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Lung Sound Analysis Provides A Useful Index For Both Airway Narrowing And Airway Inflammation In Patients With Bronchial Asthma.

Shimoda T, Obase Y, Nagasaka Y, Kishikawa R, Asai S.

J Asthma Allergy. 2019 Oct 4;12:323-329. doi: 10.2147/JAA.S216877. eCollection 2019.


The acoustic characteristics of fine crackles predict honeycombing on high-resolution computed tomography.

Fukumitsu T, Obase Y, Ishimatsu Y, Nakashima S, Ishimoto H, Sakamoto N, Nishitsuji K, Shiwa S, Sakai T, Miyahara S, Ashizawa K, Mukae H, Kozu R.

BMC Pulm Med. 2019 Aug 17;19(1):153. doi: 10.1186/s12890-019-0916-5.


Liposomal Amphotericin B Fosters the Corticosteroids' Anti-inflammatory Effect on Murine Allergic Bronchopulmonary Aspergillosis Model Airways.

Fukushima C, Matsuse H, Obase Y, Fukahori S, Tsuchida T, Kawano T, Kohno S, Mukae H.

Inflammation. 2019 Dec;42(6):2065-2071. doi: 10.1007/s10753-019-01069-z.


Serum Soluble Interleukin-2 Receptor Is a Biomarker for Pneumocystis jirovecii Pneumonia among Patients with Rheumatoid Arthritis under Methotrexate Therapy.

Sakamoto N, Hara S, Ishimoto H, Nakashima S, Yura H, Miyamura T, Okuno D, Hara A, Kakugawa T, Yamaguchi H, Obase Y, Kushima H, Ishii H, Noguchi S, Kido T, Kobayashi T, Soejima Y, Yoshioka S, Ishimatsu Y, Yatera K, Kadota JI, Mukae H.

Tohoku J Exp Med. 2019 Jul;248(3):209-216. doi: 10.1620/tjem.248.209.


Fluctuation of Hepatic Focal Nodular Hyperplasia Size with Oral Contraceptives Use.

Fukahori S, Kawano T, Obase Y, Umeyama Y, Sugasaki N, Kinoshita A, Fukushima C, Yamakawa M, Omagari K, Mukae H.

Am J Case Rep. 2019 Jul 30;20:1124-1127. doi: 10.12659/AJCR.916398.


Phase II study of nedaplatin and amrubicin as first-line treatment for advanced squamous cell lung cancer.

Taniguchi H, Yamaguchi H, Dotsu Y, Shimada M, Gyotoku H, Senju H, Takemoto S, Kitazaki T, Fukuda M, Ogawara D, Soda H, Nakatomi K, Sugasaki N, Kinoshita A, Nagashima S, Ikeda T, Nakamura Y, Sakamoto N, Obase Y, Fukuda M, Mukae H.

Thorac Cancer. 2019 Sep;10(9):1764-1769. doi: 10.1111/1759-7714.13134. Epub 2019 Jul 16.


Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study.

Miyamura T, Sakamoto N, Kakugawa T, Okuno D, Yura H, Nakashima S, Ishimoto H, Kido T, Taniguchi D, Miyazaki T, Tsuchiya T, Tsutsui S, Yamaguchi H, Obase Y, Ishimatsu Y, Ashizawa K, Nagayasu T, Mukae H.

Respir Res. 2019 Jul 15;20(1):154. doi: 10.1186/s12931-019-1128-5.


Associations of chemical composition and sources of PM2.5 with lung function of severe asthmatic adults in a low air pollution environment of urban Nagasaki, Japan.

Ng CFS, Hashizume M, Obase Y, Doi M, Tamura K, Tomari S, Kawano T, Fukushima C, Matsuse H, Chung Y, Kim Y, Kunimitsu K, Kohno S, Mukae H.

Environ Pollut. 2019 Sep;252(Pt A):599-606. doi: 10.1016/j.envpol.2019.05.117. Epub 2019 May 29.


Lung Sound Analysis and the Respiratory Cycle Dependence of Impulse Oscillometry in Asthma Patients.

Shimoda T, Obase Y, Nagasaka Y, Kishikawa R, Iwanaga T.

Intern Med. 2019 Jan 1;58(1):47-52. doi: 10.2169/internalmedicine.8226-16. Epub 2018 Aug 24.


Pulmonary Alveolar Proteinosis with Ulcerative Colitis.

Sakamoto N, Nakashima S, Ishimoto H, Kakugawa T, Hara A, Yura H, Miyamura T, Nakamichi S, Obase Y, Ishimatsu Y, Mukae H.

Intern Med. 2018 Sep 15;57(18):2705-2708. doi: 10.2169/internalmedicine.0555-17. Epub 2018 Apr 27.


Lymphocytic focus score is positively related to airway and interstitial lung diseases in primary Sjögren's syndrome.

Kakugawa T, Sakamoto N, Ishimoto H, Shimizu T, Nakamura H, Nawata A, Ito C, Sato S, Hanaka T, Oda K, Kido T, Miyamura T, Nakashima S, Aoki T, Nakamichi S, Obase Y, Saito K, Yatera K, Ishimatsu Y, Nakayama T, Korogi Y, Kawakami A, Tanaka Y, Mukae H.

Respir Med. 2018 Apr;137:95-102. doi: 10.1016/j.rmed.2018.02.023. Epub 2018 Mar 1.


Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease.

Sakamoto N, Ishimoto H, Kakugawa T, Satoh M, Hasegawa T, Tanaka S, Hara A, Nakashima S, Yura H, Miyamura T, Koyama H, Morita T, Nakamichi S, Obase Y, Ishimatsu Y, Mukae H.

BMC Pulm Med. 2018 Mar 12;18(1):44. doi: 10.1186/s12890-018-0609-5.


Clinical characteristics of patients with anti-aminoacyl-tRNA synthetase antibody positive idiopathic interstitial pneumonia.

Yura H, Sakamoto N, Satoh M, Ishimoto H, Hanaka T, Ito C, Hasegawa T, Tanaka S, Miyamura T, Nakashima S, Hara A, Kakugawa T, Oda K, Kido T, Obase Y, Ishimatsu Y, Yatera K, Kawakami A, Mukae H.

Respir Med. 2017 Nov;132:189-194. doi: 10.1016/j.rmed.2017.10.020. Epub 2017 Oct 28.


Phenotype classification using the combination of lung sound analysis and fractional exhaled nitric oxide for evaluating asthma treatment.

Shimoda T, Obase Y, Nagasaka Y, Asai S.

Allergol Int. 2018 Apr;67(2):253-258. doi: 10.1016/j.alit.2017.09.004. Epub 2017 Oct 21.


Lung Sound Analysis Is Useful for Monitoring Therapy in Patients With Bronchial Asthma.

Shimoda T, Obase Y, Nagasaka Y, Nakano H, Kishikawa R, Iwanaga T.

J Investig Allergol Clin Immunol. 2017;27(4):246-251. doi: 10.18176/jiaci.0132.


Lung sound analysis helps localize airway inflammation in patients with bronchial asthma.

Shimoda T, Obase Y, Nagasaka Y, Nakano H, Ishimatsu A, Kishikawa R, Iwanaga T.

J Asthma Allergy. 2017 Mar 27;10:99-108. doi: 10.2147/JAA.S125938. eCollection 2017.


Airway inflammation phenotype prediction in asthma patients using lung sound analysis with fractional exhaled nitric oxide.

Shimoda T, Obase Y, Nagasaka Y, Nakano H, Kishikawa R, Iwanaga T.

Allergol Int. 2017 Oct;66(4):581-585. doi: 10.1016/j.alit.2017.02.016. Epub 2017 Mar 17.


The Pathogenesis of Alcohol-Induced Airflow Limitation in Acetaldehyde Dehydrogenase 2-Deficient Mice.

Shimoda T, Obase Y, Matsuse H, Asai S, Iwanaga T.

Int Arch Allergy Immunol. 2016;171(3-4):276-284. doi: 10.1159/000452709. Epub 2017 Jan 4.


Assessment of anti-inflammatory effect from addition of a long-acting beta-2 agonist to inhaled corticosteroid.

Shimoda T, Obase Y, Kishikawa R, Mukae H, Iwanaga T.

Allergy Asthma Proc. 2016 Sep;37(5):387-93. doi: 10.2500/aap.2016.37.3975.


Peripheral bronchial obstruction evaluation in patients with asthma by lung sound analysis and impulse oscillometry.

Shimoda T, Obase Y, Nagasaka Y, Kishikawa R, Mukae H, Iwanaga T.

Allergol Int. 2017 Jan;66(1):132-138. doi: 10.1016/j.alit.2016.06.008. Epub 2016 Aug 8.


Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis.

Kakugawa T, Sakamoto N, Sato S, Yura H, Harada T, Nakashima S, Hara A, Oda K, Ishimoto H, Yatera K, Ishimatsu Y, Obase Y, Kohno S, Mukae H.

Respir Res. 2016 Jul 11;17(1):79. doi: 10.1186/s12931-016-0400-1.


Influence of cigarette smoking on airway inflammation and inhaled corticosteroid treatment in patients with asthma.

Shimoda T, Obase Y, Kishikawa R, Iwanaga T.

Allergy Asthma Proc. 2016 Jul;37(4):50-8. doi: 10.2500/aap.2016.37.3944.


Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.

Ogino K, Obase Y, Ito T, Fujimura M, Eguchi E, Kubo M, Nagaoka K, Nakamura H.

Free Radic Res. 2016;50(11):1165-1172. Epub 2016 Aug 25.


Lung sound analysis can be an index of the control of bronchial asthma.

Shimoda T, Obase Y, Nagasaka Y, Nakano H, Kishikawa R, Iwanaga T.

Allergol Int. 2017 Jan;66(1):64-69. doi: 10.1016/j.alit.2016.05.002. Epub 2016 Jun 13.


Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease.

Hanada M, Sakamoto N, Ishimatsu Y, Kakugawa T, Obase Y, Kozu R, Senjyu H, Izumikawa K, Mukae H, Kohno S.

Respirology. 2016 Aug;21(6):1088-93. doi: 10.1111/resp.12807. Epub 2016 May 13.


Trigger of bronchial hyperresponsiveness development may not always need eosinophilic airway inflammation in very early stage of asthma.

Obase Y, Shimoda T, Kishikawa R, Kohno S, Iwanaga T.

Allergy Rhinol (Providence). 2016 Jan;7(1):1-7. doi: 10.2500/ar.2016.7.0145.


Lung Sound Analysis and Airway Inflammation in Bronchial Asthma.

Shimoda T, Obase Y, Nagasaka Y, Nakano H, Kishikawa R, Iwanaga T.

J Allergy Clin Immunol Pract. 2016 May-Jun;4(3):505-11. doi: 10.1016/j.jaip.2016.02.001. Epub 2016 Mar 25.


Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis.

Sakamoto N, Kakugawa T, Hara A, Nakashima S, Yura H, Harada T, Ishimoto H, Yatera K, Kuwatsuka Y, Hara T, Ichinose K, Obase Y, Ishimatsu Y, Kohno S, Mukae H.

Respir Res. 2015 Dec 10;16:148. doi: 10.1186/s12931-015-0308-1.


Drug fever after cancer chemotherapy is most commonly observed on posttreatment days 3 and 4.

Ogawara D, Fukuda M, Ueno S, Ohue Y, Takemoto S, Mizoguchi K, Nakatomi K, Nakamura Y, Obase Y, Honda T, Tsukamoto K, Ashizawa K, Oka M, Kohno S.

Support Care Cancer. 2016 Feb;24(2):615-619. doi: 10.1007/s00520-015-2820-8. Epub 2015 Jun 25.


Serum high-sensitivity C-reactive protein can be an airway inflammation predictor in bronchial asthma.

Shimoda T, Obase Y, Kishikawa R, Iwanaga T.

Allergy Asthma Proc. 2015 Mar-Apr;36(2):e23-8. doi: 10.2500/aap.2015.36.3816.


Prediction of airway inflammation in patients with asymptomatic asthma by using lung sound analysis.

Shimoda T, Nagasaka Y, Obase Y, Kishikawa R, Iwanaga T.

J Allergy Clin Immunol Pract. 2014 Nov-Dec;2(6):727-32. doi: 10.1016/j.jaip.2014.06.017. Epub 2014 Oct 5.


Increased levels of plasma galectin-9 in patients with influenza virus infection.

Katoh S, Ikeda M, Shimizu H, Mouri K, Obase Y, Kobashi Y, Fukushima K, Hirashima M, Oka M.

Tohoku J Exp Med. 2014 Apr;232(4):263-7.


Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population.

Shimoda T, Obase Y, Kishikawa R, Iwanaga T.

Allergy Rhinol (Providence). 2013 Fall;4(3):e132-9. doi: 10.2500/ar.2013.4.0063.


Preventive effect of galectin-9 on double-stranded RNA-induced airway hyperresponsiveness in an exacerbation model of mite antigen-induced asthma in mice.

Katoh S, Shimizu H, Obase Y, Oomizu S, Niki T, Ikeda M, Mouri K, Kobashi Y, Hirashima M, Oka M.

Exp Lung Res. 2013 Dec;39(10):453-62. doi: 10.3109/01902148.2013.850558. Epub 2013 Nov 18.


Impact of inhaled corticosteroid treatment on 15-year longitudinal respiratory function changes in adult patients with bronchial asthma.

Shimoda T, Obase Y, Kishikawa R, Iwanaga T.

Int Arch Allergy Immunol. 2013;162(4):323-9. doi: 10.1159/000353910. Epub 2013 Oct 25.


Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese workers.

Ogino K, Wang DH, Kubo M, Obase Y, Setiawan H, Yan F, Takahashi H, Zhang R, Tsukiyama Y, Yoshida J, Zou Y.

Free Radic Res. 2014 Feb;48(2):137-45. doi: 10.3109/10715762.2013.842979. Epub 2013 Oct 7.


Critical role of interleukin-5 in the development of a mite antigen-induced chronic bronchial asthma model.

Shimizu H, Obase Y, Katoh S, Mouri K, Kobashi Y, Oka M.

Inflamm Res. 2013 Oct;62(10):911-7. doi: 10.1007/s00011-013-0651-y. Epub 2013 Aug 13.


Mucoid impaction of the bronchi caused by Mycobacterium avium.

Kobashi Y, Mouri K, Obase Y, Kato S, Nakata M, Oka M.

Intern Med. 2013;52(13):1537-40. Epub 2013 Jul 1.


Step-down of budesonide/formoterol in early stages of asthma treatment leads to insufficient anti-inflammatory effect.

Obase Y, Ikeda M, Kurose K, Abe M, Shimizu H, Ohue Y, Mouri K, Katoh S, Kobashi Y, Oka M.

J Asthma. 2013 Sep;50(7):718-21. doi: 10.3109/02770903.2013.795588. Epub 2013 Jun 18.


The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma.

Shimoda T, Obase Y, Kishikawa R, Iwanaga T, Miyatake A, Kasayama S.

Allergol Int. 2013 Jun;62(2):251-7. doi: 10.2332/allergolint.12-OA-0515. Epub 2013 Apr 25.


Serological assay by use of glycopeptidolipid core antigen for Mycobacterium avium complex.

Kobashi Y, Mouri K, Obase Y, Kato S, Oka M.

Scand J Infect Dis. 2013 Apr;45(4):241-9. doi: 10.3109/00365548.2012.714904. Epub 2013 Feb 7.


A case of platypnea orthodeoxia syndrome: a persistent history taking was the key to the diagnosis.

Ohfuji T, Obase Y, Ikeda M, Obase K, Hayashida A, Okura H, Kobashi Y, Yoshida K, Oka M.

Intern Med. 2012;51(13):1701-4. Epub 2012 Jul 1.


Usefulness of tuberculin skin test and three interferon-gamma release assays for the differential diagnosis of pulmonary tuberculosis.

Kobashi Y, Abe M, Mouri K, Obase Y, Miyashita N, Oka M.

Intern Med. 2012;51(10):1199-205. Epub 2012 May 15.


Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.

Katoh S, Oomizu S, Niki T, Shimizu H, Obase Y, Korenaga M, Oka M, Hirashima M.

Int Arch Allergy Immunol. 2012;158 Suppl 1:58-65. doi: 10.1159/000337769. Epub 2012 May 15.


[The relationships between the peak inspiratory flow and the characteristics factors in the asthmatics with inhaled corticosteroid -a multicenter study in Chugoku Shikoku area].

Obase Y, Kanehiro A, Tanimoto Y, Miyahara N, Oka M, Eda R, Kubota T, Yokoyama A, Wakabayashi K, Takeyama H, Okada C, Kimura G, Soda R, Takahashi K, Tanimoto M.

Arerugi. 2011 Dec;60(12):1621-9. Japanese.


Nutritional deficits in elderly smokers with respiratory symptoms that do not fulfill the criteria for COPD.

Obase Y, Mouri K, Shimizu H, Ohue Y, Kobashi Y, Kawahara K, Oka M.

Int J Chron Obstruct Pulmon Dis. 2011;6:679-83. doi: 10.2147/COPD.S25293. Epub 2011 Dec 9.


Relationship between clinical efficacy for pulmonary MAC and drug-sensitivity test for isolated MAC in a recent 6-year period.

Kobashi Y, Abe M, Mouri K, Obase Y, Kato S, Oka M.

J Infect Chemother. 2012 Aug;18(4):436-43. doi: 10.1007/s10156-011-0351-x. Epub 2011 Dec 17.


Atypical epidermolysis bullosa simplex with a missense keratin 14 mutation p.Arg125Cys.

Tsuruta D, Sowa J, Tateishi C, Obase Y, Tsubura A, Fukumoto T, Ishii M, Kobayashi H, Sakaguchi S, Hashimoto T, Hamada T.

J Dermatol. 2011 Dec;38(12):1177-9. doi: 10.1111/j.1346-8138.2011.01302.x. Epub 2011 Oct 3.


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