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Items: 1 to 50 of 51

1.

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity.

Orozco SL, Daniels BP, Yatim N, Messmer MN, Quarato G, Chen-Harris H, Cullen SP, Snyder AG, Ralli-Jain P, Frase S, Tait SWG, Green DR, Albert ML, Oberst A.

Cell Rep. 2019 Aug 27;28(9):2275-2287.e5. doi: 10.1016/j.celrep.2019.07.077.

2.

STING is required for host defense against neuropathological West Nile virus infection.

McGuckin Wuertz K, Treuting PM, Hemann EA, Esser-Nobis K, Snyder AG, Graham JB, Daniels BP, Wilkins C, Snyder JM, Voss KM, Oberst A, Lund J, Gale M Jr.

PLoS Pathog. 2019 Aug 15;15(8):e1007899. doi: 10.1371/journal.ppat.1007899. eCollection 2019 Aug.

3.

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity.

Snyder AG, Hubbard NW, Messmer MN, Kofman SB, Hagan CE, Orozco SL, Chiang K, Daniels BP, Baker D, Oberst A.

Sci Immunol. 2019 Jun 21;4(36). pii: eaaw2004. doi: 10.1126/sciimmunol.aaw2004.

PMID:
31227597
4.

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale M Jr, Loo YM, Oberst A.

Immunity. 2019 Jan 15;50(1):64-76.e4. doi: 10.1016/j.immuni.2018.11.017. Epub 2019 Jan 8.

PMID:
30635240
5.

Comparing the effects of different cell death programs in tumor progression and immunotherapy.

Messmer MN, Snyder AG, Oberst A.

Cell Death Differ. 2019 Jan;26(1):115-129. doi: 10.1038/s41418-018-0214-4. Epub 2018 Oct 19.

PMID:
30341424
6.

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.

Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.

EMBO J. 2018 Sep 3;37(17). pii: e99238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26.

7.

Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling.

Brault M, Olsen TM, Martinez J, Stetson DB, Oberst A.

J Immunol. 2018 Apr 15;200(8):2748-2756. doi: 10.4049/jimmunol.1701492. Epub 2018 Mar 14.

8.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

9.

MK2 balances inflammation and cell death.

Oberst A.

Nat Cell Biol. 2017 Sep 29;19(10):1150-1152. doi: 10.1038/ncb3619.

PMID:
28960200
10.

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, Rubio-Patiño C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG.

Nat Cell Biol. 2017 Sep;19(9):1116-1129. doi: 10.1038/ncb3596. Epub 2017 Aug 28.

11.

Programmed Cell Death and Inflammation: Winter Is Coming.

Kolb JP, Oguin TH 3rd, Oberst A, Martinez J.

Trends Immunol. 2017 Oct;38(10):705-718. doi: 10.1016/j.it.2017.06.009. Epub 2017 Jul 19. Review.

12.

RIPK3 in cell death and inflammation: the good, the bad, and the ugly.

Orozco S, Oberst A.

Immunol Rev. 2017 May;277(1):102-112. doi: 10.1111/imr.12536. Review.

13.

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.

Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L.

J Cell Biol. 2017 Jun 5;216(6):1795-1810. doi: 10.1083/jcb.201608095. Epub 2017 Apr 21.

14.

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.

Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH 3rd, Tait SWG, Martinez J, Gale M Jr, Loo YM, Oberst A.

Cell. 2017 Apr 6;169(2):301-313.e11. doi: 10.1016/j.cell.2017.03.011. Epub 2017 Mar 30.

15.

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.

Gutierrez KD, Davis MA, Daniels BP, Olsen TM, Ralli-Jain P, Tait SW, Gale M Jr, Oberst A.

J Immunol. 2017 Mar 1;198(5):2156-2164. doi: 10.4049/jimmunol.1601757. Epub 2017 Jan 27.

16.

Necroptosis in development, inflammation and disease.

Weinlich R, Oberst A, Beere HM, Green DR.

Nat Rev Mol Cell Biol. 2017 Feb;18(2):127-136. doi: 10.1038/nrm.2016.149. Epub 2016 Dec 21. Review.

PMID:
27999438
17.

Controlled detonation: evolution of necroptosis in pathogen defense.

Brault M, Oberst A.

Immunol Cell Biol. 2017 Feb;95(2):131-136. doi: 10.1038/icb.2016.117. Epub 2016 Dec 20. Review.

PMID:
27909314
18.

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.

Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE.

PLoS Pathog. 2016 Oct 13;12(10):e1005910. doi: 10.1371/journal.ppat.1005910. eCollection 2016 Oct.

19.

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S.

Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.

20.

Mito-priming as a method to engineer Bcl-2 addiction.

Lopez J, Bessou M, Riley JS, Giampazolias E, Todt F, Rochegüe T, Oberst A, Green DR, Edlich F, Ichim G, Tait SW.

Nat Commun. 2016 Feb 2;7:10538. doi: 10.1038/ncomms10538.

21.

RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

Yatim N, Jusforgues-Saklani H, Orozco S, Schulz O, Barreira da Silva R, Reis e Sousa C, Green DR, Oberst A, Albert ML.

Science. 2015 Oct 16;350(6258):328-34. doi: 10.1126/science.aad0395. Epub 2015 Sep 24.

22.

Death in the fast lane: what's next for necroptosis?

Oberst A.

FEBS J. 2016 Jul;283(14):2616-25. doi: 10.1111/febs.13520. Epub 2015 Oct 19. Review.

23.

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.

Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, Fitzgerald KA, Green DR, Zhang J, Mocarski ES, Alnemri ES.

Nat Commun. 2015 Jun 24;6:7515. doi: 10.1038/ncomms8515.

24.

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis.

Rodriguez DA, Weinlich R, Brown S, Guy C, Fitzgerald P, Dillon CP, Oberst A, Quarato G, Low J, Cripps JG, Chen T, Green DR.

Cell Death Differ. 2016 Jan;23(1):76-88. doi: 10.1038/cdd.2015.70. Epub 2015 May 29.

25.

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.

Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG.

Mol Cell. 2015 Mar 5;57(5):860-872. doi: 10.1016/j.molcel.2015.01.018. Epub 2015 Feb 19. Erratum in: Mol Cell. 2015 Jun 4;58(5):900.

26.

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity.

Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW.

Autophagy. 2014;10(12):2269-78. doi: 10.4161/15548627.2014.981914.

27.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Review.

28.

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SW, Albert ML, Green DR, Oberst A.

Cell Death Differ. 2014 Oct;21(10):1511-21. doi: 10.1038/cdd.2014.76. Epub 2014 Jun 6.

29.

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling.

Philip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90. doi: 10.1073/pnas.1403252111. Epub 2014 May 5.

30.

Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.

Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, Green DR, Espinosa JM, Thorburn A.

Cell Rep. 2014 Apr 10;7(1):45-52. doi: 10.1016/j.celrep.2014.02.036. Epub 2014 Mar 27.

31.

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A.

J Immunol. 2014 Mar 1;192(5):2029-2033. doi: 10.4049/jimmunol.1302549. Epub 2014 Jan 31.

32.

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis.

Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, Karvela M, Ichim G, Yatim N, Albert ML, Kidd G, Wakefield R, Frase S, Krautwald S, Linkermann A, Green DR.

Cell Rep. 2013 Nov 27;5(4):878-85. doi: 10.1016/j.celrep.2013.10.034. Epub 2013 Nov 21.

33.

Protective roles for caspase-8 and cFLIP in adult homeostasis.

Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR.

Cell Rep. 2013 Oct 31;5(2):340-8. doi: 10.1016/j.celrep.2013.08.045. Epub 2013 Oct 3.

34.

Autophagic cell death RIPs into tumors.

Oberst A.

Cell Death Differ. 2013 Sep;20(9):1131-2. doi: 10.1038/cdd.2013.89. No abstract available.

35.

Survival function of the FADD-CASPASE-8-cFLIP(L) complex.

Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR.

Cell Rep. 2012 May 31;1(5):401-7.

36.

Caspase 8 inhibits programmed necrosis by processing CYLD.

O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT.

Nat Cell Biol. 2011 Oct 30;13(12):1437-42. doi: 10.1038/ncb2362.

37.

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.

Oberst A, Green DR.

Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):757-63. doi: 10.1038/nrm3214. Review.

38.

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.

Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.

Mol Cell. 2011 Oct 7;44(1):9-16. doi: 10.1016/j.molcel.2011.09.003. Review.

39.

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.

Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17396-401. doi: 10.1073/pnas.1113421108. Epub 2011 Oct 3.

40.

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.

Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.

Nature. 2011 Mar 17;471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.

41.

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.

Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, Salvesen GS.

Biochem J. 2011 Feb 1;433(3):447-457. doi: 10.1042/BJ20101738.

42.

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.

Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.

J Biol Chem. 2010 May 28;285(22):16632-42. doi: 10.1074/jbc.M109.095083. Epub 2010 Mar 22. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6838.

43.

Characterization of cytoplasmic caspase-2 activation by induced proximity.

Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR.

Mol Cell. 2009 Sep 24;35(6):830-40. doi: 10.1016/j.molcel.2009.07.023.

44.

Live to dead cell imaging.

Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR.

Methods Mol Biol. 2009;559:33-48. doi: 10.1007/978-1-60327-017-5_3.

PMID:
19609747
45.

Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.

Oberst A, Bender C, Green DR.

Cell Death Differ. 2008 Jul;15(7):1139-46. doi: 10.1038/cdd.2008.65. Epub 2008 May 2. Review.

46.

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.

Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, Sharma P, Kuehn MR, Oren M, Croce CM, Bernassola F, Melino G.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11280-5. Epub 2007 Jun 25.

47.

The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.

Bernassola F, Oberst A, Melino G, Pandolfi PP.

Oncogene. 2005 Oct 20;24(46):6982-6.

PMID:
16007146
48.

Regulation of the p73 protein stability and degradation.

Oberst A, Rossi M, Salomoni P, Pandolfi PP, Oren M, Melino G, Bernassola F.

Biochem Biophys Res Commun. 2005 Jun 10;331(3):707-12. Review.

PMID:
15865926
49.

Ubiquitin-dependent degradation of p73 is inhibited by PML.

Bernassola F, Salomoni P, Oberst A, Di Como CJ, Pagano M, Melino G, Pandolfi PP.

J Exp Med. 2004 Jun 7;199(11):1545-57.

50.

A place to die for: apoptosis in cancer and infection, Capri 2002.

Oberst A, Baehrecke E, Mehmet H, Ichijo H, Gupta S.

Cell Death Differ. 2003 Mar;10(3):393-5. No abstract available.

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