Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.
Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES.
Schiebinger G, et al.
Cell. 2019 Feb 7;176(4):928-943.e22. doi: 10.1016/j.cell.2019.01.006. Epub 2019 Jan 31.
Cell. 2019.
PMID: 30712874
Free PMC article.
The analysis predicts transcription factors and paracrine signals that affect fates and experiments validate that the TF Obox6 and the cytokine GDF9 enhance reprogramming efficiency. Our approach sheds light on the process and outcome of reprogramming and provides a framew …
The analysis predicts transcription factors and paracrine signals that affect fates and experiments validate that the TF Obox6 and th …