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Sex-regulated gene dosage effect of PPARα on synaptic plasticity.

Pierrot N, Ris L, Stancu IC, Doshina A, Ribeiro F, Tyteca D, Baugé E, Lalloyer F, Malong L, Schakman O, Leroy K, Kienlen-Campard P, Gailly P, Brion JP, Dewachter I, Staels B, Octave JN.

Life Sci Alliance. 2019 Mar 20;2(2). pii: e201800262. doi: 10.26508/lsa.201800262. Print 2019 Apr.


Editorial: Risk Factors and Outcome Predicating Biomarker of Neurodegenerative Diseases.

Hu CJ, Octave JN.

Front Neurol. 2019 Feb 4;10:45. doi: 10.3389/fneur.2019.00045. eCollection 2019. No abstract available.


Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.

Tang TC, Kienlen-Campard P, Hu Y, Perrin F, Opsomer R, Octave JN, Constantinescu SN, Smith SO.

J Biol Chem. 2019 Apr 12;294(15):5854-5866. doi: 10.1074/jbc.RA118.006061. Epub 2019 Feb 12.


Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.

Stancu IC, Cremers N, Vanrusselt H, Couturier J, Vanoosthuyse A, Kessels S, Lodder C, Brône B, Huaux F, Octave JN, Terwel D, Dewachter I.

Acta Neuropathol. 2019 Apr;137(4):599-617. doi: 10.1007/s00401-018-01957-y. Epub 2019 Feb 5.


Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing.

Evrard C, Kienlen-Campard P, Coevoet M, Opsomer R, Tasiaux B, Melnyk P, Octave JN, Buée L, Sergeant N, Vingtdeux V.

Front Cell Neurosci. 2018 Nov 22;12:435. doi: 10.3389/fncel.2018.00435. eCollection 2018.


A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology.

Stanga S, Brambilla L, Tasiaux B, Dang AH, Ivanoiu A, Octave JN, Rossi D, van Pesch V, Kienlen-Campard P.

Front Neurol. 2018 May 30;9:384. doi: 10.3389/fneur.2018.00384. eCollection 2018.


β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.

Hu Y, Kienlen-Campard P, Tang TC, Perrin F, Opsomer R, Decock M, Pan X, Octave JN, Constantinescu SN, Smith SO.

Sci Rep. 2017 Dec 7;7(1):17159. doi: 10.1038/s41598-017-17144-0.


Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.

Contino S, Porporato PE, Bird M, Marinangeli C, Opsomer R, Sonveaux P, Bontemps F, Dewachter I, Octave JN, Bertrand L, Stanga S, Kienlen-Campard P.

Front Physiol. 2017 Oct 12;8:796. doi: 10.3389/fphys.2017.00796. eCollection 2017.


Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model.

Vanden Dries V, Stygelbout V, Pierrot N, Yilmaz Z, Suain V, De Decker R, Buée L, Octave JN, Brion JP, Leroy K.

Neurobiol Aging. 2017 Jul;55:202-212. doi: 10.1016/j.neurobiolaging.2017.03.031. Epub 2017 Apr 5.


Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.

Doshina A, Gourgue F, Onizuka M, Opsomer R, Wang P, Ando K, Tasiaux B, Dewachter I, Kienlen-Campard P, Brion JP, Gailly P, Octave JN, Pierrot N.

Sci Rep. 2017 Mar 23;7(1):370. doi: 10.1038/s41598-017-00325-2.


Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.

Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu IC, Vasconcelos B, Pierrot N, Faelth-Savitski M, Kienlen-Campard P, Octave JN, Bantscheff M, Drewes G, Moechars D, Dewachter I.

Acta Neuropathol. 2017 May;133(5):731-749. doi: 10.1007/s00401-016-1663-9. Epub 2017 Jan 12.


Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells.

Decock M, Stanga S, Octave JN, Dewachter I, Smith SO, Constantinescu SN, Kienlen-Campard P.

Front Aging Neurosci. 2016 May 10;8:107. doi: 10.3389/fnagi.2016.00107. eCollection 2016.


Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.

Couturier J, Stancu IC, Schakman O, Pierrot N, Huaux F, Kienlen-Campard P, Dewachter I, Octave JN.

J Neuroinflammation. 2016 Jan 27;13:20. doi: 10.1186/s12974-016-0477-y.


Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.

Vasconcelos B, Stancu IC, Buist A, Bird M, Wang P, Vanoosthuyse A, Van Kolen K, Verheyen A, Kienlen-Campard P, Octave JN, Baatsen P, Moechars D, Dewachter I.

Acta Neuropathol. 2016 Apr;131(4):549-69. doi: 10.1007/s00401-015-1525-x. Epub 2016 Jan 6.


APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.

Stanga S, Zanou N, Audouard E, Tasiaux B, Contino S, Vandermeulen G, René F, Loeffler JP, Clotman F, Gailly P, Dewachter I, Octave JN, Kienlen-Campard P.

FASEB J. 2016 May;30(5):1696-711. doi: 10.1096/fj.15-278739. Epub 2015 Dec 30.


Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.

Decock M, El Haylani L, Stanga S, Dewachter I, Octave JN, Smith SO, Constantinescu SN, Kienlen-Campard P.

FEBS Open Bio. 2015 Sep 6;5:763-73. doi: 10.1016/j.fob.2015.09.002. eCollection 2015.


Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I.

Acta Neuropathol. 2015 Jun;129(6):875-94. doi: 10.1007/s00401-015-1413-4. Epub 2015 Apr 11.


Characterization of Pterocarpus erinaceus kino extract and its gamma-secretase inhibitory properties.

Hage S, Stanga S, Marinangeli C, Octave JN, Dewachter I, Quetin-Leclercq J, Kienlen-Campard P.

J Ethnopharmacol. 2015 Apr 2;163:192-202. doi: 10.1016/j.jep.2015.01.028. Epub 2015 Jan 30.


Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.

Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero AO, Dewachter I, Octave JN, Smith SO, Constantinescu SN, Kienlen-Campard P.

J Biol Chem. 2015 Mar 13;290(11):7169-84. doi: 10.1074/jbc.M114.601286. Epub 2015 Jan 22.


Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

Marquer C, Laine J, Dauphinot L, Hanbouch L, Lemercier-Neuillet C, Pierrot N, Bossers K, Le M, Corlier F, Benstaali C, Saudou F, Thinakaran G, Cartier N, Octave JN, Duyckaerts C, Potier MC.

Mol Neurodegener. 2014 Dec 18;9:60. doi: 10.1186/1750-1326-9-60.


Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease.

Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Kienlen-Campard P, De Smet C, Octave JN.

PLoS One. 2014 Jun 11;9(6):e99467. doi: 10.1371/journal.pone.0099467. eCollection 2014.


Critical role of aquaporins in interleukin 1β (IL-1β)-induced inflammation.

Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave JN, Marbaix E, Lison D, Devuyst O, Huaux F.

J Biol Chem. 2014 May 16;289(20):13937-47. doi: 10.1074/jbc.M113.534594. Epub 2014 Apr 3.


[Cholesterol, neuronal activity and Alzheimer disease].

Pierrot N, Octave JN.

Med Sci (Paris). 2014 Mar;30(3):244-6. doi: 10.1051/medsci/20143003008. Epub 2014 Mar 31. French. No abstract available.


Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.

Stancu IC, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, Haylani LE, Couturier J, Schakman O, Gailly P, Pierrot N, Kienlen-Campard P, Octave JN, Dewachter I.

FASEB J. 2014 Jun;28(6):2620-31. doi: 10.1096/fj.13-246702. Epub 2014 Mar 6.


Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.

Tang TC, Hu Y, Kienlen-Campard P, El Haylani L, Decock M, Van Hees J, Fu Z, Octave JN, Constantinescu SN, Smith SO.

Structure. 2014 Mar 4;22(3):387-96. doi: 10.1016/j.str.2013.12.012. Epub 2014 Jan 23.


Gamma-secretase inhibitor activity of a Pterocarpus erinaceus extract.

Hage S, Marinangeli C, Stanga S, Octave JN, Quetin-Leclercq J, Kienlen-Campard P.

Neurodegener Dis. 2014;14(1):39-51. doi: 10.1159/000355557. Epub 2013 Oct 30.


Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice.

Héraud C, Goufak D, Ando K, Leroy K, Suain V, Yilmaz Z, De Decker R, Authelet M, Laporte V, Octave JN, Brion JP.

Neurobiol Dis. 2014 Feb;62:100-12. doi: 10.1016/j.nbd.2013.09.010. Epub 2013 Sep 27.


Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.

Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Brion JP, Kienlen-Campard P, De Smet C, Octave JN.

PLoS One. 2013 Sep 16;8(9):e74305. doi: 10.1371/journal.pone.0074305. eCollection 2013.


Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.

Pierrot N, Tyteca D, D'auria L, Dewachter I, Gailly P, Hendrickx A, Tasiaux B, Haylani LE, Muls N, N'kuli F, Laquerrière A, Demoulin JB, Campion D, Brion JP, Courtoy PJ, Kienlen-Campard P, Octave JN.

EMBO Mol Med. 2013 Apr;5(4):608-25. doi: 10.1002/emmm.201202215.


From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein.

Octave JN, Pierrot N, Ferao Santos S, Nalivaeva NN, Turner AJ.

J Neurochem. 2013 Jul;126(2):183-90. doi: 10.1111/jnc.12239. Epub 2013 Apr 3. Review.


Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P, Grenier-Boley B, Kamatani Y, Delepine B, Demiautte F, Zelenika D, Zommer N, Hamdane M, Bellenguez C, Dartigues JF, Hauw JJ, Letronne F, Ayral AM, Sleegers K, Schellens A, Broeck LV, Engelborghs S, De Deyn PP, Vandenberghe R, O'Donovan M, Owen M, Epelbaum J, Mercken M, Karran E, Bantscheff M, Drewes G, Joberty G, Campion D, Octave JN, Berr C, Lathrop M, Callaerts P, Mann D, Williams J, Buée L, Dewachter I, Van Broeckhoven C, Amouyel P, Moechars D, Dermaut B, Lambert JC; GERAD consortium.

Mol Psychiatry. 2013 Nov;18(11):1225-34. doi: 10.1038/mp.2013.1. Epub 2013 Feb 12.


Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.

Leroy K, Ando K, Laporte V, Dedecker R, Suain V, Authelet M, Héraud C, Pierrot N, Yilmaz Z, Octave JN, Brion JP.

Am J Pathol. 2012 Dec;181(6):1928-40. doi: 10.1016/j.ajpath.2012.08.012. Epub 2012 Sep 28.


Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization.

Ben Khalifa N, Tyteca D, Courtoy PJ, Renauld JC, Constantinescu SN, Octave JN, Kienlen-Campard P.

Neurodegener Dis. 2012;10(1-4):92-5. doi: 10.1159/000335225. Epub 2012 Feb 10.


Structural features of the KPI domain control APP dimerization, trafficking, and processing.

Ben Khalifa N, Tyteca D, Marinangeli C, Depuydt M, Collet JF, Courtoy PJ, Renauld JC, Constantinescu S, Octave JN, Kienlen-Campard P.

FASEB J. 2012 Feb;26(2):855-67. doi: 10.1096/fj.11-190207. Epub 2011 Nov 15.


Network excitability dysfunction in Alzheimer's disease: insights from in vitro and in vivo models.

Santos SF, Pierrot N, Octave JN.

Rev Neurosci. 2010;21(3):153-71. Review.


In vitro screening on β-amyloid peptide production of plants used in traditional medicine for cognitive disorders.

Hage S, Kienlen-Campard P, Octave JN, Quetin-Leclercq J.

J Ethnopharmacol. 2010 Oct 5;131(3):585-91. doi: 10.1016/j.jep.2010.07.044. Epub 2010 Jul 29.


What is the role of amyloid precursor protein dimerization?

Khalifa NB, Van Hees J, Tasiaux B, Huysseune S, Smith SO, Constantinescu SN, Octave JN, Kienlen-Campard P.

Cell Adh Migr. 2010 Apr-Jun;4(2):268-72. Epub 2010 Apr 11.


Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668.

Santos SF, Tasiaux B, Sindic C, Octave JN.

Neurobiol Aging. 2011 Dec;32(12):2308-13. doi: 10.1016/j.neurobiolaging.2010.01.006. Epub 2010 Feb 1.


Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia.

Wiame E, Tyteca D, Pierrot N, Collard F, Amyere M, Noel G, Desmedt J, Nassogne MC, Vikkula M, Octave JN, Vincent MF, Courtoy PJ, Boltshauser E, van Schaftingen E.

Biochem J. 2009 Dec 14;425(1):127-36. doi: 10.1042/BJ20091024.


Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.

Huysseune S, Kienlen-Campard P, Hébert S, Tasiaux B, Leroy K, Devuyst O, Brion JP, De Strooper B, Octave JN.

FASEB J. 2009 Dec;23(12):4158-67. doi: 10.1096/fj.09-140012. Epub 2009 Aug 17.


Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations.

Santos SF, Pierrot N, Morel N, Gailly P, Sindic C, Octave JN.

J Neurosci. 2009 Apr 15;29(15):4708-18. doi: 10.1523/JNEUROSCI.4917-08.2009.


A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.

Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, Constantinescu SN, Octave JN, Aimoto S, Smith SO.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1421-6. doi: 10.1073/pnas.0812261106. Epub 2009 Jan 21.


[The precursor of amyloid peptide in Alzheimer disease: a protein with multiple functions].

Octave JN.

Bull Mem Acad R Med Belg. 2009;164(7-9):181-6; discussion 187-8. French.


[Alzheimer's disease: cellular and molecular aspects].

Octave JN, Pierrot N.

Bull Acad Natl Med. 2008 Feb;192(2):323-31; discussion 331-2. Review. French.


Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.

Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN.

J Biol Chem. 2008 Mar 21;283(12):7733-44. doi: 10.1074/jbc.M707142200. Epub 2008 Jan 16. Erratum in: J Biol Chem. 2008 May 2;283(18):12680.


Fe65 does not stabilize AICD during activation of transcription in a luciferase assay.

Huysseune S, Kienlen-Campard P, Octave JN.

Biochem Biophys Res Commun. 2007 Sep 21;361(2):317-22. Epub 2007 Jul 17.


Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta.

Feyt C, Pierrot N, Tasiaux B, Van Hees J, Kienlen-Campard P, Courtoy PJ, Octave JN.

Biochem Biophys Res Commun. 2007 Jun 15;357(4):1004-10. Epub 2007 Apr 17.


Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.

Pierrot N, Santos SF, Feyt C, Morel M, Brion JP, Octave JN.

J Biol Chem. 2006 Dec 29;281(52):39907-14. Epub 2006 Nov 3.


Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.

Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N'Kuli F, Courtoy PJ, Octave JN.

J Neurosci Res. 2006 Nov 1;84(6):1311-22.


[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.


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