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PLoS One. 2018 Feb 5;13(2):e0192032. doi: 10.1371/journal.pone.0192032. eCollection 2018.

Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study.

Author information

1
Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, United States of America.
2
Department of Chemical Engineering, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, United States of America.
3
Institute of Mechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria.
4
Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America.
5
Department of Mechanical Engineering, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, United States of America.

Abstract

An aortic aneurysm (AA) is a focal dilatation of the aortic wall. Occurrence of AA rupture is an all too common event that is associated with high levels of patient morbidity and mortality. The decision to surgically intervene prior to AA rupture is made with recognition of significant procedural risks, and is primarily based on the maximal diameter and/or growth rate of the AA. Despite established thresholds for intervention, rupture occurs in a notable subset of patients exhibiting sub-critical maximal diameters and/or growth rates. Therefore, a pressing need remains to identify better predictors of rupture risk and ultimately integrate their measurement into clinical decision making. In this study, we use a series of finite element-based computational models that represent a range of plausible AA scenarios, and evaluate the relative sensitivity of wall stress to geometrical and mechanical properties of the aneurysmal tissue. Taken together, our findings encourage an expansion of geometrical parameters considered for rupture risk assessment, and provide perspective on the degree to which tissue mechanical properties may modulate peak stress values within aneurysmal tissue.

PMID:
29401512
PMCID:
PMC5798825
DOI:
10.1371/journal.pone.0192032
[Indexed for MEDLINE]
Free PMC Article

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