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Items: 46


Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice.

Jacob A, Ma Y, Nasiri E, Ochani M, Carrion J, Peng S, Brenner M, Huerta PT, Wang P.

Mol Med. 2019 May 30;25(1):24. doi: 10.1186/s10020-019-0092-3.


Constitutive Vagus Nerve Activation Modulates Immune Suppression in Sepsis Survivors.

Rana M, Fei-Bloom Y, Son M, La Bella A, Ochani M, Levine YA, Chiu PY, Wang P, Chavan SS, Volpe BT, Sherry B, Diamond B.

Front Immunol. 2018 Sep 6;9:2032. doi: 10.3389/fimmu.2018.02032. eCollection 2018.


B-1a cells protect mice from sepsis-induced acute lung injury.

Aziz M, Ode Y, Zhou M, Ochani M, Holodick NE, Rothstein TL, Wang P.

Mol Med. 2018 May 29;24(1):26. doi: 10.1186/s10020-018-0029-2.


Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4+ aged neutrophils.

Hirano Y, Ode Y, Ochani M, Wang P, Aziz M.

J Leukoc Biol. 2018 Dec;104(6):1159-1171. doi: 10.1002/JLB.3A0218-050R. Epub 2018 Aug 8.


The protective role of human ghrelin in sepsis: Restoration of CD4 T cell proliferation.

Zhou M, Aziz M, Ochani M, Yang WL, Sharma A, Wang P.

PLoS One. 2018 Jul 27;13(7):e0201139. doi: 10.1371/journal.pone.0201139. eCollection 2018.


Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases.

Li W, Bao G, Chen W, Qiang X, Zhu S, Wang S, He M, Ma G, Ochani M, Al-Abed Y, Yang H, Tracey KJ, Wang P, D'Angelo J, Wang H.

Sci Rep. 2018 Jan 9;8(1):166. doi: 10.1038/s41598-017-18452-1.


New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.

Qiang X, Liotta AS, Shiloach J, Gutierrez JC, Wang H, Ochani M, Ochani K, Yang H, Rabin A, LeRoith D, Lesniak MA, Böhm M, Maaser C, Kannengiesser K, Donowitz M, Rabizadeh S, Czura CJ, Tracey KJ, Westlake M, Zarfeshani A, Mehdi SF, Danoff A, Ge X, Sanyal S, Schwartz GJ, Roth J.

NPJ Biofilms Microbiomes. 2017 Nov 13;3:31. doi: 10.1038/s41522-017-0039-9. eCollection 2017.


Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wnt/β-catenin signaling.

Sharma A, Yang WL, Ochani M, Wang P.

Sci Rep. 2017 Aug 23;7(1):9235. doi: 10.1038/s41598-017-08711-6.


Neutralization of Osteopontin Ameliorates Acute Lung Injury Induced by Intestinal Ischemia-Reperfusion.

Hirano Y, Aziz M, Yang WL, Ochani M, Wang P.

Shock. 2016 Oct;46(4):431-8. doi: 10.1097/SHK.0000000000000611.


Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve.

Honig G, Mader S, Chen H, Porat A, Ochani M, Wang P, Volpe BT, Diamond B.

PLoS One. 2016 Jan 20;11(1):e0144215. doi: 10.1371/journal.pone.0144215. eCollection 2016.


Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury.

Hirano Y, Aziz M, Yang WL, Wang Z, Zhou M, Ochani M, Khader A, Wang P.

Crit Care. 2015 Feb 26;19:53. doi: 10.1186/s13054-015-0782-3.


Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation.

Silverman HA, Dancho M, Regnier-Golanov A, Nasim M, Ochani M, Olofsson PS, Ahmed M, Miller EJ, Chavan SS, Golanov E, Metz CN, Tracey KJ, Pavlov VA.

Mol Med. 2015 Mar 11;20:601-11. doi: 10.2119/molmed.2014.00147.


Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation.

Rosas-Ballina M, Valdés-Ferrer SI, Dancho ME, Ochani M, Katz D, Cheng KF, Olofsson PS, Chavan SS, Al-Abed Y, Tracey KJ, Pavlov VA.

Brain Behav Immun. 2015 Feb;44:19-27. doi: 10.1016/j.bbi.2014.07.010. Epub 2014 Jul 23.


HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.

Valdés-Ferrer SI, Rosas-Ballina M, Olofsson PS, Lu B, Dancho ME, Ochani M, Li JH, Scheinerman JA, Katz DA, Levine YA, Hudson LK, Yang H, Pavlov VA, Roth J, Blanc L, Antoine DJ, Chavan SS, Andersson U, Diamond B, Tracey KJ.

J Intern Med. 2013 Oct;274(4):381-90. doi: 10.1111/joim.12104. Epub 2013 Aug 12. Erratum in: J Intern Med. 2014 Mar;41(3):266.


Identification of pigment epithelium-derived factor as an adipocyte-derived inflammatory factor.

Chavan SS, Hudson LK, Li JH, Ochani M, Harris Y, Patel NB, Katz D, Scheinerman JA, Pavlov VA, Tracey KJ.

Mol Med. 2012 Oct 24;18:1161-8. doi: 10.2119/molmed.2012.00156.


HMGB1 mediates cognitive impairment in sepsis survivors.

Chavan SS, Huerta PT, Robbiati S, Valdes-Ferrer SI, Ochani M, Dancho M, Frankfurt M, Volpe BT, Tracey KJ, Diamond B.

Mol Med. 2012 Sep 7;18:930-7. doi: 10.2119/molmed.2012.00195.


α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.

Olofsson PS, Katz DA, Rosas-Ballina M, Levine YA, Ochani M, Valdés-Ferrer SI, Pavlov VA, Tracey KJ, Chavan SS.

Mol Med. 2012 May 9;18:539-43. doi: 10.2119/molmed.2011.00405.


Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.

Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, Mak TW, Tracey KJ.

Science. 2011 Oct 7;334(6052):98-101. doi: 10.1126/science.1209985. Epub 2011 Sep 15.


Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed mice.

Satapathy SK, Ochani M, Dancho M, Hudson LK, Rosas-Ballina M, Valdes-Ferrer SI, Olofsson PS, Harris YT, Roth J, Chavan S, Tracey KJ, Pavlov VA.

Mol Med. 2011;17(7-8):599-606. doi: 10.2119/molmed.2011.00083. Epub 2011 Jul 1.


Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity.

Al-Abed Y, Metz CN, Cheng KF, Aljabari B, VanPatten S, Blau S, Lee H, Ochani M, Pavlov VA, Coleman T, Meurice N, Tracey KJ, Miller EJ.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8224-7. doi: 10.1073/pnas.1017624108. Epub 2011 May 2.


A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.

Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, Li J, Lu B, Chavan S, Rosas-Ballina M, Al-Abed Y, Akira S, Bierhaus A, Erlandsson-Harris H, Andersson U, Tracey KJ.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11942-7. doi: 10.1073/pnas.1003893107. Epub 2010 Jun 14.


Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b.

Huston JM, Rosas-Ballina M, Xue X, Dowling O, Ochani K, Ochani M, Yeboah MM, Chatterjee PK, Tracey KJ, Metz CN.

J Immunol. 2009 Jul 1;183(1):552-9. doi: 10.4049/jimmunol.0802684.


Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels.

Huston JM, Wang H, Ochani M, Ochani K, Rosas-Ballina M, Gallowitsch-Puerta M, Ashok M, Yang L, Tracey KJ, Yang H.

J Immunol. 2008 Sep 1;181(5):3535-9.


Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia.

Rosas-Ballina M, Ochani M, Parrish WR, Ochani K, Harris YT, Huston JM, Chavan S, Tracey KJ.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11008-13. doi: 10.1073/pnas.0803237105. Epub 2008 Jul 31.


Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.

Pavlov VA, Parrish WR, Rosas-Ballina M, Ochani M, Puerta M, Ochani K, Chavan S, Al-Abed Y, Tracey KJ.

Brain Behav Immun. 2009 Jan;23(1):41-5. doi: 10.1016/j.bbi.2008.06.011. Epub 2008 Jun 27.


Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling.

Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, Ochani M, Ochani K, Yang LH, Hudson L, Lin X, Patel N, Johnson SM, Chavan S, Goldstein RS, Czura CJ, Miller EJ, Al-Abed Y, Tracey KJ, Pavlov VA.

Mol Med. 2008 Sep-Oct;14(9-10):567-74. doi: 10.2119/2008-00079.Parrish.


Cholinergic agonists attenuate renal ischemia-reperfusion injury in rats.

Yeboah MM, Xue X, Duan B, Ochani M, Tracey KJ, Susin M, Metz CN.

Kidney Int. 2008 Jul;74(1):62-9. doi: 10.1038/ki.2008.94. Epub 2008 Apr 9.


Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis.

Huston JM, Gallowitsch-Puerta M, Ochani M, Ochani K, Yuan R, Rosas-Ballina M, Ashok M, Goldstein RS, Chavan S, Pavlov VA, Metz CN, Yang H, Czura CJ, Wang H, Tracey KJ.

Crit Care Med. 2007 Dec;35(12):2762-8.


Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y.

J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25.


Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis.

Pavlov VA, Ochani M, Yang LH, Gallowitsch-Puerta M, Ochani K, Lin X, Levi J, Parrish WR, Rosas-Ballina M, Czura CJ, Larosa GJ, Miller EJ, Tracey KJ, Al-Abed Y.

Crit Care Med. 2007 Apr;35(4):1139-44.


Role of HMGB1 in apoptosis-mediated sepsis lethality.

Qin S, Wang H, Yuan R, Li H, Ochani M, Ochani K, Rosas-Ballina M, Czura CJ, Huston JM, Miller E, Lin X, Sherry B, Kumar A, Larosa G, Newman W, Tracey KJ, Yang H.

J Exp Med. 2006 Jul 10;203(7):1637-42. Epub 2006 Jul 3.


Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis.

Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, Pavlov VA, Gallowitsch-Puerta M, Ashok M, Czura CJ, Foxwell B, Tracey KJ, Ulloa L.

J Exp Med. 2006 Jul 10;203(7):1623-8. Epub 2006 Jun 19.


Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia.

Pavlov VA, Ochani M, Gallowitsch-Puerta M, Ochani K, Huston JM, Czura CJ, Al-Abed Y, Tracey KJ.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5219-23. Epub 2006 Mar 20.


The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis.

Wang H, Li W, Li J, Rendon-Mitchell B, Ochani M, Ashok M, Yang L, Yang H, Tracey KJ, Wang P, Sama AE.

J Nutr. 2006 Feb;136(2):360-5.


ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ.

J Biol Chem. 2005 Nov 4;280(44):36541-4. Epub 2005 Aug 22.


Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis.

Chen G, Li J, Qiang X, Czura CJ, Ochani M, Ochani K, Ulloa L, Yang H, Tracey KJ, Wang P, Sama AE, Wang H.

J Lipid Res. 2005 Apr;46(4):623-7. Epub 2005 Feb 1.


Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.

Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ, Ulloa L.

Nat Med. 2004 Nov;10(11):1216-21. Epub 2004 Oct 24.


Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms.

Chen G, Li J, Ochani M, Rendon-Mitchell B, Qiang X, Susarla S, Ulloa L, Yang H, Fan S, Goyert SM, Wang P, Tracey KJ, Sama AE, Wang H.

J Leukoc Biol. 2004 Nov;76(5):994-1001. Epub 2004 Aug 26.


Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R, Czura CJ, Wang H, Roth J, Warren HS, Fink MP, Fenton MJ, Andersson U, Tracey KJ.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):296-301. Epub 2003 Dec 26.


Structural basis for the proinflammatory cytokine activity of high mobility group box 1.

Li J, Kokkola R, Tabibzadeh S, Yang R, Ochani M, Qiang X, Harris HE, Czura CJ, Wang H, Ulloa L, Wang H, Warren HS, Moldawer LL, Fink MP, Andersson U, Tracey KJ, Yang H.

Mol Med. 2003 Jan-Feb;9(1-2):37-45.


IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism.

Rendon-Mitchell B, Ochani M, Li J, Han J, Wang H, Yang H, Susarla S, Czura C, Mitchell RA, Chen G, Sama AE, Tracey KJ, Wang H.

J Immunol. 2003 Apr 1;170(7):3890-7.


Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.

Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ.

Nature. 2003 Jan 23;421(6921):384-8. Epub 2002 Dec 22.


Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion.

Bernik TR, Friedman SG, Ochani M, DiRaimo R, Susarla S, Czura CJ, Tracey KJ.

J Vasc Surg. 2002 Dec;36(6):1231-6.


Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.

Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP, Tracey KJ.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12351-6. Epub 2002 Sep 3.


Pharmacological stimulation of the cholinergic antiinflammatory pathway.

Bernik TR, Friedman SG, Ochani M, DiRaimo R, Ulloa L, Yang H, Sudan S, Czura CJ, Ivanova SM, Tracey KJ.

J Exp Med. 2002 Mar 18;195(6):781-8.


The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy.

Kemeny MM, Botchkina GI, Ochani M, Bianchi M, Urmacher C, Tracey KJ.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4561-6.

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