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Items: 24


Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

Cribbs A, Hookway ES, Wells G, Lindow M, Obad S, Oerum H, Prinjha RK, Athanasou N, Sowman A, Philpott M, Penn H, Soderstrom K, Feldmann M, Oppermann U.

J Biol Chem. 2018 Feb 16;293(7):2422-2437. doi: 10.1074/jbc.RA117.000698. Epub 2018 Jan 4.


Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs.

Bernardo BC, Ooi JY, Matsumoto A, Tham YK, Singla S, Kiriazis H, Patterson NL, Sadoshima J, Obad S, Lin RC, McMullen JR.

J Physiol. 2016 Oct 15;594(20):5959-5974. doi: 10.1113/JP272512. Epub 2016 Jul 20.


Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Bernardo BC, Gao XM, Tham YK, Kiriazis H, Winbanks CE, Ooi JY, Boey EJ, Obad S, Kauppinen S, Gregorevic P, Du XJ, Lin RC, McMullen JR.

PLoS One. 2014 Feb 27;9(2):e90337. doi: 10.1371/journal.pone.0090337. eCollection 2014.


Targeting miR-21 to treat psoriasis.

Guinea-Viniegra J, Jiménez M, Schonthaler HB, Navarro R, Delgado Y, Concha-Garzón MJ, Tschachler E, Obad S, Daudén E, Wagner EF.

Sci Transl Med. 2014 Feb 26;6(225):225re1. doi: 10.1126/scitranslmed.3008089.


Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.


Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S, Roussel MF.

Cancer Res. 2013 Dec 1;73(23):7068-78. doi: 10.1158/0008-5472.CAN-13-0927. Epub 2013 Oct 21.


Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9.


LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas.

Zhang Y, Roccaro AM, Rombaoa C, Flores L, Obad S, Fernandes SM, Sacco A, Liu Y, Ngo H, Quang P, Azab AK, Azab F, Maiso P, Reagan M, Brown JR, Thai TH, Kauppinen S, Ghobrial IM.

Blood. 2012 Aug 23;120(8):1678-86. doi: 10.1182/blood-2012-02-410647. Epub 2012 Jul 13.


MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.

Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S.

Circ Res. 2012 Aug 3;111(4):415-25. doi: 10.1161/CIRCRESAHA.112.267443. Epub 2012 Jun 19.


The therapeutic potential of microRNAs in cancer.

Thorsen SB, Obad S, Jensen NF, Stenvang J, Kauppinen S.

Cancer J. 2012 May-Jun;18(3):275-84. doi: 10.1097/PPO.0b013e318258b5d6.


MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.

Meisgen F, Xu N, Wei T, Janson PC, Obad S, Broom O, Nagy N, Kauppinen S, Kemény L, Ståhle M, Pivarcsi A, Sonkoly E.

Exp Dermatol. 2012 Apr;21(4):312-4. doi: 10.1111/j.1600-0625.2012.01462.x.


Regulation of acute graft-versus-host disease by microRNA-155.

Ranganathan P, Heaphy CE, Costinean S, Stauffer N, Na C, Hamadani M, Santhanam R, Mao C, Taylor PA, Sandhu S, He G, Shana'ah A, Nuovo GJ, Lagana A, Cascione L, Obad S, Broom O, Kauppinen S, Byrd JC, Caligiuri M, Perrotti D, Hadley GA, Marcucci G, Devine SM, Blazar BR, Croce CM, Garzon R.

Blood. 2012 May 17;119(20):4786-97. doi: 10.1182/blood-2011-10-387522. Epub 2012 Mar 9.


Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.

Leucci E, Zriwil A, Gregersen LH, Jensen KT, Obad S, Bellan C, Leoncini L, Kauppinen S, Lund AH.

Oncogene. 2012 Dec 6;31(49):5081-9. doi: 10.1038/onc.2012.15. Epub 2012 Feb 6.


Inhibition of microRNA function by antimiR oligonucleotides.

Stenvang J, Petri A, Lindow M, Obad S, Kauppinen S.

Silence. 2012 Jan 9;3(1):1. doi: 10.1186/1758-907X-3-1.


Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice.

Garchow BG, Bartulos Encinas O, Leung YT, Tsao PY, Eisenberg RA, Caricchio R, Obad S, Petri A, Kauppinen S, Kiriakidou M.

EMBO Mol Med. 2011 Oct;3(10):605-15. doi: 10.1002/emmm.201100171. Epub 2011 Sep 1.


Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S.

Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786.


Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice.

Patrick DM, Montgomery RL, Qi X, Obad S, Kauppinen S, Hill JA, van Rooij E, Olson EN.

J Clin Invest. 2010 Nov;120(11):3912-6. doi: 10.1172/JCI43604. Epub 2010 Oct 18.


Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF.

Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S, Elmén J, Hedtjärn M, Straarup EM, Hansen JB, Kauppinen S.

Nucleic Acids Res. 2009 Sep;37(17):5784-92. doi: 10.1093/nar/gkp577. Epub 2009 Jul 13.


LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S.

Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26.


Regulation of the interferon-inducible p53 target gene TRIM22 (Staf50) in human T lymphocyte activation.

Obad S, Olofsson T, Mechti N, Gullberg U, Drott K.

J Interferon Cytokine Res. 2007 Oct;27(10):857-64.


Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.

Obad S, Olofsson T, Mechti N, Gullberg U, Drott K.

Leuk Res. 2007 Jul;31(7):995-1001. Epub 2007 Jan 24.


Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.

Obad S, Brunnström H, Vallon-Christersson J, Borg A, Drott K, Gullberg U.

Oncogene. 2004 May 20;23(23):4050-9.


Pycnodysostosis: refined linkage and radiation hybrid analyses reduce the critical region to 2 cM at 1q21 and map two candidate genes.

Gelb BD, Spencer E, Obad S, Edelson GJ, Faure S, Weissenbach J, Desnick RJ.

Hum Genet. 1996 Aug;98(2):141-4.


Pycnodysostosis. Orthopedic aspects with a description of 14 new cases.

Edelson JG, Obad S, Geiger R, On A, Artul HJ.

Clin Orthop Relat Res. 1992 Jul;(280):263-76.


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