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Microtubule minus-end stability is dictated by the tubulin off-rate.

Strothman C, Farmer V, Arpağ G, Rodgers N, Podolski M, Norris S, Ohi R, Zanic M.

J Cell Biol. 2019 Sep 2;218(9):2841-2853. doi: 10.1083/jcb.201905019. Epub 2019 Aug 16.


Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.

Lessard DV, Zinder OJ, Hotta T, Verhey KJ, Ohi R, Berger CL.

J Biol Chem. 2019 Apr 19;294(16):6353-6363. doi: 10.1074/jbc.RA118.005765. Epub 2019 Feb 15.


Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase.

Fonseca CL, Malaby HLH, Sepaniac LA, Martin W, Byers C, Czechanski A, Messinger D, Tang M, Ohi R, Reinholdt LG, Stumpff J.

J Cell Biol. 2019 Apr 1;218(4):1148-1163. doi: 10.1083/jcb.201807228. Epub 2019 Feb 7.


Kinesin-binding protein ensures accurate chromosome segregation by buffering KIF18A and KIF15.

Malaby HLH, Dumas ME, Ohi R, Stumpff J.

J Cell Biol. 2019 Apr 1;218(4):1218-1234. doi: 10.1083/jcb.201806195. Epub 2019 Feb 1.


Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes.

Dumas ME, Chen GY, Kendrick ND, Xu G, Larsen SD, Jana S, Waterson AG, Bauer JA, Hancock W, Sulikowski GA, Ohi R.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):148-154. doi: 10.1016/j.bmcl.2018.12.008. Epub 2018 Dec 4.


Promoting Diversity in the Cytoskeleton through STEM-Structural Transitions and Energetics of Microtubule Subunits.

Ohi R, Verhey KJ.

Dev Cell. 2018 Oct 22;47(2):137-139. doi: 10.1016/j.devcel.2018.10.008.


Processive Kinesin-14 HSET Exhibits Directional Flexibility Depending on Motor Traffic.

Reinemann DN, Norris SR, Ohi R, Lang MJ.

Curr Biol. 2018 Jul 23;28(14):2356-2362.e5. doi: 10.1016/j.cub.2018.06.055. Epub 2018 Jul 12.


Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters.

Norris SR, Jung S, Singh P, Strothman CE, Erwin AL, Ohi MD, Zanic M, Ohi R.

Nat Commun. 2018 Jul 9;9(1):2659. doi: 10.1038/s41467-018-04991-2.


SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.

Chiang YC, Park IY, Terzo EA, Tripathi DN, Mason FM, Fahey CC, Karki M, Shuster CB, Sohn BH, Chowdhury P, Powell RT, Ohi R, Tsai YS, de Cubas AA, Khan A, Davis IJ, Strahl BD, Parker JS, Dere R, Walker CL, Rathmell WK.

Cancer Res. 2018 Jun 15;78(12):3135-3146. doi: 10.1158/0008-5472.CAN-17-3460. Epub 2018 May 3.


Two mechanisms coordinate the recruitment of the chromosomal passenger complex to the plane of cell division.

Landino J, Norris SR, Li M, Ballister ER, Lampson MA, Ohi R.

Mol Biol Cell. 2017 Dec 1;28(25):3634-3646. doi: 10.1091/mbc.E17-06-0399. Epub 2017 Sep 27.


Collective Force Regulation in Anti-parallel Microtubule Gliding by Dimeric Kif15 Kinesin Motors.

Reinemann DN, Sturgill EG, Das DK, Degen MS, Vörös Z, Hwang W, Ohi R, Lang MJ.

Curr Biol. 2017 Sep 25;27(18):2810-2820.e6. doi: 10.1016/j.cub.2017.08.018. Epub 2017 Sep 14.


Cell Division: Centrosomes Have Separation Anxiety.

Norris SR, Ohi R.

Curr Biol. 2017 Jun 19;27(12):R601-R603. doi: 10.1016/j.cub.2017.04.050.


Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.

Chen GY, Kang YJ, Gayek AS, Youyen W, Tüzel E, Ohi R, Hancock WO.

ACS Chem Biol. 2017 Apr 21;12(4):1038-1046. doi: 10.1021/acschembio.6b01040. Epub 2017 Feb 22.


Resistance is not futile: Surviving Eg5 inhibition.

Dumas ME, Sturgill EG, Ohi R.

Cell Cycle. 2016 Nov;15(21):2845-2847. Epub 2016 Jun 29. No abstract available.


CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis.

Gayek AS, Ohi R.

PLoS One. 2016 Jun 9;11(6):e0157491. doi: 10.1371/journal.pone.0157491. eCollection 2016.


Loss of CENP-F results in distinct microtubule-related defects without chromosomal abnormalities.

Pfaltzgraff ER, Roth GM, Miller PM, Gintzig AG, Ohi R, Bader DM.

Mol Biol Cell. 2016 Jul 1;27(13):1990-9. doi: 10.1091/mbc.E15-12-0848. Epub 2016 May 4.


Kinesin-5 inhibitor resistance is driven by kinesin-12.

Sturgill EG, Norris SR, Guo Y, Ohi R.

J Cell Biol. 2016 Apr 25;213(2):213-27. doi: 10.1083/jcb.201507036. Epub 2016 Apr 18.


Ahead of the Curve: New Insights into Microtubule Dynamics.

Ohi R, Zanic M.

F1000Res. 2016 Mar 10;5. pii: F1000 Faculty Rev-314. doi: 10.12688/f1000research.7439.1. eCollection 2016. Review.


Expansion and concatenation of non-muscle myosin IIA filaments drive cellular contractile system formation during interphase and mitosis.

Fenix AM, Taneja N, Buttler CA, Lewis J, Van Engelenburg SB, Ohi R, Burnette DT.

Mol Biol Cell. 2016 Mar 9. pii: mbc.E15-10-0725. [Epub ahead of print]


The Timing of Midzone Stabilization during Cytokinesis Depends on Myosin II Activity and an Interaction between INCENP and Actin.

Landino J, Ohi R.

Curr Biol. 2016 Mar 7;26(5):698-706. doi: 10.1016/j.cub.2016.01.018. Epub 2016 Feb 18.


Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.

Shin Y, Du Y, Collier SE, Ohi MD, Lang MJ, Ohi R.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3826-35. doi: 10.1073/pnas.1500272112. Epub 2015 Jul 6.


Fanning the flames of CIN.

Gayek AS, Ohi R.

Cell Cycle. 2015;14(16):2560. doi: 10.1080/15384101.2015.1018053. No abstract available.


Kinesin-12 Kif15 targets kinetochore fibers through an intrinsic two-step mechanism.

Sturgill EG, Das DK, Takizawa Y, Shin Y, Collier SE, Ohi MD, Hwang W, Lang MJ, Ohi R.

Curr Biol. 2014 Oct 6;24(19):2307-13. doi: 10.1016/j.cub.2014.08.022. Epub 2014 Sep 25.


Structural and functional insights into the N-terminus of Schizosaccharomyces pombe Cdc5.

Collier SE, Voehler M, Peng D, Ohi R, Gould KL, Reiter NJ, Ohi MD.

Biochemistry. 2014 Oct 21;53(41):6439-51. doi: 10.1021/bi5008639. Epub 2014 Oct 8.


Kinetochore-microtubule stability governs the metaphase requirement for Eg5.

Gayek AS, Ohi R.

Mol Biol Cell. 2014 Jul 1;25(13):2051-60. doi: 10.1091/mbc.E14-03-0785. Epub 2014 May 7.


Microtubule-regulating kinesins.

Sturgill EG, Ohi R.

Curr Biol. 2013 Nov 4;23(21):R946-8. doi: 10.1016/j.cub.2013.08.012. No abstract available.


Microtubule-depolymerizing kinesins.

Walczak CE, Gayek S, Ohi R.

Annu Rev Cell Dev Biol. 2013;29:417-41. doi: 10.1146/annurev-cellbio-101512-122345. Epub 2013 Jul 17. Review.


Kinesin-12 differentially affects spindle assembly depending on its microtubule substrate.

Sturgill EG, Ohi R.

Curr Biol. 2013 Jul 22;23(14):1280-90. doi: 10.1016/j.cub.2013.05.043. Epub 2013 Jun 20.


Move in for the kill: motile microtubule regulators.

Su X, Ohi R, Pellman D.

Trends Cell Biol. 2012 Nov;22(11):567-75. doi: 10.1016/j.tcb.2012.08.003. Epub 2012 Sep 6. Review.


Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation.

Chen JS, Lu LX, Ohi MD, Creamer KM, English C, Partridge JF, Ohi R, Gould KL.

J Cell Biol. 2011 Nov 14;195(4):583-93. doi: 10.1083/jcb.201105074. Epub 2011 Nov 7.


A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

Stumpff J, Du Y, English CA, Maliga Z, Wagenbach M, Asbury CL, Wordeman L, Ohi R.

Mol Cell. 2011 Sep 2;43(5):764-75. doi: 10.1016/j.molcel.2011.07.022.


The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly.

Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW.

J Biol Chem. 2011 Sep 30;286(39):33992-8. doi: 10.1074/jbc.M111.258426. Epub 2011 Aug 13.


Kip3-ing kinetochores clustered.

Ohi R.

Cell Cycle. 2010 Jul 1;9(13):2497. No abstract available.


The kinesin-8 Kif18A dampens microtubule plus-end dynamics.

Du Y, English CA, Ohi R.

Curr Biol. 2010 Feb 23;20(4):374-80. doi: 10.1016/j.cub.2009.12.049. Epub 2010 Feb 11.


Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules.

Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T.

Mol Biol Cell. 2010 Jan 15;21(2):323-33. doi: 10.1091/mbc.E09-09-0816. Epub 2009 Nov 25.


Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity.

Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED.

Curr Biol. 2009 Jul 28;19(14):1210-5. doi: 10.1016/j.cub.2009.05.061. Epub 2009 Jun 18.


Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.

Germane KL, Ohi R, Goldberg MB, Spiller BW.

Biochemistry. 2008 Sep 30;47(39):10241-3. doi: 10.1021/bi801533k. Epub 2008 Sep 3.


Prenatal diagnosis and management of congenital subglottic stenosis associated with congenital esophageal atresia type C.

Sato T, Nio M, Tanaka H, Ohi R.

Eur J Pediatr Surg. 2008 Apr;18(2):131-3. doi: 10.1055/s-2007-965768.


Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites.

Efimov A, Schiefermeier N, Grigoriev I, Ohi R, Brown MC, Turner CE, Small JV, Kaverina I.

J Cell Sci. 2008 Jan 15;121(Pt 2):196-204. doi: 10.1242/jcs.012666. Erratum in: J Cell Sci. 2008 Feb 1;121(Pt 3):405. Ohi, Ryoma [added].


Problems during and after pregnancy in female patients with biliary atresia.

Sasaki H, Nio M, Hayashi Y, Ishii T, Sano N, Ohi R.

J Pediatr Surg. 2007 Aug;42(8):1329-32.


Nonredundant functions of Kinesin-13s during meiotic spindle assembly.

Ohi R, Burbank K, Liu Q, Mitchison TJ.

Curr Biol. 2007 Jun 5;17(11):953-9. Epub 2007 May 17.


Long-term outcome in type I biliary atresia.

Nio M, Sano N, Ishii T, Sasaki H, Hayashi Y, Ohi R.

J Pediatr Surg. 2006 Dec;41(12):1973-5.


Reconstruction of the proximal half of the radius using vascularized fibula: significance of soft-tissue reconstruction.

Ihara K, Shigetomi M, Muramatsu K, Goto Y, Ohi R, Kawai S.

J Shoulder Elbow Surg. 2006 Jan-Feb;15(1):124-6. No abstract available.


Concentrations of copper and zinc in liver and serum samples in biliary atresia patients at different stages of traditional surgeries.

Sato C, Koyama H, Satoh H, Hayashi Y, Chiba T, Ohi R.

Tohoku J Exp Med. 2005 Dec;207(4):271-7.


Primary tracheal schwannoma (neurilemoma) in a 9-year-old girl.

Nio M, Sano N, Kotera A, Shimanuki Y, Takeyama J, Ohi R.

J Pediatr Surg. 2005 Apr;40(4):E5-7.


Postoperative corticosteroid therapy for bile drainage in biliary atresia--a nationwide survey.

Muraji T, Nio M, Ohhama Y, Hashimoto T, Iwanaka T, Takamatsu H, Ohnuma N, Kato T, Ohi R; Japanese Biliary Atresia Society.

J Pediatr Surg. 2004 Dec;39(12):1803-5.


Cholangitis as a late complication in long-term survivors after surgery for biliary atresia.

Nio M, Sano N, Ishii T, Sasaki H, Hayashi Y, Ohi R.

J Pediatr Surg. 2004 Dec;39(12):1797-9.


XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly.

Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R.

Curr Biol. 2004 Oct 26;14(20):1801-11.


Bipolarization and poleward flux correlate during Xenopus extract spindle assembly.

Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM.

Mol Biol Cell. 2004 Dec;15(12):5603-15. Epub 2004 Sep 22.

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