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Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.
Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES. Schiebinger G, et al. Cell. 2019 Feb 7;176(4):928-943.e22. doi: 10.1016/j.cell.2019.01.006. Epub 2019 Jan 31. Cell. 2019. PMID: 30712874 Free PMC article.
The analysis predicts transcription factors and paracrine signals that affect fates and experiments validate that the TF Obox6 and the cytokine GDF9 enhance reprogramming efficiency. Our approach sheds light on the process and outcome of reprogramming and provides a framew …
The analysis predicts transcription factors and paracrine signals that affect fates and experiments validate that the TF Obox6 and th …
Mice lacking the Obox6 homeobox gene undergo normal early embryonic development and are fertile.
Cheng WC, Hsieh-Li HM, Yeh YJ, Li H. Cheng WC, et al. Dev Dyn. 2007 Sep;236(9):2636-42. doi: 10.1002/dvdy.21261. Dev Dyn. 2007. PMID: 17676645 Free article.
Obox6 is a member of the Obox (oocyte-specific homeobox) gene family. The Obox6 gene was isolated from the mouse two-cell embryonic cDNA library. ...
Obox6 is a member of the Obox (oocyte-specific homeobox) gene family. The Obox6 gene was isolated from the mouse two-cell embr
Obox, a family of homeobox genes preferentially expressed in germ cells.
Rajkovic A, Yan C, Yan W, Klysik M, Matzuk MM. Rajkovic A, et al. Genomics. 2002 May;79(5):711-7. doi: 10.1006/geno.2002.6759. Genomics. 2002. PMID: 11991721
In situ hybridization detected Obox1 and Obox6 transcripts exclusively in oocytes as early as one-layer follicles and throughout folliculogenesis. Obox1, Obox2, Obox3, Obox4, Obox5, and Obox6 map to proximal chromosome 7 in the mouse. The Obox1 and Obox2 genomic str …
In situ hybridization detected Obox1 and Obox6 transcripts exclusively in oocytes as early as one-layer follicles and throughout foll …
Obox4 regulates the expression of histone family genes and promotes differentiation of mouse embryonic stem cells.
Kim HM, Ahn HJ, Lee HS, Lee KA, Lee SM, Kim HH, Kim KS, Park KS. Kim HM, et al. FEBS Lett. 2010 Feb 5;584(3):605-11. doi: 10.1016/j.febslet.2009.12.005. Epub 2009 Dec 10. FEBS Lett. 2010. PMID: 20004198 Free article.
Obox genes are preferentially expressed in the ovary, testis and oocyte, and play important roles in many developmental processes. In this study, we report that Obox4 and Obox6 are expressed in mouse embryonic stem cells (mESCs) and that Obox4 regulates histone family gene …
Obox genes are preferentially expressed in the ovary, testis and oocyte, and play important roles in many developmental processes. In this s …
Changes of gene expression profiles in the cervical spinal cord by acupuncture in an MPTP-intoxicated mouse model: microarray analysis.
Choi YG, Yeo S, Hong YM, Kim SH, Lim S. Choi YG, et al. Gene. 2011 Jul 15;481(1):7-16. doi: 10.1016/j.gene.2011.03.006. Epub 2011 Apr 1. Gene. 2011. PMID: 21440609
Of these 11 probes, 10 probes (5 annotated genes in 10 probes: EG665033, ENSMUSG00000055323, Obox6, Pbp2 and Tmem150) were exclusively up-regulated by acupuncture at the specific acupoints except for the Fut11 because the Fut11 was commonly up-regulated by acupuncture at b …
Of these 11 probes, 10 probes (5 annotated genes in 10 probes: EG665033, ENSMUSG00000055323, Obox6, Pbp2 and Tmem150) were exclusivel …