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Items: 31

1.

A new era of proactive melanoma therapy: hit hard, hit early.

Haas L, Wiesner T, Obenauf AC.

Br J Dermatol. 2018 Apr;178(4):817-820. doi: 10.1111/bjd.16347. No abstract available.

PMID:
29668089
2.

SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.

Muhar M, Ebert A, Neumann T, Umkehrer C, Jude J, Wieshofer C, Rescheneder P, Lipp JJ, Herzog VA, Reichholf B, Cisneros DA, Hoffmann T, Schlapansky MF, Bhat P, von Haeseler A, Köcher T, Obenauf AC, Popow J, Ameres SL, Zuber J.

Science. 2018 May 18;360(6390):800-805. doi: 10.1126/science.aao2793. Epub 2018 Apr 5.

3.

Human tripartite motif protein 52 is required for cell context-dependent proliferation.

Benke S, Agerer B, Haas L, Stöger M, Lercher A, Gabler L, Kiss I, Scinicariello S, Berger W, Bergthaler A, Obenauf AC, Versteeg GA.

Oncotarget. 2018 Feb 5;9(17):13565-13581. doi: 10.18632/oncotarget.24422. eCollection 2018 Mar 2.

4.

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.

Mlecnik B, Bindea G, Angell HK, Maby P, Angelova M, Tougeron D, Church SE, Lafontaine L, Fischer M, Fredriksen T, Sasso M, Bilocq AM, Kirilovsky A, Obenauf AC, Hamieh M, Berger A, Bruneval P, Tuech JJ, Sabourin JC, Le Pessot F, Mauillon J, Rafii A, Laurent-Puig P, Speicher MR, Trajanoski Z, Michel P, Sesboüe R, Frebourg T, Pagès F, Valge-Archer V, Latouche JB, Galon J.

Immunity. 2016 Mar 15;44(3):698-711. doi: 10.1016/j.immuni.2016.02.025.

5.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Mlecnik B, Bindea G, Kirilovsky A, Angell HK, Obenauf AC, Tosolini M, Church SE, Maby P, Vasaturo A, Angelova M, Fredriksen T, Mauger S, Waldner M, Berger A, Speicher MR, Pagès F, Valge-Archer V, Galon J.

Sci Transl Med. 2016 Feb 24;8(327):327ra26. doi: 10.1126/scitranslmed.aad6352.

PMID:
26912905
6.

Metastatic colonization by circulating tumour cells.

Massagué J, Obenauf AC.

Nature. 2016 Jan 21;529(7586):298-306. doi: 10.1038/nature17038. Review.

7.

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.

Wiesner T, Lee W, Obenauf AC, Ran L, Murali R, Zhang QF, Wong EW, Hu W, Scott SN, Shah RH, Landa I, Button J, Lailler N, Sboner A, Gao D, Murphy DA, Cao Z, Shukla S, Hollmann TJ, Wang L, Borsu L, Merghoub T, Schwartz GK, Postow MA, Ariyan CE, Fagin JA, Zheng D, Ladanyi M, Busam KJ, Berger MF, Chen Y, Chi P.

Nature. 2015 Oct 15;526(7573):453-7. doi: 10.1038/nature15258. Epub 2015 Oct 7.

8.

Surviving at a Distance: Organ-Specific Metastasis.

Obenauf AC, Massagué J.

Trends Cancer. 2015 Sep;1(1):76-91. doi: 10.1016/j.trecan.2015.07.009. Epub 2015 Sep 28. Review.

9.

Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations.

Jacob LS, Vanharanta S, Obenauf AC, Pirun M, Viale A, Socci ND, Massagué J.

Cancer Res. 2015 Sep 15;75(18):3713-9. doi: 10.1158/0008-5472.CAN-15-0562. Epub 2015 Jul 24.

10.

Therapy-induced tumour secretomes promote resistance and tumour progression.

Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massagué J.

Nature. 2015 Apr 16;520(7547):368-72. doi: 10.1038/nature14336. Epub 2015 Mar 25.

11.

Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.

Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredriksen T, Lafontaine L, Bilocq AM, Kirilovsky A, Tosolini M, Waldner M, Berger A, Fridman WH, Rafii A, Valge-Archer V, Pagès F, Speicher MR, Galon J.

Sci Transl Med. 2014 Mar 19;6(228):228ra37. doi: 10.1126/scitranslmed.3007240.

12.

Serpins promote cancer cell survival and vascular co-option in brain metastasis.

Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagué J.

Cell. 2014 Feb 27;156(5):1002-16. doi: 10.1016/j.cell.2014.01.040.

13.

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pagès F, Speicher MR, Trajanoski Z, Galon J.

Immunity. 2013 Oct 17;39(4):782-95. doi: 10.1016/j.immuni.2013.10.003.

14.

Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.

Katz SF, Lechel A, Obenauf AC, Begus-Nahrmann Y, Kraus JM, Hoffmann EM, Duda J, Eshraghi P, Hartmann D, Liss B, Schirmacher P, Kestler HA, Speicher MR, Rudolph KL.

Gastroenterology. 2012 May;142(5):1229-1239.e3. doi: 10.1053/j.gastro.2012.02.009. Epub 2012 Feb 15.

PMID:
22342966
15.

High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer.

Mathiesen RR, Fjelldal R, Liestøl K, Due EU, Geigl JB, Riethdorf S, Borgen E, Rye IH, Schneider IJ, Obenauf AC, Mauermann O, Nilsen G, Christian Lingjaerde O, Børresen-Dale AL, Pantel K, Speicher MR, Naume B, Baumbusch LO.

Int J Cancer. 2012 Aug 15;131(4):E405-15. doi: 10.1002/ijc.26444. Epub 2011 Nov 9.

16.

Germline mutations in BAP1 predispose to melanocytic tumors.

Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P, Windpassinger C, Wackernagel W, Loy S, Wolf I, Viale A, Lash AE, Pirun M, Socci ND, Rütten A, Palmedo G, Abramson D, Offit K, Ott A, Becker JC, Cerroni L, Kutzner H, Bastian BC, Speicher MR.

Nat Genet. 2011 Aug 28;43(10):1018-21. doi: 10.1038/ng.910.

17.

Further evidence for the pathogenicity of 15q24 microduplications distal to the minimal critical regions.

Roetzer KM, Schwarzbraun T, Obenauf AC, Hauser E, Speicher MR.

Am J Med Genet A. 2010 Dec;152A(12):3173-8. doi: 10.1002/ajmg.a.33750.

PMID:
21108404
18.

Mutations in GNA11 in uveal melanoma.

Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC.

N Engl J Med. 2010 Dec 2;363(23):2191-9. doi: 10.1056/NEJMoa1000584. Epub 2010 Nov 17.

19.

Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes.

Obenauf AC, Schwarzbraun T, Auer M, Hoffmann EM, Waldispuehl-Geigl J, Ulz P, Günther B, Duba HC, Speicher MR, Geigl JB.

J Cell Mol Med. 2010 Aug;14(8):2078-84. doi: 10.1111/j.1582-4934.2010.01116.x.

20.

Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions.

Schallmoser K, Bartmann C, Rohde E, Bork S, Guelly C, Obenauf AC, Reinisch A, Horn P, Ho AD, Strunk D, Wagner W.

Haematologica. 2010 Jun;95(6):867-74. doi: 10.3324/haematol.2009.011692. Epub 2010 Jan 6.

21.

Platelet-derived growth factors for GMP-compliant propagation of mesenchymal stromal cells.

Schallmoser K, Rohde E, Bartmann C, Obenauf AC, Reinisch A, Strunk D.

Biomed Mater Eng. 2009;19(4-5):271-6. doi: 10.3233/BME-2009-0591.

PMID:
20042793
22.

Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms.

Wiesner T, Obenauf AC, Cota C, Fried I, Speicher MR, Cerroni L.

J Invest Dermatol. 2010 Apr;130(4):1152-7. doi: 10.1038/jid.2009.369. Epub 2009 Nov 19.

23.

Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS).

Liu Z, Obenauf AC, Speicher MR, Kopan R.

Genome Res. 2009 Nov;19(11):2081-9. doi: 10.1101/gr.093856.109. Epub 2009 Oct 1.

24.

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.

Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL.

Nat Genet. 2009 Oct;41(10):1138-43. doi: 10.1038/ng.426. Epub 2009 Aug 30.

PMID:
19718028
25.

Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays.

Geigl JB, Obenauf AC, Waldispuehl-Geigl J, Hoffmann EM, Auer M, Hörmann M, Fischer M, Trajanoski Z, Schenk MA, Baumbusch LO, Speicher MR.

Nucleic Acids Res. 2009 Aug;37(15):e105. doi: 10.1093/nar/gkp526. Epub 2009 Jun 18.

26.

Establishment and characterization of three novel cell lines - P-STS, L-STS, H-STS - derived from a human metastatic midgut carcinoid.

Pfragner R, Behmel A, Höger H, Beham A, Ingolic E, Stelzer I, Svejda B, Moser VA, Obenauf AC, Siegl V, Haas O, Niederle B.

Anticancer Res. 2009 Jun;29(6):1951-61.

27.

Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo.

Reinisch A, Hofmann NA, Obenauf AC, Kashofer K, Rohde E, Schallmoser K, Flicker K, Lanzer G, Linkesch W, Speicher MR, Strunk D.

Blood. 2009 Jun 25;113(26):6716-25. doi: 10.1182/blood-2008-09-181362. Epub 2009 Mar 25.

28.

Predictive diagnosis of the cancer prone Li-Fraumeni syndrome by accident: new challenges through whole genome array testing.

Schwarzbraun T, Obenauf AC, Langmann A, Gruber-Sedlmayr U, Wagner K, Speicher MR, Kroisel PM.

J Med Genet. 2009 May;46(5):341-4. doi: 10.1136/jmg.2008.064972. Epub 2009 Mar 5.

29.

9p21 deletion in primary cutaneous large B-cell lymphoma, leg type, may escape detection by standard FISH assays.

Wiesner T, Obenauf AC, Geigl JB, Vallant EM, Speicher MR, Fink-Puches R, Kerl H, Cerroni L.

J Invest Dermatol. 2009 Jan;129(1):238-40. doi: 10.1038/jid.2008.224. Epub 2008 Aug 14. No abstract available.

30.

Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum.

Schallmoser K, Rohde E, Reinisch A, Bartmann C, Thaler D, Drexler C, Obenauf AC, Lanzer G, Linkesch W, Strunk D.

Tissue Eng Part C Methods. 2008 Sep;14(3):185-96. doi: 10.1089/ten.tec.2008.0060.

PMID:
18620484
31.

Defining 'chromosomal instability'.

Geigl JB, Obenauf AC, Schwarzbraun T, Speicher MR.

Trends Genet. 2008 Feb;24(2):64-9. doi: 10.1016/j.tig.2007.11.006. Epub 2008 Jan 14. Review.

PMID:
18192061

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