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Characterization and Outcomes of Patients With Hansen Disease Treated at the Los Angeles County Hospital.

Chow M, Shue L, Sierro T, Tran K, Vaccaro S, Ochoa MT.

JAMA Dermatol. 2019 Aug 7. doi: 10.1001/jamadermatol.2019.1732. [Epub ahead of print] No abstract available.


The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy.

R Andrade P, Mehta M, Lu J, M B Teles R, Montoya D, O Scumpia P, Nunes Sarno E, Ochoa MT, Ma F, Pellegrini M, Modlin RL.

PLoS Negl Trop Dis. 2019 Jul 25;13(7):e0007589. doi: 10.1371/journal.pntd.0007589. eCollection 2019 Jul.


IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.

Weiss DI, Ma F, Merleev AA, Maverakis E, Gilliet M, Balin SJ, Bryson BD, Ochoa MT, Pellegrini M, Bloom BR, Modlin RL.

J Immunol. 2019 Aug 15;203(4):911-921. doi: 10.4049/jimmunol.1900318. Epub 2019 Jun 24.


Sorafenib Toxicity Mimicking Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome

Salame N, Chow ML, Ochoa MT, Compoginis G, Crew AB.

J Drugs Dermatol. 2019 May 1;18(5):468-469.


Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.

Dang AT, Teles RM, Liu PT, Choi A, Legaspi A, Sarno EN, Ochoa MT, Parvatiyar K, Cheng G, Gilliet M, Bloom BR, Modlin RL.

JCI Insight. 2019 Apr 18;4(8). pii: 126955. doi: 10.1172/jci.insight.126955. eCollection 2019 Apr 18.


IL-26 contributes to host defense against intracellular bacteria.

Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL.

J Clin Invest. 2019 Apr 2;129(5):1926-1939. doi: 10.1172/JCI99550. eCollection 2019 Apr 2.


Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria.

Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL.

Sci Immunol. 2018 Aug 31;3(26). pii: eaat7668. doi: 10.1126/sciimmunol.aat7668.


Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843. doi: 10.1172/jci.insight.88843.


S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL.

PLoS Pathog. 2016 Jun 29;12(6):e1005705. doi: 10.1371/journal.ppat.1005705. eCollection 2016 Jun.


Thomas Herald Rea, MD (1929-2016).

Ochoa MT, Vaccaro S, Jerskey R, Mora H, Peng D, Modlin RL.

Lepr Rev. 2016 Mar;87(1):130-1. No abstract available.


IL-27 Suppresses Antimicrobial Activity in Human Leprosy.

Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL.

J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.


T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols.

Preza GC, Yang OO, Elliott J, Anton PA, Ochoa MT.

PLoS One. 2015 Apr 9;10(4):e0122723. doi: 10.1371/journal.pone.0122723. eCollection 2015.


Recognizing and managing the immunologic reactions in leprosy.

Kamath S, Vaccaro SA, Rea TH, Ochoa MT.

J Am Acad Dermatol. 2014 Oct;71(4):795-803. doi: 10.1016/j.jaad.2014.03.034. Epub 2014 Apr 24. Review.


Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages.

Preza GC, Tanner K, Elliott J, Yang OO, Anton PA, Ochoa MT.

AIDS Res Hum Retroviruses. 2014 Mar;30(3):241-9. doi: 10.1089/AID.2013.0145. Epub 2013 Dec 10.


NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.

Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL.

Nat Med. 2012 Mar 25;18(4):555-63. doi: 10.1038/nm.2650.


Mobile teledermatology: As doctors and patients are increasingly mobile, technology keeps us connected.

Farshidi D, Craft N, Ochoa MT.

Skinmed. 2011 Jul-Aug;9(4):231-8. Review.


Human immunodeficiency virus and leishmaniasis.

Ezra N, Ochoa MT, Craft N.

J Glob Infect Dis. 2010 Sep;2(3):248-57. doi: 10.4103/0974-777X.68528.


Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy.

Teles RM, Krutzik SR, Ochoa MT, Oliveira RB, Sarno EN, Modlin RL.

Infect Immun. 2010 Nov;78(11):4634-43. doi: 10.1128/IAI.00454-10. Epub 2010 Aug 16.


A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy.

Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ.

Immunology. 2010 Nov;131(3):405-14. doi: 10.1111/j.1365-2567.2010.03314.x.


New World cutaneous leishmaniasis: current challenges in diagnosis and parenteral treatment.

Zaghi D, Panosian C, Gutierrez MA, Gregson A, Taylor E, Ochoa MT.

J Am Acad Dermatol. 2011 Mar;64(3):587-92. doi: 10.1016/j.jaad.2009.08.045. Epub 2010 May 21.


Integrated pathways for neutrophil recruitment and inflammation in leprosy.

Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL.

J Infect Dis. 2010 Feb 15;201(4):558-69. doi: 10.1086/650318.


Divergence of macrophage phagocytic and antimicrobial programs in leprosy.

Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL.

Cell Host Microbe. 2009 Oct 22;6(4):343-53. doi: 10.1016/j.chom.2009.09.002.


Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma.

Ribas A, Comin-Anduix B, Chmielowski B, Jalil J, de la Rocha P, McCannel TA, Ochoa MT, Seja E, Villanueva A, Oseguera DK, Straatsma BR, Cochran AJ, Glaspy JA, Hui L, Marincola FM, Wang E, Economou JS, Gomez-Navarro J.

Clin Cancer Res. 2009 Oct 1;15(19):6267-76. doi: 10.1158/1078-0432.CCR-09-1254. Epub 2009 Sep 29.


Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.

Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL.

J Clin Invest. 2008 Aug;118(8):2917-28. doi: 10.1172/JCI34189.


"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.

Ochoa MT, Loncaric A, Krutzik SR, Becker TC, Modlin RL.

J Invest Dermatol. 2008 Sep;128(9):2225-31. doi: 10.1038/jid.2008.56. Epub 2008 Mar 13.


LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells.

Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL.

J Immunol. 2007 Dec 15;179(12):8128-36.


Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences.

Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL.

Immunology. 2007 Dec;122(4):522-31. Epub 2007 Jul 16.


Regulation of human T-cell homing receptor expression in cutaneous bacterial infection.

Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL.

Immunology. 2007 Apr;120(4):518-25.


Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion.

Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL.

Immunology. 2007 Mar;120(3):354-61. Epub 2006 Nov 28.


Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.

Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S.

J Immunol. 2006 Aug 1;177(3):1864-71. Erratum in: J Immunol. 2008 Jan 1;180(1):664.


TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response.

Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL.

J Immunol. 2006 Jul 1;177(1):298-305.


Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation.

Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED.

J Immunol. 2006 Mar 15;176(6):3536-47.


Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL.

Science. 2006 Mar 24;311(5768):1770-3. Epub 2006 Feb 23.


TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.

Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL.

Nat Med. 2005 Jun;11(6):653-60. Epub 2005 May 8.


Mohs' micrographic surgery of a proliferating trichilemmal tumor in a young black man.

Tierney E, Ochoa MT, Rudkin G, Soriano TT.

Dermatol Surg. 2005 Mar;31(3):359-63.


Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.

Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL.

J Clin Invest. 2004 Mar;113(5):701-8.


Use of genetic profiling in leprosy to discriminate clinical forms of the disease.

Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL.

Science. 2003 Sep 12;301(5639):1527-30.


Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.

Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL.

Nat Med. 2003 May;9(5):525-32. Epub 2003 Apr 14.


Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy.

Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL.

Infect Immun. 2003 Mar;71(3):1427-33.


Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue.

Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA.

Immunology. 2003 Jan;108(1):10-5.


Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.

Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL.

J Immunol. 2002 Aug 1;169(3):1535-41.


Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns.

García VE, Quiroga MF, Ochoa MT, Ochoa L, Pasquinelli V, Fainboim L, Olivares LM, Valdez R, Sordelli DO, Aversa G, Modlin RL, Sieling PA.

J Immunol. 2001 Nov 15;167(10):5719-24.


Induction of direct antimicrobial activity through mammalian toll-like receptors.

Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL.

Science. 2001 Feb 23;291(5508):1544-7.


Role of granulysin in immunity to leprosy.

Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL.

Lepr Rev. 2000 Dec;71 Suppl:S115; discussion S115-6. No abstract available.


T-cell release of granulysin contributes to host defense in leprosy.

Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL.

Nat Med. 2001 Feb;7(2):174-9.


Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10.

Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL.

J Immunol. 2000 Oct 1;165(7):3804-10.


Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions.

Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL.

J Immunol. 2000 May 1;164(9):4790-6.


Insulin-like growth factor-I, but not growth hormone, is dependent on a high protein intake to increase nitrogen balance in the rat.

Sánchez-Gómez M, Malmlöf K, Mejía W, Bermudez A, Ochoa MT, Carrasco-Rodríguez S, Skottner A.

Br J Nutr. 1999 Feb;81(2):145-52.


Positive IgG Western blot for Borrelia burgdorferi in Colombia.

Palacios R, Osorio LE, Giraldo LE, Torres AJ, Philipp MT, Ochoa MT.

Mem Inst Oswaldo Cruz. 1999 Jul-Aug;94(4):499-503.

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