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Items: 26


Revisiting hypoxia therapies for tuberculosis.

Oehlers SH.

Clin Sci (Lond). 2019 Jun 17;133(12):1271-1280. doi: 10.1042/CS20190415. Print 2019 Jun 28. Review.


The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets.

Black HD, Xu W, Hortle E, Robertson SI, Britton WJ, Kaur A, New EJ, Witting PK, Chami B, Oehlers SH.

Free Radic Biol Med. 2019 May 1;135:157-166. doi: 10.1016/j.freeradbiomed.2019.03.010. Epub 2019 Mar 14.


Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish.

Hortle E, Johnson KE, Johansen MD, Nguyen T, Shavit JA, Britton WJ, Tobin DM, Oehlers SH.

J Infect Dis. 2019 Mar 16. pii: jiz110. doi: 10.1093/infdis/jiz110. [Epub ahead of print]


Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility.

Johansen MD, Hortle E, Kasparian JA, Romero A, Novoa B, Figueras A, Britton WJ, de Silva K, Purdie AC, Oehlers SH.

Fish Shellfish Immunol. 2018 Dec;83:238-242. doi: 10.1016/j.fsi.2018.09.037. Epub 2018 Sep 13.


Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models.

Johansen MD, Kasparian JA, Hortle E, Britton WJ, Purdie AC, Oehlers SH.

Dev Comp Immunol. 2018 Nov;88:169-172. doi: 10.1016/j.dci.2018.07.022. Epub 2018 Jul 21.


Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.

Spain M, Wong JK, Nagalingam G, Batten JM, Hortle E, Oehlers SH, Jiang XF, Murage HE, Orford JT, Crisologo P, Triccas JA, Rutledge PJ, Todd MH.

J Med Chem. 2018 Apr 26;61(8):3595-3608. doi: 10.1021/acs.jmedchem.7b01569. Epub 2018 Apr 5.


Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.

Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, Ko DC.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7746-E7755. doi: 10.1073/pnas.1706070114. Epub 2017 Aug 21. Erratum in: Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10852. Proc Natl Acad Sci U S A. 2017 Nov 27;:.


A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.

Oehlers SH, Flores MV, Hall CJ, Wang L, Ko DC, Crosier KE, Crosier PS.

FEBS J. 2017 Feb;284(3):402-413. doi: 10.1111/febs.13976. Epub 2017 Jan 9.


Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.

Cronan MR, Beerman RW, Rosenberg AF, Saelens JW, Johnson MG, Oehlers SH, Sisk DM, Jurcic Smith KL, Medvitz NA, Miller SE, Trinh LA, Fraser SE, Madden JF, Turner J, Stout JE, Lee S, Tobin DM.

Immunity. 2016 Oct 18;45(4):861-876. doi: 10.1016/j.immuni.2016.09.014.


Infection-Induced Vascular Permeability Aids Mycobacterial Growth.

Oehlers SH, Cronan MR, Beerman RW, Johnson MG, Huang J, Kontos CD, Stout JE, Tobin DM.

J Infect Dis. 2017 Mar 1;215(5):813-817. doi: 10.1093/infdis/jiw355.


Live Imaging of Host-Pathogen Interactions in Zebrafish Larvae.

Matty MA, Oehlers SH, Tobin DM.

Methods Mol Biol. 2016;1451:207-23. doi: 10.1007/978-1-4939-3771-4_14.


CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections.

Cronan MR, Rosenberg AF, Oehlers SH, Saelens JW, Sisk DM, Jurcic Smith KL, Lee S, Tobin DM.

Dis Model Mech. 2015 Dec;8(12):1643-50. doi: 10.1242/dmm.021394. Epub 2015 Oct 8.


Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion.

Tenor JL, Oehlers SH, Yang JL, Tobin DM, Perfect JR.

MBio. 2015 Sep 29;6(5):e01425-15. doi: 10.1128/mBio.01425-15.


CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.

Wang L, Oehlers SH, Espenschied ST, Rawls JF, Tobin DM, Ko DC.

Genome Biol. 2015 Sep 15;16:190. doi: 10.1186/s13059-015-0722-1.


A zebrafish model of inflammatory lymphangiogenesis.

Okuda KS, Misa JP, Oehlers SH, Hall CJ, Ellett F, Alasmari S, Lieschke GJ, Crosier KE, Crosier PS, Astin JW.

Biol Open. 2015 Sep 14;4(10):1270-80. doi: 10.1242/bio.013540.


Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis.

Chew TS, O'Shea NR, Sewell GW, Oehlers SH, Mulvey CM, Crosier PS, Godovac-Zimmermann J, Bloom SL, Smith AM, Segal AW.

Dis Model Mech. 2015 Aug 1;8(8):817-29. doi: 10.1242/dmm.020362. Epub 2015 Jun 4.


Interception of host angiogenic signalling limits mycobacterial growth.

Oehlers SH, Cronan MR, Scott NR, Thomas MI, Okuda KS, Walton EM, Beerman RW, Crosier PS, Tobin DM.

Nature. 2015 Jan 29;517(7536):612-5. doi: 10.1038/nature13967. Epub 2014 Nov 24.


Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production.

Hall CJ, Boyle RH, Astin JW, Flores MV, Oehlers SH, Sanderson LE, Ellett F, Lieschke GJ, Crosier KE, Crosier PS.

Cell Metab. 2013 Aug 6;18(2):265-78. doi: 10.1016/j.cmet.2013.06.018.


Chemically induced intestinal damage models in zebrafish larvae.

Oehlers SH, Flores MV, Hall CJ, Okuda KS, Sison JO, Crosier KE, Crosier PS.

Zebrafish. 2013 Jun;10(2):184-93. doi: 10.1089/zeb.2012.0824. Epub 2013 Feb 28.


Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.

Oehlers SH, Flores MV, Hall CJ, Crosier KE, Crosier PS.

Dis Model Mech. 2012 Jul;5(4):457-67. doi: 10.1242/dmm.009365. Epub 2012 Apr 19.


Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide.

Hall CJ, Flores MV, Oehlers SH, Sanderson LE, Lam EY, Crosier KE, Crosier PS.

Cell Stem Cell. 2012 Feb 3;10(2):198-209. doi: 10.1016/j.stem.2012.01.007.


The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish.

Oehlers SH, Flores MV, Hall CJ, Swift S, Crosier KE, Crosier PS.

Dis Model Mech. 2011 Nov;4(6):832-41. doi: 10.1242/dmm.006122. Epub 2011 Jul 4.


Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation.

Crawford KC, Vega Flores M, Oehlers SH, Hall CJ, Crosier KE, Crosier PS.

Genesis. 2011 Dec;49(12):905-11. doi: 10.1002/dvg.20767. Epub 2011 Oct 13.


A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents.

Oehlers SH, Flores MV, Okuda KS, Hall CJ, Crosier KE, Crosier PS.

Dev Dyn. 2011 Jan;240(1):288-98. doi: 10.1002/dvdy.22519.


Topographical distribution of antimicrobial genes in the zebrafish intestine.

Oehlers SH, Flores MV, Chen T, Hall CJ, Crosier KE, Crosier PS.

Dev Comp Immunol. 2011 Mar;35(3):385-91. doi: 10.1016/j.dci.2010.11.008. Epub 2010 Nov 25.


Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation.

Oehlers SH, Flores MV, Hall CJ, O'Toole R, Swift S, Crosier KE, Crosier PS.

Dev Comp Immunol. 2010 Mar;34(3):352-9. doi: 10.1016/j.dci.2009.11.007. Epub 2009 Dec 1.


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