6. doi: 10.1016/j.jhep.2012.03.012. Epub 2012 Apr 17.


Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis.

Sugiura T, Dohi Y, Yamashita S, Ohte N, Ito S, Iwaki S, Hirowatari Y, Ohkawa R, Mishima Y, Yatomi Y, Kimura G, Fujii S.

Coron Artery Dis. 2012 Jun;23(4):234-8. doi: 10.1097/MCA.0b013e328351ab0a.


Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome.

Dohi T, Miyauchi K, Okazaki S, Yokoyama T, Ohkawa R, Nakamura K, Yanagisawa N, Tsuboi S, Ogita M, Yokoyama K, Kurata T, Yatomi Y, Daida H.

Atherosclerosis. 2011 Dec;219(2):907-12. doi: 10.1016/j.atherosclerosis.2011.09.019. Epub 2011 Sep 17.


Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome.

Dohi T, Miyauchi K, Ohkawa R, Nakamura K, Kishimoto T, Miyazaki T, Nishino A, Nakajima N, Yaginuma K, Tamura H, Kojima T, Yokoyama K, Kurata T, Shimada K, Yatomi Y, Daida H.

Clin Chim Acta. 2012 Jan 18;413(1-2):207-12. doi: 10.1016/j.cca.2011.09.027. Epub 2011 Sep 29.


Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension.

Masuda A, Fujii T, Iwasawa Y, Nakamura K, Ohkawa R, Igarashi K, Okudaira S, Ikeda H, Kozuma S, Aoki J, Yatomi Y.

Clin Chim Acta. 2011 Oct 9;412(21-22):1944-50. doi: 10.1016/j.cca.2011.06.039. Epub 2011 Jul 14.


Autotaxin as a novel serum marker of liver fibrosis.

Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.

Clin Chim Acta. 2011 Jun 11;412(13-14):1201-6. doi: 10.1016/j.cca.2011.03.014. Epub 2011 Mar 17.


Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.

Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, Takuwa N, Gonda K, Yamamoto Y, Ohkawa R, Nishiuchi T, Sugimoto N, Yatomi Y, Mitsumori K, Asano M, Kinoshita M, Takuwa Y.

J Clin Invest. 2010 Nov;120(11):3979-95. doi: 10.1172/JCI42315. Epub 2010 Oct 18. Erratum in: J Clin Invest. 2012 Jan;122(1):419. Retraction in: J Clin Invest. 2012 Mar;122(3):1131.


A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples.

Nakamura K, Igarashi K, Ohkawa R, Saiki N, Nagasaki M, Uno K, Hayashi N, Sawada T, Syukuya K, Yokota H, Arai H, Ikeda H, Aoki J, Yatomi Y.

Clin Chim Acta. 2010 Aug 5;411(15-16):1090-4. doi: 10.1016/j.cca.2010.04.006. Epub 2010 Apr 11.


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