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Items: 1 to 50 of 401

1.

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus.

Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA Jr, Dikalov SI, Zaika AI.

Cell Mol Gastroenterol Hepatol. 2019;7(2):480-482.e7. doi: 10.1016/j.jcmgh.2018.10.017. Epub 2018 Nov 8. No abstract available.

2.

First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.

Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O.

BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7.

3.

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.

Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA.

Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22.

4.

Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial.

Plewes K, Kingston HWF, Ghose A, Wattanakul T, Hassan MMU, Haider MS, Dutta PK, Islam MA, Alam S, Jahangir SM, Zahed ASM, Sattar MA, Chowdhury MAH, Herdman MT, Leopold SJ, Ishioka H, Piera KA, Charunwatthana P, Silamut K, Yeo TW, Lee SJ, Mukaka M, Maude RJ, Turner GDH, Faiz MA, Tarning J, Oates JA, Anstey NM, White NJ, Day NPJ, Hossain MA, Roberts Ii LJ, Dondorp AM.

Clin Infect Dis. 2018 Sep 14;67(7):991-999. doi: 10.1093/cid/ciy213.

5.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA.

Cancer Prev Res (Phila). 2016 Nov;9(11):855-865. Epub 2016 Aug 23.

6.

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers.

Zagol-Ikapite I, Sosa IR, Oram D, Judd A, Amarnath K, Amarnath V, Stec D, Oates JA, Boutaud O.

J Lipid Res. 2015 Nov;56(11):2196-205. doi: 10.1194/jlr.P063271. Epub 2015 Sep 16.

7.

Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension.

Tu W, Decker BS, He Z, Erdel BL, Eckert GJ, Hellman RN, Murray MD, Oates JA, Pratt JH.

J Gen Intern Med. 2016 Jan;31(1):30-6. doi: 10.1007/s11606-015-3469-1.

8.

Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial.

Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ 2nd, Ware LB; Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis Study Group.

Crit Care Med. 2015 Mar;43(3):534-41. doi: 10.1097/CCM.0000000000000718.

9.

Protein modification by adenine propenal.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ.

Chem Res Toxicol. 2014 Oct 20;27(10):1732-42. doi: 10.1021/tx500218g. Epub 2014 Sep 24.

10.

Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA.

Biochemistry. 2014 Apr 22;53(15):2436-41. doi: 10.1021/bi401673b. Epub 2014 Apr 11.

11.

Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues.

Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ 2nd, Oates JA, Porter NA, Boutaud O.

ACS Med Chem Lett. 2013 Aug 8;4(8):710-714.

12.

Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome.

Kawai VK, Avalos I, Oeser A, Oates JA, Milne GL, Solus JF, Chung CP, Stein CM.

Arthritis Care Res (Hoboken). 2014 Feb;66(2):285-92. doi: 10.1002/acr.22169.

13.

The President's Address: Clinical Investigation is a Pathway to Discovery.

Oates JA.

Trans Am Clin Climatol Assoc. 2012;123:1-8. No abstract available.

14.

Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation.

Yin H, Vergeade A, Shi Q, Zackert WE, Gruenberg KC, Bokiej M, Amin T, Ying W, Masterson TS, Zinkel SS, Oates JA, Boutaud O, Roberts LJ 2nd.

Biochem Biophys Res Commun. 2012 Jun 29;423(2):224-8. doi: 10.1016/j.bbrc.2012.05.058. Epub 2012 May 23.

15.

Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome.

Smith JP, Haddad EV, Taylor MB, Oram D, Blakemore D, Chen Q, Boutaud O, Oates JA.

Hypertension. 2012 Mar;59(3):719-25. doi: 10.1161/HYPERTENSIONAHA.111.181404. Epub 2012 Feb 6.

16.

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.

Duggan KC, Hermanson DJ, Musee J, Prusakiewicz JJ, Scheib JL, Carter BD, Banerjee S, Oates JA, Marnett LJ.

Nat Chem Biol. 2011 Nov;7(11):803-9.

17.

On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry.

Chacon A, Zagol-Ikapitte I, Amarnath V, Reyzer ML, Oates JA, Caprioli RM, Boutaud O.

J Mass Spectrom. 2011 Aug;46(8):840-6. doi: 10.1002/jms.1958.

18.

Cardiovascular risk markers and mechanisms in targeting the COX pathway for colorectal cancer prevention.

Oates JA.

Cancer Prev Res (Phila). 2011 Aug;4(8):1145-8. doi: 10.1158/1940-6207.CAPR-11-0333.

19.

Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies.

Zagol-Ikapitte I, Amarnath V, Jadhav S, Oates JA, Boutaud O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1098-104. doi: 10.1016/j.jchromb.2011.03.026. Epub 2011 Mar 21.

20.

Functional characterization of mutations in inherited human cPLA₂ deficiency.

Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O.

Biochemistry. 2011 Mar 15;50(10):1731-8. doi: 10.1021/bi101877n. Epub 2011 Feb 9.

21.

Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.

Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):435-42. doi: 10.1161/ATVBAHA.110.219527. Epub 2010 Dec 2.

22.

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.

Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ.

J Biol Chem. 2010 Nov 5;285(45):34950-9. doi: 10.1074/jbc.M110.162982. Epub 2010 Sep 1.

23.

Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes.

Boutaud O, Oates JA.

Methods Mol Biol. 2010;644:67-90. doi: 10.1007/978-1-59745-364-6_7.

PMID:
20645166
24.

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ 2nd, Davies SS.

Pharmaceutics. 2010 Mar;2(1):18-29.

25.

Kindred with prominent corneal nerves associated with a mutation in codon 804 of RET on chromosome 10q11.

Ong DS, Lakhani V, Oates JA Jr, O'Day DM.

Arch Ophthalmol. 2010 Feb;128(2):247-9. doi: 10.1001/archophthalmol.2009.389. No abstract available.

PMID:
20142552
26.

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure.

Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ 2nd.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2699-704. doi: 10.1073/pnas.0910174107. Epub 2010 Feb 1.

27.

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte I, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts Ii LJ, Davies SS.

Pharmaceutics. 2010 Feb 1;2(1):18-29.

28.

Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis.

Zagol-Ikapitte I, Amarnath V, Bala M, Roberts LJ 2nd, Oates JA, Boutaud O.

Chem Res Toxicol. 2010 Jan;23(1):240-50. doi: 10.1021/tx900407a.

29.

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA.

Org Biomol Chem. 2009 Dec 21;7(24):5103-12. doi: 10.1039/b912528k. Epub 2009 Oct 20.

30.

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin.

Carrier EJ, Amarnath V, Oates JA, Boutaud O.

Biochemistry. 2009 Nov 17;48(45):10775-81. doi: 10.1021/bi9015132.

31.

Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death.

Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, Oates JA.

J Am Soc Hypertens. 2008 Sep-Oct;2(5):355-65.

32.

2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation.

Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW; American College of Cardiology Foundation; American Heart Association.

J Am Coll Cardiol. 2009 Apr 14;53(15):e1-e90. doi: 10.1016/j.jacc.2008.11.013. No abstract available. Erratum in: J Am Coll Cardiol. 2009 Dec 15;54(25):2464.

33.

2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation.

Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW.

Circulation. 2009 Apr 14;119(14):e391-479. doi: 10.1161/CIRCULATIONAHA.109.192065. Epub 2009 Mar 26. Review. No abstract available. Erratum in: Circulation. 2010 Mar 30;121(12):e258.

PMID:
19324966
34.

The enteropathy of prostaglandin deficiency.

Adler DH, Phillips JA 3rd, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA.

J Gastroenterol. 2009;44 Suppl 19:1-7. doi: 10.1007/s00535-008-2253-y. Epub 2009 Jan 16.

35.

Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.

Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF.

Cell Metab. 2008 Dec;8(6):492-501. doi: 10.1016/j.cmet.2008.09.005.

36.

Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.

Adler DH, Cogan JD, Phillips JA 3rd, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA.

J Clin Invest. 2008 Jun;118(6):2121-31. doi: 10.1172/JCI30473. Erratum in: J Clin Invest. 2009 Sep;119(9):2844.

37.

A patient with adult erythermalgia: evidence suggesting an autoimmune etiology.

Jackson AL, Oates JA.

Am J Med Sci. 2008 Apr;335(4):320-2. doi: 10.1097/MAJ.0b013e31812f65e7.

38.

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase.

Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O, Oates JA.

Biochem Pharmacol. 2008 Apr 1;75(7):1472-81. doi: 10.1016/j.bcp.2007.12.005. Epub 2007 Dec 27.

39.

The relationship between dose of vitamin E and suppression of oxidative stress in humans.

Roberts LJ 2nd, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD.

Free Radic Biol Med. 2007 Nov 15;43(10):1388-93. Epub 2007 Jul 4.

40.

Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ 2nd.

Biochemistry. 2006 Dec 26;45(51):15756-67. Epub 2006 Dec 6.

41.

Neurological picture. Fast-growing adenoid cystic carcinoma: a neurotropic malignancy.

Oates JA, Kinsella DC, Gutowski NJ.

J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1039. No abstract available.

42.

An aspirin responsive non-progressive chronic chorea.

Oates JA, Lovett JK, Gutowski NJ.

J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):277-8. No abstract available.

43.
44.

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42.

Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA.

J Neurochem. 2006 Feb;96(4):917-23. Epub 2006 Jan 12.

45.

Aspirin resistance and its implications in clinical practice.

Eikelboom J, Feldman M, Mehta SR, Michelson AD, Oates JA, Topol E.

MedGenMed. 2005 Jul 11;7(3):76.

46.

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society.

Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW, Antman EM, Smith SC Jr, Adams CD, Anderson JL, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B; American College of Cardiology; American Heart Association Task Force on Practice Guidelines; American College of Chest Physicians; International Society for Heart and Lung Transplantation; Heart Rhythm Society.

Circulation. 2005 Sep 20;112(12):e154-235. Epub 2005 Sep 13. No abstract available.

PMID:
16160202
47.

Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers.

McAdam BF, Byrne D, Morrow JD, Oates JA.

Circulation. 2005 Aug 16;112(7):1024-9. Epub 2005 Aug 8.

PMID:
16087791
48.

Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.

Burleigh ME, Babaev VR, Yancey PG, Major AS, McCaleb JL, Oates JA, Morrow JD, Fazio S, Linton MF.

J Mol Cell Cardiol. 2005 Sep;39(3):443-52.

PMID:
16040051
49.

Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity.

Zagol-Ikapitte I, Masterson TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA.

J Neurochem. 2005 Aug;94(4):1140-5. Epub 2005 Jun 30.

50.

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice.

Burleigh ME, Babaev VR, Patel MB, Crews BC, Remmel RP, Morrow JD, Oates JA, Marnett LJ, Fazio S, Linton MF.

Biochem Pharmacol. 2005 Aug 1;70(3):334-42.

PMID:
15950196

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