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Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients.

Wu JF, Muthusamy A, Al-Ghalith GA, Knights D, Guo B, Wu B, Remmel RP, Schladt DP, Alegre ML, Oetting WS, Jacobson PA, Israni AK.

Clin Transplant. 2018 Oct 29:e13436. doi: 10.1111/ctr.13436. [Epub ahead of print]


Tacrolimus trough and dose intra-patient variability and CYP3A5 genotype: Effects on acute rejection and graft failure in European American and African American kidney transplant recipients.

Seibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA.

Clin Transplant. 2018 Oct 14:e13424. doi: 10.1111/ctr.13424. [Epub ahead of print]


Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination.

Scheibner A, Remmel R, Schladt D, Oetting WS, Guan W, Wu B, Dorr C, Israni A, Jacobson PA.

Pharmacotherapy. 2018 May 26. doi: 10.1002/phar.2131. [Epub ahead of print]


NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD.

Snoek R, van Setten J, Keating BJ, Israni AK, Jacobson PA, Oetting WS, Matas AJ, Mannon RB, Zhang Z, Zhang W, Hao K, Murphy B, Reindl-Schwaighofer R, Heinzl A, Oberbauer R, Viklicky O, Conlon PJ, Stapleton CP, Bakker SJL, Snieder H, Peters EDJ, van der Zwaag B, Knoers NVAM, de Borst MH, van Eerde AM.

J Am Soc Nephrol. 2018 Jun;29(6):1772-1779. doi: 10.1681/ASN.2017111200. Epub 2018 Apr 13.


Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients.

Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Dorr C, Mannon RB, Matas AJ, Israni AK, Jacobson PA.

Pharmacogenomics. 2018 Feb;19(3):175-184. doi: 10.2217/pgs-2017-0187. Epub 2018 Jan 10.


Methods and tools for assessing the impact of genetic variations: The 2017 Annual Scientific Meeting of the Human Genome Variation Society.

Oetting WS, Béroud C, Brenner SE, Greenblatt MS, Karchin R, Mooney SD.

Hum Mutat. 2018 Mar;39(3):454-458. doi: 10.1002/humu.23393. Epub 2018 Jan 15. No abstract available.


Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.

Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA.

Pharmacogenomics J. 2018 May 22;18(3):501-505. doi: 10.1038/tpj.2017.49. Epub 2017 Nov 21.


Concepts of Genomics in Kidney Transplantation.

Oetting WS, Dorr C, Remmel RP, Matas AJ, Israni AK, Jacobson PA.

Curr Transplant Rep. 2017 Jun;4(2):116-123. doi: 10.1007/s40472-017-0153-x. Epub 2017 May 24.


Genetics of acute rejection after kidney transplantation.

Dorr CR, Oetting WS, Jacobson PA, Israni AK.

Transpl Int. 2018 Mar;31(3):263-277. doi: 10.1111/tri.13084. Epub 2017 Nov 8. Review.


Implementing pharmacogenomics in modern health care: The 2017 scientific meeting of the Human Genome Variation Society.

Lanting P, Oetting WS.

Hum Mutat. 2017 Nov;38(11):1606-1610. doi: 10.1002/humu.23300. Epub 2017 Aug 3. No abstract available.


CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.

Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK.

Drug Metab Dispos. 2017 Aug;45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22.


Non-Coding Variation: The 2016 Annual Scientific Meeting of the Human Genome Variation Society.

Oetting WS, Béroud C, Brenner SE, Greenblatt M, Karchin R, Mooney SD, Sunyaev S.

Hum Mutat. 2017 Apr;38(4):460-463. doi: 10.1002/humu.23169. Epub 2017 Feb 14. No abstract available.


Validation Is Critical for Genome-Wide Association Study-Based Associations.

Oetting WS, Jacobson PA, Israni AK.

Am J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. No abstract available.


Clinical Interpretation of Variants from Next-Generation Sequencing: The 2016 Scientific Meeting of the Human Genome Variation Society.

Oetting WS, Brookes AJ, Béroud C, Taschner PE.

Hum Mutat. 2016 Oct;37(10):1110-3. doi: 10.1002/humu.23059. Epub 2016 Aug 21.


Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society.

Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE.

Hum Mutat. 2016 Apr;37(4):406-11. doi: 10.1002/humu.22958. Epub 2016 Feb 12. No abstract available.


Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.

Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA.

Pharmacogenomics J. 2017 Jan;17(1):61-68. doi: 10.1038/tpj.2015.87. Epub 2015 Dec 15.


Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.

Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C, Sanghavi K, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA; DeKAF Investigators.

Am J Transplant. 2016 Feb;16(2):574-82. doi: 10.1111/ajt.13495. Epub 2015 Oct 20.


Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

Kalman LV, Agúndez J, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Caudle K, Coulthard SA, Daly AK, Del Tredici A, den Dunnen JT, Drozda K, Everts RE, Flockhart D, Freimuth RR, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale RF, van Schaik R, Whirl-Carrillo M, Yeo K, Zanger UM.

Clin Pharmacol Ther. 2016 Feb;99(2):172-85. doi: 10.1002/cpt.280. Epub 2015 Nov 20. Review.


Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.

Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.

Genome Med. 2015 Oct 1;7:90. doi: 10.1186/s13073-015-0211-x.


Multigene predictors of tacrolimus exposure in kidney transplant recipients.

Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, Matas AJ, Remmel RP, Jacobson PA; DeKAF Investigators.

Pharmacogenomics. 2015 Jul;16(8):841-54. doi: 10.2217/pgs.15.42. Epub 2015 Jun 12.


Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.

Dorr C, Wu B, Guan W, Muthusamy A, Sanghavi K, Schladt DP, Maltzman JS, Scherer SE, Brott MJ, Matas AJ, Jacobson PA, Oetting WS, Israni AK.

PLoS One. 2015 May 6;10(5):e0125045. doi: 10.1371/journal.pone.0125045. eCollection 2015.


Germline & somatic mosaicism: the 2014 annual scientific meeting of the Human Genome Variation Society.

Oetting WS, Greenblatt MS, Brookes AJ, Karchin R, Mooney SD.

Hum Mutat. 2015 Mar;36(3):390-3. doi: 10.1002/humu.22757. No abstract available.


Functional Fcgamma receptor polymorphisms are associated with human allergy.

Wu J, Lin R, Huang J, Guan W, Oetting WS, Sriramarao P, Blumenthal MN.

PLoS One. 2014 Feb 21;9(2):e89196. doi: 10.1371/journal.pone.0089196. eCollection 2014.


Telomere length of recipients and living kidney donors and chronic graft dysfunction in kidney transplants.

Oetting WS, Guan W, Schladt DP, Wildebush WA, Becker J, Thyagarajan B, Jacobson PA, Matas AJ, Israni AK.

Transplantation. 2014 Feb 15;97(3):325-9. doi: 10.1097/01.TP.0000436705.87898.88.


Clinically relevant variants - identifying, collecting, interpreting, and disseminating: the 2013 annual scientific meeting of the Human Genome Variation Society.

Stanley CM, Sunyaev SR, Greenblatt MS, Oetting WS.

Hum Mutat. 2014 Apr;35(4):505-10. doi: 10.1002/humu.22516.


Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample.

Irons DE, Iacono WG, Oetting WS, Kirkpatrick RM, Vrieze SI, Miller MB, McGue M.

Alcohol Clin Exp Res. 2014 Apr;38(4):938-47. doi: 10.1111/acer.12352. Epub 2014 Jan 24.


Clinical applications of next-generation sequencing: the 2013 human genome variation society scientific meeting.

Ellard S, Patrinos GP, Oetting WS.

Hum Mutat. 2013 Nov;34(11):1583-7. doi: 10.1002/humu.22400. Epub 2013 Sep 4.


A genome-wide association study of behavioral disinhibition.

McGue M, Zhang Y, Miller MB, Basu S, Vrieze S, Hicks B, Malone S, Oetting WS, Iacono WG.

Behav Genet. 2013 Sep;43(5):363-73. doi: 10.1007/s10519-013-9606-x. Epub 2013 Aug 14.


Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF Genomics.

Israni AK, Riad SM, Leduc R, Oetting WS, Guan W, Schladt D, Matas AJ, Jacobson PA; DeKAF Genomics Investigators.

Transpl Int. 2013 Oct;26(10):982-9. doi: 10.1111/tri.12155. Epub 2013 Jul 24.


Transplant rejection and risk: in search of the genetic dark matter.

Oetting WS, Jacobson PA, Israni AK.

J Gastrointestin Liver Dis. 2013 Jun;22(2):125-6. No abstract available.


Getting ready for the Human Phenome Project: the 2012 forum of the Human Variome Project.

Oetting WS, Robinson PN, Greenblatt MS, Cotton RG, Beck T, Carey JC, Doelken SC, Girdea M, Groza T, Hamilton CM, Hamosh A, Kerner B, MacArthur JA, Maglott DR, Mons B, Rehm HL, Schofield PN, Searle BA, Smedley D, Smith CL, Bernstein IT, Zankl A, Zhao EY.

Hum Mutat. 2013 Apr;34(4):661-6. doi: 10.1002/humu.22293.


The Minnesota Center for Twin and Family Research genome-wide association study.

Miller MB, Basu S, Cunningham J, Eskin E, Malone SM, Oetting WS, Schork N, Sul JH, Iacono WG, McGue M.

Twin Res Hum Genet. 2012 Dec;15(6):767-74. doi: 10.1017/thg.2012.62.


Inflammation in the setting of chronic allograft dysfunction post-kidney transplant: phenotype and genotype.

Israni AK, Leduc R, Jacobson PA, Wildebush W, Guan W, Schladt D, Matas AJ, Oetting WS; DeKAF Genomics Investigators.

Clin Transplant. 2013 May-Jun;27(3):348-58. doi: 10.1111/ctr.12074. Epub 2013 Jan 27.


Autosomal dominant mesomandibular fibro-osseous dysplasia: a self-resolving inherited fibro-osseous lesion of the jaws.

Koutlas IG, Forsman CL, Kyrkanides S, Oetting WS, Petryk A.

Front Physiol. 2012 Dec 6;3:458. doi: 10.3389/fphys.2012.00458. eCollection 2012.


Donor polymorphisms of toll-like receptor 4 associated with graft failure in liver transplant recipients.

Oetting WS, Guan W, Schladt DP, Leduc RE, Jacobson PA, Matas AJ, Chinnakotla S, Schröppel B, Murphy BT, Israni AK.

Liver Transpl. 2012 Dec;18(12):1399-405. doi: 10.1002/lt.23549.


Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs.

Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, Israni A.

Am J Transplant. 2012 Dec;12(12):3326-36. doi: 10.1111/j.1600-6143.2012.04232.x. Epub 2012 Sep 4.


Validation of tacrolimus equation to predict troughs using genetic and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Schladt DP, Oetting WS, Leduc RE, Israni AK, Guan W, Matas AJ, Jacobson PA.

Pharmacogenomics. 2012 Jul;13(10):1141-7. doi: 10.2217/pgs.12.98.


Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.

Irons DE, Iacono WG, Oetting WS, McGue M.

Alcohol Clin Exp Res. 2012 Nov;36(11):1882-91. doi: 10.1111/j.1530-0277.2012.01809.x. Epub 2012 May 7.


High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions.

Fang G, Haznadar M, Wang W, Yu H, Steinbach M, Church TR, Oetting WS, Van Ness B, Kumar V.

PLoS One. 2012;7(4):e33531. doi: 10.1371/journal.pone.0033531. Epub 2012 Apr 19.


Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: results from a kidney transplant consortium.

Jacobson PA, Schladt D, Israni A, Oetting WS, Lin YC, Leduc R, Guan W, Lamba V, Matas AJ; DeKAF Investigators.

Transplantation. 2012 Mar 27;93(6):624-31. doi: 10.1097/TP.0b013e3182461288.


Exome and genome analysis as a tool for disease identification and treatment: the 2011 Human Genome Variation Society scientific meeting.

Oetting WS.

Hum Mutat. 2012 Mar;33(3):586-90. doi: 10.1002/humu.22018. Epub 2012 Jan 31.


Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort.

Oetting WS, Schladt DP, Leduc RE, Jacobson PA, Guan W, Matas AJ, Israni A; DeKAF Investigators.

Transpl Int. 2011 Dec;24(12):1231-8. doi: 10.1111/j.1432-2277.2011.01359.x. Epub 2011 Sep 29.


Multilocus association testing with penalized regression.

Basu S, Pan W, Shen X, Oetting WS.

Genet Epidemiol. 2011 Dec;35(8):755-65. doi: 10.1002/gepi.20625. Epub 2011 Sep 15.


Validation of genetic variants associated with early acute rejection in kidney allograft transplantation.

Oetting WS, Zhu Y, Brott MJ, Matas AJ, Cordner GK, Pan W.

Clin Transplant. 2012 May-Jun;26(3):418-23. doi: 10.1111/j.1399-0012.2011.01522.x. Epub 2011 Sep 15.


Clarity and claims in variation/mutation databasing.

Dalgleish R, Oetting WS, Auerbach AD, Beckmann JS, Cambon-Thomsen A, Devereau A, Greenblatt MS, Patrinos GP, Taylor GR, Vihinen M, Brookes AJ.

Nat Biotechnol. 2011 Sep 8;29(9):790-2; author reply 792-4. doi: 10.1038/nbt.1961. No abstract available.


A dimension reduction approach for modeling multi-locus interaction in case-control studies.

Basu S, Pan W, Oetting WS.

Hum Hered. 2011;71(4):234-45. doi: 10.1159/000328842. Epub 2011 Jul 6.


Dosing equation for tacrolimus using genetic variants and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Oetting WS, Israni AK, Jacobson PA.

Br J Clin Pharmacol. 2011 Dec;72(6):948-57. doi: 10.1111/j.1365-2125.2011.04039.x.


Molecular testing in congenital adrenal hyperplasia due to 21α-hydroxylase deficiency in the era of newborn screening.

Sarafoglou K, Lorentz CP, Otten N, Oetting WS, Grebe SK.

Clin Genet. 2012 Jul;82(1):64-70. doi: 10.1111/j.1399-0004.2011.01694.x. Epub 2011 Jun 3.


Exploring the functional consequences of genomic variation: the 2010 Human Genome Variation Society Scientific Meeting.

Oetting WS.

Hum Mutat. 2011 Apr;32(4):486-90. doi: 10.1002/humu.21443. Epub 2011 Feb 17.


Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium.

Jacobson PA, Oetting WS, Brearley AM, Leduc R, Guan W, Schladt D, Matas AJ, Lamba V, Julian BA, Mannon RB, Israni A; DeKAF Investigators.

Transplantation. 2011 Feb 15;91(3):300-8. doi: 10.1097/TP.0b013e318200e991.

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