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Items: 1 to 50 of 225

1.

Targeting NAD(P)H:Quinone Oxidoreductase (NQO1) in Pancreatic Cancer.

Lewis AM, Ough M, Du J, Tsao MS, Oberley LW, Cullen JJ.

Mol Carcinog. 2017 Jul;56(7):1825-1834. doi: 10.1002/mc.20199. Epub 2006 Mar 27.

PMID:
28639725
2.

Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics.

Carr WJ, Oberley-Deegan RE, Zhang Y, Oberley CC, Oberley LW, Dunnwald M.

Histochem Cell Biol. 2011 Mar;135(3):293-304. doi: 10.1007/s00418-011-0786-2. Epub 2011 Feb 24.

3.

Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer.

Sun WG, Weydert CJ, Zhang Y, Yu L, Liu J, Spitz DR, Cullen JJ, Oberley LW.

Cancers (Basel). 2010 Feb 12;2(1):68-87. doi: 10.3390/cancers2010068.

4.

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts.

Du C, Gao Z, Venkatesha VA, Kalen AL, Chaudhuri L, Spitz DR, Cullen JJ, Oberley LW, Goswami PC.

Cancer Biol Ther. 2009 Oct;8(20):1962-71. Epub 2009 Oct 29.

5.

Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion.

Teoh ML, Fitzgerald MP, Oberley LW, Domann FE.

Cancer Res. 2009 Aug 1;69(15):6355-63. doi: 10.1158/0008-5472.CAN-09-1195. Epub 2009 Jul 14.

6.

Enhancing the antitumor activity of adriamycin and ionizing radiation.

Sun W, Kalen AL, Smith BJ, Cullen JJ, Oberley LW.

Cancer Res. 2009 May 15;69(10):4294-300. doi: 10.1158/0008-5472.CAN-09-0396. Epub 2009 Apr 28.

7.

Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation.

Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR.

Biochem J. 2009 Feb 15;418(1):29-37. doi: 10.1042/BJ20081258.

8.

Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells.

Hitchler MJ, Oberley LW, Domann FE.

Free Radic Biol Med. 2008 Dec 1;45(11):1573-80. doi: 10.1016/j.freeradbiomed.2008.09.005. Epub 2008 Sep 18.

9.

Extracellular redox state regulates features associated with prostate cancer cell invasion.

Chaiswing L, Zhong W, Cullen JJ, Oberley LW, Oberley TD.

Cancer Res. 2008 Jul 15;68(14):5820-6. doi: 10.1158/0008-5472.CAN-08-0162.

10.

Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide.

Kaewpila S, Venkataraman S, Buettner GR, Oberley LW.

Cancer Res. 2008 Apr 15;68(8):2781-8. doi: 10.1158/0008-5472.CAN-07-2635.

11.

Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth.

Sarsour EH, Venkataraman S, Kalen AL, Oberley LW, Goswami PC.

Aging Cell. 2008 Jun;7(3):405-17. doi: 10.1111/j.1474-9726.2008.00384.x. Epub 2008 Mar 10.

12.

Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth.

Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW.

Free Radic Biol Med. 2008 Mar 1;44(5):856-67. Epub 2007 Nov 28.

13.

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress.

Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR.

Free Radic Biol Med. 2008 Mar 1;44(5):826-34. Epub 2007 Nov 28.

14.

Modulation of reactive oxygen species in pancreatic cancer.

Teoh ML, Sun W, Smith BJ, Oberley LW, Cullen JJ.

Clin Cancer Res. 2007 Dec 15;13(24):7441-50.

15.

Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase.

Menon SG, Sarsour EH, Kalen AL, Venkataraman S, Hitchler MJ, Domann FE, Oberley LW, Goswami PC.

Cancer Res. 2007 Jul 1;67(13):6392-9.

16.

Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels.

Zimmerman MC, Oberley LW, Flanagan SW.

J Neurochem. 2007 Aug;102(3):609-18. Epub 2007 Mar 23.

17.

Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.

Du J, Daniels DH, Asbury C, Venkataraman S, Liu J, Spitz DR, Oberley LW, Cullen JJ.

J Biol Chem. 2006 Dec 8;281(49):37416-26. Epub 2006 Oct 13.

18.

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

Luo J, Li L, Zhang Y, Spitz DR, Buettner GR, Oberley LW, Domann FE.

Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1307-14.

PMID:
16910778
19.

Enzymatic activity is necessary for the tumor-suppressive effects of MnSOD.

Zhang Y, Smith BJ, Oberley LW.

Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1283-93.

PMID:
16910776
20.

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth.

Weydert CJ, Waugh TA, Ritchie JM, Iyer KS, Smith JL, Li L, Spitz DR, Oberley LW.

Free Radic Biol Med. 2006 Jul 15;41(2):226-37. Epub 2006 May 4.

PMID:
16814103
21.

Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transfer.

Niu G, Anderson RD, Madsen MT, Graham MM, Oberley LW, Domann FE.

Nucl Med Biol. 2006 Apr;33(3):391-8.

PMID:
16631088
23.

Metastatic progression of pancreatic cancer: changes in antioxidant enzymes and cell growth.

Lewis A, Du J, Liu J, Ritchie JM, Oberley LW, Cullen JJ.

Clin Exp Metastasis. 2005;22(7):523-32. Epub 2006 Feb 11.

PMID:
16475022
24.

Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.

Liu J, Du J, Zhang Y, Sun W, Smith BJ, Oberley LW, Cullen JJ.

Hum Gene Ther. 2006 Jan;17(1):105-16.

PMID:
16409129
25.

Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging.

Zhang HJ, Doctrow SR, Oberley LW, Kregel KC.

J Appl Physiol (1985). 2006 Apr;100(4):1385-91. Epub 2005 Oct 27.

26.
27.

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

Wang M, Kirk JS, Venkataraman S, Domann FE, Zhang HJ, Schafer FQ, Flanagan SW, Weydert CJ, Spitz DR, Buettner GR, Oberley LW.

Oncogene. 2005 Dec 8;24(55):8154-66.

PMID:
16170370
28.

A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis.

Tome ME, Johnson DB, Rimsza LM, Roberts RA, Grogan TM, Miller TP, Oberley LW, Briehl MM.

Blood. 2005 Nov 15;106(10):3594-601. Epub 2005 Aug 4.

29.

Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer.

Lewis AM, Ough M, Hinkhouse MM, Tsao MS, Oberley LW, Cullen JJ.

Mol Carcinog. 2005 Aug;43(4):215-24. Erratum in: Mol Carcinog. 2017 Jul;56(7):1825-1834.

PMID:
16003741
30.

Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.

Gavrila D, Li WG, McCormick ML, Thomas M, Daugherty A, Cassis LA, Miller FJ Jr, Oberley LW, Dellsperger KC, Weintraub NL.

Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1671-7. Epub 2005 Jun 2.

31.

A role for manganese superoxide dismutase in apoptosis after photosensitization.

Dolgachev V, Oberley LW, Huang TT, Kraniak JM, Tainsky MA, Hanada K, Separovic D.

Biochem Biophys Res Commun. 2005 Jul 1;332(2):411-7.

PMID:
15894290
32.

Mechanism of the tumor suppressive effect of MnSOD overexpression.

Oberley LW.

Biomed Pharmacother. 2005 May;59(4):143-8. Epub 2005 Mar 19. Review.

PMID:
15862707
33.

MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.

Liu Y, Borchert GL, Donald SP, Surazynski A, Hu CA, Weydert CJ, Oberley LW, Phang JM.

Carcinogenesis. 2005 Aug;26(8):1335-42. Epub 2005 Apr 7.

PMID:
15817612
34.

Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts.

Sarsour EH, Agarwal M, Pandita TK, Oberley LW, Goswami PC.

J Biol Chem. 2005 May 6;280(18):18033-41. Epub 2005 Mar 2.

35.

Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.

Ough M, Lewis A, Bey EA, Gao J, Ritchie JM, Bornmann W, Boothman DA, Oberley LW, Cullen JJ.

Cancer Biol Ther. 2005 Jan;4(1):95-102. Epub 2005 Jan 15.

PMID:
15662131
36.
37.

Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma.

Ough M, Lewis A, Zhang Y, Hinkhouse MM, Ritchie JM, Oberley LW, Cullen JJ.

Free Radic Res. 2004 Nov;38(11):1223-33.

PMID:
15621700
38.

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR.

J Biol Chem. 2005 Feb 11;280(6):4254-63. Epub 2004 Nov 23.

39.

Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells.

Venkataraman S, Jiang X, Weydert C, Zhang Y, Zhang HJ, Goswami PC, Ritchie JM, Oberley LW, Buettner GR.

Oncogene. 2005 Jan 6;24(1):77-89.

PMID:
15543233
40.

Effect of expression of manganese superoxide dismutase in baculovirus-infected insect cells.

Wang Y, Oberley LW, Howe D, Jarvis DL, Chauhan G, Murhammer DW.

Appl Biochem Biotechnol. 2004 Nov;119(2):181-93.

PMID:
15531788
41.

Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia.

Venkataraman S, Wagner BA, Jiang X, Wang HP, Schafer FQ, Ritchie JM, Patrick BC, Oberley LW, Buettner GR.

Free Radic Res. 2004 Oct;38(10):1119-32.

PMID:
15512801
42.

Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress.

Zhang HJ, Doctrow SR, Xu L, Oberley LW, Beecher B, Morrison J, Oberley TD, Kregel KC.

FASEB J. 2004 Oct;18(13):1547-9. Epub 2004 Aug 19.

PMID:
15319374
43.

Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase.

He T, Peterson TE, Holmuhamedov EL, Terzic A, Caplice NM, Oberley LW, Katusic ZS.

Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2021-7. Epub 2004 Aug 19.

PMID:
15319267
44.

Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal.

Ridnour LA, Oberley TD, Oberley LW.

Antioxid Redox Signal. 2004 Jun;6(3):501-12.

PMID:
15130277
45.

Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype.

Liu J, Hinkhouse MM, Sun W, Weydert CJ, Ritchie JM, Oberley LW, Cullen JJ.

Hum Gene Ther. 2004 Mar;15(3):239-50.

PMID:
15018733
46.

High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages.

Carter AB, Tephly LA, Venkataraman S, Oberley LW, Zhang Y, Buettner GR, Spitz DR, Hunninghake GW.

Am J Respir Cell Mol Biol. 2004 Jul;31(1):43-53. Epub 2004 Feb 12.

PMID:
14962975
47.

MnSOD up-regulates maspin tumor suppressor gene expression in human breast and prostate cancer cells.

Duan H, Zhang HJ, Yang JQ, Oberley LW, Futscher BW, Domann FE.

Antioxid Redox Signal. 2003 Oct;5(5):677-88.

PMID:
14580325
48.

Heat-induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation.

Zhang HJ, Xu L, Drake VJ, Xie L, Oberley LW, Kregel KC.

FASEB J. 2003 Dec;17(15):2293-5. Epub 2003 Sep 18.

PMID:
14500545
49.

Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.

Cullen JJ, Hinkhouse MM, Grady M, Gaut AW, Liu J, Zhang YP, Weydert CJ, Domann FE, Oberley LW.

Cancer Res. 2003 Sep 1;63(17):5513-20.

50.

L-PhGPx expression can be suppressed by antisense oligodeoxynucleotides.

Zhao L, Wang HP, Zhang HJ, Weydert CJ, Domann FE, Oberley LW, Buettner GR.

Arch Biochem Biophys. 2003 Sep 15;417(2):212-8.

PMID:
12941303

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