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Items: 1 to 50 of 218

1.

Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice.

Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

Biol Pharm Bull. 2019;42(11):1921-1925. doi: 10.1248/bpb.b19-00546.

2.

Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.

Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun. 2019 Nov 12;519(3):613-619. doi: 10.1016/j.bbrc.2019.09.021. Epub 2019 Sep 17.

PMID:
31540689
3.

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.

Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M.

Br J Pharmacol. 2019 Sep;176(18):3723-3738. doi: 10.1111/bph.14777. Epub 2019 Aug 6.

PMID:
31241172
4.

Chronopharmacological strategies focused on chrono-drug discovery.

Ohdo S, Koyanagi S, Matsunaga N.

Pharmacol Ther. 2019 Oct;202:72-90. doi: 10.1016/j.pharmthera.2019.05.018. Epub 2019 Jun 5. Review.

PMID:
31173839
5.

Microcurrent stimulation activates the circadian machinery in mice.

Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun. 2019 May 28;513(2):293-299. doi: 10.1016/j.bbrc.2019.02.022. Epub 2019 Mar 31.

PMID:
30944082
6.

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.

Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.

Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14.

PMID:
30643284
7.

Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.

Katamune C, Koyanagi S, Hashikawa KI, Kusunose N, Akamine T, Matsunaga N, Ohdo S.

J Biol Chem. 2019 Jan 11;294(2):547-558. doi: 10.1074/jbc.RA118.004942. Epub 2018 Nov 14.

PMID:
30429219
8.

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells.

Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T.

Jpn J Ophthalmol. 2018 Nov;62(6):677-685. doi: 10.1007/s10384-018-0622-5. Epub 2018 Sep 24.

PMID:
30250985
9.

Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.

Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):1063-1069. doi: 10.1016/j.bbrc.2018.06.117. Epub 2018 Jun 30.

PMID:
29958886
10.

Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.

Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.

Sci Rep. 2018 Jun 13;8(1):9072. doi: 10.1038/s41598-018-27280-w.

11.

Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model.

Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun. 2018 Sep 3;503(1):181-187. doi: 10.1016/j.bbrc.2018.05.209. Epub 2018 Jun 8.

PMID:
29864425
12.

Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor.

Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.

Cancer Res. 2018 Jul 1;78(13):3698-3708. doi: 10.1158/0008-5472.CAN-17-4034. Epub 2018 May 7.

13.

Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.

Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

J Pharmacol Sci. 2018 Apr;136(4):228-233. doi: 10.1016/j.jphs.2018.01.008. Epub 2018 Mar 12.

14.

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice.

Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun. 2018 Mar 25;498(1):86-91. doi: 10.1016/j.bbrc.2017.11.162. Epub 2018 Feb 19.

PMID:
29470987
15.

Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.

Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S.

J Biol Chem. 2017 Dec 29;292(52):21397-21406. doi: 10.1074/jbc.M117.791285. Epub 2017 Nov 3.

16.

Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis.

Hashikawa KI, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.

Sci Rep. 2017 Aug 30;7(1):9995. doi: 10.1038/s41598-017-10599-1.

17.

Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.

Dilixiati A, Koyanagi S, Kusunose N, Matsunaga N, Ohdo S.

J Pharmacol Sci. 2017 Aug;134(4):211-217. doi: 10.1016/j.jphs.2017.07.004. Epub 2017 Aug 11.

18.

Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells.

Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Masuda S, Matsunaga N, Koyanagi S, Ohdo S.

Eur J Pharmacol. 2017 Apr 5;800:48-56. doi: 10.1016/j.ejphar.2017.02.025. Epub 2017 Feb 17.

19.

Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression.

Shibata T, Watari K, Izumi H, Kawahara A, Hattori S, Fukumitsu C, Murakami Y, Takahashi R, Toh U, Ito KI, Ohdo S, Tanaka M, Kage M, Kuwano M, Ono M.

Cancer Res. 2017 Jan 15;77(2):545-556. doi: 10.1158/0008-5472.CAN-16-1593. Epub 2016 Nov 22.

20.

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S.

EBioMedicine. 2016 Nov;13:262-273. doi: 10.1016/j.ebiom.2016.10.008. Epub 2016 Oct 6.

21.

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.

Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S.

Nat Commun. 2016 Oct 14;7:13102. doi: 10.1038/ncomms13102.

22.

Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study.

Elsayed M, Kobayashi D, Kubota T, Matsunaga N, Murata R, Yoshizawa Y, Watanabe N, Matsuura T, Tsurudome Y, Ogino T, Ohdo S, Shimazoe T.

Biol Pharm Bull. 2016 Aug 1;39(8):1238-46. doi: 10.1248/bpb.b15-00746. Epub 2016 May 14.

23.

Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation.

Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.

J Biol Chem. 2016 May 13;291(20):10541-50. doi: 10.1074/jbc.M115.706481. Epub 2016 Mar 9.

24.

Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.

Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S.

J Biol Chem. 2016 Mar 25;291(13):7017-28. doi: 10.1074/jbc.M115.713412. Epub 2016 Jan 21.

25.

Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.

Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.

J Biol Chem. 2016 Mar 4;291(10):4913-27. doi: 10.1074/jbc.M115.696930. Epub 2016 Jan 4.

26.

Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.

Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo S, Kubota T.

Biochem Biophys Res Commun. 2015 Nov 6;467(1):157-63. doi: 10.1016/j.bbrc.2015.09.086. Epub 2015 Sep 25.

PMID:
26403971
27.

Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice.

Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguchi M, Matsunaga N, Ohdo S.

J Pharmacol Exp Ther. 2015 Jul;354(1):65-72. doi: 10.1124/jpet.115.223891. Epub 2015 May 11.

PMID:
25962390
28.

Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys.

Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S.

Mol Pharmacol. 2015 Jul;88(1):29-37. doi: 10.1124/mol.114.096735. Epub 2015 Apr 21.

PMID:
25901027
29.

Statin inhibits the expression of secretory phospholipase A2 and subsequent monocyte chemoattractant protein-1 in human endothelial cells.

Sonoki K, Iwase M, Ohdo S, Ieiri I, Takata Y, Kitazono T.

J Cardiovasc Pharmacol. 2014 Dec;64(6):489-96. doi: 10.1097/FJC.0000000000000147.

PMID:
25490414
30.

Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.

Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.

Mol Pharmacol. 2015 Feb;87(2):314-22. doi: 10.1124/mol.114.094979. Epub 2014 Nov 24.

PMID:
25422143
31.

Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.

Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.

J Biol Chem. 2014 Sep 5;289(36):25296-305. doi: 10.1074/jbc.M114.577023. Epub 2014 Jul 11.

32.

Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.

Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.

Mol Pharmacol. 2014 May;85(5):715-22. doi: 10.1124/mol.113.089805. Epub 2014 Feb 24.

PMID:
24567546
33.

[Chrono-drug delivery system based on the circadian rhythm of transferrin receptor].

Matsunaga N, Okazaki F, Koyanagi S, Ohdo S.

Nihon Rinsho. 2013 Dec;71(12):2200-5. Review. Japanese.

PMID:
24437279
34.

24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks.

Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.

J Invest Dermatol. 2014 Jun;134(6):1636-1644. doi: 10.1038/jid.2014.13. Epub 2014 Jan 13.

35.

Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.

Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S.

Cancer Res. 2014 Jan 15;74(2):543-51. doi: 10.1158/0008-5472.CAN-12-3241. Epub 2013 Nov 19. Erratum in: Cancer Res. 2014 Mar 1;74(5):1621.

36.

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S.

Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H.

Sci Rep. 2013 Sep 25;3:2744. doi: 10.1038/srep02744.

37.

Two-dimensional high-performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes.

Karakawa S, Miyoshi Y, Konno R, Koyanagi S, Mita M, Ohdo S, Hamase K.

Anal Bioanal Chem. 2013 Oct;405(25):8083-91. doi: 10.1007/s00216-013-7071-2. Epub 2013 Jun 4.

PMID:
23732868
38.

Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells.

Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.

Cancer Res. 2013 Apr 15;73(8):2639-49. doi: 10.1158/0008-5472.CAN-12-2492. Epub 2013 Apr 11.

39.

Molecular mechanism regulating 24-hour rhythm of dopamine D3 receptor expression in mouse ventral striatum.

Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.

Mol Pharmacol. 2013 May;83(5):959-67. doi: 10.1124/mol.112.083535. Epub 2013 Feb 21.

PMID:
23429911
40.

Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.

Tomishima Y, Ishitsuka Y, Matsunaga N, Nagatome M, Furusho H, Irikura M, Ohdo S, Irie T.

BMC Gastroenterol. 2013 Jan 30;13:21. doi: 10.1186/1471-230X-13-21.

41.

Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.

Ogi S, Fujita H, Kashihara M, Yamamoto C, Sonoda K, Okamoto I, Nakagawa K, Ohdo S, Tanaka Y, Kuwano M, Ono M.

Cancer Sci. 2013 May;104(5):573-83. doi: 10.1111/cas.12117. Epub 2013 Mar 8.

42.

A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson's disease.

Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada K, Koyanagi S, Ohdo S.

Neuromolecular Med. 2013 Jun;15(2):238-51. doi: 10.1007/s12017-012-8214-x. Epub 2013 Jan 5.

PMID:
23292542
43.

The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.

Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.

Hum Immunol. 2013 Apr;74(4):433-8. doi: 10.1016/j.humimm.2012.11.060. Epub 2012 Dec 29.

44.

IL-6 receptor is a possible target against growth of metastasized lung tumor cells in the brain.

Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto N, Teramoto N, Fujita K, Ohdo S, Iguchi H.

Int J Mol Sci. 2012 Dec 27;14(1):515-26. doi: 10.3390/ijms14010515.

45.

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.

Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.

J Biol Chem. 2012 Oct 12;287(42):35669-77. doi: 10.1074/jbc.M112.357871. Epub 2012 Aug 10.

46.

Telmisartan and N-acetylcysteine suppress group V secretory phospholipase A2 expression in TNFα-stimulated human endothelial cells and reduce associated atherogenicity.

Sonoki K, Iwase M, Ohdo S, Ieiri I, Matsuyama N, Takata Y, Kitazono T.

J Cardiovasc Pharmacol. 2012 Oct;60(4):367-74. doi: 10.1097/FJC.0b013e3182646ccc.

PMID:
22743636
47.

Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.

Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S.

Mol Pharmacol. 2012 Aug;82(2):264-70. doi: 10.1124/mol.112.079079. Epub 2012 May 9.

PMID:
22572884
48.

Intestinal expression of mouse Abcg2/breast cancer resistance protein (BCRP) gene is under control of circadian clock-activating transcription factor-4 pathway.

Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S.

J Biol Chem. 2012 May 18;287(21):17224-31. doi: 10.1074/jbc.M111.333377. Epub 2012 Mar 6.

49.

Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells.

Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshiyama Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S.

Mol Pharmacol. 2012 May;81(5):739-47. doi: 10.1124/mol.111.076406. Epub 2012 Feb 21.

PMID:
22355045
50.

Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.

Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.

Cancer Res. 2012 Jan 15;72(2):395-401. doi: 10.1158/0008-5472.CAN-11-1891. Epub 2011 Nov 18.

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