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Items: 1 to 50 of 93


Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice.

Sullivan KA, Bever SR, McKim DB, Godbout JP, Sheridan JF, Obrietan K, Pyter LM.

Brain Behav Immun. 2019 Aug;80:805-817. doi: 10.1016/j.bbi.2019.05.028. Epub 2019 May 17.


A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.

Hegazi S, Lowden C, Rios Garcia J, Cheng AH, Obrietan K, Levine JD, Cheng HM.

Int J Mol Sci. 2019 May 13;20(9). pii: E2363. doi: 10.3390/ijms20092363. Review.


Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress.

Aten S, Page CE, Kalidindi A, Wheaton KL, Niraula A, Godbout JP, Hoyt KR, Obrietan K.

Data Brief. 2018 Nov 13;21:2323-2329. doi: 10.1016/j.dib.2018.11.042. eCollection 2018 Dec.


miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior.

Aten S, Page CE, Kalidindi A, Wheaton K, Niraula A, Godbout JP, Hoyt KR, Obrietan K.

Neuropharmacology. 2019 Jan;144:256-270. doi: 10.1016/j.neuropharm.2018.10.020. Epub 2018 Oct 18.


The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus.

Wheaton KL, Hansen KF, Aten S, Sullivan KA, Yoon H, Hoyt KR, Obrietan K.

J Biol Rhythms. 2018 Oct;33(5):497-514. doi: 10.1177/0748730418791713. Epub 2018 Sep 3.


Modulation of learning and memory by the genetic disruption of circadian oscillator populations.

Snider KH, Obrietan K.

Physiol Behav. 2018 Oct 1;194:387-393. doi: 10.1016/j.physbeh.2018.06.035. Epub 2018 Jun 23.


Commentary: miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock.

Mendoza-Viveros L, Obrietan K, Cheng HM.

J Neurol Neuromedicine. 2018;3(1):21-25. doi: 10.29245/2572.942X/2017/1.1169. Epub 2018 Feb 27.


miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition.

Aten S, Hansen KF, Snider K, Wheaton K, Kalidindi A, Garcia A, Alzate-Correa D, Hoyt KR, Obrietan K.

Learn Mem. 2018 Apr 16;25(5):214-229. doi: 10.1101/lm.047191.117. Print 2018 May.


Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms.

Snider KH, Sullivan KA, Obrietan K.

Neural Plast. 2018 Feb 8;2018:7292540. doi: 10.1155/2018/7292540. eCollection 2018. Review.


Circadian expression and functional characterization of PEA-15 within the mouse suprachiasmatic nucleus.

Wheaton K, Aten S, Queiroz LS, Sullivan K, Oberdick J, Hoyt KR, Obrietan K.

Eur J Neurosci. 2018 Apr;47(7):845-857. doi: 10.1111/ejn.13850. Epub 2018 Feb 19.


Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus.

Choi YS, Horning P, Aten S, Karelina K, Alzate-Correa D, Arthur JSC, Hoyt KR, Obrietan K.

ASN Neuro. 2017 Sep-Oct;9(5):1759091417726607. doi: 10.1177/1759091417726607.


Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture.

Matsu-Ura T, Dovzhenok A, Aihara E, Rood J, Le H, Ren Y, Rosselot AE, Zhang T, Lee C, Obrietan K, Montrose MH, Lim S, Moore SR, Hong CI.

Mol Cell. 2016 Dec 1;64(5):900-912. doi: 10.1016/j.molcel.2016.10.015. Epub 2016 Nov 17.


The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition.

Aten S, Hansen KF, Hoyt KR, Obrietan K.

RNA Dis. 2016;3(2). pii: e1375. Epub 2016 Aug 2.


Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain.

Choi YS, Lee B, Hansen KF, Aten S, Horning P, Wheaton KL, Impey S, Hoyt KR, Obrietan K.

Neuroscience. 2016 Sep 7;331:1-12. doi: 10.1016/j.neuroscience.2016.06.010. Epub 2016 Jun 11.


Modulation of learning and memory by the targeted deletion of the circadian clock gene Bmal1 in forebrain circuits.

Snider KH, Dziema H, Aten S, Loeser J, Norona FE, Hoyt K, Obrietan K.

Behav Brain Res. 2016 Jul 15;308:222-35. doi: 10.1016/j.bbr.2016.04.027. Epub 2016 May 4.


Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.

Hansen KF, Sakamoto K, Aten S, Snider KH, Loeser J, Hesse AM, Page CE, Pelz C, Arthur JS, Impey S, Obrietan K.

Learn Mem. 2016 Jan 15;23(2):61-71. doi: 10.1101/lm.039578.115. Print 2016 Feb.


Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.

Karelina K, Liu Y, Alzate-Correa D, Wheaton KL, Hoyt KR, Arthur JS, Obrietan K.

Neuroscience. 2015 Jan 29;285:292-302. doi: 10.1016/j.neuroscience.2014.10.053. Epub 2014 Nov 14.


Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing.

Hansen KF, Sakamoto K, Pelz C, Impey S, Obrietan K.

Sci Rep. 2014 Nov 6;4:6930. doi: 10.1038/srep06930.


MicroRNAs: fundamental regulators of gene expression in major affective disorders and suicidal behavior?

Serafini G, Pompili M, Hansen KF, Obrietan K, Dwivedi Y, Amore M, Shomron N, Girardi P.

Front Cell Neurosci. 2013 Nov 15;7:208. doi: 10.3389/fncel.2013.00208. eCollection 2013. No abstract available.


Ribosomal S6 kinase regulates ischemia-induced progenitor cell proliferation in the adult mouse hippocampus.

Karelina K, Alzate-Correa D, Obrietan K.

Exp Neurol. 2014 Mar;253:72-81. doi: 10.1016/j.expneurol.2013.11.022. Epub 2013 Dec 1.


The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p.

Serafini G, Pompili M, Hansen KF, Obrietan K, Dwivedi Y, Shomron N, Girardi P.

Cell Mol Neurobiol. 2014 Jan;34(1):17-30. doi: 10.1007/s10571-013-9997-5. Epub 2013 Nov 9. Review.


MicroRNA as therapeutic targets for treatment of depression.

Hansen KF, Obrietan K.

Neuropsychiatr Dis Treat. 2013;9:1011-21. doi: 10.2147/NDT.S34811. Epub 2013 Jul 29.


A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis.

Lesiak A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF, Obrietan K, Appleyard SM, Impey S, Wayman GA.

PLoS One. 2013 Jun 6;8(6):e64658. doi: 10.1371/journal.pone.0064658. Print 2013.


Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock.

Sakamoto K, Norona FE, Alzate-Correa D, Scarberry D, Hoyt KR, Obrietan K.

J Neurosci. 2013 May 22;33(21):9021-7. doi: 10.1523/JNEUROSCI.4202-12.2013.


Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.

Cao R, Butcher GQ, Karelina K, Arthur JS, Obrietan K.

Eur J Neurosci. 2013 Jan;37(1):130-40. doi: 10.1111/ejn.12028. Epub 2012 Nov 6.


MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement.

Karelina K, Hansen KF, Choi YS, DeVries AC, Arthur JS, Obrietan K.

Learn Mem. 2012 Oct 17;19(11):550-60. doi: 10.1101/lm.025775.112.


Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.

Choi YS, Karelina K, Alzate-Correa D, Hoyt KR, Impey S, Arthur JS, Obrietan K.

J Neurochem. 2012 Dec;123(5):676-88. doi: 10.1111/jnc.12035. Epub 2012 Oct 25.


miRNA-132: a dynamic regulator of cognitive capacity.

Hansen KF, Karelina K, Sakamoto K, Wayman GA, Impey S, Obrietan K.

Brain Struct Funct. 2013 May;218(3):817-31. doi: 10.1007/s00429-012-0431-4. Epub 2012 Jun 16.


The circadian molecular clock creates epidermal stem cell heterogeneity.

Janich P, Pascual G, Merlos-Suárez A, Batlle E, Ripperger J, Albrecht U, Cheng HY, Obrietan K, Di Croce L, Benitah SA.

Nature. 2011 Nov 9;480(7376):209-14. doi: 10.1038/nature10649.


Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus.

Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H.

Nat Commun. 2011;2:327. doi: 10.1038/ncomms1316.


Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus.

Cao R, Anderson FE, Jung YJ, Dziema H, Obrietan K.

Neuroscience. 2011 May 5;181:79-88. doi: 10.1016/j.neuroscience.2011.03.005. Epub 2011 Mar 5.


MicroRNAs: a potential interface between the circadian clock and human health.

Hansen KF, Sakamoto K, Obrietan K.

Genome Med. 2011 Feb 17;3(2):10. doi: 10.1186/gm224.


mTOR Signaling and Entrainment of the Mammalian Circadian Clock.

Cao R, Obrietan K.

Mol Cell Pharmacol. 2010;2(4):125-130.


CREB influences timing and entrainment of the SCN circadian clock.

Lee B, Li A, Hansen KF, Cao R, Yoon JH, Obrietan K.

J Biol Rhythms. 2010 Dec;25(6):410-20. doi: 10.1177/0748730410381229.


Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory.

Hansen KF, Sakamoto K, Wayman GA, Impey S, Obrietan K.

PLoS One. 2010 Nov 29;5(11):e15497. doi: 10.1371/journal.pone.0015497.


CREB: a multifaceted regulator of neuronal plasticity and protection.

Sakamoto K, Karelina K, Obrietan K.

J Neurochem. 2011 Jan;116(1):1-9. doi: 10.1111/j.1471-4159.2010.07080.x. Epub 2010 Dec 2. Review.


Cannabinoids excite circadian clock neurons.

Acuna-Goycolea C, Obrietan K, van den Pol AN.

J Neurosci. 2010 Jul 28;30(30):10061-6. doi: 10.1523/JNEUROSCI.5838-09.2010.


Proteomic profiling of the epileptic dentate gyrus.

Li A, Choi YS, Dziema H, Cao R, Cho HY, Jung YJ, Obrietan K.

Brain Pathol. 2010 Nov;20(6):1077-89. doi: 10.1111/j.1750-3639.2010.00414.x. Epub 2010 Jul 4.


Mammalian target of rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock.

Cao R, Li A, Cho HY, Lee B, Obrietan K.

J Neurosci. 2010 May 5;30(18):6302-14. doi: 10.1523/JNEUROSCI.5482-09.2010.


An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling.

Impey S, Davare M, Lesiak A, Fortin D, Ando H, Varlamova O, Obrietan K, Soderling TR, Goodman RH, Wayman GA.

Mol Cell Neurosci. 2010 Jan;43(1):146-56. doi: 10.1016/j.mcn.2009.10.005. Epub 2009 Oct 20. Erratum in: Mol Cell Neurosci. 2012 Feb;49(2):250. Lasiek, Adam [corrected to Lesiak, Adam].


CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease.

Choi YS, Lee B, Cho HY, Reyes IB, Pu XA, Saido TC, Hoyt KR, Obrietan K.

Neurobiol Dis. 2009 Nov;36(2):259-68. doi: 10.1016/j.nbd.2009.07.014. Epub 2009 Jul 24.


Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.

Cheng HY, Alvarez-Saavedra M, Dziema H, Choi YS, Li A, Obrietan K.

Hum Mol Genet. 2009 Aug 15;18(16):3110-24. doi: 10.1093/hmg/ddp252. Epub 2009 May 28.


The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death.

Lee B, Cao R, Choi YS, Cho HY, Rhee AD, Hah CK, Hoyt KR, Obrietan K.

J Neurochem. 2009 Mar;108(5):1251-65. doi: 10.1111/j.1471-4159.2008.05864.x. Epub 2009 Jan 28.


An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.

Wayman GA, Davare M, Ando H, Fortin D, Varlamova O, Cheng HY, Marks D, Obrietan K, Soderling TR, Goodman RH, Impey S.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9093-8. doi: 10.1073/pnas.0803072105. Epub 2008 Jun 24.


Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock.

Cao R, Lee B, Cho HY, Saklayen S, Obrietan K.

Mol Cell Neurosci. 2008 Jul;38(3):312-24. doi: 10.1016/j.mcn.2008.03.005. Epub 2008 Mar 25.


Revealing a role of microRNAs in the regulation of the biological clock.

Cheng HY, Obrietan K.

Cell Cycle. 2007 Dec 15;6(24):3034-5. Epub 2007 Oct 1. Review.


Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.

Zhao M, Choi YS, Obrietan K, Dudek SM.

J Neurosci. 2007 Oct 31;27(44):12025-32.


Protein kinase C modulates the phase-delaying effects of light in the mammalian circadian clock.

Lee B, Almad A, Butcher GQ, Obrietan K.

Eur J Neurosci. 2007 Jul;26(2):451-62.


microRNA modulation of circadian-clock period and entrainment.

Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K.

Neuron. 2007 Jun 7;54(5):813-29.

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