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The murine IgH locus contains a distinct DNA sequence motif for the chromatin regulatory factor CTCF.

Ciccone DN, Namiki Y, Chen C, Morshead KB, Wood AL, Johnston CM, Morris JW, Wang Y, Sadreyev R, Corcoran AE, Matthews AGW, Oettinger MA.

J Biol Chem. 2019 Sep 13;294(37):13580-13592. doi: 10.1074/jbc.RA118.007348. Epub 2019 Jul 8.


Low-Input MNase Accessibility of Chromatin (Low-Input MACC).

Lion M, Tolstorukov MY, Oettinger MA.

Curr Protoc Mol Biol. 2019 Jun;127(1):e91. doi: 10.1002/cpmb.91.


TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM.

Cancer Discov. 2017 Nov;7(11):1336-1353. doi: 10.1158/2159-8290.CD-17-0267. Epub 2017 Oct 3.


Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.

Pulivarthy SR, Lion M, Kuzu G, Matthews AG, Borowsky ML, Morris J, Kingston RE, Dennis JH, Tolstorukov MY, Oettinger MA.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6427-E6436. Epub 2016 Oct 3.


Compound heterozygous mutation of Rag1 leading to Omenn syndrome.

Matthews AG, Briggs CE, Yamanaka K, Small TN, Mooster JL, Bonilla FA, Oettinger MA, Butte MJ.

PLoS One. 2015 Apr 7;10(4):e0121489. doi: 10.1371/journal.pone.0121489. eCollection 2015.


Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA.

Cell Rep. 2012 Feb 23;1(2):83-90.


Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations.

Balter BB, Ciccone DN, Oettinger MA, Selsing E.

Mol Immunol. 2012 Aug;52(1):1-8. doi: 10.1016/j.molimm.2012.04.006. Epub 2012 May 11.


Regulation of RAG transposition.

Matthews AG, Oettinger MA.

Adv Exp Med Biol. 2009;650:16-31. Review.


RAG: a recombinase diversified.

Matthews AG, Oettinger MA.

Nat Immunol. 2009 Aug;10(8):817-21. doi: 10.1038/ni.1776. Epub 2009 Jul 21. Review.


Pillars article: the V(D)J recombination activating gene, RAG-1. 1989.

Schatz DG, Oettinger MA, Baltimore D.

J Immunol. 2008 Jan 1;180(1):5-18. No abstract available.


RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.

Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA.

Nature. 2007 Dec 13;450(7172):1106-10. Epub 2007 Nov 21.


The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.

Ramón-Maiques S, Kuo AJ, Carney D, Matthews AG, Oettinger MA, Gozani O, Yang W.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18993-8. Epub 2007 Nov 19.


A PHD finger motif in the C terminus of RAG2 modulates recombination activity.

Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP.

J Biol Chem. 2005 Aug 5;280(31):28701-10. Epub 2005 Jun 17.


The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast.

Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA.

J Biol Chem. 2005 May 27;280(21):20247-52. Epub 2005 Mar 9.


Molecular biology: hairpins at split ends in DNA.

Oettinger MA.

Nature. 2004 Dec 23;432(7020):960-1. No abstract available.


How to keep V(D)J recombination under control.

Oettinger MA.

Immunol Rev. 2004 Aug;200:165-81. Review.


ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays.

Patenge N, Elkin SK, Oettinger MA.

J Biol Chem. 2004 Aug 20;279(34):35360-7. Epub 2004 Jun 16.


Ordered DNA release and target capture in RAG transposition.

Matthews AG, Elkin SK, Oettinger MA.

EMBO J. 2004 Mar 10;23(5):1198-206. Epub 2004 Feb 26.


Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci.

Ciccone DN, Morshead KB, Oettinger MA.

Methods Enzymol. 2004;376:334-48. Review. No abstract available.


DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.

Park EJ, Chan DW, Park JH, Oettinger MA, Kwon J.

Nucleic Acids Res. 2003 Dec 1;31(23):6819-27.


V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence.

Montalbano A, Ogwaro KM, Tang A, Matthews AG, Larijani M, Oettinger MA, Feeney AJ.

J Immunol. 2003 Nov 15;171(10):5296-304.


V(D)J recombination and RAG-mediated transposition in yeast.

Clatworthy AE, Valencia MA, Haber JE, Oettinger MA.

Mol Cell. 2003 Aug;12(2):489-99.


Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4.

Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11577-82. Epub 2003 Sep 19.


The C-terminal portion of RAG2 protects against transposition in vitro.

Elkin SK, Matthews AG, Oettinger MA.

EMBO J. 2003 Apr 15;22(8):1931-8.


Nonhomologous end joining and V(D)J recombination require an additional factor.

Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, Harville TO, West SC, Oettinger MA, Jeggo PA.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2462-7. Epub 2003 Feb 25.


Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.

Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1820-5. Epub 2003 Feb 6.


Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.

Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1209-14. Epub 2003 Jan 16.


DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.

O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, Concannon P.

Mol Cell. 2001 Dec;8(6):1175-85.


Assembly of the RAG1/RAG2 synaptic complex.

Mundy CL, Patenge N, Matthews AG, Oettinger MA.

Mol Cell Biol. 2002 Jan;22(1):69-77.


Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.

Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B.

J Biol Chem. 2001 Aug 17;276(33):31124-32. Epub 2001 May 10.


Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA.

Kwon J, Morshead KB, Guyon JR, Kingston RE, Oettinger MA.

Mol Cell. 2000 Nov;6(5):1037-48.


V(D)J recombination: site-specific cleavage and repair.

Kim DR, Park SJ, Oettinger MA.

Mol Cells. 2000 Aug 31;10(4):367-74. Review.


Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.

Kim DR, Dai Y, Mundy CL, Yang W, Oettinger MA.

Genes Dev. 1999 Dec 1;13(23):3070-80.


V(D)J recombination: on the cutting edge.

Oettinger MA.

Curr Opin Cell Biol. 1999 Jun;11(3):325-9. Review.


Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.

Steen SB, Han JO, Mundy C, Oettinger MA, Roth DB.

Mol Cell Biol. 1999 Apr;19(4):3010-7.


Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

Kwon J, Imbalzano AN, Matthews A, Oettinger MA.

Mol Cell. 1998 Dec;2(6):829-39.


Functional analysis of coordinated cleavage in V(D)J recombination.

Kim DR, Oettinger MA.

Mol Cell Biol. 1998 Aug;18(8):4679-88.


DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences.

Cuomo CA, Mundy CL, Oettinger MA.

Mol Cell Biol. 1996 Oct;16(10):5683-90.


Cutting apart V(D)J recombination.

Oettinger MA.

Curr Opin Genet Dev. 1996 Apr;6(2):141-5. Review.


Regions of RAG1 protein critical for V(D)J recombination.

Kirch SA, Sudarsanam P, Oettinger MA.

Eur J Immunol. 1996 Apr;26(4):886-91.


Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA.

Cell. 1995 Nov 3;83(3):387-95.


DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.

Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM.

Science. 1995 Feb 24;267(5201):1178-83.


Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.

Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA.

Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6156-60.


Analysis of regions of RAG-2 important for V(D)J recombination.

Cuomo CA, Oettinger MA.

Nucleic Acids Res. 1994 May 25;22(10):1810-4.


Activation of V(D)J recombination by RAG1 and RAG2.

Oettinger MA.

Trends Genet. 1992 Dec;8(12):413-6. Review.


The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice.

Oettinger MA, Stanger B, Schatz DG, Glaser T, Call K, Housman D, Baltimore D.

Immunogenetics. 1992;35(2):97-101.


V(D)J recombination: molecular biology and regulation.

Schatz DG, Oettinger MA, Schlissel MS.

Annu Rev Immunol. 1992;10:359-83. Review. No abstract available.


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