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First international TNBC conference meeting report.

Rida P, Ogden A, Ellis IO, Varga Z, Wolff AC, Traina TA, Hatzis C, Palmer JR, Ambrosone CB, Lehmann BD, Nanda R, Montgomery Rice V, Brawley OW, Torres MA, Rakha E, Aneja R.

Breast Cancer Res Treat. 2018 Jun;169(3):407-412. doi: 10.1007/s10549-018-4692-3. Epub 2018 Feb 8. Review.


Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.

Helal CJ, Arnold E, Boyden T, Chang C, Chappie TA, Fisher E, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Pandit J, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, McGinnis D, O'Connor RE, O'Donnell CJ, Ogden A, Piotrowski M, Schmidt CJ, Seymour PA, Ueno H, Vansell N, Verhoest PR, Yang EX.

J Med Chem. 2018 Feb 8;61(3):1001-1018. doi: 10.1021/acs.jmedchem.7b01466. Epub 2018 Jan 16.


Phragmoplast microtubule dynamics - a game of zones.

Smertenko A, Hewitt SL, Jacques CN, Kacprzyk R, Liu Y, Marcec MJ, Moyo L, Ogden A, Oung HM, Schmidt S, Serrano-Romero EA.

J Cell Sci. 2018 Jan 29;131(2). pii: jcs203331. doi: 10.1242/jcs.203331. Review.


Commentary: Design and Testing of 2 Novel Scores that Predict Global Sagittal Alignment Utilizing Cervical or Lumbar Plain Radiographs.

Ogden AT.

Neurosurgery. 2018 Feb 1;82(2):172. doi: 10.1093/neuros/nyx180. No abstract available.


Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort.

Burris HA, Bakewell S, Bendell JC, Infante J, Jones SF, Spigel DR, Weiss GJ, Ramanathan RK, Ogden A, Von Hoff D.

ESMO Open. 2017 Feb 23;1(6):e000154. doi: 10.1136/esmoopen-2016-000154. eCollection 2016.


Subependymomas Are Low-Grade Heterogeneous Glial Neoplasms Defined by Subventricular Zone Lineage Markers.

D'Amico RS, Praver M, Zanazzi GJ, Englander ZK, Sims JS, Samanamud JL, Ogden AT, McCormick PC, Feldstein NA, McKhann GM 2nd, Sisti MB, Canoll P, Bruce JN.

World Neurosurg. 2017 Nov;107:451-463. doi: 10.1016/j.wneu.2017.08.009. Epub 2017 Aug 10.


Integrated analysis of zone-specific protein and metabolite profiles within nitrogen-fixing Medicago truncatula-Sinorhizobium medicae nodules.

Ogden AJ, Gargouri M, Park J, Gang DR, Kahn ML.

PLoS One. 2017 Jul 10;12(7):e0180894. doi: 10.1371/journal.pone.0180894. eCollection 2017.


Centrosome amplification: a suspect in breast cancer and racial disparities.

Ogden A, Rida PCG, Aneja R.

Endocr Relat Cancer. 2017 Sep;24(9):T47-T64. doi: 10.1530/ERC-17-0072. Epub 2017 May 17. Review.


Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors.

Ogden A, Rida PC, Aneja R.

Sci Rep. 2017 Mar 21;7(1):262. doi: 10.1038/s41598-017-00363-w.


Assessment of Paraspinal Muscle Cross-sectional Area After Lumbar Decompression: Minimally Invasive Versus Open Approaches.

Bresnahan LE, Smith JS, Ogden AT, Quinn S, Cybulski GR, Simonian N, Natarajan RN, Fessler RD, Fessler RG.

Clin Spine Surg. 2017 Apr;30(3):E162-E168. doi: 10.1097/BSD.0000000000000038.


Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells.

Mittal K, Choi DH, Ogden A, Donthamsetty S, Melton BD, Gupta MV, Pannu V, Cantuaria G, Varambally S, Reid MD, Jonsdottir K, Janssen EA, Aleskandarany MA, Ellis IO, Rakha EA, Rida PC, Aneja R.

Sci Rep. 2017 Mar 8;7:43984. doi: 10.1038/srep43984.


Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.

Ogden A, Garlapati C, Li XB, Turaga RC, Oprea-Ilies G, Wright N, Bhattarai S, Mittal K, Wetherilt CS, Krishnamurti U, Reid MD, Jones M, Gupta M, Osan R, Pattni S, Riaz A, Klimov S, Rao A, Cantuaria G, Rida PC, Aneja R.

Sci Rep. 2017 Feb 20;7:42289. doi: 10.1038/srep42289.


In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects.

Delnomdedieu M, Forsberg A, Ogden A, Fazio P, Yu CR, Stenkrona P, Duvvuri S, David W, Al-Tawil N, Vitolo OV, Amini N, Nag S, Halldin C, Varrone A.

Neuropharmacology. 2017 May 1;117:171-181. doi: 10.1016/j.neuropharm.2017.01.016. Epub 2017 Jan 22.


A multicentre study of the precision and accuracy of the TruSlice and TruSlice Digital histological dissection devices.

Orchard GE, Shams M, Nwokie T, Fernando P, Bulut C, Quaye CJ, Gabriel J, Ramji Z, Georgaki A, Watt M, Cole Z, Stewart K, McTaggart V, Padayachy S, Long AM, Ogden A, Andrews C, Birchall A, Shams F, Neesam H, Haine N.

Br J Biomed Sci. 2016 Oct;73(4):163-167.


The histamine skin prick test: An analysis of the method for use in clinical trials.

Brevard J, Elder MA, Berman G, Tan Y, Volfson D, Ogden A, Evans B, Bednar MM.

Ann Allergy Asthma Immunol. 2016 Oct;117(4):433-435. doi: 10.1016/j.anai.2016.07.026. Epub 2016 Aug 9. No abstract available.


Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription.

Kang J, Kusnadi EP, Ogden AJ, Hicks RJ, Bammert L, Kutay U, Hung S, Sanij E, Hannan RD, Hannan KM, Pearson RB.

Oncotarget. 2016 Aug 2;7(31):48887-48904. doi: 10.18632/oncotarget.10346.


Diverse roles of HDAC6 in viral infection: Implications for antiviral therapy.

Zhang L, Ogden A, Aneja R, Zhou J.

Pharmacol Ther. 2016 Aug;164:120-5. doi: 10.1016/j.pharmthera.2016.04.005. Epub 2016 Apr 23. Review.


First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430.

Naganawa M, Waterhouse RN, Nabulsi N, Lin SF, Labaree D, Ropchan J, Tarabar S, DeMartinis N, Ogden A, Banerjee A, Huang Y, Carson RE.

J Nucl Med. 2016 Sep;57(9):1388-95. doi: 10.2967/jnumed.115.166850. Epub 2016 Apr 21.


Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and PSD95.

Li B, Rex E, Wang H, Qian Y, Ogden AM, Bleakman D, Johnson KW.

Assay Drug Dev Technol. 2016 Mar;14(2):131-43. doi: 10.1089/adt.2015.689.


Case report: A medieval case of molar-incisor-hypomineralisation.

Curzon ME, Ogden AR, Williams-Ward M, Cleaton-Jones PE.

Br Dent J. 2015 Dec 18;219(12):583-7. doi: 10.1038/sj.bdj.2015.957.


Residual Hole Orientation After Plate Removal: Effect on the Clavicle.

James J, Ogden A, Mukherjee D, Jaeblon T.

Orthopedics. 2015 Nov;38(11):e1034-9. doi: 10.3928/01477447-20151020-13.


Microtubule-Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer Chemotherapy.

Xie S, Ogden A, Aneja R, Zhou J.

Med Res Rev. 2016 Mar;36(2):300-12. doi: 10.1002/med.21378. Epub 2015 Sep 1. Review.


Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum.

Wilson JM, Ogden AM, Loomis S, Gilmour G, Baucum AJ 2nd, Belecky-Adams TL, Merchant KM.

Neuropharmacology. 2015 Dec;99:379-86. doi: 10.1016/j.neuropharm.2015.08.008. Epub 2015 Aug 7.


Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse.

Ogden A, Rida PC, Knudsen BS, Kucuk O, Aneja R.

Cancer Lett. 2015 Oct 28;367(2):89-92. doi: 10.1016/j.canlet.2015.06.025. Epub 2015 Jul 13. Review.


The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.

Rida PC, LiVecche D, Ogden A, Zhou J, Aneja R.

Med Res Rev. 2015 Sep;35(5):1072-96. doi: 10.1002/med.21357. Epub 2015 Jul 14. Review.


Amplified centrosomes may underlie aggressive disease course in pancreatic ductal adenocarcinoma.

Mittal K, Ogden A, Reid MD, Rida PC, Varambally S, Aneja R.

Cell Cycle. 2015;14(17):2798-809. doi: 10.1080/15384101.2015.1068478.


Pediatric Supracondylar Fractures: Variation in Fracture Patterns and the Biomechanical Effects of Pin Configuration.

Jaeblon T, Anthony S, Ogden A, Andary JJ.

J Pediatr Orthop. 2016 Dec;36(8):787-792.


Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

Watzlawik JO, Kahoud RJ, O'Toole RJ, White KA, Ogden AR, Painter MM, Wootla B, Papke LM, Denic A, Weimer JM, Carey WA, Rodriguez M.

PLoS One. 2015 May 28;10(5):e0128007. doi: 10.1371/journal.pone.0128007. eCollection 2015.


Unique microenvironmental responses to PDGF stimulation in brain and spinal cord gliomas determine tumor phenotype.

Ellis JA, Castelli M, Assanah M, Bruce JN, Canoll P, Ogden AT.

J Neurooncol. 2015 May;123(1):27-33. doi: 10.1007/s11060-015-1769-2. Epub 2015 Apr 14.


HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients.

Pannu V, Rida PC, Ogden A, Turaga RC, Donthamsetty S, Bowen NJ, Rudd K, Gupta MV, Reid MD, Cantuaria G, Walczak CE, Aneja R.

Oncotarget. 2015 Mar 20;6(8):6076-91.


Die-hard survivors: heterogeneity in apoptotic thresholds may underlie chemoresistance.

Ogden A, Rida PC, Reid MD, Kucuk O, Aneja R.

Expert Rev Anticancer Ther. 2015 Mar;15(3):277-81. doi: 10.1586/14737140.2015.1016425. Epub 2015 Feb 19.


Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells.

Pannu V, Rida PC, Celik B, Turaga RC, Ogden A, Cantuaria G, Gopalakrishnan J, Aneja R.

Cell Death Dis. 2014 Nov 20;5:e1538. doi: 10.1038/cddis.2014.505.


KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.

Pawar S, Donthamsetty S, Pannu V, Rida P, Ogden A, Bowen N, Osan R, Cantuaria G, Aneja R.

J Ovarian Res. 2014 May 12;7:53. doi: 10.1186/1757-2215-7-53. eCollection 2014.


Mitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis.

Donthamsetty S, Brahmbhatt M, Pannu V, Rida PC, Ramarathinam S, Ogden A, Cheng A, Singh KK, Aneja R.

Cell Cycle. 2014;13(13):2056-63. doi: 10.4161/cc.29061. Epub 2014 May 5.


Adjustment of suboptimally placed lumbar pedicle screws decreases pullout strength and alters biomechanics of the construct: a pilot cadaveric study.

Wadhwa RK, Thakur JD, Khan IS, James J, Ahmed O, Zhang S, Henderson B, Ogden A, Guthikonda B, Nanda A.

World Neurosurg. 2015 Mar;83(3):368-75. doi: 10.1016/j.wneu.2014.04.065. Epub 2014 May 2.


Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death.

Ogden A, Cheng A, Rida PC, Pannu V, Osan R, Clewley R, Aneja R.

Cell Death Dis. 2014 May 1;5:e1204. doi: 10.1038/cddis.2014.164.


Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model.

Liu J, Ogden A, Comery TA, Spiros A, Roberts P, Geerts H.

CPT Pharmacometrics Syst Pharmacol. 2014 Apr 23;3:e111. doi: 10.1038/psp.2014.7.


INDs for PET molecular imaging probes-approach by an academic institution.

Mosessian S, Duarte-Vogel SM, Stout DB, Roos KP, Lawson GW, Jordan MC, Ogden A, Matter C, Sadeghi S, Mills GQ, Schelbert HR, Radu CG, Czernin J, Couto M, Phelps ME.

Mol Imaging Biol. 2014 Aug;16(4):441-8. doi: 10.1007/s11307-014-0735-2.


Interphase microtubules: chief casualties in the war on cancer?

Ogden A, Rida PC, Reid MD, Aneja R.

Drug Discov Today. 2014 Jul;19(7):824-9. doi: 10.1016/j.drudis.2013.10.022. Epub 2013 Nov 4. Review.


GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24.


GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6459-62. doi: 10.1016/j.bmcl.2013.09.046. Epub 2013 Sep 25.


Primary dural repair in minimally invasive spine surgery.

Haque RM, Hashmi SZ, Ahmed Y, Uddin O, Ogden AT, Fessler R.

Case Rep Med. 2013;2013:876351. doi: 10.1155/2013/876351. Epub 2013 May 30.


Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.

Plummer MS, Cornicelli J, Roark H, Skalitzky DJ, Stankovic CJ, Bove S, Pandit J, Goodman A, Hicks J, Shahripour A, Beidler D, Lu XK, Sanchez B, Whitehead C, Sarver R, Braden T, Gowan R, Shen XQ, Welch K, Ogden A, Sadagopan N, Baum H, Miller H, Banotai C, Spessard C, Lightle S.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3443-7. doi: 10.1016/j.bmcl.2013.03.082. Epub 2013 Mar 29.


Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.

Plummer MS, Cornicelli J, Roark H, Skalitzky DJ, Stankovic CJ, Bove S, Pandit J, Goodman A, Hicks J, Shahripour A, Beidler D, Lu XK, Sanchez B, Whitehead C, Sarver R, Braden T, Gowan R, Shen XQ, Welch K, Ogden A, Sadagopan N, Baum H, Miller H, Banotai C, Spessard C, Lightle S.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3438-42. doi: 10.1016/j.bmcl.2013.03.072. Epub 2013 Mar 28.


Modelling the burden of bovine TB infection.

Ogden AL.

Vet Rec. 2012 Nov 24;171(21):540; discussion 540. doi: 10.1136/vr.e7877. No abstract available.


Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration.

Ogden A, Rida PC, Aneja R.

Cancer Metastasis Rev. 2013 Jun;32(1-2):269-87. doi: 10.1007/s10555-012-9413-5. Review.


Biomechanical performance of rigid compared to dynamic anterior cervical plating: analysis of adjacent upper and lower level compressive forces.

Connor DE Jr, Shamieh KS, Ogden AL, Mukherjee DP, Sin A, Nanda A.

J Clin Neurosci. 2012 Dec;19(12):1706-10. doi: 10.1016/j.jocn.2012.03.026. Epub 2012 Oct 17.


Minimally invasive thoracic microendoscopic diskectomy: surgical technique and case series.

Smith JS, Eichholz KM, Shafizadeh S, Ogden AT, O'Toole JE, Fessler RG.

World Neurosurg. 2013 Sep-Oct;80(3-4):421-7. doi: 10.1016/j.wneu.2012.05.031. Epub 2012 Oct 5.


Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.

Pannu V, Rida PC, Ogden A, Clewley R, Cheng A, Karna P, Lopus M, Mishra RC, Zhou J, Aneja R.

Cell Death Dis. 2012 Jul 12;3:e346. doi: 10.1038/cddis.2012.82.


Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy.

Ogden A, Rida PC, Aneja R.

Cell Death Differ. 2012 Aug;19(8):1255-67. doi: 10.1038/cdd.2012.61. Epub 2012 Jun 1. Review.

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