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Items: 45

1.

Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis.

Bartsch YC, Rahmöller J, Mertes MMM, Eiglmeier S, Lorenz FKM, Stoehr AD, Braumann D, Lorenz AK, Winkler A, Lilienthal GM, Petry J, Hobusch J, Steinhaus M, Hess C, Holecska V, Schoen CT, Oefner CM, Leliavski A, Blanchard V, Ehlers M.

Front Immunol. 2018 Jun 6;9:1183. doi: 10.3389/fimmu.2018.01183. eCollection 2018.

2.

A microfluidics assay to study invasion of human placental trophoblast cells.

Abbas Y, Oefner CM, Polacheck WJ, Gardner L, Farrell L, Sharkey A, Kamm R, Moffett A, Oyen ML.

J R Soc Interface. 2017 May;14(130). pii: 20170131. doi: 10.1098/rsif.2017.0131.

3.

Collagen type IV at the fetal-maternal interface.

Oefner CM, Sharkey A, Gardner L, Critchley H, Oyen M, Moffett A.

Placenta. 2015 Jan;36(1):59-68. doi: 10.1016/j.placenta.2014.10.012. Epub 2014 Nov 1.

4.

Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs.

Oefner CM, Winkler A, Hess C, Lorenz AK, Holecska V, Huxdorf M, Schommartz T, Petzold D, Bitterling J, Schoen AL, Stoehr AD, Vu Van D, Darcan-Nikolaisen Y, Blanchard V, Schmudde I, Laumonnier Y, Ströver HA, Hegazy AN, Eiglmeier S, Schoen CT, Mertes MM, Loddenkemper C, Löhning M, König P, Petersen A, Luger EO, Collin M, Köhl J, Hutloff A, Hamelmann E, Berger M, Wardemann H, Ehlers M.

J Allergy Clin Immunol. 2012 Jun;129(6):1647-55.e13. doi: 10.1016/j.jaci.2012.02.037. Epub 2012 Apr 12.

PMID:
22502800
5.

Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity.

Jansen JA, van Veen TA, de Jong S, van der Nagel R, van Stuijvenberg L, Driessen H, Labzowski R, Oefner CM, Bosch AA, Nguyen TQ, Goldschmeding R, Vos MA, de Bakker JM, van Rijen HV.

Circ Arrhythm Electrophysiol. 2012 Apr;5(2):380-90. doi: 10.1161/CIRCEP.111.966580. Epub 2012 Feb 24.

PMID:
22368123
6.

Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.

Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. doi: 10.1107/S0907444909013936. Epub 2009 Jul 10.

PMID:
19622858
7.

Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.

Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE.

J Antimicrob Chemother. 2009 Apr;63(4):687-98. doi: 10.1093/jac/dkp024. Epub 2009 Feb 11.

PMID:
19211577
8.

Structure of human endothelin-converting enzyme I complexed with phosphoramidon.

Schulz H, Dale GE, Karimi-Nejad Y, Oefner C.

J Mol Biol. 2009 Jan 9;385(1):178-87. doi: 10.1016/j.jmb.2008.10.052. Epub 2008 Nov 1.

PMID:
18992253
9.

Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.

Oefner C, Pierau S, Schulz H, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):975-81. Epub 2007 Aug 17.

PMID:
17704566
10.

Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.

Oefner C, Schulz H, D'Arcy A, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):613-8. Epub 2006 May 12.

PMID:
16699188
11.
12.

Structure-based design, synthesis, and in vitro evaluation of nonpeptidic neprilysin inhibitors.

Sahli S, Stump B, Welti T, Blum-Kaelin D, Aebi JD, Oefner C, Böhm HJ, Diederich F.

Chembiochem. 2004 Jul 5;5(7):996-1000. No abstract available.

PMID:
15239059
13.

Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.

Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C.

J Med Chem. 2004 Mar 11;47(6):1325-8. Erratum in: J Med Chem. 2005 Jan 13;48(1):336. MacSweeney, Aengus [changed to Mac Sweeney, Aengus.

PMID:
14998322
14.

Structural analysis of neprilysin with various specific and potent inhibitors.

Oefner C, Roques BP, Fournie-Zaluski MC, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):392-6. Epub 2004 Jan 23.

PMID:
14747736
15.

The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors.

Oefner C, Douangamath A, D'Arcy A, Häfeli S, Mareque D, Mac Sweeney A, Padilla J, Pierau S, Schulz H, Thormann M, Wadman S, Dale GE.

J Mol Biol. 2003 Sep 5;332(1):13-21.

PMID:
12946343
16.

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.

Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1206-12. Epub 2003 Jun 27.

PMID:
12832764
17.

The protein as a variable in protein crystallization.

Dale GE, Oefner C, D'Arcy A.

J Struct Biol. 2003 Apr;142(1):88-97. Review.

PMID:
12718922
18.
19.

Piperidine renin inhibitors: from leads to drug candidates.

Märki HP, Binggeli A, Bittner B, Bohner-Lang V, Breu V, Bur D, Coassolo PH, Clozel JP, D'Arcy A, Doebeli H, Fischli W, Funk CH, Foricher J, Giller T, Grüninger F, Guenzi A, Güller R, Hartung T, Hirth G, Jenny CH, Kansy M, Klinkhammer U, Lave T, Lohri B, Luft FC, Mervaala EM, Müller DN, Müller M, Montavon F, Oefner CH, Qiu C, Reichel A, Sanwald-Ducray P, Scalone M, Schleimer M, Schmid R, Stadler H, Treiber A, Valdenaire O, Vieira E, Waldmeier P, Wiegand-Chou R, Wilhelm M, Wostl W, Zell M, Zell R.

Farmaco. 2001 Jan-Feb;56(1-2):21-7.

PMID:
11347960
20.

Purification and crystallization of the extracellular domain of human neutral endopeptidase (neprilysin) expressed in Pichia pastoris.

Dale GE, D'Arcy B, Yuvaniyama C, Wipf B, Oefner C, D'Arcy A.

Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):894-7.

PMID:
10930836
21.

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.

Oefner C, D'Arcy A, Hennig M, Winkler FK, Dale GE.

J Mol Biol. 2000 Feb 18;296(2):341-9.

PMID:
10669592
22.

Piperidine-renin inhibitors compounds with improved physicochemical properties.

Güller R, Binggeli A, Breu V, Bur D, Fischli W, Hirth G, Jenny C, Kansy M, Montavon F, Müller M, Oefner C, Stadler H, Vieira E, Wilhelm M, Wostl W, Märki HP.

Bioorg Med Chem Lett. 1999 May 17;9(10):1403-8.

PMID:
10360745
23.

Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.

Vieira E, Binggeli A, Breu V, Bur D, Fischli W, Güller R, Hirth G, Märki HP, Müller M, Oefner C, Scalone M, Stadler H, Wilhelm M, Wostl W.

Bioorg Med Chem Lett. 1999 May 17;9(10):1397-402.

PMID:
10360744
24.

The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.

Hennig M, Dale GE, D'arcy A, Danel F, Fischer S, Gray CP, Jolidon S, Müller F, Page MG, Pattison P, Oefner C.

J Mol Biol. 1999 Mar 26;287(2):211-9.

PMID:
10080886
25.

Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

Oefner C, Binggeli A, Breu V, Bur D, Clozel JP, D'Arcy A, Dorn A, Fischli W, Grüninger F, Güller R, Hirth G, Märki H, Mathews S, M ller M, Ridley RG, Stadler H, Vieira E, Wilhelm M, Winkler F, Wostl W.

Chem Biol. 1999 Mar;6(3):127-31.

26.

Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.

Heinze-Krauss I, Angehrn P, Charnas RL, Gubernator K, Gutknecht EM, Hubschwerlen C, Kania M, Oefner C, Page MG, Sogabe S, Specklin JL, Winkler F.

J Med Chem. 1998 Oct 8;41(21):3961-71.

PMID:
9767633
27.

Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.

Hennig M, D'Arcy A, Hampele IC, Page MG, Oefner C, Dale GE.

Nat Struct Biol. 1998 May;5(5):357-62.

PMID:
9586996
28.

Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.

Moon RP, Bur D, Loetscher H, D'Arcy A, Tyas L, Oefner C, Grueninger-Leitch F, Mona D, Rupp K, Dorn A, Matile H, Certa U, Berry C, Kay J, Ridley RG.

Adv Exp Med Biol. 1998;436:397-406. Review. No abstract available.

PMID:
9561248
29.

Analysis of three human interleukin 5 structures suggests a possible receptor binding mechanism.

Verschelde JL, Ampe C, Guisez Y, Oefner C, Vandekerckhove J, Tavernier J.

FEBS Lett. 1998 Mar 13;424(3):121-6. Review.

30.

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

Hampele IC, D'Arcy A, Dale GE, Kostrewa D, Nielsen J, Oefner C, Page MG, Schönfeld HJ, Stüber D, Then RL.

J Mol Biol. 1997 Apr 25;268(1):21-30.

PMID:
9149138
31.

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

Dale GE, Broger C, D'Arcy A, Hartman PG, DeHoogt R, Jolidon S, Kompis I, Labhardt AM, Langen H, Locher H, Page MG, Stüber D, Then RL, Wipf B, Oefner C.

J Mol Biol. 1997 Feb 14;266(1):23-30.

PMID:
9054967
32.

Recombinant human renin produced in different expression systems: biochemical properties and 3D structure.

Mathews S, Döbeli H, Pruschy M, Bosser R, D'Arcy A, Oefner C, Zulauf M, Gentz R, Breu V, Matile H, Schlaeger J, Fischli W.

Protein Expr Purif. 1996 Feb;7(1):81-91.

PMID:
9172787
33.

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.

Tavernier J, Tuypens T, Verhee A, Plaetinck G, Devos R, Van der Heyden J, Guisez Y, Oefner C.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):5194-8.

34.

Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors.

Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA.

Structure. 1993 Oct 15;1(2):153-9.

PMID:
8069627
35.

Expression, purification and crystallization of fully active, glycosylated human interleukin-5.

Guisez Y, Oefner C, Winkler FK, Schlaeger EJ, Zulauf M, Van der Heyden J, Plaetinck G, Cornelis S, Tavernier J, Fiers W, et al.

FEBS Lett. 1993 Sep 27;331(1-2):49-52.

36.
37.

The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.

Winkler FK, Banner DW, Oefner C, Tsernoglou D, Brown RS, Heathman SP, Bryan RK, Martin PD, Petratos K, Wilson KS.

EMBO J. 1993 May;12(5):1781-95.

38.

Crystal structure of human platelet-derived growth factor BB.

Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M.

EMBO J. 1992 Nov;11(11):3921-6.

39.

Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.

Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I.

Science. 1991 Aug 23;253(5022):872-9.

PMID:
1678899
40.

Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.

Oefner C, D'Arcy A, Daly JJ, Gubernator K, Charnas RL, Heinze I, Hubschwerlen C, Winkler FK.

Nature. 1990 Jan 18;343(6255):284-8.

PMID:
2300174
41.

Crystal structure of human dihydrofolate reductase complexed with folate.

Oefner C, D'Arcy A, Winkler FK.

Eur J Biochem. 1988 Jun 1;174(2):377-85.

42.

Structure refined to 2A of a nicked DNA octanucleotide complex with DNase I.

Suck D, Lahm A, Oefner C.

Nature. 1988 Mar 31;332(6163):464-8.

PMID:
3352748
43.

Crystallographic refinement and structure of DNase I at 2 A resolution.

Oefner C, Suck D.

J Mol Biol. 1986 Dec 5;192(3):605-32.

PMID:
3560229
44.
45.

Three-dimensional structure of bovine pancreatic DNase I at 2.5 A resolution.

Suck D, Oefner C, Kabsch W.

EMBO J. 1984 Oct;3(10):2423-30.

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