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Pharmacological properties of β-adrenoceptors mediating rat superior mesenteric artery relaxation and the effects of chemical sympathetic denervation.

Obara K, Shigematsu M, Takahasi H, Iiboshi Y, Yoshioka K, Kasuya Y, Tanaka Y.

Life Sci. 2020 Jan 15;241:117155. doi: 10.1016/j.lfs.2019.117155. Epub 2019 Dec 16.


Effectiveness of L-Menthol Spray Application on Lesions for the Endoscopic Clarification of Early Gastric Cancer: Evaluation by the Color Difference.

Kikuchi H, Hikichi T, Watanabe K, Nakamura J, Hashimoto M, Kato T, Obara K, Ohira H.

Digestion. 2019 Dec 10:1-9. doi: 10.1159/000504667. [Epub ahead of print]


Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial.

Fukuda T, Obara K, Saito J, Umeda S, Ano Y.

J Agric Food Chem. 2020 Jan 8;68(1):206-212. doi: 10.1021/acs.jafc.9b06660. Epub 2019 Dec 27.


Perinatal outcome in preterm premature rupture of membranes before 37 weeks of gestation.

Swiatkowska-Freund M, Traczyk-Łos A, Partyka A, Obara K, Damdinsuren A, Preis K.

Ginekol Pol. 2019;90(11):645-650. doi: 10.5603/GP.2019.0109.


Free Tube Graft Urethroplasty for Repair of Hypospadias.

Obara K, Hoshii T, Hoshino S, Yamana K, Anraku T, Maruyama R, Kuroki H, Ishizaki F, Yamazaki H, Tomita Y.

Urol Int. 2019 Dec 4:1-5. doi: 10.1159/000504146. [Epub ahead of print]


N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane.

Obara K, Kotani T, Nakatogawa H, Kihara A, Kamura T.

Cell Struct Funct. 2020 Jan 11;45(1):1-8. doi: 10.1247/csf.19021. Epub 2019 Nov 30.


Pharmacological Characteristics of Anxiolytics on Acetylcholine-Induced Contractions in Rat Detrusor Smooth Muscle.

Obara K, Ao L, Shimada T, Horiguchi S, Ikarashi T, Ogawa T, Yoshioka K, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.

Pharmacology. 2019 Oct 25:1-8. doi: 10.1159/000503885. [Epub ahead of print]


Arm movements induced by noninvasive optogenetic stimulation of the motor cortex in the common marmoset.

Ebina T, Obara K, Watakabe A, Masamizu Y, Terada SI, Matoba R, Takaji M, Hatanaka N, Nambu A, Mizukami H, Yamamori T, Matsuzaki M.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22844-22850. doi: 10.1073/pnas.1903445116. Epub 2019 Oct 21.


Sustainable Effects of Distigmine Bromide on Urinary Bladder Contractile Function.

Obara K, Tanaka Y.

Pharmacology. 2019 Oct 15:1-10. doi: 10.1159/000503453. [Epub ahead of print] Review.


Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation.

Shirai K, Obara K, Tohgi N, Yamazaki A, Aki R, Hamada Y, Arakawa N, Singh SR, Hoffman RM, Amoh Y.

Tissue Cell. 2019 Aug;59:33-38. doi: 10.1016/j.tice.2019.06.001. Epub 2019 Jun 21.


Effects of Distigmine on the Mechanical Activity of Urinary Bladder Smooth Muscle.

Obara K, Tanaka Y.

Biol Pharm Bull. 2019;42(7):1064-1068. doi: 10.1248/bpb.b19-00201. Review.


Hair-follicle-associated pluripotent stem cells derived from cryopreserved intact human hair follicles sustain multilineage differentiation potential.

Obara K, Tohgi N, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y.

Sci Rep. 2019 Jun 27;9(1):9326. doi: 10.1038/s41598-019-45740-9.


Episodic tremor and slip silently invades strongly locked megathrust in the Nankai Trough.

Kano M, Kato A, Obara K.

Sci Rep. 2019 Jun 25;9(1):9270. doi: 10.1038/s41598-019-45781-0.


Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex.

Obara K, Horiguchi S, Shimada T, Ikarashi T, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.

J Pharmacol Sci. 2019 Jun;140(2):197-200. doi: 10.1016/j.jphs.2019.05.006. Epub 2019 May 27.


[Association between health literacy and behavior regarding health checkups and health counseling in Japanese employees: A comprehensive health literacy survey of a Japanese railway company].

Kimura N, Obara K, Akibayashi N, Miyamoto T.

Sangyo Eiseigaku Zasshi. 2019 Jul 25;61(4):123-132. doi: 10.1539/sangyoeisei.2018-039-B. Epub 2019 May 31. Japanese.


Clinical utility of the 2016 ASE/EACVI recommendations for the evaluation of left ventricular diastolic function in the stratification of post-discharge prognosis in patients with acute heart failure.

Machino-Ohtsuka T, Seo Y, Ishizu T, Hamada-Harimura Y, Yamamoto M, Sato K, Sai S, Sugano A, Obara K, Yoshida I, Nishi I, Aonuma K, Ieda M.

Eur Heart J Cardiovasc Imaging. 2019 Oct 1;20(10):1129-1137. doi: 10.1093/ehjci/jez082.


Supplementation With Whey Peptide Rich in β-Lactolin Improves Cognitive Performance in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Study.

Kita M, Kobayashi K, Obara K, Koikeda T, Umeda S, Ano Y.

Front Neurosci. 2019 Apr 24;13:399. doi: 10.3389/fnins.2019.00399. eCollection 2019.


Inhibition of Recombinant Human Acetylcholinesterase Activity by Antipsychotics.

Obara K, Fujii A, Arie C, Harada N, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.

Pharmacology. 2019;104(1-2):43-50. doi: 10.1159/000500227. Epub 2019 May 8.


[Angiotensin II Regulates Excitability and Contractile Functions of Myocardium and Smooth Muscles through Autonomic Nervous Transmission].

Yamaki F, Obara K, Tanaka Y.

Yakugaku Zasshi. 2019;139(5):793-805. doi: 10.1248/yakushi.19-00002. Review. Japanese.


Noradrenaline-Induced Relaxation of Urinary Bladder Smooth Muscle Is Primarily Triggered through the β3-Adrenoceptor in Rats.

Obara K, Suzuki S, Shibata H, Yoneyama N, Hamamatsu S, Yamaki F, Higai K, Tanaka Y.

Biol Pharm Bull. 2019;42(5):736-743. doi: 10.1248/bpb.b18-00903.


Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics.

Ohfuji S, Furuichi Y, Akahoshi T, Kage M, Obara K, Hashizume M, Matsuura T, Fukushima W, Nakamura Y.

Hepatol Res. 2019 Aug;49(8):890-901. doi: 10.1111/hepr.13343. Epub 2019 Apr 25.


Clinical Outcomes and Adverse Events of Endoscopic Submucosal Dissection for Gastric Tube Cancer after Esophagectomy.

Watanabe K, Hikichi T, Nakamura J, Hashimoto M, Takagi T, Suzuki R, Sugimoto M, Kikuchi H, Konno N, Takasumi M, Sato Y, Irie H, Obara K, Ohira H.

Gastroenterol Res Pract. 2019 Mar 3;2019:2836860. doi: 10.1155/2019/2836860. eCollection 2019.


Retrospective Analysis to Determine the Optimal Timing to Discontinue Continuous Antibiotic Prophylaxis in Patients with Primary Vesicoureteral Reflux.

Anraku T, Obara K, Tasaki M, Tomita Y.

Urol Int. 2019;102(4):462-467. doi: 10.1159/000497312. Epub 2019 Mar 27.


Evaluation of the potentiating effects of antidepressants on the contractile response to noradrenaline in guinea pig urethra smooth muscles.

Obara K, Imanaka S, Fukuhara H, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.

Clin Exp Pharmacol Physiol. 2019 May;46(5):444-455. doi: 10.1111/1440-1681.13072. Epub 2019 Mar 7.


Assessment of Inhibitory Effects of Hypnotics on Acetylcholine-Induced Contractions in Isolated Rat Urinary Bladder Smooth Muscle.

Obara K, Ao L, Ogawa T, Ikarashi T, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.

Biol Pharm Bull. 2019;42(2):280-288. doi: 10.1248/bpb.b18-00829.


Geriatric nutritional risk index predicts all-cause deaths in heart failure with preserved ejection fraction.

Nishi I, Seo Y, Hamada-Harimura Y, Yamamoto M, Ishizu T, Sugano A, Sato K, Sai S, Obara K, Suzuki S, Koike A, Aonuma K, Ieda M; Ibaraki Cardiovascular Assessment Study-Heart Failure Investigators.

ESC Heart Fail. 2019 Apr;6(2):396-405. doi: 10.1002/ehf2.12405. Epub 2019 Feb 1.


Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.

Obara K, Michino M, Ito M, Ao L, Sawada A, Yamaki F, Matsuo K, Yoshio T, Tanaka Y.

Pharmacology. 2019;103(3-4):189-201. doi: 10.1159/000495616. Epub 2019 Jan 29.


Different Impact of Changes in Left Ventricular Ejection Fraction Between Heart Failure Classifications in Patients With Acute Decompensated Heart Failure.

Yamamoto M, Seo Y, Ishizu T, Nishi I, Hamada-Harimura Y, Machino-Ohtsuka T, Sato K, Sai S, Nakatsukasa T, Sugano A, Baba M, Obara K, Aonuma K, Ieda M.

Circ J. 2019 Feb 25;83(3):584-594. doi: 10.1253/circj.CJ-18-0881. Epub 2019 Jan 23.


Pleural dedifferentiated liposarcoma: A case report.

Matsukuma S, Oshika Y, Utsumi Y, Obara K, Tanimoto T, Katsurada Y, Takeo H.

Mol Clin Oncol. 2019 Jan;10(1):132-136. doi: 10.3892/mco.2018.1757. Epub 2018 Nov 5.


Successful Endoscopic Closure Using Polyglycolic Acid Sheets with Fibrin Glue for Nonhealing Duodenal Ulcer with Perforation after Proton Beam Therapy of Liver Tumor.

Watanabe K, Hikichi T, Nakamura J, Hashimoto M, Takagi T, Suzuki R, Sugimoto M, Konno N, Takasumi M, Sato Y, Irie H, Kimura T, Kenjo A, Marubashi S, Obara K, Ohira H.

Case Rep Gastroenterol. 2018 Nov 28;12(3):679-685. doi: 10.1159/000494918. eCollection 2018 Sep-Dec.


Primary isolated bone marrow diffuse large B cell lymphoma with long-term complete remission.

Nishida H, Suzuki H, Hori M, Obara K.

Leuk Res Rep. 2018 Jul 11;10:11-15. doi: 10.1016/j.lrr.2018.05.004. eCollection 2018.


Soluble ST2 and brain natriuretic peptide predict different mode of death in patients with heart failure and preserved ejection fraction.

Sugano A, Seo Y, Ishizu T, Sai S, Yamamoto M, Hamada-Harimura Y, Machino-Ohtsuka T, Obara K, Nishi I, Aonuma K, Nogami A.

J Cardiol. 2019 Apr;73(4):326-332. doi: 10.1016/j.jjcc.2018.10.012. Epub 2018 Dec 20.


Focal positivity of immunohistochemical markers for pulmonary squamous cell carcinoma in primary pulmonary choriocarcinoma: A histopathological study.

Matsukuma S, Obara K, Utsumi Y, Miyai K, Takeo H, Oshika Y, Sensaki K.

Oncol Lett. 2018 Dec;16(6):7256-7263. doi: 10.3892/ol.2018.9525. Epub 2018 Sep 28.


A case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with cytotoxic phenotype showing multiple ulcers on the entire body.

Obara K, Mii S, Amoh Y.

J Cutan Pathol. 2019 Feb;46(2):148-151. doi: 10.1111/cup.13386. Epub 2018 Dec 10.


Incremental Prognostic Value of Right Ventricular Strain in Patients With Acute Decompensated Heart Failure.

Hamada-Harimura Y, Seo Y, Ishizu T, Nishi I, Machino-Ohtsuka T, Yamamoto M, Sugano A, Sato K, Sai S, Obara K, Yoshida I, Aonuma K; ICAS-HF Investigators.

Circ Cardiovasc Imaging. 2018 Oct;11(10):e007249. doi: 10.1161/CIRCIMAGING.117.007249.


Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial.

Watanabe K, Hikichi T, Takagi T, Suzuki R, Nakamura J, Sugimoto M, Kikuchi H, Konno N, Takasumi M, Sato Y, Hashimoto M, Irie H, Obara K, Ohira H.

Fukushima J Med Sci. 2018 Dec 8;64(3):133-141. doi: 10.5387/fms.2018-21. Epub 2018 Oct 21.


Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury.

Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, Aki R, Singh SR, Hoffman RM, Amoh Y.

Stem Cell Rev Rep. 2019 Feb;15(1):59-66. doi: 10.1007/s12015-018-9856-3.


The Host Stomatal Density Determines Resistance to Septoria gentianae in Japanese Gentian.

Tateda C, Obara K, Abe Y, Sekine R, Nekoduka S, Hikage T, Nishihara M, Sekine KT, Fujisaki K.

Mol Plant Microbe Interact. 2019 Apr;32(4):428-436. doi: 10.1094/MPMI-05-18-0114-R. Epub 2019 Feb 15.


Comparison of effects of aldosterone receptor antagonists spironolactone and eplerenone on cardiovascular outcomes and safety in patients with acute decompensated heart failure.

Yamamoto M, Seo Y, Ishizu T, Nishi I, Hamada-Harimura Y, Machino-Ohtsuka T, Higuchi H, Sai S, Nakatsukasa T, Sugano A, Baba M, Obara K, Aonuma K.

Heart Vessels. 2019 Feb;34(2):279-289. doi: 10.1007/s00380-018-1250-1. Epub 2018 Sep 10.


Invasive form of ciliated muconodular papillary tumor of the lung: A case report and review of the literature.

Miyai K, Takeo H, Nakayama T, Obara K, Aida S, Sato K, Matsukuma S.

Pathol Int. 2018 Sep;68(9):530-535. doi: 10.1111/pin.12708. Epub 2018 Jul 24. Review.


Hydroxyobtustyrene protects neuronal cells from chemical hypoxia-induced cell death.

Iwai T, Obara K, Ito C, Furukawa H, Oka JI.

J Nat Med. 2018 Sep;72(4):915-921. doi: 10.1007/s11418-018-1224-8. Epub 2018 Jul 9.


A unique case of a huge mixed squamous cell and glandular papilloma of non-endobronchial origin with a peripheral growth.

Yabuki K, Matsuyama A, Obara K, Takenaka M, Tanaka F, Nakatani Y, Hisaoka M.

Respir Med Case Rep. 2018 May 4;24:108-112. doi: 10.1016/j.rmcr.2018.05.001. eCollection 2018.


A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.

Fukuda T, Haraguchi A, Takahashi M, Nakaoka T, Fukazawa M, Okubo J, Ozaki M, Kanatome A, Ohya R, Miura Y, Obara K, Shibata S.

Chronobiol Int. 2018 Sep;35(10):1445-1455. doi: 10.1080/07420528.2018.1490315. Epub 2018 Jul 3.


Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle.

Chino D, Sone T, Yamazaki K, Tsuruoka Y, Yamagishi R, Shiina S, Obara K, Yamaki F, Higai K, Tanaka Y.

J Smooth Muscle Res. 2018;54(0):13-27. doi: 10.1540/jsmr.54.13.


β-Adrenoceptor subtypes and cAMP role in adrenaline- and noradrenaline-induced relaxation in the rat thoracic aorta.

Shiina S, Kanemura A, Suzuki C, Yamaki F, Obara K, Chino D, Tanaka Y.

J Smooth Muscle Res. 2018;54(0):1-12. doi: 10.1540/jsmr.54.1.


Strength of tremor patches along deep transition zone of a megathrust.

Kano M, Kato A, Ando R, Obara K.

Sci Rep. 2018 Feb 26;8(1):3655. doi: 10.1038/s41598-018-22048-8.


Utility of Nutritional Screening in Predicting Short-Term Prognosis of Heart Failure Patients.

Nishi I, Seo Y, Hamada-Harimura Y, Sato K, Sai S, Yamamoto M, Ishizu T, Sugano A, Obara K, Wu L, Suzuki S, Koike A, Aonuma K; Ibaraki Cardiovascular Assessment Study-Heart Failure Investigators.

Int Heart J. 2018 Mar 30;59(2):354-360. doi: 10.1536/ihj.17-073. Epub 2018 Feb 23.


Severe course of neuromyelitis optica in a female patient with chronic C hepatitis.

Obara K, Waliszewska-Prosół M, Budrewicz S, Szewczyk P, Ejma M.

Neurol Neurochir Pol. 2018 May - Jun;52(3):397-400. doi: 10.1016/j.pjnns.2018.01.004. Epub 2018 Feb 6.


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