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Items: 47


Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.

Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE Jr.

Immunity. 2018 Aug 21;49(2):363-374.e10. doi: 10.1016/j.immuni.2018.06.018. Epub 2018 Jul 17.


Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters.

Norris SR, Jung S, Singh P, Strothman CE, Erwin AL, Ohi MD, Zanic M, Ohi R.

Nat Commun. 2018 Jul 9;9(1):2659. doi: 10.1038/s41467-018-04991-2.


Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA.

Raghunathan K, Foegeding NJ, Campbell AM, Cover TL, Ohi MD, Kenworthy AK.

Infect Immun. 2018 Apr 23;86(5). pii: e00872-17. doi: 10.1128/IAI.00872-17. Print 2018 May.


Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.

Mousa JJ, Binshtein E, Human S, Fong RH, Alvarado G, Doranz BJ, Moore ML, Ohi MD, Crowe JE Jr.

PLoS Pathog. 2018 Feb 22;14(2):e1006837. doi: 10.1371/journal.ppat.1006837. eCollection 2018 Feb.


Structural basis of arrestin-3 activation and signaling.

Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM.

Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8.


Structural and functional analyses of the spliceosome requires a multi-disciplinary approach.

Ohi MD.

Methods. 2017 Aug 1;125:1-2. doi: 10.1016/j.ymeth.2017.07.022. No abstract available.


Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.

J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.


Peripheral myelin protein 22 alters membrane architecture.

Mittendorf KF, Marinko JT, Hampton CM, Ke Z, Hadziselimovic A, Schlebach JP, Law CL, Li J, Wright ER, Sanders CR, Ohi MD.

Sci Adv. 2017 Jul 5;3(7):e1700220. doi: 10.1126/sciadv.1700220. eCollection 2017 Jul.


Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, Fischer P, Sher X, Gupta P, Lacy DB, Therien AG.

J Mol Biol. 2017 Apr 7;429(7):1030-1044. doi: 10.1016/j.jmb.2017.02.010. Epub 2017 Feb 21.


Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.

Mousa JJ, Sauer MF, Sevy AM, Finn JA, Bates JT, Alvarado G, King HG, Loerinc LB, Fong RH, Doranz BJ, Correia BE, Kalyuzhniy O, Wen X, Jardetzky TS, Schief WR, Ohi MD, Meiler J, Crowe JE Jr.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6849-E6858. Epub 2016 Oct 17.


While the revolution will not be crystallized, biochemistry reigns supreme.

Takizawa Y, Binshtein E, Erwin AL, Pyburn TM, Mittendorf KF, Ohi MD.

Protein Sci. 2017 Jan;26(1):69-81. doi: 10.1002/pro.3054. Epub 2016 Oct 6. Review.


A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain.

González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL.

Infect Immun. 2016 Aug 19;84(9):2662-70. doi: 10.1128/IAI.00254-16. Print 2016 Sep.


Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin.

Pyburn TM, Foegeding NJ, González-Rivera C, McDonald NA, Gould KL, Cover TL, Ohi MD.

Mol Microbiol. 2016 Oct;102(1):22-36. doi: 10.1111/mmi.13443. Epub 2016 Jul 8.


An Overview of Helicobacter pylori VacA Toxin Biology.

Foegeding NJ, Caston RR, McClain MS, Ohi MD, Cover TL.

Toxins (Basel). 2016 Jun 3;8(6). pii: E173. doi: 10.3390/toxins8060173. Review.


The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis.

McDonald NA, Takizawa Y, Feoktistova A, Xu P, Ohi MD, Vander Kooi CW, Gould KL.

Cell Rep. 2016 Jan 26;14(3):534-546. doi: 10.1016/j.celrep.2015.12.062. Epub 2016 Jan 14.


Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex.

Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL.

MBio. 2016 Jan 12;7(1):e02001-15. doi: 10.1128/mBio.02001-15.


Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.

McDonald NA, Vander Kooi CW, Ohi MD, Gould KL.

Dev Cell. 2015 Dec 21;35(6):725-36. doi: 10.1016/j.devcel.2015.11.023.


Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.

Shin Y, Du Y, Collier SE, Ohi MD, Lang MJ, Ohi R.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3826-35. doi: 10.1073/pnas.1500272112. Epub 2015 Jul 6.


Cryo-electron microscopy and the amazing race to atomic resolution.

Binshtein E, Ohi MD.

Biochemistry. 2015 May 26;54(20):3133-41. doi: 10.1021/acs.biochem.5b00114. Epub 2015 May 14. Review.


Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements.

Gao M, Thomson TC, Creed TM, Tu S, Loganathan SN, Jackson CA, McCluskey P, Lin Y, Collier SE, Weng Z, Lasko P, Ohi MD, Arkov AL.

EMBO Rep. 2015 Mar;16(3):379-86. doi: 10.15252/embr.201439694. Epub 2015 Jan 18.


Kinesin-12 Kif15 targets kinetochore fibers through an intrinsic two-step mechanism.

Sturgill EG, Das DK, Takizawa Y, Shin Y, Collier SE, Ohi MD, Hwang W, Lang MJ, Ohi R.

Curr Biol. 2014 Oct 6;24(19):2307-13. doi: 10.1016/j.cub.2014.08.022. Epub 2014 Sep 25.


Structural and functional insights into the N-terminus of Schizosaccharomyces pombe Cdc5.

Collier SE, Voehler M, Peng D, Ohi R, Gould KL, Reiter NJ, Ohi MD.

Biochemistry. 2014 Oct 21;53(41):6439-51. doi: 10.1021/bi5008639. Epub 2014 Oct 8.


Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease.

Folkmann AW, Collier SE, Zhan X, Aditi, Ohi MD, Wente SR.

Cell. 2013 Oct 24;155(3):582-93. doi: 10.1016/j.cell.2013.09.023. Epub 2013 Oct 24.


Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Livesay SB, Collier SE, Bitton DA, Bähler J, Ohi MD.

Eukaryot Cell. 2013 Nov;12(11):1472-89. doi: 10.1128/EC.00140-13. Epub 2013 Sep 6.


Molecular assembly of botulinum neurotoxin progenitor complexes.

Benefield DA, Dessain SK, Shine N, Ohi MD, Lacy DB.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5630-5. doi: 10.1073/pnas.1222139110. Epub 2013 Mar 18.


Nature of KaiB-KaiC binding in the cyanobacterial circadian oscillator.

Pattanayek R, Yadagiri KK, Ohi MD, Egli M.

Cell Cycle. 2013 Mar 1;12(5):810-7. doi: 10.4161/cc.23757. Epub 2013 Feb 6.


Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin.

Chambers MG, Pyburn TM, González-Rivera C, Collier SE, Eli I, Yip CK, Takizawa Y, Lacy DB, Cover TL, Ohi MD.

J Mol Biol. 2013 Feb 8;425(3):524-35. doi: 10.1016/j.jmb.2012.11.020. Epub 2012 Nov 20.


The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins.

Cox RG, Livesay SB, Johnson M, Ohi MD, Williams JV.

J Virol. 2012 Nov;86(22):12148-60. doi: 10.1128/JVI.01133-12. Epub 2012 Aug 29.


Tailoring of membrane proteins by alternative splicing of pre-mRNA.

Mittendorf KF, Deatherage CL, Ohi MD, Sanders CR.

Biochemistry. 2012 Jul 17;51(28):5541-56. Epub 2012 Jun 29. Review.


Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function.

Johnson AE, Collier SE, Ohi MD, Gould KL.

J Biol Chem. 2012 Jul 27;287(31):25741-8. doi: 10.1074/jbc.M112.349712. Epub 2012 Jun 5.


Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation.

Chen JS, Lu LX, Ohi MD, Creamer KM, English C, Partridge JF, Ohi R, Gould KL.

J Cell Biol. 2011 Nov 14;195(4):583-93. doi: 10.1083/jcb.201105074. Epub 2011 Nov 7.


The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly.

Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW.

J Biol Chem. 2011 Sep 30;286(39):33992-8. doi: 10.1074/jbc.M111.258426. Epub 2011 Aug 13.


Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Ren L, McLean JR, Hazbun TR, Fields S, Vander Kooi C, Ohi MD, Gould KL.

PLoS One. 2011 Feb 28;6(2):e16719. doi: 10.1371/journal.pone.0016719. Erratum in: PLoS One. 2011;6(9). doi: 10.1371/annotation/62e74a1c-c922-495b-9aaf-eebfe6b85ff5.


State of the APC/C: organization, function, and structure.

McLean JR, Chaix D, Ohi MD, Gould KL.

Crit Rev Biochem Mol Biol. 2011 Apr;46(2):118-36. doi: 10.3109/10409238.2010.541420. Epub 2011 Jan 24. Review.


Structural organization of the functional domains of Clostridium difficile toxins A and B.

Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13467-72. doi: 10.1073/pnas.1002199107. Epub 2010 Jul 12.


Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH, Ohi MD, Ballif BA, Chen JS, McLeod I, McDonald WH, Gygi SP, Yates JR 3rd, Gould KL.

Mol Cell. 2010 Jul 9;39(1):86-99. doi: 10.1016/j.molcel.2010.06.012.


Reconstitution of Helicobacter pylori VacA toxin from purified components.

González-Rivera C, Gangwer KA, McClain MS, Eli IM, Chambers MG, Ohi MD, Lacy DB, Cover TL.

Biochemistry. 2010 Jul 13;49(27):5743-52. doi: 10.1021/bi100618g.


The Prp19 WD40 domain contains a conserved protein interaction region essential for its function.

Vander Kooi CW, Ren L, Xu P, Ohi MD, Gould KL, Chazin WJ.

Structure. 2010 May 12;18(5):584-93. doi: 10.1016/j.str.2010.02.015.


Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.

Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T.

Mol Cell. 2007 Dec 14;28(5):871-85.


Structural characterization of the fission yeast U5.U2/U6 spliceosome complex.

Ohi MD, Ren L, Wall JS, Gould KL, Walz T.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3195-200. Epub 2007 Feb 20.


Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.

Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA.

Nature. 2007 Jan 25;445(7126):394-8. Epub 2007 Jan 14.


The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases.

Vander Kooi CW, Ohi MD, Rosenberg JA, Oldham ML, Newcomer ME, Gould KL, Chazin WJ.

Biochemistry. 2006 Jan 10;45(1):121-30.


Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.

Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D.

Curr Biol. 2004 Dec 29;14(24):2283-8. Erratum in: Curr Biol. 2006 Dec 19;16(24):2488.


Structural and functional analysis of essential pre-mRNA splicing factor Prp19p.

Ohi MD, Vander Kooi CW, Rosenberg JA, Ren L, Hirsch JP, Chazin WJ, Walz T, Gould KL.

Mol Cell Biol. 2005 Jan;25(1):451-60.


Structural insights into the U-box, a domain associated with multi-ubiquitination.

Ohi MD, Vander Kooi CW, Rosenberg JA, Chazin WJ, Gould KL.

Nat Struct Biol. 2003 Apr;10(4):250-5.


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