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Items: 1 to 50 of 215

1.

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene.

Okuda T, Kawashima Y, Kasahara Y, Takagi T, Yamamoto J, Iwai S, Obika S.

Chem Commun (Camb). 2019 Nov 19;55(93):14062-14065. doi: 10.1039/c9cc06498b.

PMID:
31693023
2.

Nucleobase Derivatives Induce In-Source Decay of Oligonucleotides as New MALDI Matrices.

Kimura S, Fujisaka A, Obika S.

Rapid Commun Mass Spectrom. 2019 Oct 28. doi: 10.1002/rcm.8620. [Epub ahead of print]

PMID:
31658399
3.

Evaluation of off-target effects of gapmer antisense oligonucleotides using human cells.

Yoshida T, Naito Y, Yasuhara H, Sasaki K, Kawaji H, Kawai J, Naito M, Okuda H, Obika S, Inoue T.

Genes Cells. 2019 Dec;24(12):827-835. doi: 10.1111/gtc.12730. Epub 2019 Nov 12.

PMID:
31637814
4.

Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides.

Yamamoto T, Sawamura M, Terada C, Kashiwada K, Wada F, Yamayoshi A, Obika S, Harada-Shiba M.

Nucleosides Nucleotides Nucleic Acids. 2019 Oct 16:1-10. doi: 10.1080/15257770.2019.1677911. [Epub ahead of print]

PMID:
31617782
5.

Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base.

Moai Y, Hiroaki H, Obika S, Kodama T.

Nucleosides Nucleotides Nucleic Acids. 2019 Oct 12:1-10. doi: 10.1080/15257770.2019.1675169. [Epub ahead of print]

PMID:
31608780
6.

Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties.

Fujii A, Nakagawa O, Kishimoto Y, Nakatsuji Y, Nozaki N, Obika S.

Chembiochem. 2019 Sep 30. doi: 10.1002/cbic.201900536. [Epub ahead of print]

PMID:
31568630
7.

Synthesis of 2'-C,4'-C-Methyleneoxy-Bridged Thymidine Derivatives and Properties of Modified Oligonucleotides.

Osawa T, Kim H, Shoji M, Saijo M, Dohi M, Ito Y, Obika S, Hari Y.

J Org Chem. 2019 Nov 1;84(21):13336-13344. doi: 10.1021/acs.joc.9b01496. Epub 2019 Oct 10.

PMID:
31565938
8.

Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides.

Yamamoto T, Terada C, Kashiwada K, Yamayoshi A, Harada-Shiba M, Obika S.

Curr Protoc Nucleic Acid Chem. 2019 Sep;78(1):e99. doi: 10.1002/cpnc.99.

PMID:
31529782
9.

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.

Matsumoto S, Yamamichi T, Shinzawa K, Kasahara Y, Nojima S, Kodama T, Obika S, Takehara T, Morii E, Okuyama H, Kikuchi A.

Nat Commun. 2019 Aug 28;10(1):3882. doi: 10.1038/s41467-019-11533-x.

10.

Highly efficient silencing of microRNA by heteroduplex oligonucleotides.

Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T.

Nucleic Acids Res. 2019 Aug 22;47(14):7321-7332. doi: 10.1093/nar/gkz492.

11.

A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma.

Matsushita K, Okuda T, Mori S, Konno M, Eguchi H, Asai A, Koseki J, Iwagami Y, Yamada D, Akita H, Asaoka T, Noda T, Kawamoto K, Gotoh K, Kobayashi S, Kasahara Y, Morihiro K, Satoh T, Doki Y, Mori M, Ishii H, Obika S.

ChemMedChem. 2019 Aug 6;14(15):1384-1391. doi: 10.1002/cmdc.201900324. Epub 2019 Jul 4.

PMID:
31207139
12.

Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides.

Shimo T, Tachibana K, Kawawaki Y, Watahiki Y, Ishigaki T, Nakatsuji Y, Hara T, Kawakami J, Obika S.

Chem Commun (Camb). 2019 Jun 11;55(48):6850-6853. doi: 10.1039/c8cc09648a.

PMID:
31123731
13.

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer.

Shimojo M, Kasahara Y, Inoue M, Tsunoda SI, Shudo Y, Kurata T, Obika S.

Sci Rep. 2019 May 20;9(1):7618. doi: 10.1038/s41598-019-43100-1.

14.

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.

Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H.

Sci Rep. 2019 May 21;9(1):7567. doi: 10.1038/s41598-019-43772-9.

15.
16.

Effective syntheses of 2',4'-BNANC monomers bearing adenine, guanine, thymine, and 5-methylcytosine, and the properties of oligonucleotides fully modified with 2',4'-BNANC.

Fujisaka A, Hari Y, Takuma H, Rahman SMA, Yoshikawa H, Pang J, Imanishi T, Obika S.

Bioorg Med Chem. 2019 Apr 15;27(8):1728-1741. doi: 10.1016/j.bmc.2019.02.034. Epub 2019 Feb 22.

PMID:
30862430
17.

1,3,9-Triaza-2-oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self-Base Pairs with Three AgI Ions in a Duplex.

Fujii A, Nakagawa O, Kishimoto Y, Okuda T, Nakatsuji Y, Nozaki N, Kasahara Y, Obika S.

Chemistry. 2019 Jun 4;25(31):7443-7448. doi: 10.1002/chem.201900373. Epub 2019 Apr 10.

PMID:
30843298
18.

Detection of esterase activity by chromogenic and fluorogenic probe based on an O-nitrobenzoxadiazole (O-NBD) unit.

Okada K, Yamaguchi T, Dodo K, Sodeoka M, Obika S.

Bioorg Med Chem. 2019 Apr 1;27(7):1444-1448. doi: 10.1016/j.bmc.2019.02.036. Epub 2019 Feb 18.

PMID:
30795989
19.

Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.

Harada T, Matsumoto S, Hirota S, Kimura H, Fujii S, Kasahara Y, Gon H, Yoshida T, Itoh T, Haraguchi N, Mizushima T, Noda T, Eguchi H, Nojima S, Morii E, Fukumoto T, Obika S, Kikuchi A.

Mol Cancer Ther. 2019 Mar;18(3):602-612. doi: 10.1158/1535-7163.MCT-18-0824. Epub 2019 Jan 15.

PMID:
30647122
20.

Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase.

Habuchi T, Yamaguchi T, Aoyama H, Horiba M, Ito KR, Obika S.

J Org Chem. 2019 Feb 1;84(3):1430-1439. doi: 10.1021/acs.joc.8b02863. Epub 2019 Jan 24.

PMID:
30632750
21.

Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.

Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.

Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706. doi: 10.1016/j.bbrc.2018.12.164. Epub 2019 Jan 2.

PMID:
30611571
22.

High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives.

Kataoka Y, Fujita H, Afanaseva A, Nagao C, Mizuguchi K, Kasahara Y, Obika S, Kuwahara M.

Biochemistry. 2019 Feb 12;58(6):493-498. doi: 10.1021/acs.biochem.8b01181. Epub 2019 Jan 7.

PMID:
30595015
23.

Thioamide-Bridged Nucleic Acid (thioAmNA) Containing Thymine or 2-Thiothymine: Duplex-Forming Ability, Base Discrimination, and Enzymatic Stability.

Habuchi T, Yamaguchi T, Obika S.

Chembiochem. 2019 Apr 15;20(8):1060-1067. doi: 10.1002/cbic.201800702. Epub 2019 Mar 4.

PMID:
30552742
24.

Inhibition of LINE-1 Retrotransposition by Capsaicin.

Nishikawa Y, Nakayama R, Obika S, Ohsaki E, Ueda K, Honda T.

Int J Mol Sci. 2018 Oct 19;19(10). pii: E3243. doi: 10.3390/ijms19103243.

25.

Correction: Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1.

Tanaka K, Kasahara Y, Miyamoto Y, Okuda T, Kasai T, Onodera K, Kuwahara M, Oka M, Yoneda Y, Obika S.

Org Biomol Chem. 2018 Oct 17;16(40):7530. doi: 10.1039/c8ob90140f.

PMID:
30283945
26.

Optimization of 2',4'-BNA/LNA-Based Oligonucleotides for Splicing Modulation In Vitro.

Shimo T, Obika S.

Methods Mol Biol. 2018;1828:395-411. doi: 10.1007/978-1-4939-8651-4_25.

PMID:
30171556
27.

2'-O,4'-C-Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex.

Nakagawa O, Fujii A, Kishimoto Y, Nakatsuji Y, Nozaki N, Obika S.

Chembiochem. 2018 Nov 16;19(22):2372-2379. doi: 10.1002/cbic.201800448. Epub 2018 Oct 18.

PMID:
30168891
28.

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe]).

Horie N, Kumagai S, Kotobuki Y, Yamaguchi T, Obika S.

Org Biomol Chem. 2018 Sep 11;16(35):6531-6536. doi: 10.1039/c8ob01307a.

PMID:
30160290
29.

Development of a detection method for antisense oligonucleotides in mouse kidneys by matrix-assisted laser desorption/ionization imaging mass spectrometry.

Yokoi H, Kasahara Y, Obika S, Doi T, Kamada H.

Rapid Commun Mass Spectrom. 2018 Dec 15;32(23):1984-1990. doi: 10.1002/rcm.8274.

PMID:
30152908
30.

Synthesis and biophysical properties of 5'-thio-2',4'-BNA/LNA oligonucleotide.

Islam MA, Fujisaka A, Mori S, Ito KR, Yamaguchi T, Obika S.

Bioorg Med Chem. 2018 Jul 23;26(12):3634-3638. doi: 10.1016/j.bmc.2018.05.040. Epub 2018 May 23.

PMID:
29886084
31.

Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1.

Tanaka K, Kasahara Y, Miyamoto Y, Okuda T, Kasai T, Onodera K, Kuwahara M, Oka M, Yoneda Y, Obika S.

Org Biomol Chem. 2018 Jun 20;16(24):4456-4463. doi: 10.1039/c8ob00706c. Erratum in: Org Biomol Chem. 2018 Oct 17;16(40):7530. Takumi, Okuda [corrected to Okuda, Takumi].

PMID:
29850750
32.
33.

Effective gene silencing activity of prodrug-type 2'-O-methyldithiomethyl siRNA compared with non-prodrug-type 2'-O-methyl siRNA.

Hayashi J, Nishigaki M, Ochi Y, Wada SI, Wada F, Nakagawa O, Obika S, Harada-Shiba M, Urata H.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2171-2174. doi: 10.1016/j.bmcl.2018.05.016. Epub 2018 May 8.

PMID:
29764744
34.

Estimated number of off-target candidate sites for antisense oligonucleotides in human mRNA sequences.

Yoshida T, Naito Y, Sasaki K, Uchida E, Sato Y, Naito M, Kawanishi T, Obika S, Inoue T.

Genes Cells. 2018 Jun;23(6):448-455. doi: 10.1111/gtc.12587. Epub 2018 Apr 18.

35.

Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides.

Mori S, Morihiro K, Okuda T, Kasahara Y, Obika S.

Chem Sci. 2017 Dec 6;9(5):1112-1118. doi: 10.1039/c7sc04318j. eCollection 2018 Feb 7.

36.

Generation of splice switching oligonucleotides targeting the Cockayne syndrome group B gene product in order to change the diseased cell state.

Sin Y, Makimura F, Saijo M, Obika S.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):163-169. doi: 10.1016/j.bbrc.2018.04.015. Epub 2018 Apr 9.

PMID:
29625109
37.

Synthetic Method for 2'-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction.

Sawamoto H, Arai Y, Yamakoshi S, Obika S, Kawanishi E.

Org Lett. 2018 Apr 6;20(7):1928-1931. doi: 10.1021/acs.orglett.8b00476. Epub 2018 Mar 12.

PMID:
29528240
38.

Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.

Wada F, Yamamoto T, Ueda T, Sawamura M, Wada S, Harada-Shiba M, Obika S.

Nucleic Acid Ther. 2018 Feb;28(1):50-57. doi: 10.1089/nat.2017.0698. Epub 2018 Jan 23.

PMID:
29360004
39.

A novel human muscle cell model of Duchenne muscular dystrophy created by CRISPR/Cas9 and evaluation of antisense-mediated exon skipping.

Shimo T, Hosoki K, Nakatsuji Y, Yokota T, Obika S.

J Hum Genet. 2018 Mar;63(3):365-375. doi: 10.1038/s10038-017-0400-0. Epub 2018 Jan 16.

PMID:
29339778
40.

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes.

Setoguchi K, Cui L, Hachisuka N, Obchoei S, Shinkai K, Hyodo F, Kato K, Wada F, Yamamoto T, Harada-Shiba M, Obika S, Nakano K.

Mol Ther Nucleic Acids. 2017 Dec 15;9:170-181. doi: 10.1016/j.omtn.2017.09.004. Epub 2017 Sep 14.

41.

Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base.

Kishimoto Y, Fujii A, Nakagawa O, Nagata T, Yokota T, Hari Y, Obika S.

Org Biomol Chem. 2017 Oct 4;15(38):8145-8152. doi: 10.1039/c7ob01874f.

PMID:
28920119
42.

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged thymidine derivatives.

Osawa T, Sawamura M, Wada F, Yamamoto T, Obika S, Hari Y.

Org Biomol Chem. 2017 May 10;15(18):3955-3963. doi: 10.1039/c7ob00698e.

PMID:
28440828
43.

Small Nucleolar Noncoding RNA SNORA23, Up-Regulated in Human Pancreatic Ductal Adenocarcinoma, Regulates Expression of Spectrin Repeat-Containing Nuclear Envelope 2 to Promote Growth and Metastasis of Xenograft Tumors in Mice.

Cui L, Nakano K, Obchoei S, Setoguchi K, Matsumoto M, Yamamoto T, Obika S, Shimada K, Hiraoka N.

Gastroenterology. 2017 Jul;153(1):292-306.e2. doi: 10.1053/j.gastro.2017.03.050. Epub 2017 Apr 5.

PMID:
28390868
44.

Evaluation of size-exclusion chromatography for the analysis of phosphorothioate oligonucleotides.

Shimoyama A, Fujisaka A, Obika S.

J Pharm Biomed Anal. 2017 Mar 20;136:55-65. doi: 10.1016/j.jpba.2016.12.036. Epub 2016 Dec 29.

PMID:
28063336
45.

Systematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21.

Nahar S, Singh A, Morihiro K, Moai Y, Kodama T, Obika S, Maiti S.

Biochemistry. 2016 Dec 20;55(50):7023-7032. Epub 2016 Dec 5.

PMID:
27992999
46.

Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle.

Hara T, Kodama T, Takegaki Y, Morihiro K, Ito KR, Obika S.

J Org Chem. 2017 Jan 6;82(1):25-36. doi: 10.1021/acs.joc.6b02525. Epub 2016 Dec 15.

PMID:
27958739
47.

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.

Mitsuoka Y, Yamamoto T, Kugimiya A, Waki R, Wada F, Tahara S, Sawamura M, Noda M, Fujimura Y, Kato Y, Hari Y, Obika S.

J Org Chem. 2017 Jan 6;82(1):12-24. doi: 10.1021/acs.joc.6b02417. Epub 2016 Dec 12.

PMID:
27936689
48.

In vitro and in vivo biophysical properties of oligonucleotides containing 5'-thio nucleosides.

Islam MA, Waki R, Fujisaka A, Ito KR, Obika S.

Drug Discov Ther. 2016;10(5):263-270.

49.

Biological applications of xeno nucleic acids.

Morihiro K, Kasahara Y, Obika S.

Mol Biosyst. 2017 Jan 31;13(2):235-245. doi: 10.1039/c6mb00538a. Review.

PMID:
27827481
50.

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.

Morihara H, Yamamoto T, Oiwa H, Tonegawa K, Tsuchiyama D, Kawakatsu I, Obana M, Maeda M, Mohri T, Obika S, Fujio Y, Nakayama H.

J Cardiovasc Pharmacol Ther. 2017 May;22(3):273-282. doi: 10.1177/1074248416676392. Epub 2016 Nov 2.

PMID:
27811197

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