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Items: 1 to 50 of 74

1.

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.

Chang K, Kang P, Liu Y, Huang K, Miao T, Sagona AP, Nezis IP, Bodmer R, Ocorr K, Bai H.

Autophagy. 2019 Dec 29:1-16. doi: 10.1080/15548627.2019.1704117. [Epub ahead of print]

PMID:
31884871
2.

The Functional Polymorphism R129W in the BVES Gene Is Associated with Sporadic Tetralogy of Fallot in the Han Chinese Population.

Shi Y, Li Y, Wang Y, Zhuang J, Wang H, Hu M, Mo X, Yue S, Chen Y, Fan X, Chen J, Cai W, Zhu X, Wan Y, Zhong Y, Ye X, Li F, Zhou Z, Dai G, Luo R, Ocorr K, Jiang Z, Li X, Zhu P, Wu X, Yuan W.

Genet Test Mol Biomarkers. 2019 Sep;23(9):601-609. doi: 10.1089/gtmb.2019.0085. Epub 2019 Aug 6.

PMID:
31386585
3.

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.

Walls SM, Cammarato A, Chatfield DA, Ocorr K, Harris GL, Bodmer R.

Cell Rep. 2018 Mar 6;22(10):2702-2715. doi: 10.1016/j.celrep.2018.02.034.

4.

The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila.

Zeng Q, Wan Y, Zhu P, Zhao M, Jiang F, Chen J, Tang M, Zhu X, Li Y, Zha H, Wang Y, Hu M, Mo X, Zhang Y, Chen Y, Chen Y, Ye X, Bodmer R, Ocorr K, Jiang Z, Zhuang J, Yuan W, Wu X.

Curr Mol Med. 2018 Mar 9;17(7):509-517. doi: 10.2174/1566524018666180212145714.

5.

Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.

Zarndt R, Walls SM, Ocorr K, Bodmer R.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001706. doi: 10.1161/CIRCGENETICS.117.001706. Erratum in: Circ Cardiovasc Genet. 2017 Dec;10(6):e000041.

6.

Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo.

Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad GG, McCulloch AD.

J Physiol. 2017 Sep 1;595(17):5797-5813. doi: 10.1113/JP274556. Epub 2017 Jul 27.

7.

Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.

Ocorr K, Zambon A, Nudell Y, Pineda S, Diop S, Tang M, Akasaka T, Taylor E.

PLoS Genet. 2017 May 19;13(5):e1006786. doi: 10.1371/journal.pgen.1006786. eCollection 2017 May.

8.

Experimental Evolution and Heart Function in Drosophila.

Shahrestani P, Burke MK, Birse R, Kezos JN, Ocorr K, Mueller LD, Rose MR, Bodmer R.

Physiol Biochem Zool. 2017 Mar/Apr;90(2):281-293. doi: 10.1086/689288. Epub 2016 Nov 21.

9.

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.

Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI.

J Mol Biol. 2016 Jun 5;428(11):2446-2461. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20.

10.

SPARC-Dependent Cardiomyopathy in Drosophila.

Hartley PS, Motamedchaboki K, Bodmer R, Ocorr K.

Circ Cardiovasc Genet. 2016 Apr;9(2):119-29. doi: 10.1161/CIRCGENETICS.115.001254. Epub 2016 Feb 2.

11.

Cardiac responses to hypoxia and reoxygenation in Drosophila.

Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1347-57. doi: 10.1152/ajpregu.00164.2015. Epub 2015 Sep 16.

12.

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.

Ivy JR, Drechsler M, Catterson JH, Bodmer R, Ocorr K, Paululat A, Hartley PS.

PLoS One. 2015 Aug 24;10(8):e0134620. doi: 10.1371/journal.pone.0134620. eCollection 2015.

13.

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ.

Sci Transl Med. 2015 Jun 17;7(292):292ra99. doi: 10.1126/scitranslmed.aaa5843.

14.

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.

Martínez-Morentin L, Martínez L, Piloto S, Yang H, Schon EA, Garesse R, Bodmer R, Ocorr K, Cervera M, Arredondo JJ.

Hum Mol Genet. 2015 Jul 1;24(13):3608-22. doi: 10.1093/hmg/ddv106. Epub 2015 Mar 19.

15.

PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.

Diop SB, Bisharat-Kernizan J, Birse RT, Oldham S, Ocorr K, Bodmer R.

Cell Rep. 2015 Mar 10;10(9):1572-1584. doi: 10.1016/j.celrep.2015.02.022. Epub 2015 Mar 5.

16.

Enhanced assessment of contractile dynamics in Drosophila hearts.

Cammarato A, Ocorr S, Ocorr K.

Biotechniques. 2015 Feb 1;58(2):77-80. doi: 10.2144/000114255. eCollection 2015 Feb.

17.

Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.

Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):355-67. doi: 10.1165/rcmb.2014-0235OC.

18.

Methods to assess Drosophila heart development, function and aging.

Ocorr K, Vogler G, Bodmer R.

Methods. 2014 Jun 15;68(1):265-72. doi: 10.1016/j.ymeth.2014.03.031. Epub 2014 Apr 12. Review.

19.

ROS regulate cardiac function via a distinct paracrine mechanism.

Lim HY, Wang W, Chen J, Ocorr K, Bodmer R.

Cell Rep. 2014 Apr 10;7(1):35-44. doi: 10.1016/j.celrep.2014.02.029. Epub 2014 Mar 20.

20.

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.

Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K.

Aging Cell. 2014 Jun;13(3):431-40. doi: 10.1111/acel.12193. Epub 2014 Jan 9.

21.

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.

Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K, Melkani GC.

Rare Dis. 2014 Nov 3;2(1):e968003. doi: 10.4161/2167549X.2014.968003. eCollection 2014.

22.

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K.

PLoS Genet. 2013;9(12):e1004024. doi: 10.1371/journal.pgen.1004024. Epub 2013 Dec 19.

23.

The role of pygopus in the differentiation of intracardiac valves in Drosophila.

Tang M, Yuan W, Bodmer R, Wu X, Ocorr K.

Genesis. 2014 Jan;52(1):19-28. doi: 10.1002/dvg.22724. Epub 2013 Nov 21.

24.

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

Tang M, Yuan W, Fan X, Liu M, Bodmer R, Ocorr K, Wu X.

Circ Cardiovasc Genet. 2013 Oct;6(5):472-80. doi: 10.1161/CIRCGENETICS.113.000253. Epub 2013 Sep 17.

25.

CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis.

Wang X, Liao P, Fan X, Wan Y, Wang Y, Li Y, Jiang Z, Ye X, Mo X, Ocorr K, Deng Y, Wu X, Yuan W.

Curr Mol Med. 2013 Sep;13(8):1385-96.

PMID:
23906331
26.

Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.

Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T.

PLoS Genet. 2013 Jun;9(6):e1003597. doi: 10.1371/journal.pgen.1003597. Epub 2013 Jun 27.

27.

In vivo cardiac reprogramming contributes to zebrafish heart regeneration.

Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC.

Nature. 2013 Jun 27;498(7455):497-501. doi: 10.1038/nature12322. Epub 2013 Jun 19.

28.

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.

Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R.

PLoS One. 2013 Apr 29;8(4):e62909. doi: 10.1371/journal.pone.0062909. Print 2013.

29.

A Drosophila model of high sugar diet-induced cardiomyopathy.

Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R.

PLoS Genet. 2013;9(1):e1003175. doi: 10.1371/journal.pgen.1003175. Epub 2013 Jan 10.

30.

Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.

Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP.

PLoS One. 2012;7(6):e39581. doi: 10.1371/journal.pone.0039581. Epub 2012 Jun 21.

31.

BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.

Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM.

Heart Rhythm. 2012 May;9(5):812-20. doi: 10.1016/j.hrthm.2011.11.055. Epub 2011 Dec 2.

32.

Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.

Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E.

PLoS Genet. 2011 Nov;7(11):e1002344. doi: 10.1371/journal.pgen.1002344. Epub 2011 Nov 3.

33.

The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model.

Melkani GC, Bodmer R, Ocorr K, Bernstein SI.

PLoS One. 2011;6(7):e22579. doi: 10.1371/journal.pone.0022579. Epub 2011 Jul 25.

34.

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

Eleftherianos I, Won S, Chtarbanova S, Squiban B, Ocorr K, Bodmer R, Beutler B, Hoffmann JA, Imler JL.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12024-9. doi: 10.1073/pnas.1108926108. Epub 2011 Jun 30.

35.

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R.

J Cell Biol. 2011 Jun 27;193(7):1181-96. doi: 10.1083/jcb.201006114. Epub 2011 Jun 20.

36.

Cloning and characterization of the cardiac-specific Lrrc10 promoter.

Fan X, Yang Q, Wang Y, Zhang Y, Wang J, Yuan J, Li Y, Wang Y, Deng Y, Yuan W, Mo X, Wan Y, Ocorr K, Yang X, Wu X.

BMB Rep. 2011 Feb;44(2):123-8. doi: 10.5483/BMBRep.2011.44.2.123.

37.

Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.

Lim HY, Wang W, Wessells RJ, Ocorr K, Bodmer R.

Genes Dev. 2011 Jan 15;25(2):189-200. doi: 10.1101/gad.1992411.

38.

Drosophila as a model to study cardiac aging.

Nishimura M, Ocorr K, Bodmer R, Cartry J.

Exp Gerontol. 2011 May;46(5):326-30. doi: 10.1016/j.exger.2010.11.035. Epub 2010 Dec 3. Review.

39.

High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.

Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S.

Cell Metab. 2010 Nov 3;12(5):533-44. doi: 10.1016/j.cmet.2010.09.014.

40.

SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.

Luo N, Li G, Li Y, Fan X, Wang Y, Ye X, Mo X, Zhou J, Yuan W, Tan M, Xie H, Ocorr K, Bodmer R, Deng Y, Wu X.

BMB Rep. 2010 May;43(5):355-61.

41.

The effect of excess expression of GFP in a novel heart-specific green fluorescence zebrafish regulated by nppa enhancer at early embryonic development.

Huang W, Deng Y, Dong W, Yuan W, Wan Y, Mo X, Li Y, Wang Z, Wang Y, Ocorr K, Zhang B, Lin S, Wu X.

Mol Biol Rep. 2011 Feb;38(2):793-9. doi: 10.1007/s11033-010-0168-1. Epub 2010 Apr 10.

PMID:
20383585
42.

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.

Cell. 2010 Apr 2;141(1):142-53. doi: 10.1016/j.cell.2010.02.023.

43.

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.

Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M.

Science. 2010 Mar 5;327(5970):1223-8. doi: 10.1126/science.1182228.

44.

KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.

Hu J, Yuan W, Tang M, Wang Y, Fan X, Mo X, Li Y, Ying Z, Wan Y, Ocorr K, Bodmer R, Deng Y, Wu X.

BMB Rep. 2010 Jan;43(1):17-22.

45.

Fluorescent labeling of Drosophila heart structures.

Alayari NN, Vogler G, Taghli-Lamallem O, Ocorr K, Bodmer R, Cammarato A.

J Vis Exp. 2009 Oct 13;(32). pii: 1423. doi: 10.3791/1423.

46.

Visualizing the beating heart in Drosophila.

Vogler G, Ocorr K.

J Vis Exp. 2009 Sep 28;(31). pii: 1425. doi: 10.3791/1425.

47.

Semi-automated Optical Heartbeat Analysis of small hearts.

Ocorr K, Fink M, Cammarato A, Bernstein S, Bodmer R.

J Vis Exp. 2009 Sep 16;(31). pii: 1435. doi: 10.3791/1435.

48.

Drug discovery through functional screening in the Drosophila heart.

Akasaka T, Ocorr K.

Methods Mol Biol. 2009;577:235-49. doi: 10.1007/978-1-60761-232-2_18.

PMID:
19718521
49.

Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner.

Shahrestani P, Leung HT, Le PK, Pak WL, Tse S, Ocorr K, Huang T.

PLoS One. 2009 Aug 31;4(8):e6867. doi: 10.1371/journal.pone.0006867.

50.

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.

Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, Lim HY, Elmén L, Hayes M, Oldham S, Bodmer R.

Aging Cell. 2009 Sep;8(5):542-52. doi: 10.1111/j.1474-9726.2009.00504.x. Epub 2009 Jul 9.

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