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Items: 36

1.

Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop.

Janus BM, van Dyk N, Zhao X, Howell KA, Soto C, Aman MJ, Li Y, Fuerst TR, Ofek G.

Nat Commun. 2018 Sep 26;9(1):3934. doi: 10.1038/s41467-018-06113-4.

2.

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.

Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF.

Sci Immunol. 2017 Jan 27;2(7). pii: eaal2200. doi: 10.1126/sciimmunol.aal2200.

3.

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.

Soto C, Ofek G, Joyce MG, Zhang B, McKee K, Longo NS, Yang Y, Huang J, Parks R, Eudailey J, Lloyd KE, Alam SM, Haynes BF; NISC Comparative Sequencing Program, Mullikin JC, Connors M, Mascola JR, Shapiro L, Kwong PD.

PLoS One. 2016 Jun 14;11(6):e0157409. doi: 10.1371/journal.pone.0157409. eCollection 2016.

4.

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.

Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD.

J Virol. 2016 Jun 10;90(13):5899-5914. doi: 10.1128/JVI.03246-15. Print 2016 Jul 1.

5.

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.

Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD.

Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun 22.

6.

HIV. Expanding the breadth of an HIV-1 vaccine.

Ofek G, Diskin R.

Science. 2014 Dec 12;346(6215):1290-1. doi: 10.1126/science.aaa2315. No abstract available.

PMID:
25504701
7.

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.

Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD.

Nat Struct Mol Biol. 2014 Dec;21(12):1058-67. doi: 10.1038/nsmb.2922. Epub 2014 Nov 24.

8.

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD.

Nature. 2014 Oct 23;514(7523):455-61. doi: 10.1038/nature13808. Epub 2014 Oct 8.

9.

Transplanting supersites of HIV-1 vulnerability.

Zhou T, Zhu J, Yang Y, Gorman J, Ofek G, Srivatsan S, Druz A, Lees CR, Lu G, Soto C, Stuckey J, Burton DR, Koff WC, Connors M, Kwong PD.

PLoS One. 2014 Jul 3;9(7):e99881. doi: 10.1371/journal.pone.0099881. eCollection 2014. Erratum in: PLoS One. 2014;9(8); e105659. doi: 10.1371/journal.pone.0105659. Kwon, Peter D [corrected to Kwong, Peter D].

10.

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.

Georgiev IS, Rudicell RS, Saunders KO, Shi W, Kirys T, McKee K, O'Dell S, Chuang GY, Yang ZY, Ofek G, Connors M, Mascola JR, Nabel GJ, Kwong PD.

J Immunol. 2014 Feb 1;192(3):1100-1106. doi: 10.4049/jimmunol.1302515. Epub 2014 Jan 3.

11.

Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6.

Ofek G, Zirkle B, Yang Y, Zhu Z, McKee K, Zhang B, Chuang GY, Georgiev IS, O'Dell S, Doria-Rose N, Mascola JR, Dimitrov DS, Kwong PD.

J Virol. 2014 Mar;88(5):2426-41. doi: 10.1128/JVI.02837-13. Epub 2013 Dec 11.

12.

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.

Georgiev IS, Doria-Rose NA, Zhou T, Kwon YD, Staupe RP, Moquin S, Chuang GY, Louder MK, Schmidt SD, Altae-Tran HR, Bailer RT, McKee K, Nason M, O'Dell S, Ofek G, Pancera M, Srivatsan S, Shapiro L, Connors M, Migueles SA, Morris L, Nishimura Y, Martin MA, Mascola JR, Kwong PD.

Science. 2013 May 10;340(6133):751-6. doi: 10.1126/science.1233989.

13.

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.

Zhu J, Ofek G, Yang Y, Zhang B, Louder MK, Lu G, McKee K, Pancera M, Skinner J, Zhang Z, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Simek M, Burton DR, Koff WC; NISC Comparative Sequencing Program, Mullikin JC, Mascola JR, Shapiro L, Kwong PD.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6470-5. doi: 10.1073/pnas.1219320110. Epub 2013 Mar 27.

14.

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.

Huang J, Ofek G, Laub L, Louder MK, Doria-Rose NA, Longo NS, Imamichi H, Bailer RT, Chakrabarti B, Sharma SK, Alam SM, Wang T, Yang Y, Zhang B, Migueles SA, Wyatt R, Haynes BF, Kwong PD, Mascola JR, Connors M.

Nature. 2012 Nov 15;491(7424):406-12. doi: 10.1038/nature11544. Epub 2012 Sep 18.

15.

Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics.

Zhu J, O'Dell S, Ofek G, Pancera M, Wu X, Zhang B, Zhang Z; NISC Comparative Sequencing Program, Mullikin JC, Simek M, Burton DR, Koff WC, Shapiro L, Mascola JR, Kwong PD.

Front Microbiol. 2012 Sep 11;3:315. eCollection 2012.

16.

The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation.

Dowling EP, Ronan W, Ofek G, Deshpande VS, McMeeking RM, Athanasiou KA, McGarry JP.

J R Soc Interface. 2012 Dec 7;9(77):3469-79. doi: 10.1098/rsif.2012.0428. Epub 2012 Jul 18.

17.

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.

Dennison SM, Sutherland LL, Jaeger FH, Anasti KM, Parks R, Stewart S, Bowman C, Xia SM, Zhang R, Shen X, Scearce RM, Ofek G, Yang Y, Kwong PD, Santra S, Liao HX, Tomaras G, Letvin NL, Chen B, Alam SM, Haynes BF.

PLoS One. 2011;6(11):e27824. doi: 10.1371/journal.pone.0027824. Epub 2011 Nov 30.

18.

Novel application of cytodetachment technology to the analysis of dental implant surfaces.

Bhatavadekar NB, Hu J, Keys K, Ofek G, Athanasiou KA.

Int J Oral Maxillofac Implants. 2011 Sep-Oct;26(5):985-90.

PMID:
22010080
19.

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization.

Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL.

Nat Struct Mol Biol. 2011 Oct 16;18(11):1235-43. doi: 10.1038/nsmb.2154.

20.

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies.

Zhu Z, Qin HR, Chen W, Zhao Q, Shen X, Schutte R, Wang Y, Ofek G, Streaker E, Prabakaran P, Fouda GG, Liao HX, Owens J, Louder M, Yang Y, Klaric KA, Moody MA, Mascola JR, Scott JK, Kwong PD, Montefiori D, Haynes BF, Tomaras GD, Dimitrov DS.

J Virol. 2011 Nov;85(21):11401-8. doi: 10.1128/JVI.05312-11. Epub 2011 Aug 31. Erratum in: J Virol. 2013 Nov;87(24):13936.

21.

Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis.

Jiang T, Petersen RR, Call G, Ofek G, Gao J, Yao JQ.

J Biomed Mater Res B Appl Biomater. 2011 May;97(2):355-63. doi: 10.1002/jbm.b.31822. Epub 2011 Mar 25.

PMID:
21442745
22.

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant.

Guenaga J, Dosenovic P, Ofek G, Baker D, Schief WR, Kwong PD, Karlsson Hedestam GB, Wyatt RT.

PLoS One. 2011 Jan 26;6(1):e16074. doi: 10.1371/journal.pone.0016074.

23.

Elicitation of structure-specific antibodies by epitope scaffolds.

Ofek G, Guenaga FJ, Schief WR, Skinner J, Baker D, Wyatt R, Kwong PD.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7. doi: 10.1073/pnas.1004728107. Epub 2010 Sep 27.

24.

Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region.

Ofek G, McKee K, Yang Y, Yang ZY, Skinner J, Guenaga FJ, Wyatt R, Zwick MB, Nabel GJ, Mascola JR, Kwong PD.

J Virol. 2010 Mar;84(6):2955-62. doi: 10.1128/JVI.02257-09. Epub 2009 Dec 30.

25.

Unique biomechanical interactions between myeloma cells and bone marrow stroma cells.

Feng Y, Ofek G, Choi DS, Wen J, Hu J, Zhao H, Zu Y, Athanasiou KA, Chang CC.

Prog Biophys Mol Biol. 2010 Sep;103(1):148-56. doi: 10.1016/j.pbiomolbio.2009.10.004. Epub 2009 Oct 17. Review.

PMID:
19840813
26.

Contribution of the cytoskeleton to the compressive properties and recovery behavior of single cells.

Ofek G, Wiltz DC, Athanasiou KA.

Biophys J. 2009 Oct 7;97(7):1873-82. doi: 10.1016/j.bpj.2009.07.050.

27.

Biomechanics of single chondrocytes under direct shear.

Ofek G, Dowling EP, Raphael RM, McGarry JP, Athanasiou KA.

Biomech Model Mechanobiol. 2010 Apr;9(2):153-62. doi: 10.1007/s10237-009-0166-1. Epub 2009 Jul 31.

PMID:
19644718
28.

Mechanical characterization of differentiated human embryonic stem cells.

Ofek G, Willard VP, Koay EJ, Hu JC, Lin P, Athanasiou KA.

J Biomech Eng. 2009 Jun;131(6):061011. doi: 10.1115/1.3127262.

29.

In situ mechanical properties of the chondrocyte cytoplasm and nucleus.

Ofek G, Natoli RM, Athanasiou KA.

J Biomech. 2009 May 11;42(7):873-7. doi: 10.1016/j.jbiomech.2009.01.024. Epub 2009 Mar 3.

30.

Matrix development in self-assembly of articular cartilage.

Ofek G, Revell CM, Hu JC, Allison DD, Grande-Allen KJ, Athanasiou KA.

PLoS One. 2008 Jul 30;3(7):e2795. doi: 10.1371/journal.pone.0002795.

31.

Effects of TGF-beta1 and IGF-I on the compressibility, biomechanics, and strain-dependent recovery behavior of single chondrocytes.

Koay EJ, Ofek G, Athanasiou KA.

J Biomech. 2008;41(5):1044-52. doi: 10.1016/j.jbiomech.2007.12.006. Epub 2008 Jan 28.

PMID:
18222457
32.

Distribution and three-dimensional structure of AIDS virus envelope spikes.

Zhu P, Liu J, Bess J Jr, Chertova E, Lifson JD, Grisé H, Ofek GA, Taylor KA, Roux KH.

Nature. 2006 Jun 15;441(7095):847-52. Epub 2006 May 24.

PMID:
16728975
33.

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope.

Ofek G, Tang M, Sambor A, Katinger H, Mascola JR, Wyatt R, Kwong PD.

J Virol. 2004 Oct;78(19):10724-37.

34.

Enhancing protein crystallization through precipitant synergy.

Majeed S, Ofek G, Belachew A, Huang CC, Zhou T, Kwong PD.

Structure. 2003 Sep;11(9):1061-70.

35.

Diurnal variations in cardiovascular function and glucose regulation in normotensive humans.

Biston P, Van Cauter E, Ofek G, Linkowski P, Polonsky KS, Degaute JP.

Hypertension. 1996 Nov;28(5):863-71.

PMID:
8901836
36.

Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers.

Van Cauter E, Sturis J, Byrne MM, Blackman JD, Leproult R, Ofek G, L'Hermite-Balériaux M, Refetoff S, Turek FW, Van Reeth O.

Am J Physiol. 1994 Jun;266(6 Pt 1):E953-63.

PMID:
8023927

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