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Items: 22

1.

Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition.

Basu D, Huggins LA, Scerbo D, Obunike J, Mullick AE, Rothenberg PL, Di Prospero NA, Eckel RH, Goldberg IJ.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2207-2216. doi: 10.1161/ATVBAHA.118.311339.

PMID:
30354257
2.

Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E.

Millar JS, Lassman ME, Thomas T, Ramakrishnan R, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Wagner JA, Holleran S, Obunike J, Liu Y, Aoujil S, Standiford T, Gutstein DE, Ginsberg HN, Rader DJ, Reyes-Soffer G.

J Lipid Res. 2017 Jun;58(6):1214-1220. doi: 10.1194/jlr.M074880. Epub 2017 Mar 17.

3.

Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans.

Reyes-Soffer G, Pavlyha M, Ngai C, Thomas T, Holleran S, Ramakrishnan R, Karmally W, Nandakumar R, Fontanez N, Obunike J, Marcovina SM, Lichtenstein AH, Matthan NR, Matta J, Maroccia M, Becue F, Poitiers F, Swanson B, Cowan L, Sasiela WJ, Surks HK, Ginsberg HN.

Circulation. 2017 Jan 24;135(4):352-362. doi: 10.1161/CIRCULATIONAHA.116.025253. Epub 2016 Dec 16.

4.

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.

Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ.

J Clin Invest. 2016 Apr 1;126(4):1603-4. doi: 10.1172/JCI87364. Epub 2016 Apr 1. No abstract available.

5.

Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans.

Reyes-Soffer G, Moon B, Hernandez-Ono A, Dionizovik-Dimanovski M, Jimenez J, Obunike J, Thomas T, Ngai C, Fontanez N, Donovan DS, Karmally W, Holleran S, Ramakrishnan R, Mittleman RS, Ginsberg HN.

Sci Transl Med. 2016 Jan 27;8(323):323ra12. doi: 10.1126/scitranslmed.aad2195. Erratum in: Sci Transl Med. 2016 Feb 10;8(325):325er3. Dionizovick-Dimanovski, Marija [corrected to Dionizovik-Dimanovski, Marija].

6.

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.

Millar JS, Reyes-Soffer G, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Pollan L, Tohyama J, Johnson-Levonas AO, Wagner JA, Holleran S, Obunike J, Liu Y, Ramakrishnan R, Lassman ME, Gutstein DE, Ginsberg HN, Rader DJ.

J Clin Invest. 2015 Jun;125(6):2510-22. doi: 10.1172/JCI80025. Epub 2015 May 11. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1603-4.

7.

Lipolysis, and not hepatic lipogenesis, is the primary modulator of triglyceride levels in streptozotocin-induced diabetic mice.

Willecke F, Scerbo D, Nagareddy P, Obunike JC, Barrett TJ, Abdillahi ML, Trent CM, Huggins LA, Fisher EA, Drosatos K, Goldberg IJ.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):102-10. doi: 10.1161/ATVBAHA.114.304615. Epub 2014 Nov 13.

8.

Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.

Garcia-Arcos I, Hiyama Y, Drosatos K, Bharadwaj KG, Hu Y, Son NH, O'Byrne SM, Chang CL, Deckelbaum RJ, Takahashi M, Westerterp M, Obunike JC, Jiang H, Yagyu H, Blaner WS, Goldberg IJ.

J Biol Chem. 2013 May 17;288(20):14046-58. doi: 10.1074/jbc.M113.469270. Epub 2013 Mar 31.

9.

Transcytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor.

Obunike JC, Lutz EP, Li Z, Paka L, Katopodis T, Strickland DK, Kozarsky KF, Pillarisetti S, Goldberg IJ.

J Biol Chem. 2001 Mar 23;276(12):8934-41. Epub 2000 Dec 19.

10.

Influence of glucose on production and N-sulfation of heparan sulfate in cultured adipocyte cells.

Parthasarathy N, Gotow LF, Bottoms JD, Obunike JC, Naggi A, Casu B, Goldberg IJ, Wagner WD.

Mol Cell Biochem. 2000 Oct;213(1-2):1-9.

PMID:
11129947
11.
12.

The heparin-binding proteins apolipoprotein E and lipoprotein lipase enhance cellular proteoglycan production.

Obunike JC, Pillarisetti S, Paka L, Kako Y, Butteri MJ, Ho YY, Wagner WD, Yamada N, Mazzone T, Deckelbaum RJ, Goldberg IJ.

Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):111-8.

PMID:
10634807
13.

Perlecan mediates the antiproliferative effect of apolipoprotein E on smooth muscle cells. An underlying mechanism for the modulation of smooth muscle cell growth?

Paka L, Goldberg IJ, Obunike JC, Choi SY, Saxena U, Goldberg ID, Pillarisetti S.

J Biol Chem. 1999 Dec 17;274(51):36403-8.

15.

Subendothelial retention of lipoprotein (a). Evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix.

Pillarisetti S, Paka L, Obunike JC, Berglund L, Goldberg IJ.

J Clin Invest. 1997 Aug 15;100(4):867-74.

16.

Lipoprotein lipase can function as a monocyte adhesion protein.

Obunike JC, Paka S, Pillarisetti S, Goldberg IJ.

Arterioscler Thromb Vasc Biol. 1997 Jul;17(7):1414-20.

PMID:
9261275
17.

Lipoprotein lipase degradation by adipocytes: receptor-associated protein (RAP)-sensitive and proteoglycan-mediated pathways.

Obunike JC, Sivaram P, Paka L, Low MG, Goldberg IJ.

J Lipid Res. 1996 Nov;37(11):2439-49.

18.
19.

Differentiated macrophages synthesize a heparan sulfate proteoglycan and an oversulfated chondroitin sulfate proteoglycan that bind lipoprotein lipase.

Edwards IJ, Xu H, Obunike JC, Goldberg IJ, Wagner WD.

Arterioscler Thromb Vasc Biol. 1995 Mar;15(3):400-9.

PMID:
7749850
20.

Lipoprotein lipase hydrolysis of retinyl ester. Possible implications for retinoid uptake by cells.

Blaner WS, Obunike JC, Kurlandsky SB, al-Haideri M, Piantedosi R, Deckelbaum RJ, Goldberg IJ.

J Biol Chem. 1994 Jun 17;269(24):16559-65.

21.

Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins.

Obunike JC, Edwards IJ, Rumsey SC, Curtiss LK, Wagner WD, Deckelbaum RJ, Goldberg IJ.

J Biol Chem. 1994 May 6;269(18):13129-35.

22.

Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages.

Rumsey SC, Obunike JC, Arad Y, Deckelbaum RJ, Goldberg IJ.

J Clin Invest. 1992 Oct;90(4):1504-12.

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