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Items: 1 to 50 of 81

1.

Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models.

Tkaczyk C, Semenova E, Shi YY, Rosenthal K, Oganesyan V, Warrener P, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01033-18. doi: 10.1128/AAC.01033-18. Print 2018 Nov.

2.

Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates.

Tabor DE, Oganesyan V, Keller AE, Yu L, McLaughlin RE, Song E, Warrener P, Rosenthal K, Esser M, Qi Y, Ruzin A, Stover CK, DiGiandomenico A.

J Infect Dis. 2018 Nov 5;218(12):1983-1994. doi: 10.1093/infdis/jiy438.

PMID:
30016475
3.

Direct Prediction of EPR Spectra from Lipid Bilayers: Understanding Structure and Dynamics in Biological Membranes.

Catte A, White GF, Wilson MR, Oganesyan VS.

Chemphyschem. 2018 Sep 5;19(17):2183-2193. doi: 10.1002/cphc.201800386. Epub 2018 Jun 19.

4.

All-atom molecular dynamics simulations of spin labelled double and single-strand DNA for EPR studies.

Prior C, Danilāne L, Oganesyan VS.

Phys Chem Chem Phys. 2018 May 16;20(19):13461-13472. doi: 10.1039/c7cp08625c.

PMID:
29725672
5.

Crystal structure of the human 4-1BB/4-1BBL complex.

Gilbreth RN, Oganesyan VY, Amdouni H, Novarra S, Grinberg L, Barnes A, Baca M.

J Biol Chem. 2018 Jun 22;293(25):9880-9891. doi: 10.1074/jbc.RA118.002803. Epub 2018 May 2.

PMID:
29720399
6.

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.

Oganesyan V, Peng L, Bee JS, Li J, Perry SR, Comer F, Xu L, Cook K, Senthil K, Clarke L, Rosenthal K, Gao C, Damschroder M, Wu H, Dall'Acqua W.

J Biol Chem. 2018 Jun 1;293(22):8439-8448. doi: 10.1074/jbc.M117.818013. Epub 2018 Apr 18.

7.

Antimicrobial action of the cationic peptide, chrysophsin-3: a coarse-grained molecular dynamics study.

Catte A, Wilson MR, Walker M, Oganesyan VS.

Soft Matter. 2018 Apr 18;14(15):2796-2807. doi: 10.1039/c7sm02152f.

PMID:
29595197
8.

Fixed Points of Wegner-Wilson Flows and Many-Body Localization.

Pekker D, Clark BK, Oganesyan V, Refael G.

Phys Rev Lett. 2017 Aug 18;119(7):075701. doi: 10.1103/PhysRevLett.119.075701. Epub 2017 Aug 16.

PMID:
28949663
9.

Prediction of EPR Spectra of Lyotropic Liquid Crystals using a Combination of Molecular Dynamics Simulations and the Model-Free Approach.

Prior C, Oganesyan VS.

Chemistry. 2017 Sep 21;23(53):13192-13204. doi: 10.1002/chem.201702682. Epub 2017 Aug 23.

PMID:
28741312
10.

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP.

J Biol Chem. 2017 Feb 10;292(6):2510-2518. doi: 10.1074/jbc.M116.767186. Epub 2016 Dec 23.

11.

Molecular electrometer and binding of cations to phospholipid bilayers.

Catte A, Girych M, Javanainen M, Loison C, Melcr J, Miettinen MS, Monticelli L, Määttä J, Oganesyan VS, Ollila OH, Tynkkynen J, Vilov S.

Phys Chem Chem Phys. 2016 Nov 30;18(47):32560-32569.

PMID:
27874109
12.

A combined EPR and MD simulation study of a nitroxyl spin label with restricted internal mobility sensitive to protein dynamics.

Oganesyan VS, Chami F, White GF, Thomson AJ.

J Magn Reson. 2017 Jan;274:24-35. doi: 10.1016/j.jmr.2016.11.001. Epub 2016 Nov 4.

PMID:
27842258
13.

Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes.

Serrano PN, Wang H, Crack JC, Prior C, Hutchings MI, Thomson AJ, Kamali S, Yoda Y, Zhao J, Hu MY, Alp EE, Oganesyan VS, Le Brun NE, Cramer SP.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14575-14579. doi: 10.1002/anie.201607033. Epub 2016 Oct 25.

14.

Muonium Chemistry at Diiron Subsite Analogues of [FeFe]-Hydrogenase.

Wright JA, Peck JN, Cottrell SP, Jablonskytė A, Oganesyan VS, Pickett CJ, Jayasooriya UA.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14580-14583. doi: 10.1002/anie.201607109. Epub 2016 Oct 14.

15.

Generation and Characterization of an IgG4 Monomeric Fc Platform.

Shan L, Colazet M, Rosenthal KL, Yu XQ, Bee JS, Ferguson A, Damschroder MM, Wu H, Dall'Acqua WF, Tsui P, Oganesyan V.

PLoS One. 2016 Aug 1;11(8):e0160345. doi: 10.1371/journal.pone.0160345. eCollection 2016.

16.

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893.

Tabor DE, Yu L, Mok H, Tkaczyk C, Sellman BR, Wu Y, Oganesyan V, Slidel T, Jafri H, McCarthy M, Bradford P, Esser MT.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5312-21. doi: 10.1128/AAC.00357-16. Print 2016 Sep.

17.
18.

Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer.

Jiang L, Huang J, Higgs BW, Hu Z, Xiao Z, Yao X, Conley S, Zhong H, Liu Z, Brohawn P, Shen D, Wu S, Ge X, Jiang Y, Zhao Y, Lou Y, Morehouse C, Zhu W, Sebastian Y, Czapiga M, Oganesyan V, Fu H, Niu Y, Zhang W, Streicher K, Tice D, Zhao H, Zhu M, Xu L, Herbst R, Su X, Gu Y, Li S, Huang L, Gu J, Han B, Jallal B, Shen H, Yao Y.

PLoS Genet. 2016 Apr 19;12(4):e1005895. doi: 10.1371/journal.pgen.1005895. eCollection 2016 Apr.

19.

Correction: EPR detection and characterisation of a paramagnetic Mo(iii) dihydride intermediate involved in electrocatalytic hydrogen evolution.

Prior C, Webster LR, Ibrahim SK, Wright JA, Alghamdi AF, Oganesyan VS, Pickett CJ.

Dalton Trans. 2016 Apr 28;45(16):7178. doi: 10.1039/c6dt90066f.

PMID:
27067815
20.

Enantiopure Ferrocene-Based Planar-Chiral Iridacycles: Stereospecific Control of Iridium-Centred Chirality.

Arthurs RA, Ismail M, Prior CC, Oganesyan VS, Horton PN, Coles SJ, Richards CJ.

Chemistry. 2016 Feb 24;22(9):3065-72. doi: 10.1002/chem.201504458. Epub 2016 Jan 25.

PMID:
26809030
21.

EPR detection and characterisation of a paramagnetic Mo(iii) dihydride intermediate involved in electrocatalytic hydrogen evolution.

Prior C, Webster LR, Ibrahim SK, Wright JA, Alghamdi AF, Oganesyan VS, Pickett CJ.

Dalton Trans. 2016 Feb 14;45(6):2399-403. doi: 10.1039/c5dt04432d. Epub 2016 Jan 14. Erratum in: Dalton Trans. 2016 Apr 28;45(16):7178.

PMID:
26763207
22.

Rate of Molecular Transfer of Allyl Alcohol across an AOT Surfactant Layer Using Muon Spin Spectroscopy.

Jayasooriya UA, Clayden NJ, Steytler DC, Oganesyan VS, Peck JN, Khasanov R, Scheuermann R, Stoykov A.

Langmuir. 2016 Jan 26;32(3):664-72. doi: 10.1021/acs.langmuir.5b03482. Epub 2016 Jan 11.

PMID:
26716949
23.

Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding.

Oganesyan V, Mazor Y, Yang C, Cook KE, Woods RM, Ferguson A, Bowen MA, Martin T, Zhu J, Wu H, Dall'Acqua WF.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2354-61. doi: 10.1107/S1399004715018015. Epub 2015 Oct 31.

24.

Emergent surface superconductivity in the topological insulator Sb2Te3.

Zhao L, Deng H, Korzhovska I, Begliarbekov M, Chen Z, Andrade E, Rosenthal E, Pasupathy A, Oganesyan V, Krusin-Elbaum L.

Nat Commun. 2015 Sep 11;6:8279. doi: 10.1038/ncomms9279.

PMID:
26359207
25.

Exploring structural and electronic effects in three isomers of tris{bis(trifluoromethyl)phenyl}borane: towards the combined electrochemical-frustrated Lewis pair activation of H2.

Blagg RJ, Lawrence EJ, Resner K, Oganesyan VS, Herrington TJ, Ashley AE, Wildgoose GG.

Dalton Trans. 2016 Apr 14;45(14):6023-31. doi: 10.1039/c5dt01918d. Epub 2015 Jul 28.

26.

Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.

Oganesyan V, Peng L, Woods RM, Wu H, Dall'Acqua WF.

J Biol Chem. 2015 Jun 12;290(24):14979-85. doi: 10.1074/jbc.M115.652156. Epub 2015 Apr 29.

27.

Improving target cell specificity using a novel monovalent bispecific IgG design.

Mazor Y, Oganesyan V, Yang C, Hansen A, Wang J, Liu H, Sachsenmeier K, Carlson M, Gadre DV, Borrok MJ, Yu XQ, Dall'Acqua W, Wu H, Chowdhury PS.

MAbs. 2015;7(2):377-89. doi: 10.1080/19420862.2015.1007816. Erratum in: MAbs. 2016 May-Jun;8(4):839.

28.

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody.

Peng L, Oganesyan V, Wu H, Dall'Acqua WF, Damschroder MM.

MAbs. 2015;7(2):428-39. doi: 10.1080/19420862.2015.1007810.

29.

pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling.

Borrok MJ, Wu Y, Beyaz N, Yu XQ, Oganesyan V, Dall'Acqua WF, Tsui P.

J Biol Chem. 2015 Feb 13;290(7):4282-90. doi: 10.1074/jbc.M114.603712. Epub 2014 Dec 23.

30.

Mechanisms of neutralization of a human anti-α-toxin antibody.

Oganesyan V, Peng L, Damschroder MM, Cheng L, Sadowska A, Tkaczyk C, Sellman BR, Wu H, Dall'Acqua WF.

J Biol Chem. 2014 Oct 24;289(43):29874-80. doi: 10.1074/jbc.M114.601328. Epub 2014 Sep 10.

31.

Singular robust room-temperature spin response from topological Dirac fermions.

Zhao L, Deng H, Korzhovska I, Chen Z, Konczykowski M, Hruban A, Oganesyan V, Krusin-Elbaum L.

Nat Mater. 2014 Jun;13(6):580-5. doi: 10.1038/nmat3962. Epub 2014 May 18. Erratum in: Nat Mater. 2014 Jul;13(7):756.

PMID:
24836736
32.

An electrochemical study of frustrated Lewis pairs: a metal-free route to hydrogen oxidation.

Lawrence EJ, Oganesyan VS, Hughes DL, Ashley AE, Wildgoose GG.

J Am Chem Soc. 2014 Apr 23;136(16):6031-6. doi: 10.1021/ja500477g. Epub 2014 Apr 10.

33.

Structural insights into neonatal Fc receptor-based recycling mechanisms.

Oganesyan V, Damschroder MM, Cook KE, Li Q, Gao C, Wu H, Dall'Acqua WF.

J Biol Chem. 2014 Mar 14;289(11):7812-24. doi: 10.1074/jbc.M113.537563. Epub 2014 Jan 27.

34.

Simulation of electron paramagnetic resonance spectra of spin-labeled molecules from replica-exchange molecular dynamics.

Tyrrell S, Oganesyan VS.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Oct;88(4):042701. Epub 2013 Oct 3.

PMID:
24229207
35.

Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes.

Oganesyan V, Ferguson A, Grinberg L, Wang L, Phipps S, Chacko B, Drabic S, Thisted T, Baca M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):1045-8. doi: 10.1107/S1744309113022847. Epub 2013 Aug 21.

36.

Probing columnar discotic liquid crystals by EPR spectroscopy with a rigid-core nitroxide spin probe.

Gopee H, Cammidge AN, Oganesyan VS.

Angew Chem Int Ed Engl. 2013 Aug 19;52(34):8917-20. doi: 10.1002/anie.201303194. Epub 2013 Jul 22. No abstract available.

37.

Multispin correlations and pseudo-thermalization of the transient density matrix in solid-state NMR: free induction decay and magic echo.

Morgan SW, Oganesyan V, Boutis GS.

Phys Rev B Condens Matter Mater Phys. 2012 Dec 14;8672(21). pii: e214410.

38.

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-alpha toxin antibody fragment and alpha toxin.

Oganesyan V, Barnes A, Tkaczyk C, Ferguson A, Wu H, Dall'Acqua WF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):302-5. doi: 10.1107/S1744309113002881. Epub 2013 Feb 23.

39.

Unexpected weak magnetic exchange coupling between haem and non-haem iron in the catalytic site of nitric oxide reductase (NorBC) from Paracoccus denitrificans1.

Van Wonderen JH, Oganesyan VS, Watmough NJ, Richardson DJ, Thomson AJ, Cheesman MR.

Biochem J. 2013 May 1;451(3):389-94. doi: 10.1042/BJ20121406.

PMID:
23421449
40.

Exploring the fate of the tris(pentafluorophenyl)borane radical anion in weakly coordinating solvents.

Lawrence EJ, Oganesyan VS, Wildgoose GG, Ashley AE.

Dalton Trans. 2013 Jan 21;42(3):782-9. doi: 10.1039/c2dt31622f.

PMID:
23201974
41.

Paramagnetic bridging hydrides of relevance to catalytic hydrogen evolution at metallosulfur centers.

Jablonskytė A, Wright JA, Fairhurst SA, Peck JN, Ibrahim SK, Oganesyan VS, Pickett CJ.

J Am Chem Soc. 2011 Nov 23;133(46):18606-9. doi: 10.1021/ja2087536. Epub 2011 Nov 2.

PMID:
22035325
42.

Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.

Peng L, Oganesyan V, Damschroder MM, Wu H, Dall'Acqua WF.

J Mol Biol. 2011 Oct 21;413(2):390-405. doi: 10.1016/j.jmb.2011.08.018. Epub 2011 Aug 16.

PMID:
21867711
43.

Prediction of nitroxide spin label EPR spectra from MD trajectories: application to myoglobin.

Kuprusevicius E, White G, Oganesyan VS.

Faraday Discuss. 2011;148:283-98; discussion 299-314.

PMID:
21322490
44.

A general approach for prediction of motional EPR spectra from Molecular Dynamics (MD) simulations: application to spin labelled protein.

Oganesyan VS.

Phys Chem Chem Phys. 2011 Mar 14;13(10):4724-37. doi: 10.1039/c0cp01068e. Epub 2011 Jan 31.

PMID:
21279205
45.

Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.

Crack JC, Smith LJ, Stapleton MR, Peck J, Watmough NJ, Buttner MJ, Buxton RS, Green J, Oganesyan VS, Thomson AJ, Le Brun NE.

J Am Chem Soc. 2011 Feb 2;133(4):1112-21. doi: 10.1021/ja109581t. Epub 2010 Dec 23.

46.

Prediction of EPR spectra of liquid crystals with doped spin probes from fully atomistic molecular dynamics simulations: exploring molecular order and dynamics at the phase transition.

Kuprusevicius E, Edge R, Gopee H, Cammidge AN, McInnes EJ, Wilson MR, Oganesyan VS.

Chemistry. 2010 Oct 11;16(38):11558-62. doi: 10.1002/chem.201001439. Epub 2010 Sep 8.

PMID:
20827705
47.

The third hydrogenase: a ferracyclic carbamoyl with close structural analogy to the active site of Hmd.

Turrell PJ, Wright JA, Peck JN, Oganesyan VS, Pickett CJ.

Angew Chem Int Ed Engl. 2010 Oct 4;49(41):7508-11. doi: 10.1002/anie.201004189. No abstract available.

PMID:
20740518
48.

Nitroxide spin labels as EPR reporters of the relaxation and magnetic properties of the heme-copper site in cytochrome bo3, E. coli.

Oganesyan VS, White GF, Field S, Marritt S, Gennis RB, Yap LL, Thomson AJ.

J Biol Inorg Chem. 2010 Nov;15(8):1255-64. doi: 10.1007/s00775-010-0683-5. Epub 2010 Jul 11.

PMID:
20623242
49.

Magnetic circular dichroism spectroscopy as a probe of the structures of the metal sites in metalloproteins.

McMaster J, Oganesyan VS.

Curr Opin Struct Biol. 2010 Oct;20(5):615-22. doi: 10.1016/j.sbi.2010.06.006. Epub 2010 Jul 7. Review.

PMID:
20619632
50.

Crystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen.

Oganesyan V, Damschroder MM, Phipps S, Wilson SD, Cook KE, Wu H, Dall'Acqua WF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):730-3. doi: 10.1107/S1744309110015861. Epub 2010 May 29.

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