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Items: 24

1.

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases.

Yuan J, Amin P, Ofengeim D.

Nat Rev Neurosci. 2018 Nov 22. doi: 10.1038/s41583-018-0093-1. [Epub ahead of print] Review.

PMID:
30467385
2.

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.

Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J.

Cell Death Differ. 2018 Oct 19. doi: 10.1038/s41418-018-0215-3. [Epub ahead of print]

PMID:
30341420
3.

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.

Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J.

Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23.

PMID:
30146158
4.

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.

Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5944-E5953. doi: 10.1073/pnas.1806973115. Epub 2018 Jun 11.

PMID:
29891719
5.

Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD.

Chen H, Kankel MW, Su SC, Han SWS, Ofengeim D.

Cell Death Differ. 2018 Mar;25(4):646-660. doi: 10.1038/s41418-018-0060-4. Epub 2018 Feb 19. Review.

PMID:
29459769
6.

Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.

Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J.

Cell Death Dis. 2018 Jan 26;9(2):138. doi: 10.1038/s41419-017-0170-9.

7.

RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.

Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8788-E8797. doi: 10.1073/pnas.1714175114. Epub 2017 Sep 13.

8.

Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time.

Ofengeim D, Giagtzoglou N, Huh D, Zou C, Yuan J.

Trends Mol Med. 2017 Jun;23(6):563-576. doi: 10.1016/j.molmed.2017.04.006. Epub 2017 May 10. Review.

9.

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.

Hwang JY, Gertner M, Pontarelli F, Court-Vazquez B, Bennett MV, Ofengeim D, Zukin RS.

Cell Death Differ. 2017 Feb;24(2):317-329. doi: 10.1038/cdd.2016.140. Epub 2016 Dec 9.

10.

Activation of necroptosis in human and experimental cholestasis.

Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, Gaspar MM, Cortez-Pinto H, Castro RE, Yuan J, Rodrigues CM.

Cell Death Dis. 2016 Sep 29;7(9):e2390. doi: 10.1038/cddis.2016.280.

11.

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.

Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803.

12.

Corrigendum: Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2016 Apr 1;30(7):870. doi: 10.1101/gad.280453.116.

13.

Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H.

J Cell Biol. 2016 Mar 28;212(7):881-2. doi: 10.1083/jcb.20150304403082016c. Epub 2016 Mar 21. No abstract available.

14.

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H.

J Cell Biol. 2015 Aug 31;210(5):705-16. doi: 10.1083/jcb.201503044. Erratum in: J Cell Biol. 2016 Mar 28;212(7):881-2.

15.

Activation of necroptosis in multiple sclerosis.

Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, Qi C, Yu Q, Trapp B, Yuan J.

Cell Rep. 2015 Mar 24;10(11):1836-49.

16.

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.

Ofengeim D, Yuan J.

Nat Rev Mol Cell Biol. 2013 Nov;14(11):727-36. doi: 10.1038/nrm3683. Epub 2013 Oct 16. Review.

PMID:
24129419
17.

Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113. Erratum in: Genes Dev. 2016 Apr 1;30(7):870. Genes Dev. 2013 Sep 1;27(17):1947.

18.

Mouse Transient Global Ischemia Two-Vessel Occlusion Model.

Pontarelli F, Ofengeim D, Zukin RS, Jonas EA.

Bio Protoc. 2012 Sep 20;2(18). pii: e262.

19.

N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.

Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA.

Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054.

20.

Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening.

Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A.

J Biol Chem. 2012 Mar 16;287(12):8714-23. doi: 10.1074/jbc.M111.290957. Epub 2012 Jan 25.

21.

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.

Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A, Zukin RS.

Nat Neurosci. 2009 May;12(5):618-26. doi: 10.1038/nn.2299. Epub 2009 Apr 6.

22.

Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons.

Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4892-7. doi: 10.1073/pnas.0800628105. Epub 2008 Mar 17. Erratum in: Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16855-7.

23.

Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain.

Bonanni L, Chachar M, Jover-Mengual T, Li H, Jones A, Yokota H, Ofengeim D, Flannery RJ, Miyawaki T, Cho CH, Polster BM, Pypaert M, Hardwick JM, Sensi SL, Zukin RS, Jonas EA.

J Neurosci. 2006 Jun 21;26(25):6851-62.

24.

Sound transmission in the lung as a function of lung volume.

Bergstresser T, Ofengeim D, Vyshedskiy A, Shane J, Murphy R.

J Appl Physiol (1985). 2002 Aug;93(2):667-74.

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