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Items: 1 to 50 of 301

1.

Adgrf5 contributes to patterning of the endothelial deep layer in retina.

Niaudet C, Petkova M, Jung B, Lu S, Laviña B, Offermanns S, Brakebusch C, Betsholtz C.

Angiogenesis. 2019 Jun 29. doi: 10.1007/s10456-019-09674-0. [Epub ahead of print]

PMID:
31256320
2.

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S.

J Clin Invest. 2019 Jun 17;129(7):2775-2791. doi: 10.1172/JCI123825. eCollection 2019 Jun 17.

3.

A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development.

Helker CSM, Mullapudi ST, Mueller LM, Preussner J, Tunaru S, Skog O, Kwon HB, Kreuder F, Lancman JJ, Bonnavion R, Dong PDS, Looso M, Offermanns S, Korsgren O, Spagnoli FM, Stainier DYR.

Development. 2019 Jul 24;146(14). pii: dev172569. doi: 10.1242/dev.172569.

PMID:
31142539
4.

Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation.

Wettschureck N, Strilic B, Offermanns S.

Physiol Rev. 2019 Jul 1;99(3):1467-1525. doi: 10.1152/physrev.00037.2018.

PMID:
31140373
5.

The polarity protein Scrib limits atherosclerosis development in mice.

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP.

Cardiovasc Res. 2019 Apr 5. pii: cvz093. doi: 10.1093/cvr/cvz093. [Epub ahead of print]

PMID:
30949676
6.

The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits.

de Castro Abrantes H, Briquet M, Schmuziger C, Restivo L, Puyal J, Rosenberg N, Rocher AB, Offermanns S, Chatton JY.

J Neurosci. 2019 Jun 5;39(23):4422-4433. doi: 10.1523/JNEUROSCI.2092-18.2019. Epub 2019 Mar 29.

PMID:
30926749
7.

Author Correction: Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system.

Kaur H, Carvalho J, Looso M, Singh P, Chennupati R, Preussner J, Günther S, Albarrán-Juárez J, Tischner D, Classen S, Offermanns S, Wettschureck N.

Nat Commun. 2019 Mar 28;10(1):1448. doi: 10.1038/s41467-019-09334-3.

8.

TAK1 regulates endothelial cell necroptosis and tumor metastasis.

Yang L, Joseph S, Sun T, Hoffmann J, Thevissen S, Offermanns S, Strilic B.

Cell Death Differ. 2019 Jan 25. doi: 10.1038/s41418-018-0271-8. [Epub ahead of print]

PMID:
30683914
9.

Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.

Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR.

Eur Respir J. 2019 Mar 7;53(3). pii: 1800840. doi: 10.1183/13993003.00840-2018. Print 2019 Mar.

PMID:
30578393
10.

Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture.

Villahoz S, Yunes-Leites PS, Méndez-Barbero N, Urso K, Bonzon-Kulichenko E, Ortega S, Nistal JF, Vazquez J, Offermanns S, Redondo JM, Campanero MR.

Nat Commun. 2018 Nov 15;9(1):4795. doi: 10.1038/s41467-018-07071-7.

11.

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR.

Nat Commun. 2018 Nov 2;9(1):4600. doi: 10.1038/s41467-018-06833-7.

12.

Translating biased signaling in the ghrelin receptor system into differential in vivo functions.

Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst B.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10255-E10264. doi: 10.1073/pnas.1804003115. Epub 2018 Oct 9.

13.

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation.

Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S.

J Exp Med. 2018 Oct 1;215(10):2655-2672. doi: 10.1084/jem.20180483. Epub 2018 Sep 7.

14.

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.

Wannick M, Assmann JC, Vielhauer JF, Offermanns S, Zillikens D, Sadik CD, Schwaninger M.

Front Immunol. 2018 Aug 14;9:1890. doi: 10.3389/fimmu.2018.01890. eCollection 2018.

15.

The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.

Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR.

Nat Commun. 2018 Jul 19;9(1):2815. doi: 10.1038/s41467-018-05043-5.

16.

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP.

Vardjan N, Chowdhury HH, Horvat A, Velebit J, Malnar M, Muhič M, Kreft M, Krivec ŠG, Bobnar ST, Miš K, Pirkmajer S, Offermanns S, Henriksen G, Storm-Mathisen J, Bergersen LH, Zorec R.

Front Mol Neurosci. 2018 May 8;11:148. doi: 10.3389/fnmol.2018.00148. eCollection 2018.

17.

β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway.

Chen Y, Ouyang X, Hoque R, Garcia-Martinez I, Yousaf MN, Tonack S, Offermanns S, Dubuquoy L, Louvet A, Mathurin P, Massey V, Schnabl B, Bataller RA, Mehal WZ.

J Hepatol. 2018 Sep;69(3):687-696. doi: 10.1016/j.jhep.2018.04.004. Epub 2018 Apr 27.

PMID:
29705237
18.

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1.

Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, Offermanns S.

Nat Commun. 2018 Jan 12;9(1):177. doi: 10.1038/s41467-017-02539-4.

19.

Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes.

Rödiger M, Werno MW, Wilhelmi I, Baumeier C, Hesse D, Wettschureck N, Offermanns S, Song K, Krauß M, Schürmann A.

Mol Metab. 2018 Feb;8:167-179. doi: 10.1016/j.molmet.2017.11.011. Epub 2017 Nov 22.

20.

Members of Bitter Taste Receptor Cluster Tas2r143/Tas2r135/Tas2r126 Are Expressed in the Epithelium of Murine Airways and Other Non-gustatory Tissues.

Liu S, Lu S, Xu R, Atzberger A, Günther S, Wettschureck N, Offermanns S.

Front Physiol. 2017 Oct 30;8:849. doi: 10.3389/fphys.2017.00849. eCollection 2017.

21.

Three-Month Endothelial Human Endothelin-1 Overexpression Causes Blood Pressure Elevation and Vascular and Kidney Injury.

Coelho SC, Berillo O, Caillon A, Ouerd S, Fraulob-Aquino JC, Barhoumi T, Offermanns S, Paradis P, Schiffrin EL.

Hypertension. 2018 Jan;71(1):208-216. doi: 10.1161/HYPERTENSIONAHA.117.09925. Epub 2017 Nov 13.

PMID:
29133362
22.

Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.

Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B.

J Clin Invest. 2017 Nov 1;127(11):4148-4162. doi: 10.1172/JCI83626. Epub 2017 Oct 16.

23.

Intravascular Survival and Extravasation of Tumor Cells.

Strilic B, Offermanns S.

Cancer Cell. 2017 Sep 11;32(3):282-293. doi: 10.1016/j.ccell.2017.07.001. Review.

24.

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells.

Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A.

Front Immunol. 2017 Aug 28;8:1036. doi: 10.3389/fimmu.2017.01036. eCollection 2017.

25.

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.

Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M.

Nat Commun. 2017 Sep 7;8(1):484. doi: 10.1038/s41467-017-00604-6.

26.

An X-linked Myh11-CreERT2 mouse line resulting from Y to X chromosome-translocation of the Cre allele.

Liao M, Zhou J, Wang F, Ali YH, Chan KL, Zou F, Offermanns S, Jiang Z, Jiang Z.

Genesis. 2017 Sep;55(9). doi: 10.1002/dvg.23054.

27.

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gröne HJ, Offermanns S.

PLoS One. 2017 Aug 14;12(8):e0183166. doi: 10.1371/journal.pone.0183166. eCollection 2017.

28.

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, Günther S, Wanke F, Moos S, Siller N, Breuer J, Schwab N, Zipp F, Waisman A, Kurschus FC, Offermanns S, Wettschureck N.

JCI Insight. 2017 Aug 3;2(15). pii: 95063. doi: 10.1172/jci.insight.95063. eCollection 2017 Aug 3.

29.

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.

Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R.

Nat Commun. 2017 Aug 2;8(1):176. doi: 10.1038/s41467-017-00341-w.

30.

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system.

Kaur H, Carvalho J, Looso M, Singh P, Chennupati R, Preussner J, Günther S, Albarrán-Juárez J, Tischner D, Classen S, Offermanns S, Wettschureck N.

Nat Commun. 2017 Jun 16;8:15700. doi: 10.1038/ncomms15700. Erratum in: Nat Commun. 2019 Mar 28;10(1):1448.

31.

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW.

Curr Biol. 2017 Jun 19;27(12):1791-1800.e5. doi: 10.1016/j.cub.2017.05.022. Epub 2017 Jun 1.

32.

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.

Schmitz K, Brunkhorst R, de Bruin N, Mayer CA, Häussler A, Ferreiros N, Schiffmann S, Parnham MJ, Tunaru S, Chun J, Offermanns S, Foerch C, Scholich K, Vogt J, Wicker S, Lötsch J, Geisslinger G, Tegeder I.

Acta Neuropathol Commun. 2017 Jun 2;5(1):42. doi: 10.1186/s40478-017-0446-4.

33.

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling.

Brown K, Filuta A, Ludwig MG, Seuwen K, Jaros J, Vidal S, Arora K, Naren AP, Kandasamy K, Parthasarathi K, Offermanns S, Mason RJ, Miller WE, Whitsett JA, Bridges JP.

JCI Insight. 2017 Jun 2;2(11). pii: 93700. doi: 10.1172/jci.insight.93700. eCollection 2017 Jun 2.

34.

Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.

Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T.

J Exp Med. 2017 Jul 3;214(7):1877-1888. doi: 10.1084/jem.20161924. Epub 2017 May 26.

35.

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.

Morland C, Andersson KA, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, Stølen T, Hennestad E, Moldestad O, Cai Y, Puchades M, Offermanns S, Vervaeke K, Bjørås M, Wisløff U, Storm-Mathisen J, Bergersen LH.

Nat Commun. 2017 May 23;8:15557. doi: 10.1038/ncomms15557.

36.

The Max Planck Institute for Heart and Lung Research Curiosity-Driven Basic Research to Fight Cardio-Pulmonary Diseases.

Braun T, Offermanns S, Stainier DYR, Seeger W.

Circ Res. 2017 Apr 28;120(9):1386-1389. doi: 10.1161/CIRCRESAHA.117.310763. Review. No abstract available.

PMID:
28450360
37.

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure.

Kroetsch JT, Levy AS, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov SA, Backx PH, Heximer SP, Bolz SS.

Nat Commun. 2017 Apr 5;8:14805. doi: 10.1038/ncomms14805.

38.

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.

Hohmann SW, Angioni C, Tunaru S, Lee S, Woolf CJ, Offermanns S, Geisslinger G, Scholich K, Sisignano M.

Sci Rep. 2017 Mar 27;7(1):446. doi: 10.1038/s41598-017-00591-0.

39.

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS.

PLoS One. 2017 Mar 16;12(3):e0173692. doi: 10.1371/journal.pone.0173692. eCollection 2017.

40.

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.

Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K.

J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27.

41.

Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation.

Idris-Khodja N, Ouerd S, Trindade M, Gornitsky J, Rehman A, Barhoumi T, Offermanns S, Gonzalez FJ, Neves MF, Paradis P, Schiffrin EL.

J Hypertens. 2017 Jul;35(7):1390-1401. doi: 10.1097/HJH.0000000000001324.

42.

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism.

Offermanns S.

Trends Endocrinol Metab. 2017 Mar;28(3):227-236. doi: 10.1016/j.tem.2016.11.007. Epub 2017 Jan 10. Review.

PMID:
28087125
43.

LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction.

Dancs PT, Ruisanchez É, Balogh A, Panta CR, Miklós Z, Nüsing RM, Aoki J, Chun J, Offermanns S, Tigyi G, Benyó Z.

FASEB J. 2017 Apr;31(4):1547-1555. doi: 10.1096/fj.201600735R. Epub 2017 Jan 9.

44.

Regeneration of fat cells from myofibroblasts during wound healing.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G.

Science. 2017 Feb 17;355(6326):748-752. doi: 10.1126/science.aai8792. Epub 2017 Jan 5.

45.

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.

Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T.

J Cell Biol. 2017 Jan 2;216(1):199-215. doi: 10.1083/jcb.201602002. Epub 2016 Dec 22.

46.

PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells.

Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, Zhang W, Hong Z, Offermanns S, Rehman J, Malik AB.

Stem Cell Reports. 2016 Dec 13;7(6):1050-1058. doi: 10.1016/j.stemcr.2016.10.006. Epub 2016 Nov 17.

47.

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Errea A, Cayet D, Marchetti P, Tang C, Kluza J, Offermanns S, Sirard JC, Rumbo M.

PLoS One. 2016 Nov 15;11(11):e0163694. doi: 10.1371/journal.pone.0163694. eCollection 2016.

48.

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.

Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S.

Nat Cell Biol. 2016 Dec;18(12):1357-1366. doi: 10.1038/ncb3436. Epub 2016 Nov 7.

49.

Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.

John AE, Wilson MR, Habgood A, Porte J, Tatler AL, Stavrou A, Miele G, Jolly L, Knox AJ, Takata M, Offermanns S, Jenkins RG.

Sci Signal. 2016 Oct 25;9(451):ra104.

50.

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.

Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S.

J Clin Invest. 2016 Dec 1;126(12):4527-4536. doi: 10.1172/JCI87343. Epub 2016 Oct 31.

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