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Items: 36


Microbiota Manipulation as a Metagenomic Therapeutic Approach for Rare Inherited Metabolic Disorders.

Kirby TO, Brown M, Ochoa-Repáraz J, Roullet JB, Gibson KM.

Clin Pharmacol Ther. 2019 Jul 4. doi: 10.1002/cpt.1503. [Epub ahead of print] No abstract available.


The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue.

Kirby TO, Ochoa-Repáraz J.

Med Sci (Basel). 2018 Aug 24;6(3). pii: E69. doi: 10.3390/medsci6030069. Review.


Progress and perspectives in plant sterol and plant stanol research.

Jones PJH, Shamloo M, MacKay DS, Rideout TC, Myrie SB, Plat J, Roullet JB, Baer DJ, Calkins KL, Davis HR, Barton Duell P, Ginsberg H, Gylling H, Jenkins D, Lütjohann D, Moghadasian M, Moreau RA, Mymin D, Ostlund RE Jr, Ras RT, Ochoa Reparaz J, Trautwein EA, Turley S, Vanmierlo T, Weingärtner O.

Nutr Rev. 2018 Oct 1;76(10):725-746. doi: 10.1093/nutrit/nuy032.


The Microbiome and Neurologic Disease: Past and Future of a 2-Way Interaction.

Ochoa-Repáraz J, Kasper LH.

Neurotherapeutics. 2018 Jan;15(1):1-4. doi: 10.1007/s13311-018-0604-9. No abstract available.


The Gut Microbiome and Multiple Sclerosis.

Ochoa-Repáraz J, Kirby TO, Kasper LH.

Cold Spring Harb Perspect Med. 2018 Jun 1;8(6). pii: a029017. doi: 10.1101/cshperspect.a029017. Review.


A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis.

Colpitts SL, Kasper EJ, Keever A, Liljenberg C, Kirby T, Magori K, Kasper LH, Ochoa-Repáraz J.

Gut Microbes. 2017 Nov 2;8(6):561-573. doi: 10.1080/19490976.2017.1353843. Epub 2017 Aug 4.


The chicken or the egg dilemma: intestinal dysbiosis in multiple sclerosis.

Ochoa-Repáraz J, Magori K, Kasper LH.

Ann Transl Med. 2017 Mar;5(6):145. doi: 10.21037/atm.2017.01.18.


Induction of gut regulatory CD39+ T cells by teriflunomide protects against EAE.

Ochoa-Repáraz J, Colpitts SL, Kircher C, Kasper EJ, Telesford KM, Begum-Haque S, Pant A, Kasper LH.

Neurol Neuroimmunol Neuroinflamm. 2016 Oct 12;3(6):e291. eCollection 2016 Dec.


The influence of gut-derived CD39 regulatory T cells in CNS demyelinating disease.

Ochoa-Repáraz J, Kasper LH.

Transl Res. 2017 Jan;179:126-138. doi: 10.1016/j.trsl.2016.07.016. Epub 2016 Jul 28. Review.


The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?

Ochoa-Repáraz J, Kasper LH.

Curr Obes Rep. 2016 Mar;5(1):51-64. doi: 10.1007/s13679-016-0191-1. Review.


A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.

Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, Begum-Haque S, Kasper DL, Kasper LH.

Gut Microbes. 2015 Jul 4;6(4):234-42. doi: 10.1080/19490976.2015.1056973.


Gut microbiome and the risk factors in central nervous system autoimmunity.

Ochoa-Repáraz J, Kasper LH.

FEBS Lett. 2014 Nov 17;588(22):4214-22. doi: 10.1016/j.febslet.2014.09.024. Epub 2014 Oct 5. Review.


Development of a bacterial nanoparticle vaccine.

Gamazo C, Ochoa-Repáraz J, Tamayo I, Camacho A, Irache JM.

Methods Mol Biol. 2015;1225:139-49. doi: 10.1007/978-1-4939-1625-2_10.


Gut commensalism, cytokines, and central nervous system demyelination.

Telesford K, Ochoa-Repáraz J, Kasper LH.

J Interferon Cytokine Res. 2014 Aug;34(8):605-14. doi: 10.1089/jir.2013.0134. Review.


An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling.

Wang Y, Telesford KM, Ochoa-Repáraz J, Haque-Begum S, Christy M, Kasper EJ, Wang L, Wu Y, Robson SC, Kasper DL, Kasper LH.

Nat Commun. 2014 Jul 21;5:4432. doi: 10.1038/ncomms5432.


A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation.

Wang Y, Begum-Haque S, Telesford KM, Ochoa-Repáraz J, Christy M, Kasper EJ, Kasper DL, Robson SC, Kasper LH.

Gut Microbes. 2014 Jul 1;5(4):552-61. doi: 10.4161/gmic.29797. Epub 2014 Jul 9.


Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms.

Dasgupta S, Erturk-Hasdemir D, Ochoa-Reparaz J, Reinecker HC, Kasper DL.

Cell Host Microbe. 2014 Apr 9;15(4):413-23. doi: 10.1016/j.chom.2014.03.006.


Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORγt responses and by increasing IL-10 production in experimental allergic encephalomyelitis.

Begum-Haque S, Christy M, Wang Y, Kasper E, Ochoa-Reparaz J, Smith JY, Haque A, Kasper LH.

J Neuroimmunol. 2013 Jan 15;254(1-2):117-24. doi: 10.1016/j.jneuroim.2012.10.003. Epub 2012 Nov 7.


Bystander-mediated stimulation of proteolipid protein-specific regulatory T (Treg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-β.

Jun S, Ochoa-Repáraz J, Zlotkowska D, Hoyt T, Pascual DW.

J Neuroimmunol. 2012 Apr;245(1-2):39-47. doi: 10.1016/j.jneuroim.2012.02.003. Epub 2012 Mar 13.


Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease.

Ochoa-Repáraz J, Mielcarz DW, Begum-Haque S, Kasper LH.

Ann Neurol. 2011 Feb;69(2):240-7. doi: 10.1002/ana.22344. Review.


Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora.

Ochoa-Repáraz J, Mielcarz DW, Haque-Begum S, Kasper LH.

Gut Microbes. 2010 Mar;1(2):103-108. Epub 2010 Feb 15.


Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate.

Begum-Haque S, Christy M, Ochoa-Reparaz J, Nowak EC, Mielcarz D, Haque A, Kasper LH.

J Neuroimmunol. 2011 Mar;232(1-2):136-44. doi: 10.1016/j.jneuroim.2010.10.031. Epub 2010 Nov 26.


Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.

Ochoa-Repáraz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH.

J Immunol. 2010 Oct 1;185(7):4101-8. doi: 10.4049/jimmunol.1001443. Epub 2010 Sep 3.


Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitation.

Tamayo I, Irache JM, Mansilla C, Ochoa-Repáraz J, Lasarte JJ, Gamazo C.

Clin Vaccine Immunol. 2010 Sep;17(9):1356-62. doi: 10.1128/CVI.00164-10. Epub 2010 Jul 14.


A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease.

Ochoa-Repáraz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH.

Mucosal Immunol. 2010 Sep;3(5):487-95. doi: 10.1038/mi.2010.29. Epub 2010 Jun 9.


IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).

Rynda A, Maddaloni M, Ochoa-Repáraz J, Callis G, Pascual DW.

PLoS One. 2010 Jan 14;5(1):e8720. doi: 10.1371/journal.pone.0008720.


Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis.

Begum-Haque S, Sharma A, Christy M, Lentini T, Ochoa-Reparaz J, Fayed IF, Mielcarz D, Haque A, Kasper LH.

J Neuroimmunol. 2010 Feb 26;219(1-2):47-53. doi: 10.1016/j.jneuroim.2009.11.016. Epub 2010 Jan 19.


Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis.

Ochoa-Repáraz J, Mielcarz DW, Ditrio LE, Burroughs AR, Foureau DM, Haque-Begum S, Kasper LH.

J Immunol. 2009 Nov 15;183(10):6041-50. doi: 10.4049/jimmunol.0900747. Epub 2009 Oct 19.


IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independently of autoantigen.

Ochoa-Repáraz J, Rynda A, Ascón MA, Yang X, Kochetkova I, Riccardi C, Callis G, Trunkle T, Pascual DW.

J Immunol. 2008 Jul 15;181(2):954-68.


Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.

Rynda A, Maddaloni M, Mierzejewska D, Ochoa-Repáraz J, Maslanka T, Crist K, Riccardi C, Barszczewska B, Fujihashi K, McGhee JR, Pascual DW.

J Immunol. 2008 Apr 15;180(8):5187-200.


Tolerance in the absence of autoantigen.

Pascual DW, Ochoa-Repáraz J, Rynda A, Yang X.

Endocr Metab Immune Disord Drug Targets. 2007 Sep;7(3):203-10. Review.


Attenuated Coxiella burnetii phase II causes a febrile response in gamma interferon knockout and Toll-like receptor 2 knockout mice and protects against reinfection.

Ochoa-Repáraz J, Sentissi J, Trunkle T, Riccardi C, Pascual DW.

Infect Immun. 2007 Dec;75(12):5845-58. Epub 2007 Sep 24.


Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis.

Ochoa-Repáraz J, Riccardi C, Rynda A, Jun S, Callis G, Pascual DW.

J Immunol. 2007 Feb 1;178(3):1791-9.


Partially assembled K99 fimbriae are required for protection.

Ascón MA, Ochoa-Repáraz J, Walters N, Pascual DW.

Infect Immun. 2005 Nov;73(11):7274-80.


Protective ability of subcellular extracts from Salmonella Enteritidis and from a rough isogenic mutant against salmonellosis in mice.

Ochoa-Repáraz J, García B, Solano C, Lasa I, Irache JM, Gamazo C.

Vaccine. 2005 Feb 10;23(12):1491-501.


Humoral immune response in hens naturally infected with Salmonella Enteritidis against outer membrane proteins and other surface structural antigens.

Ochoa-Repáraz J, Sesma B, Alvarez M, Jesús Renedo M, Irache JM, Gamazo C.

Vet Res. 2004 May-Jun;35(3):291-8.

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