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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity.

Gemble S, Simon A, Pennetier C, Dumont M, Hervé S, Meitinger F, Oegema K, Rodriguez R, Almouzni G, Fachinetti D, Basto R.

Curr Biol. 2019 Aug 7. pii: S0960-9822(19)30932-7. doi: 10.1016/j.cub.2019.07.052. [Epub ahead of print]


A high-content imaging approach to profile C. elegans embryonic development.

Wang S, Ochoa SD, Khaliullin RN, Gerson-Gurwitz A, Hendel JM, Zhao Z, Biggs R, Chisholm AD, Desai A, Oegema K, Green RA.

Development. 2019 Apr 11;146(7). pii: dev174029. doi: 10.1242/dev.174029.


The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis.

Cheerambathur DK, Prevo B, Chow TL, Hattersley N, Wang S, Zhao Z, Kim T, Gerson-Gurwitz A, Oegema K, Green R, Desai A.

Dev Cell. 2019 Mar 25;48(6):864-872.e7. doi: 10.1016/j.devcel.2019.02.002. Epub 2019 Feb 28.


The ARP2/3 complex prevents excessive formin activity during cytokinesis.

Chan FY, Silva AM, Saramago J, Pereira-Sousa J, Brighton HE, Pereira M, Oegema K, Gassmann R, Carvalho AX.

Mol Biol Cell. 2019 Jan 1;30(1):96-107. doi: 10.1091/mbc.E18-07-0471. Epub 2018 Nov 7.


CFI-400945 is not a selective cellular PLK4 inhibitor.

Oegema K, Davis RL, Lara-Gonzalez P, Desai A, Shiau AK.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10808-E10809. doi: 10.1073/pnas.1813310115. Epub 2018 Oct 30. No abstract available.


CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia.

Lee KY, Green RA, Gutierrez E, Gomez-Cavazos JS, Kolotuev I, Wang S, Desai A, Groisman A, Oegema K.

Elife. 2018 Jul 10;7. pii: e36919. doi: 10.7554/eLife.36919.


A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans.

Khaliullin RN, Green RA, Shi LZ, Gomez-Cavazos JS, Berns MW, Desai A, Oegema K.

Elife. 2018 Jul 2;7. pii: e36073. doi: 10.7554/eLife.36073.


Employing the one-cell C. elegans embryo to study cell division processes.

Hattersley N, Lara-Gonzalez P, Cheerambathur D, Gomez-Cavazos JS, Kim T, Prevo B, Khaliullin R, Lee KY, Ohta M, Green R, Oegema K, Desai A.

Methods Cell Biol. 2018;144:185-231. doi: 10.1016/bs.mcb.2018.03.008. Epub 2018 May 1.


Correction: Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation (doi:10.1242/dev.126615).

Quintin S, Wang S, Pontabry J, Bender A, Robin F, Hyenne V, Landmann F, Gally C, Oegema K, Labouesse M.

Development. 2018 May 14;145(10). pii: dev167262. doi: 10.1242/dev.167262. No abstract available.


TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.

Mangal S, Sacher J, Kim T, Osório DS, Motegi F, Carvalho AX, Oegema K, Zanin E.

J Cell Biol. 2018 Mar 5;217(3):837-848. doi: 10.1083/jcb.201706021. Epub 2018 Jan 8.


Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.

Kim T, Lara-Gonzalez P, Prevo B, Meitinger F, Cheerambathur DK, Oegema K, Desai A.

Genes Dev. 2017 Jun 1;31(11):1089-1094. doi: 10.1101/gad.302067.117. Epub 2017 Jul 11.


A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans.

Wang S, Tang NH, Lara-Gonzalez P, Zhao Z, Cheerambathur DK, Prevo B, Chisholm AD, Desai A, Oegema K.

Development. 2017 Jul 15;144(14):2694-2701. doi: 10.1242/dev.150094. Epub 2017 Jun 15.


Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.

Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett KD, Oegema K, Desai A.

Dev Cell. 2017 May 22;41(4):424-437.e4. doi: 10.1016/j.devcel.2017.04.013.


How centrioles acquire the ability to reproduce.

Ohta M, Desai A, Oegema K.

Elife. 2017 Mar 8;6. pii: e25358. doi: 10.7554/eLife.25358.


GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.

Xing M, Peterman MC, Davis RL, Oegema K, Shiau AK, Field SJ.

Mol Biol Cell. 2016 Dec 1;27(24):3828-3840. Epub 2016 Oct 5.


A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly.

Hattersley N, Cheerambathur D, Moyle M, Stefanutti M, Richardson A, Lee KY, Dumont J, Oegema K, Desai A.

Dev Cell. 2016 Sep 12;38(5):463-77. doi: 10.1016/j.devcel.2016.08.006.


Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation.

Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB.

Biol Open. 2016 Oct 15;5(10):1431-1440. doi: 10.1242/bio.020990.


53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K.

J Cell Biol. 2016 Jul 18;214(2):155-66. doi: 10.1083/jcb.201604081.


A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.

Gerson-Gurwitz A, Wang S, Sathe S, Green R, Yeo GW, Oegema K, Desai A.

Cell. 2016 Apr 7;165(2):396-409. doi: 10.1016/j.cell.2016.02.040. Epub 2016 Mar 24.


Correction: Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans.

Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A.

J Cell Biol. 2016 Mar 14;212(6):737. doi: 10.1083/jcb.20141203502192016c. Epub 2016 Mar 7. No abstract available.


Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation.

Quintin S, Wang S, Pontabry J, Bender A, Robin F, Hyenne V, Landmann F, Gally C, Oegema K, Labouesse M.

Development. 2016 Jan 1;143(1):160-73. doi: 10.1242/dev.126615. Epub 2015 Nov 19. Erratum in: Development. 2018 May 14;145(10 ):.


Methods in Cell Biology. Centrosome & Centriole. Preface.

Basto R, Oegema K.

Methods Cell Biol. 2015;129:xvii-xix. No abstract available.


NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.

Wang S, Wu D, Quintin S, Green RA, Cheerambathur DK, Ochoa SD, Desai A, Oegema K.

Elife. 2015 Sep 15;4:e08649. doi: 10.7554/eLife.08649.


Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans.

Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A.

J Cell Biol. 2015 May 25;209(4):507-17. doi: 10.1083/jcb.201412035. Epub 2015 May 18. Erratum in: J Cell Biol. 2016 Mar 14;212(6):737.


Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.

Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA.

Science. 2015 May 15;348(6236):808-12. doi: 10.1126/science.aaa3923.


Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.

Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K.

Science. 2015 Jun 5;348(6239):1155-60. doi: 10.1126/science.aaa5111. Epub 2015 Apr 30.


Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.

Monen J, Hattersley N, Muroyama A, Stevens D, Oegema K, Desai A.

PLoS One. 2015 Apr 28;10(4):e0125382. doi: 10.1371/journal.pone.0125382. eCollection 2015.


The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Folco HD, Campbell CS, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SIS, Desai A.

Curr Biol. 2015 Feb 2;25(3):348-356. doi: 10.1016/j.cub.2014.11.060. Epub 2015 Jan 22.


The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.

Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm AD.

Cell Rep. 2014 Nov 6;9(3):874-83. doi: 10.1016/j.celrep.2014.09.054. Epub 2014 Oct 23.


The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix.

Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA.

Mol Biol Cell. 2014 Oct 1;25(19):2984-92. doi: 10.1091/mbc.E13-09-0514. Epub 2014 Aug 7.


Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.

Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G.

Structure. 2014 Aug 5;22(8):1090-1104. doi: 10.1016/j.str.2014.05.009. Epub 2014 Jun 26.


A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.

Moyle MW, Kim T, Hattersley N, Espeut J, Cheerambathur DK, Oegema K, Desai A.

J Cell Biol. 2014 Mar 3;204(5):647-57. doi: 10.1083/jcb.201311015. Epub 2014 Feb 24.


Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.

Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K.

Genes Dev. 2014 Jan 15;28(2):121-6. doi: 10.1101/gad.230599.113.


Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline.

Stevens D, Oegema K, Desai A.

Curr Biol. 2013 Dec 2;23(23):2400-6. doi: 10.1016/j.cub.2013.10.015. Epub 2013 Nov 14.


Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.

Cheerambathur DK, Gassmann R, Cook B, Oegema K, Desai A.

Science. 2013 Dec 6;342(6163):1239-42. doi: 10.1126/science.1246232. Epub 2013 Nov 14.


The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules.

Green RA, Mayers JR, Wang S, Lewellyn L, Desai A, Audhya A, Oegema K.

J Cell Biol. 2013 Nov 11;203(3):505-20. doi: 10.1083/jcb.201306036.


Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.

Cottee MA, Muschalik N, Wong YL, Johnson CM, Johnson S, Andreeva A, Oegema K, Lea SM, Raff JW, van Breugel M.

Elife. 2013 Sep 17;2:e01071. doi: 10.7554/eLife.01071.


A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis.

Zanin E, Desai A, Poser I, Toyoda Y, Andree C, Moebius C, Bickle M, Conradt B, Piekny A, Oegema K.

Dev Cell. 2013 Sep 16;26(5):496-510. doi: 10.1016/j.devcel.2013.08.005. Epub 2013 Sep 5.


Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

Lettman MM, Wong YL, Viscardi V, Niessen S, Chen SH, Shiau AK, Zhou H, Desai A, Oegema K.

Dev Cell. 2013 May 13;25(3):284-98. doi: 10.1016/j.devcel.2013.03.011.


Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.


Hierarchical assembly of the eggshell and permeability barrier in C. elegans.

Olson SK, Greenan G, Desai A, Müller-Reichert T, Oegema K.

J Cell Biol. 2012 Aug 20;198(4):731-48. doi: 10.1083/jcb.201206008.


Cytokinesis in animal cells.

Green RA, Paluch E, Oegema K.

Annu Rev Cell Dev Biol. 2012;28:29-58. doi: 10.1146/annurev-cellbio-101011-155718. Epub 2012 Jul 9. Review.


An inverse relationship to germline transcription defines centromeric chromatin in C. elegans.

Gassmann R, Rechtsteiner A, Yuen KW, Muroyama A, Egelhofer T, Gaydos L, Barron F, Maddox P, Essex A, Monen J, Ercan S, Lieb JD, Oegema K, Strome S, Desai A.

Nature. 2012 Apr 8;484(7395):534-7. doi: 10.1038/nature10973.


Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.

Espeut J, Cheerambathur DK, Krenning L, Oegema K, Desai A.

J Cell Biol. 2012 Feb 20;196(4):469-82. doi: 10.1083/jcb.201111107. Epub 2012 Feb 13.


Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.

Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, Graham M, Reue K, Dixon JE, Goodman JM.

J Biol Chem. 2012 Jan 27;287(5):3123-37. doi: 10.1074/jbc.M111.324350. Epub 2011 Dec 1.


Affinity purification of protein complexes in C. elegans.

Zanin E, Dumont J, Gassmann R, Cheeseman I, Maddox P, Bahmanyar S, Carvalho A, Niessen S, Yates JR 3rd, Oegema K, Desai A.

Methods Cell Biol. 2011;106:289-322. doi: 10.1016/B978-0-12-544172-8.00011-6.


Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.

Yuen KW, Nabeshima K, Oegema K, Desai A.

Curr Biol. 2011 Nov 8;21(21):1800-7. doi: 10.1016/j.cub.2011.09.016. Epub 2011 Oct 20.


Acute drug treatment in the early C. elegans embryo.

Carvalho A, Olson SK, Gutierrez E, Zhang K, Noble LB, Zanin E, Desai A, Groisman A, Oegema K.

PLoS One. 2011;6(9):e24656. doi: 10.1371/journal.pone.0024656. Epub 2011 Sep 14.


Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest.

Stevens D, Gassmann R, Oegema K, Desai A.

PLoS One. 2011;6(8):e22969. doi: 10.1371/journal.pone.0022969. Epub 2011 Aug 2.


A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K.

Cell. 2011 Apr 29;145(3):470-82. doi: 10.1016/j.cell.2011.03.037.

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