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Items: 1 to 50 of 404

1.

A fructan from Anemarrhena asphodeloides Bunge showing neuroprotective and immunoregulatory effects.

Zhang S, Zhang Q, An L, Zhang J, Li Z, Zhang J, Li Y, Tuerhong M, Ohizumi Y, Jin J, Xu J, Guo Y.

Carbohydr Polym. 2020 Feb 1;229:115477. doi: 10.1016/j.carbpol.2019.115477. Epub 2019 Oct 17.

PMID:
31826524
2.

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer's Disease and Parkinson's Disease.

Nakajima A, Ohizumi Y.

Int J Mol Sci. 2019 Jul 10;20(14). pii: E3380. doi: 10.3390/ijms20143380. Review.

3.

Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii.

Liu F, Zhang Q, Yang X, Xi Y, Zhang X, Wang H, Zhang J, Tuerhong M, Jin DQ, Lee D, Xu J, Ohizumi Y, Shuai L, Guo Y.

Bioorg Chem. 2019 Aug;89:102995. doi: 10.1016/j.bioorg.2019.102995. Epub 2019 May 23.

PMID:
31185389
4.

Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities.

Shuo Y, Zhang C, Yang X, Liu F, Zhang Q, Li A, Ma J, Lee D, Ohizumi Y, Guo Y.

J Nat Med. 2019 Sep;73(4):826-833. doi: 10.1007/s11418-019-01324-5. Epub 2019 Jun 10.

PMID:
31183662
5.

Bioactive Diterpenoids from the Stems of Euphorbia antiquorum.

Liang Y, An L, Shi Z, Zhang X, Xie C, Tuerhong M, Song Z, Ohizumi Y, Lee D, Shuai L, Xu J, Guo Y.

J Nat Prod. 2019 Jun 28;82(6):1634-1644. doi: 10.1021/acs.jnatprod.9b00134. Epub 2019 Jun 10.

PMID:
31180680
6.

Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS.

Dong B, An L, Yang X, Zhang X, Zhang J, Tuerhong M, Jin DQ, Ohizumi Y, Lee D, Xu J, Guo Y.

Bioorg Chem. 2019 Jun;87:585-593. doi: 10.1016/j.bioorg.2019.03.051. Epub 2019 Mar 22.

PMID:
30928880
7.

Bioactive terpenoids from Euonymus verrucosus var. pauciflorus showing NO inhibitory activities.

Yang Y, Yang X, Zhang X, Song Z, Liu F, Liang Y, Zhang J, Jin DQ, Xu J, Lee D, Tuerhong M, Ohizumi Y, Guo Y.

Bioorg Chem. 2019 Jun;87:447-456. doi: 10.1016/j.bioorg.2019.03.022. Epub 2019 Mar 15.

PMID:
30925429
8.

NO inhibitory phytochemicals as potential anti-inflammatory agents from the twigs of Trigonostemon heterophyllus.

Xi Y, An L, Yang X, Song Z, Zhang J, Tuerhong M, Jin DQ, Ohizumi Y, Lee D, Xu J, Guo Y.

Bioorg Chem. 2019 Jun;87:417-424. doi: 10.1016/j.bioorg.2019.03.029. Epub 2019 Mar 15.

PMID:
30921743
9.

Cytotoxic clerodane diterpenoids from the leaves of Casearia kurzii.

Ma J, Yang X, Zhang Q, Zhang X, Xie C, Tuerhong M, Zhang J, Jin DQ, Lee D, Xu J, Ohizumi Y, Guo Y.

Bioorg Chem. 2019 Apr;85:558-567. doi: 10.1016/j.bioorg.2019.01.048. Epub 2019 Feb 2.

PMID:
30807898
10.

Bioactive Diterpenoids from the Stems of Euphorbia royleana.

Wang P, Xie C, An L, Yang X, Xi Y, Yuan S, Zhang C, Tuerhong M, Jin DQ, Lee D, Zhang J, Ohizumi Y, Xu J, Guo Y.

J Nat Prod. 2019 Feb 22;82(2):183-193. doi: 10.1021/acs.jnatprod.8b00493. Epub 2019 Feb 7.

PMID:
30730729
11.

Nitric oxide inhibitory limonoids as potential anti-neuroinflammatory agents from Swietenia mahagoni.

Shi Z, An L, Yang X, Xi Y, Zhang C, Shuo Y, Zhang J, Jin DQ, Ohizumi Y, Lee D, Xu J, Guo Y.

Bioorg Chem. 2019 Mar;84:177-185. doi: 10.1016/j.bioorg.2018.11.012. Epub 2018 Nov 19.

PMID:
30502629
12.

Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.

Kimura J, Shimizu K, Kajima K, Yokosuka A, Mimaki Y, Oku N, Ohizumi Y.

Biol Pharm Bull. 2018;41(4):451-457. doi: 10.1248/bpb.b17-00364.

13.

Seco-labdane diterpenoids from the leaves of Callicarpa nudiflora showing nitric oxide inhibitory activity.

Sun X, Liu F, Yang X, Wang J, Dong B, Xie C, Jin DQ, Zhang J, Lee D, Ohizumi Y, Xu J, Guo Y.

Phytochemistry. 2018 May;149:31-41. doi: 10.1016/j.phytochem.2018.02.001. Epub 2018 Feb 15.

PMID:
29455054
14.

NO inhibitors function as potential anti-neuroinflammatory agents for AD from the flowers of Inula japonica.

Liu F, Dong B, Yang X, Yang Y, Zhang J, Jin DQ, Ohizumi Y, Lee D, Xu J, Guo Y.

Bioorg Chem. 2018 Apr;77:168-175. doi: 10.1016/j.bioorg.2018.01.009. Epub 2018 Jan 4.

PMID:
29421695
15.

NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera.

Ma J, Ren Q, Dong B, Shi Z, Zhang J, Jin DQ, Xu J, Ohizumi Y, Lee D, Guo Y.

Bioorg Chem. 2018 Feb;76:449-457. doi: 10.1016/j.bioorg.2017.12.008. Epub 2017 Dec 5.

PMID:
29275263
16.

Nitric oxide inhibitors with a spiro diterpenoid skeleton from Scutellaria formosana: Structures, NO inhibitory effects, and interactions with iNOS.

Wang P, Yang X, Liu F, Liang Y, Su G, Tuerhong M, Jin DQ, Xu J, Lee D, Ohizumi Y, Guo Y.

Bioorg Chem. 2018 Feb;76:53-60. doi: 10.1016/j.bioorg.2017.10.008. Epub 2017 Oct 21.

PMID:
29128707
17.

Nitric oxide inhibitory daphnane diterpenoids as potential anti-neuroinflammatory agents for AD from the twigs of Trigonostemon thyrsoideus.

Liu F, Yang X, Ma J, Yang Y, Xie C, Tuerhong M, Jin DQ, Xu J, Lee D, Ohizumi Y, Guo Y.

Bioorg Chem. 2017 Dec;75:149-156. doi: 10.1016/j.bioorg.2017.09.007. Epub 2017 Sep 7.

PMID:
28950242
18.

Polycyclic phloroglucinols as PTP1B inhibitors from Hypericum longistylum: Structures, PTP1B inhibitory activities, and interactions with PTP1B.

Cao X, Yang X, Wang P, Liang Y, Liu F, Tuerhong M, Jin DQ, Xu J, Lee D, Ohizumi Y, Guo Y.

Bioorg Chem. 2017 Dec;75:139-148. doi: 10.1016/j.bioorg.2017.09.001. Epub 2017 Sep 6.

PMID:
28946049
19.

Clerodane diterpenoids from Scutellaria formosana with inhibitory effects on NO production and interactions with iNOS protein.

Wang P, Liu F, Yang X, Liang Y, Li S, Su G, Jin DQ, Ohizumi Y, Xu J, Guo Y.

Phytochemistry. 2017 Dec;144:141-150. doi: 10.1016/j.phytochem.2017.09.005.

PMID:
28934646
20.

Phytochemicals with NO inhibitory effects and interactions with iNOS protein from Trigonostemon howii.

Ma J, Yang X, Wang P, Dong B, Su G, Tuerhong M, Jin DQ, Xu J, Lee D, Ohizumi Y, Lin J, Guo Y.

Bioorg Chem. 2017 Dec;75:71-77. doi: 10.1016/j.bioorg.2017.08.008. Epub 2017 Aug 24.

PMID:
28917124
21.

Extraction of nobiletin from Citrus Unshiu peels by supercritical fluid and its CRE-mediated transcriptional activity.

Oba C, Ota M, Nomura K, Fujiwara H, Takito J, Sato Y, Ohizumi Y, Inomata H.

Phytomedicine. 2017 Apr 15;27:33-38. doi: 10.1016/j.phymed.2017.01.014. Epub 2017 Jan 31.

PMID:
28314477
22.

Unfolding of the myosin head by purealin in glycerol.

Takito J, Kobayashi J, Nakamura M, Ohizumi Y, Nonomura Y.

Anat Sci Int. 2018 Mar;93(2):197-202. doi: 10.1007/s12565-017-0389-7. Epub 2017 Jan 11.

PMID:
28078539
23.

Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS.

Li S, Sun X, Li Y, Liu F, Ma J, Tong L, Su G, Xu J, Ohizumi Y, Lee D, Guo Y.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):670-674. doi: 10.1016/j.bmcl.2016.11.044. Epub 2016 Nov 17.

PMID:
27989668
24.

Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS.

Xu J, Wang M, Sun X, Ren Q, Cao X, Li S, Su G, Tuerhong M, Lee D, Ohizumi Y, Bartlam M, Guo Y.

J Nat Prod. 2016 Nov 23;79(11):2924-2932. Epub 2016 Nov 14.

PMID:
27933899
25.

Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS.

Xu J, Peng M, Sun X, Liu X, Tong L, Su G, Ohizumi Y, Lee D, Guo Y.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4785-4789. doi: 10.1016/j.bmcl.2016.08.026. Epub 2016 Aug 10.

PMID:
27570243
26.

Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities.

Xu J, Cao X, Liu F, Ma J, Liu X, Tong L, Su G, Ohizumi Y, Lee D, Wang L, Guo Y.

Fitoterapia. 2016 Sep;113:144-50. doi: 10.1016/j.fitote.2016.07.017. Epub 2016 Aug 2.

PMID:
27491755
27.

Diterpenoids from Callicarpa kwangtungensis and their NO inhibitory effects.

Xu J, Li S, Sun X, Ma J, Liu F, Tong L, Lee D, Ohizumi Y, Tuerhong M, Guo Y.

Fitoterapia. 2016 Sep;113:151-7. doi: 10.1016/j.fitote.2016.07.012. Epub 2016 Aug 1.

PMID:
27491749
28.

Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells.

Takito J, Kimura J, Kajima K, Uozumi N, Watanabe M, Yokosuka A, Mimaki Y, Nakamura M, Ohizumi Y.

Can J Physiol Pharmacol. 2016 Jul;94(7):728-33. doi: 10.1139/cjpp-2015-0394. Epub 2016 Feb 12.

PMID:
27128150
29.

Di- and Triterpenoids from the Leaves of Casearia balansae and Neurite Outgrowth Promoting Effects of PC12 Cells.

Xu J, Kang J, Sun X, Cao X, Rena K, Lee D, Ren Q, Li S, Ohizumi Y, Guo Y.

J Nat Prod. 2016 Jan 22;79(1):170-9. doi: 10.1021/acs.jnatprod.5b00815. Epub 2015 Dec 24.

PMID:
26699618
30.

Characterization and Biological Evaluation of Diterpenoids from Casearia graveolens.

Xu J, Ji F, Sun X, Cao X, Li S, Ohizumi Y, Guo Y.

J Nat Prod. 2015 Nov 25;78(11):2648-56. doi: 10.1021/acs.jnatprod.5b00583. Epub 2015 Oct 16.

PMID:
26474353
31.

Bioactive Diterpenoids from the Leaves of Callicarpa macrophylla.

Xu J, Sun Y, Wang M, Ren Q, Li S, Wang H, Sun X, Jin DQ, Sun H, Ohizumi Y, Guo Y.

J Nat Prod. 2015 Jul 24;78(7):1563-9. doi: 10.1021/acs.jnatprod.5b00018. Epub 2015 Jun 25.

PMID:
26110519
32.

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).

Nakajima A, Aoyama Y, Shin EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi T, Ohizumi Y, Yamada K.

Behav Brain Res. 2015 Aug 1;289:69-77. doi: 10.1016/j.bbr.2015.04.028. Epub 2015 Apr 22.

PMID:
25913833
33.

[A new strategy for preventive and functional therapeutic methods for dementia--approach using natural products].

Ohizumi Y.

Yakugaku Zasshi. 2015;135(3):449-64. doi: 10.1248/yakushi.14-00245. Review. Japanese.

34.

Bioactive clerodane diterpenoids from the twigs of Casearia balansae.

Xu J, Zhang Q, Wang M, Ren Q, Sun Y, Jin DQ, Xie C, Chen H, Ohizumi Y, Guo Y.

J Nat Prod. 2014 Oct 24;77(10):2182-9. doi: 10.1021/np5003516. Epub 2014 Oct 6.

PMID:
25286284
35.

Roles of basic amino acid residues in the activity of μ-conotoxin GIIIA and GIIIB, peptide blockers of muscle sodium channels.

Sato K, Yamaguchi Y, Ishida Y, Ohizumi Y.

Chem Biol Drug Des. 2015 Apr;85(4):488-93. doi: 10.1111/cbdd.12433. Epub 2014 Sep 30.

PMID:
25228447
36.

Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies.

Nakajima A, Ohizumi Y, Yamada K.

Clin Psychopharmacol Neurosci. 2014 Aug;12(2):75-82. doi: 10.9758/cpn.2014.12.2.75. Epub 2014 Aug 12. Review.

37.

Characterization and NO inhibitory activities of chemical constituents from an edible plant Petasites tatewakianus.

Wang M, Zhang Q, Wang H, Ren Q, Sun Y, Xie C, Xu J, Jin DQ, Ohizumi Y, Guo Y.

J Agric Food Chem. 2014 Sep 24;62(38):9362-7. doi: 10.1021/jf5034224. Epub 2014 Sep 12.

PMID:
25188451
38.

Terpenoids from Tripterygium hypoglaucum and their inhibition of LPS-induced NO production.

Zhao P, Wang H, Jin DQ, Ohizumi Y, Xu J, Guo Y.

Biosci Biotechnol Biochem. 2014;78(3):370-3. doi: 10.1080/09168451.2014.890035. Epub 2014 Apr 16.

PMID:
25036821
39.

Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.

Kimura J, Nemoto K, Degawa M, Yokosuka A, Mimaki Y, Shimizu K, Oku N, Ohizumi Y.

Biol Pharm Bull. 2014;37(9):1555-8. Epub 2014 Jun 26.

40.

Sesquiterpenes inhibiting the microglial activation from Laurus nobilis.

Chen H, Xie C, Wang H, Jin DQ, Li S, Wang M, Ren Q, Xu J, Ohizumi Y, Guo Y.

J Agric Food Chem. 2014 May 21;62(20):4784-8. doi: 10.1021/jf501515v. Epub 2014 May 12.

PMID:
24801989
41.

Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells.

Fujiwara H, Kimura J, Sakamoto M, Yokosuka A, Mimaki Y, Murata K, Yamaguchi K, Ohizumi Y.

Can J Physiol Pharmacol. 2014 May;92(5):351-5. doi: 10.1139/cjpp-2013-0440. Epub 2014 Mar 7.

PMID:
24784468
42.

Two novel clerodane diterpenenes with NGF-potentiating activities from the twigs of Croton yanhuii.

Sun Y, Wang M, Ren Q, Li S, Xu J, Ohizumi Y, Xie C, Jin DQ, Guo Y.

Fitoterapia. 2014 Jun;95:229-33. doi: 10.1016/j.fitote.2014.03.012. Epub 2014 Mar 29.

PMID:
24685507
43.

Diterpenes inhibiting NO production from Euphorbia helioscopia.

Chen H, Wang H, Yang B, Jin DQ, Yang S, Wang M, Xu J, Ohizumi Y, Guo Y.

Fitoterapia. 2014 Jun;95:133-8. doi: 10.1016/j.fitote.2014.03.010. Epub 2014 Mar 16.

PMID:
24641945
44.

Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats.

Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N.

Brain Res. 2014 Apr 22;1559:46-54. doi: 10.1016/j.brainres.2014.02.007. Epub 2014 Feb 15.

PMID:
24534366
45.

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice.

Yabuki Y, Ohizumi Y, Yokosuka A, Mimaki Y, Fukunaga K.

Neuroscience. 2014 Feb 14;259:126-41. doi: 10.1016/j.neuroscience.2013.11.051. Epub 2013 Dec 4.

PMID:
24316474
46.

6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.

Kimura J, Nemoto K, Yokosuka A, Mimaki Y, Degawa M, Ohizumi Y.

Biol Pharm Bull. 2013;36(10):1646-9. Epub 2013 Aug 9.

47.

Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.

Ikeda A, Nemoto K, Yoshida C, Miyata S, Mori J, Soejima S, Yokosuka A, Mimaki Y, Ohizumi Y, Degawa M.

Neurosci Lett. 2013 Aug 9;549:135-9. doi: 10.1016/j.neulet.2013.06.004. Epub 2013 Jun 14.

PMID:
23774476
48.

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.

Nakajima A, Aoyama Y, Nguyen TT, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y, Yamada K.

Behav Brain Res. 2013 Aug 1;250:351-60. doi: 10.1016/j.bbr.2013.05.025. Epub 2013 May 25.

PMID:
23714077
49.

Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.

Nemoto K, Ikeda A, Yoshida C, Kimura J, Mori J, Fujiwara H, Yokosuka A, Mimaki Y, Ohizumi Y, Degawa M.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):530-4. doi: 10.1016/j.bbrc.2013.01.024. Epub 2013 Jan 12.

PMID:
23321314
50.

Four new myrsinol diterpenes from Euphorbia prolifera.

Xu J, Yang B, Fang L, Wang S, Guo Y, Yamakuni T, Ohizumi Y.

J Nat Med. 2013 Apr;67(2):333-8. doi: 10.1007/s11418-012-0688-1. Epub 2012 Jul 31.

PMID:
22847378

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