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Items: 35

1.

TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells.

Khanom US, Ohigashi I, Fujimori S, Kondo K, Takada K, Takahama Y.

J Immunol. 2019 Aug 15;203(4):881-887. doi: 10.4049/jimmunol.1900097. Epub 2019 Jun 24.

2.

Thymus machinery for T-cell selection.

Kondo K, Ohigashi I, Takahama Y.

Int Immunol. 2019 Mar 5;31(3):119-125. doi: 10.1093/intimm/dxy081.

PMID:
30476234
3.

A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node.

Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, Rahman MA, Kawamura T, Shichida Y, Umemoto E, Miyasaka M, Ludewig B, Takahama Y, Nagasawa T, Katakai T.

Front Immunol. 2018 Oct 2;9:2196. doi: 10.3389/fimmu.2018.02196. eCollection 2018.

4.

Thymoproteasome and peptidic self.

Takahama Y, Ohigashi I, Murata S, Tanaka K.

Immunogenetics. 2019 Mar;71(3):217-221. doi: 10.1007/s00251-018-1081-3. Epub 2018 Oct 15. Review.

PMID:
30324237
5.

Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7+ Progenitors to the Thymus.

Cosway EJ, Ohigashi I, Schauble K, Parnell SM, Jenkinson WE, Luther S, Takahama Y, Anderson G.

J Immunol. 2018 Jul 15;201(2):516-523. doi: 10.4049/jimmunol.1800348. Epub 2018 May 21.

6.

Cellularity of Thymic Epithelial Cells in the Postnatal Mouse.

Sakata M, Ohigashi I, Takahama Y.

J Immunol. 2018 Feb 15;200(4):1382-1388. doi: 10.4049/jimmunol.1701235. Epub 2018 Jan 3.

7.

Essential role of CCL21 in establishment of central self-tolerance in T cells.

Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.

J Exp Med. 2017 Jul 3;214(7):1925-1935. doi: 10.1084/jem.20161864. Epub 2017 Jun 13.

8.

A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.

Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.

JCI Insight. 2017 May 18;2(10). pii: 93664. doi: 10.1172/jci.insight.93664. eCollection 2017 May 18.

9.

Generation of diversity in thymic epithelial cells.

Takahama Y, Ohigashi I, Baik S, Anderson G.

Nat Rev Immunol. 2017 May;17(5):295-305. doi: 10.1038/nri.2017.12. Epub 2017 Mar 20. Review.

PMID:
28317923
10.

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus.

Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y.

Nat Commun. 2017 Feb 8;8:14419. doi: 10.1038/ncomms14419.

11.

Development and developmental potential of cortical thymic epithelial cells.

Ohigashi I, Kozai M, Takahama Y.

Immunol Rev. 2016 May;271(1):10-22. doi: 10.1111/imr.12404. Review.

PMID:
27088904
12.

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.

Mayer CE, Žuklys S, Zhanybekova S, Ohigashi I, Teh HY, Sansom SN, Shikama-Dorn N, Hafen K, Macaulay IC, Deadman ME, Ponting CP, Takahama Y, Holländer GA.

Eur J Immunol. 2016 Apr;46(4):846-56. doi: 10.1002/eji.201545995. Epub 2016 Jan 18.

13.

Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors.

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.

Cell Rep. 2015 Nov 17;13(7):1432-1443. doi: 10.1016/j.celrep.2015.10.012. Epub 2015 Nov 5.

14.

Flow Cytometry Analysis of Thymic Epithelial Cells and Their Subpopulations.

Ohigashi I, Takahama Y.

Methods Mol Biol. 2016;1323:65-73. doi: 10.1007/978-1-4939-2809-5_5.

PMID:
26294398
15.

CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.

Ohigashi I, Takahama Y.

Eur J Immunol. 2014 Oct;44(10):2872-5. doi: 10.1002/eji.201445091.

16.

Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia.

Matsui N, Ohigashi I, Tanaka K, Sakata M, Furukawa T, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R.

J Neuroimmunol. 2014 Apr 15;269(1-2):56-61. doi: 10.1016/j.jneuroim.2014.01.011. Epub 2014 Jan 28.

PMID:
24556356
17.

Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.

J Immunol. 2014 Jan 15;192(2):630-40. doi: 10.4049/jimmunol.1302550. Epub 2013 Dec 13.

18.

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21107-12. doi: 10.1073/pnas.1314859111. Epub 2013 Dec 9.

19.

Serial progression of cortical and medullary thymic epithelial microenvironments.

Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE.

Eur J Immunol. 2014 Jan;44(1):16-22. doi: 10.1002/eji.201344110. Epub 2013 Dec 4. Review. Erratum in: Eur J Immunol. 2014 Jul;44(7):2197.

20.

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Holländer GA, Takahama Y.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9885-90. doi: 10.1073/pnas.1301799110. Epub 2013 May 29.

21.

Development and function of cortical thymic epithelial cells.

Takada K, Ohigashi I, Kasai M, Nakase H, Takahama Y.

Curr Top Microbiol Immunol. 2014;373:1-17. doi: 10.1007/82_2013_322. Review.

PMID:
23612989
22.

Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.

Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y.

J Immunol. 2013 May 15;190(10):5110-7. doi: 10.4049/jimmunol.1203203. Epub 2013 Apr 12.

23.

Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes.

Nakagawa Y, Ohigashi I, Nitta T, Sakata M, Tanaka K, Murata S, Kanagawa O, Takahama Y.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20572-7. doi: 10.1073/pnas.1213069109. Epub 2012 Nov 27.

24.

The development of T lymphocytes in fetal thymus organ culture.

Nitta T, Ohigashi I, Takahama Y.

Methods Mol Biol. 2013;946:85-102. doi: 10.1007/978-1-62703-128-8_6.

PMID:
23179827
25.

Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.

Roberts NA, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger JM, Simon AK, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G.

Immunity. 2012 Mar 23;36(3):427-37. doi: 10.1016/j.immuni.2012.01.016. Epub 2012 Mar 15.

26.

Effects of RANKL on the thymic medulla.

Ohigashi I, Nitta T, Lkhagvasuren E, Yasuda H, Takahama Y.

Eur J Immunol. 2011 Jul;41(7):1822-7. doi: 10.1002/eji.201141480.

27.

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.

Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bösl MR, Holländer GA, Hayashi Y, Malefyt Rde W, Nitta T, Takahama Y.

J Exp Med. 2011 Feb 14;208(2):383-94. doi: 10.1084/jem.20102327. Epub 2011 Feb 7.

28.

Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.

Ohigashi I, Yamasaki Y, Hirashima T, Takahama Y.

PLoS One. 2010 Dec 22;5(12):e14391. doi: 10.1371/journal.pone.0014391.

29.

Cytokine crosstalk for thymic medulla formation.

Nitta T, Ohigashi I, Nakagawa Y, Takahama Y.

Curr Opin Immunol. 2011 Apr;23(2):190-7. doi: 10.1016/j.coi.2010.12.002. Epub 2010 Dec 30. Review.

PMID:
21194915
30.

Undiminished regulatory T cells in the thymus of patients with myasthenia gravis.

Matsui N, Nakane S, Saito F, Ohigashi I, Nakagawa Y, Kurobe H, Takizawa H, Mitsui T, Kondo K, Kitagawa T, Takahama Y, Kaji R.

Neurology. 2010 Mar 9;74(10):816-20. doi: 10.1212/WNL.0b013e3181d31e47.

PMID:
20211905
31.

Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.

Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y.

Blood. 2009 Mar 26;113(13):2976-87. doi: 10.1182/blood-2008-06-164921. Epub 2009 Jan 22.

32.

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.

Immunity. 2008 Sep 19;29(3):438-50. doi: 10.1016/j.immuni.2008.06.018.

33.

IAN family critically regulates survival and development of T lymphocytes.

Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y.

PLoS Biol. 2006 Apr;4(4):e103. Epub 2006 Mar 7.

34.

CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.

Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M, Boyd RL, Takahama Y.

Immunity. 2006 Feb;24(2):165-77.

35.

Differentiation phenotypes of pancreatic islet beta- and alpha-cells are closely related with homeotic genes and a group of differentially expressed genes.

Mizusawa N, Hasegawa T, Ohigashi I, Tanaka-Kosugi C, Harada N, Itakura M, Yoshimoto K.

Gene. 2004 Apr 28;331:53-63.

PMID:
15094191

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