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Reply to: MIDN locus structural variants and Parkinson's disease risk.

Obara Y, Sato H, Nakayama T, Kato T, Ishii K.

Ann Clin Transl Neurol. 2020 Mar 22. doi: 10.1002/acn3.51011. [Epub ahead of print] No abstract available.


Effects of ruminal administration of soy sauce oil on functional fatty acids in the rumen, blood and milk of dairy cows.

Konno D, Takahashi M, Osaka I, Orihashi T, Sakai K, Sera K, Obara Y, Kobayashi Y.

Asian-Australas J Anim Sci. 2020 Feb 25. doi: 10.5713/ajas.19.0913. [Epub ahead of print]


Effect of ruminal administration of soy sauce oil on rumen fermentation, milk production and blood parameters in dairy cows.

Konno D, Takahashi M, Osaka I, Orihashi T, Sakai K, Sera K, Obara Y, Kobayashi Y.

Asian-Australas J Anim Sci. 2019 Dec 24. doi: 10.5713/ajas.19.0617. [Epub ahead of print]


Erratum to: Swift Efficacy with Infliximab 4 Years after Initial Standard Induction Therapy Followed by Severe Delayed Infusion Reaction in Crohn's Disease.

Chiba M, Tsuji T, Nakane K, Obara Y, Komatsu M.

Inflamm Bowel Dis. 2020 Mar 4;26(4):e31. doi: 10.1093/ibd/izaa008. No abstract available.


Swift Efficacy with Infliximab 4 Years after Initial Standard Induction Therapy Followed by Severe Delayed Infusion Reaction in Crohn's Disease.

Chiba M, Tsuji T, Nakane K, Obara Y, Komatsu M.

Inflamm Bowel Dis. 2020 Jan 1;26(1):e4. doi: 10.1093/ibd/izz273. No abstract available.


Advanced multispectral image-processing endoscopy system for visualizing two-dimensional hemoglobin saturation and relative hemoglobin concentration.

Chiba T, Obara Y, Murata M, Akahoshi T.

Endosc Int Open. 2019 Nov;7(11):E1442-E1447. doi: 10.1055/a-0990-9189. Epub 2019 Oct 22.


Midnolin is a confirmed genetic risk factor for Parkinson's disease.

Obara Y, Sato H, Nakayama T, Kato T, Ishii K.

Ann Clin Transl Neurol. 2019 Nov;6(11):2205-2211. doi: 10.1002/acn3.50914. Epub 2019 Oct 6.


Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine.

Takano Y, Hirano M, Machida T, Obara Y, Hamaue N, Fujita K, Taniguchi M, Endo T, Shiga S, Machida M, Iizuka K, Hirafuji M.

J Pharmacol Sci. 2019 Sep;141(1):32-40. doi: 10.1016/j.jphs.2019.09.001. Epub 2019 Sep 10.


Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.

Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K.

J Biol Chem. 2019 Nov 1;294(44):16049-16061. doi: 10.1074/jbc.RA119.007416. Epub 2019 Sep 10.


KCNQ1 is internalized by activation of α1 adrenergic receptors.

Kurakami K, Norota I, Nasu F, Ohshima S, Nagasawa Y, Konno Y, Obara Y, Ishii K.

Biochem Pharmacol. 2019 Nov;169:113628. doi: 10.1016/j.bcp.2019.113628. Epub 2019 Sep 3.


Relapse Prevention by Plant-Based Diet Incorporated into Induction Therapy for Ulcerative Colitis: A Single-Group Trial.

Chiba M, Nakane K, Tsuji T, Tsuda S, Ishii H, Ohno H, Watanabe K, Obara Y, Komatsu M, Sugawara T.

Perm J. 2019;23. doi: 10.7812/TPP/18-220.


Development of 6-Axis Orthodontic Force and Moment Sensing Device for Decreasing Accident of Orthodontic Treatment.

Shimoda K, Takemura H, Obara Y, Shigeta M, Soga K, Suga K, Lai WJ, Kim S, Kanno Z, Uo M.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1797-1800. doi: 10.1109/EMBC.2018.8512648.


Trans-scaphoid Perilunate Fracture-dislocation with Concomitant Lunotriquetral Ligament Disruption: A Case Report.

Sonoki K, Tomori Y, Obara Y, Nanno M, Kodera N, Takai S.

J Nippon Med Sch. 2018;85(4):231-235. doi: 10.1272/jnms.JNMS.2018_85-36.


ERK5 Phosphorylates Kv4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells.

Kashino Y, Obara Y, Okamoto Y, Saneyoshi T, Hayashi Y, Ishii K.

Int J Mol Sci. 2018 Jul 10;19(7). pii: E2008. doi: 10.3390/ijms19072008.


Increase of frontal cerebral blood volume during transcranial magnetic stimulation in depression is related to treatment effectiveness: A pilot study with near-infrared spectroscopy.

Shinba T, Kariya N, Matsuda S, Matsuda H, Obara Y.

Psychiatry Clin Neurosci. 2018 Aug;72(8):602-610. doi: 10.1111/pcn.12680. Epub 2018 Jul 2.


Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine.

Obara Y, Machida T, Takano Y, Shiga S, Suzuki A, Hamaue N, Iizuka K, Hirafuji M.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):847-858. doi: 10.1007/s00210-018-1493-5. Epub 2018 May 15.


Enhanced circular dichroism at elevated temperatures through complexation-induced transformation of a three-layer cyclophane with dualistic dynamic helicity.

Katoono R, Obara Y, Fujiwara K, Suzuki T.

Chem Sci. 2018 Jan 23;9(8):2222-2229. doi: 10.1039/c7sc05242a. eCollection 2018 Feb 28.


Dynamic or undynamic chirality generated by helical arrangement of a shape-persistent ring and rod doubly bridged in a molecule.

Katoono R, Obara Y, Kusaka K, Suzuki T.

Chem Commun (Camb). 2018 Jan 18;54(7):735-738. doi: 10.1039/c7cc09485j.


Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression.

Wu M, Obara Y, Ohshima S, Nagasawa Y, Ishii K.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):409-415. doi: 10.1016/j.bbrc.2017.09.009. Epub 2017 Sep 5.


Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease.

Obara Y, Imai T, Sato H, Takeda Y, Kato T, Ishii K.

Sci Rep. 2017 Jul 19;7(1):5885. doi: 10.1038/s41598-017-05456-0.


Femtosecond time-resolved X-ray absorption spectroscopy of anatase TiO2 nanoparticles using XFEL.

Obara Y, Ito H, Ito T, Kurahashi N, Thürmer S, Tanaka H, Katayama T, Togashi T, Owada S, Yamamoto YI, Karashima S, Nishitani J, Yabashi M, Suzuki T, Misawa K.

Struct Dyn. 2017 Jun 30;4(4):044033. doi: 10.1063/1.4989862. eCollection 2017 Jul.


Inhibitory effects of local anesthetics on the proteasome and their biological actions.

Bahrudin U, Unno M, Nishio K, Kita A, Li P, Kato M, Inoue M, Tsujitani S, Murakami T, Sugiyama R, Saeki Y, Obara Y, Tanaka K, Yamaguchi H, Sakane I, Kawata Y, Itoh T, Ninomiya H, Hisatome I, Morimoto Y.

Sci Rep. 2017 Jul 11;7(1):5079. doi: 10.1038/s41598-017-04652-2.


Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity.

Okuda-Tanino A, Sugawara D, Tashiro T, Iwashita M, Obara Y, Moriya T, Tsushima C, Saigusa D, Tomioka Y, Ishii K, Nakahata N.

PLoS One. 2017 Mar 10;12(3):e0173628. doi: 10.1371/journal.pone.0173628. eCollection 2017.


Expression of Extracellular Signal-regulated Kinase 5 and Ankyrin Repeat Domain 1 in Composite Pheochromocytoma and Ganglioneuroblastoma Detected Incidentally in the Adult Adrenal Gland.

Suenaga S, Ichiyanagi O, Ito H, Naito S, Kato T, Nagaoka A, Kato T, Yamakawa M, Obara Y, Tsuchiya N.

Intern Med. 2016;55(24):3611-3621. Epub 2016 Dec 15.


Ultraviolet photochemical reaction of [Fe(III)(C2O4)3](3-) in aqueous solutions studied by femtosecond time-resolved X-ray absorption spectroscopy using an X-ray free electron laser.

Ogi Y, Obara Y, Katayama T, Suzuki YI, Liu SY, Bartlett NC, Kurahashi N, Karashima S, Togashi T, Inubushi Y, Ogawa K, Owada S, Rubešová M, Yabashi M, Misawa K, Slavíček P, Suzuki T.

Struct Dyn. 2015 Apr 23;2(3):034901. doi: 10.1063/1.4918803. eCollection 2015 May.


ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.

Obara Y, Nagasawa R, Nemoto W, Pellegrino MJ, Takahashi M, Habecker BA, Stork PJS, Ichiyanagi O, Ito H, Tomita Y, Ishii K, Nakahata N.

Cell Signal. 2016 Mar;28(3):177-189. doi: 10.1016/j.cellsig.2015.12.016. Epub 2015 Dec 29.


Direct label-free measurement of the distribution of small molecular weight compound inside thick biological tissue using coherent Raman microspectroscopy.

Kawagishi M, Obara Y, Suzuki T, Hayashi M, Misawa K, Terada S.

Sci Rep. 2015 Sep 10;5:13868. doi: 10.1038/srep13868.


The Clinical Outcome of Anatomical Reattachment of the TFCC to the Ulnar Fovea using an ECU Half-Slip and an Interference Screw.

Nakamura T, Obara Y.

Handchir Mikrochir Plast Chir. 2015 Oct;47(5):290-6. doi: 10.1055/s-0035-1559652. Epub 2015 Aug 20.


Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription.

Honda T, Obara Y, Yamauchi A, Couvillon AD, Mason JJ, Ishii K, Nakahata N.

PLoS One. 2015 Feb 17;10(2):e0117914. doi: 10.1371/journal.pone.0117914. eCollection 2015.


Time course of osteonecrosis in rabbit articular intercalated bone: line scan spectroscopic imaging and correlation with histology.

Obara Y, Nakamura T, Shinmoto H, Osada N, Yamabe E, Sato K, Toyama Y.

Magn Reson Med Sci. 2015;14(1):57-64. doi: 10.2463/mrms.2013-0129. Epub 2014 Dec 15.


Is PIP2 involved in the insulin effect?

Ishii K, Wu M, Obara Y.

Channels (Austin). 2014;8(5):391-2. doi: 10.4161/19336950.2014.948758. No abstract available.


The majority of early primordial germ cells acquire pluripotency by AKT activation.

Matsui Y, Takehara A, Tokitake Y, Ikeda M, Obara Y, Morita-Fujimura Y, Kimura T, Nakano T.

Development. 2014 Dec;141(23):4457-67. doi: 10.1242/dev.113779. Epub 2014 Oct 30.


Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice.

Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y.

PLoS One. 2014 Oct 27;9(10):e111432. doi: 10.1371/journal.pone.0111432. eCollection 2014.


Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats.

Takano Y, Machida T, Obara Y, Hirano M, Kudo S, Takagi M, Hamaue N, Iizuka K, Hirafuji M.

Eur J Pharmacol. 2014 Oct 5;740:496-503. doi: 10.1016/j.ejphar.2014.06.038. Epub 2014 Jun 27.


Clinical effects of long-term (36-month) lanthanum carbonate administration in hemodialysis patients in Japan.

Kishi Y, Obara Y, Hara K, Yamashiro H, Kurosawa N, Takada D.

Ther Apher Dial. 2014 Jun;18 Suppl 1:9-13. doi: 10.1111/1744-9987.12197.


Femtosecond time-resolved X-ray absorption spectroscopy of liquid using a hard X-ray free electron laser in a dual-beam dispersive detection method.

Obara Y, Katayama T, Ogi Y, Suzuki T, Kurahashi N, Karashima S, Chiba Y, Isokawa Y, Togashi T, Inubushi Y, Yabashi M, Suzuki T, Misawa K.

Opt Express. 2014 Jan 13;22(1):1105-13. doi: 10.1364/OE.22.001105.


Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1.

Wu M, Obara Y, Norota I, Nagasawa Y, Ishii K.

Pflugers Arch. 2014 May;466(5):937-46. doi: 10.1007/s00424-013-1352-7. Epub 2013 Sep 26.


Neurite outgrowth of PC12 cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor.

Nishina A, Kimura H, Tsukagoshi H, Kozawa K, Koketsu M, Ninomiya M, Sato D, Obara Y, Furukawa S.

Neurochem Res. 2013 Nov;38(11):2397-407. doi: 10.1007/s11064-013-1152-7. Epub 2013 Sep 21.


Real-time NMR monitoring of protein-folding kinetics by a recycle flow system for temperature jump.

Yamasaki K, Obara Y, Hasegawa M, Tanaka H, Yamasaki T, Wakuda T, Okada M, Kohzuma T.

Anal Chem. 2013 Oct 15;85(20):9439-43. doi: 10.1021/ac401579e. Epub 2013 Sep 27.


Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization.

Ando K, Fukuhara S, Moriya T, Obara Y, Nakahata N, Mochizuki N.

J Cell Biol. 2013 Sep 16;202(6):901-16. doi: 10.1083/jcb.201301115. Epub 2013 Sep 9.


Effects of astaxanthin on antioxidation in human aqueous humor.

Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M, Obara Y.

J Clin Biochem Nutr. 2013 Jul;53(1):1-7. doi: 10.3164/jcbn.13-6. Epub 2013 May 18.


[Roles of ERK5 in neuronal cells].

Obara Y, Ishii K.

Nihon Yakurigaku Zasshi. 2013 Jun;141(6):354. Review. Japanese. No abstract available.


[Roles of ERK5 in neuronal cells].

Obara Y.

Nihon Yakurigaku Zasshi. 2013 May;141(5):251-5. Review. Japanese. No abstract available.


[Multiple functions of Gh/transglutaminase 2].

Obara Y, Ishii K.

Nihon Yakurigaku Zasshi. 2013 Apr;141(4):225. Review. Japanese. No abstract available.


Time course of changes in antioxidant activity of milk from dairy cows fed a trehalose-supplemented diet.

Aoki N, Sato K, Kanda S, Mukai K, Obara Y, Itabashi H.

Anim Sci J. 2013 Jan;84(1):42-7. doi: 10.1111/j.1740-0929.2012.01040.x. Epub 2012 Jul 31.


Changes in circulating adiponectin and metabolic hormone concentrations during periparturient and lactation periods in Holstein dairy cows.

Ohtani Y, Takahashi T, Sato K, Ardiyanti A, Song SH, Sato R, Onda K, Wada Y, Obara Y, Suzuki K, Hagino A, Roh SG, Katoh K.

Anim Sci J. 2012 Dec;83(12):788-95. doi: 10.1111/j.1740-0929.2012.01029.x. Epub 2012 Jun 6.


Gα(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.

Obara Y, Yanagihata Y, Abe T, Dafik L, Ishii K, Nakahata N.

Cell Signal. 2013 Mar;25(3):589-97. doi: 10.1016/j.cellsig.2012.11.021. Epub 2012 Nov 29.


Endocytic regulation of voltage-dependent potassium channels in the heart.

Ishii K, Norota I, Obara Y.

J Pharmacol Sci. 2012;120(4):264-9. Epub 2012 Nov 20. Review.


Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A₂ receptor: dependency on receptor isoforms and downstream signaling types.

Goto S, Saito M, Obara Y, Moriya T, Nakahata N.

Eur J Pharmacol. 2012 Oct 15;693(1-3):15-24. doi: 10.1016/j.ejphar.2012.07.046. Epub 2012 Aug 21.


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