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Overexpression of an LaeA-like Methyltransferase Upregulates Secondary Metabolite Production in Aspergillus nidulans.

Grau MF, Entwistle R, Oakley CE, Wang CCC, Oakley BR.

ACS Chem Biol. 2019 Jul 19;14(7):1643-1651. doi: 10.1021/acschembio.9b00380. Epub 2019 Jul 2.


Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans.

Elramli N, Karahoda B, Sarikaya-Bayram Ö, Frawley D, Ulas M, Oakley CE, Oakley BR, Seiler S, Bayram Ö.

PLoS Genet. 2019 Mar 18;15(3):e1008053. doi: 10.1371/journal.pgen.1008053. eCollection 2019 Mar.


SUMOlock reveals a more complete Aspergillus nidulans SUMOylome.

Horio T, Szewczyk E, Oakley CE, Osmani AH, Osmani SA, Oakley BR.

Fungal Genet Biol. 2019 Jun;127:50-59. doi: 10.1016/j.fgb.2019.03.002. Epub 2019 Mar 5.


Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans.

Grau MF, Entwistle R, Chiang YM, Ahuja M, Oakley CE, Akashi T, Wang CCC, Todd RB, Oakley BR.

ACS Chem Biol. 2018 Nov 16;13(11):3193-3205. doi: 10.1021/acschembio.8b00679. Epub 2018 Oct 29.


Cyclins in aspergilli: Phylogenetic and functional analyses of group I cyclins.

Paolillo V, Jenkinson CB, Horio T, Oakley BR.

Stud Mycol. 2018 Sep;91:1-22. doi: 10.1016/j.simyco.2018.06.002. Epub 2018 Jun 20.


New multi-marker strains and complementing genes for Aspergillus nidulans molecular biology.

Dohn JW Jr, Grubbs AW, Oakley CE, Oakley BR.

Fungal Genet Biol. 2018 Feb;111:1-6. doi: 10.1016/j.fgb.2018.01.003. Epub 2018 Jan 5.


A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici.

Zhang P, Wang X, Fan A, Zheng Y, Liu X, Wang S, Zou H, Oakley BR, Keller NP, Yin WB.

Mol Microbiol. 2017 Aug;105(3):469-483. doi: 10.1111/mmi.13711. Epub 2017 Jun 6.


The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro.

Kaur K, Wu X, Fields JK, Johnson DK, Lan L, Pratt M, Somoza AD, Wang CCC, Karanicolas J, Oakley BR, Xu L, De Guzman RN.

PLoS One. 2017 Apr 17;12(4):e0175471. doi: 10.1371/journal.pone.0175471. eCollection 2017.


Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan.

Sung CT, Chang SL, Entwistle R, Ahn G, Lin TS, Petrova V, Yeh HH, Praseuth MB, Chiang YM, Oakley BR, Wang CCC.

Fungal Genet Biol. 2017 Apr;101:1-6. doi: 10.1016/j.fgb.2017.01.006. Epub 2017 Jan 17.


Discovery of McrA, a master regulator of Aspergillus secondary metabolism.

Oakley CE, Ahuja M, Sun WW, Entwistle R, Akashi T, Yaegashi J, Guo CJ, Cerqueira GC, Russo Wortman J, Wang CC, Chiang YM, Oakley BR.

Mol Microbiol. 2017 Jan;103(2):347-365. doi: 10.1111/mmi.13562. Epub 2016 Nov 14.


Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor.

Yeh HH, Ahuja M, Chiang YM, Oakley CE, Moore S, Yoon O, Hajovsky H, Bok JW, Keller NP, Wang CC, Oakley BR.

ACS Chem Biol. 2016 Aug 19;11(8):2275-84. doi: 10.1021/acschembio.6b00213. Epub 2016 Jun 21.


Onychomycosis and its Chemotherapy.

Basha A, Basha F, Ali SK, Hanson PR, Oakley BR, Hajovsky H, Mitscher LA.

Curr Med Chem. 2016 May 27;23(16):1609-24. Review.


Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin.

Chiang YM, Ahuja M, Oakley CE, Entwistle R, Asokan A, Zutz C, Wang CC, Oakley BR.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1662-5. doi: 10.1002/anie.201507097. Epub 2015 Nov 13.


Spatial regulation of a common precursor from two distinct genes generates metabolite diversity.

Guo CJ, Sun WW, Bruno KS, Oakley BR, Keller NP, Wang CCC.

Chem Sci. 2015 Oct 1;6(10):5913-5921. doi: 10.1039/c5sc01058f. Epub 2015 Jul 13.


γ-Tubulin complexes in microtubule nucleation and beyond.

Oakley BR, Paolillo V, Zheng Y.

Mol Biol Cell. 2015 Sep 1;26(17):2957-62. doi: 10.1091/mbc.E14-11-1514.


The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.

Wang B, Li K, Jin M, Qiu R, Liu B, Oakley BR, Xiang X.

Fungal Genet Biol. 2015 Sep;82:51-5. doi: 10.1016/j.fgb.2015.06.005. Epub 2015 Jun 24.


Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro.

Paranjape SR, Riley AP, Somoza AD, Oakley CE, Wang CC, Prisinzano TE, Oakley BR, Gamblin TC.

ACS Chem Neurosci. 2015 May 20;6(5):751-60. doi: 10.1021/acschemneuro.5b00013. Epub 2015 Apr 15.


Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.

Edgerton H, Paolillo V, Oakley BR.

Mol Microbiol. 2015 Feb;95(3):442-57. doi: 10.1111/mmi.12871. Epub 2014 Dec 30.


Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases.

Liu T, Sanchez JF, Chiang YM, Oakley BR, Wang CC.

Org Lett. 2014 Mar 21;16(6):1676-9. doi: 10.1021/ol5003384. Epub 2014 Mar 5.


Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde.

Paranjape SR, Chiang YM, Sanchez JF, Entwistle R, Wang CC, Oakley BR, Gamblin TC.

Planta Med. 2014 Jan;80(1):77-85. doi: 10.1055/s-0033-1360180. Epub 2014 Jan 10.


Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans.

Yaegashi J, Oakley BR, Wang CC.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):433-42. doi: 10.1007/s10295-013-1386-z. Epub 2013 Dec 17. Review.


Recent progress in the chemotherapy of human fungal diseases. Emphasis on 1,3-β-glucan synthase and chitin synthase inhibitors.

Basha A, Basha F, Ali SK, Hanson PR, Mitscher LA, Oakley BR.

Curr Med Chem. 2013;20(38):4859-87. Review.


Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans.

Yaegashi J, Praseuth MB, Tyan SW, Sanchez JF, Entwistle R, Chiang YM, Oakley BR, Wang CC.

Org Lett. 2013 Jun 7;15(11):2862-5. doi: 10.1021/ol401187b. Epub 2013 May 24.


An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans.

Chiang YM, Oakley CE, Ahuja M, Entwistle R, Schultz A, Chang SL, Sung CT, Wang CC, Oakley BR.

J Am Chem Soc. 2013 May 22;135(20):7720-31. doi: 10.1021/ja401945a. Epub 2013 May 9.


Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping.

Yeh HH, Chang SL, Chiang YM, Bruno KS, Oakley BR, Wu TK, Wang CC.

Org Lett. 2013 Feb 15;15(4):756-9. doi: 10.1021/ol303328t. Epub 2013 Jan 31.


Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.

Guo CJ, Knox BP, Chiang YM, Lo HC, Sanchez JF, Lee KH, Oakley BR, Bruno KS, Wang CC.

Org Lett. 2012 Nov 16;14(22):5684-7. doi: 10.1021/ol302682z. Epub 2012 Nov 1.


Tools for manipulation of secondary metabolism pathways: rapid promoter replacements and gene deletions in Aspergillus nidulans.

Oakley CE, Edgerton-Morgan H, Oakley BR.

Methods Mol Biol. 2012;944:143-61. doi: 10.1007/978-1-62703-122-6_10.


γ-Tubulin plays a key role in inactivating APC/C(Cdh1) at the G(1)-S boundary.

Edgerton-Morgan H, Oakley BR.

J Cell Biol. 2012 Sep 3;198(5):785-91. doi: 10.1083/jcb.201203115. Epub 2012 Aug 27.


Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production.

Soukup AA, Chiang YM, Bok JW, Reyes-Dominguez Y, Oakley BR, Wang CC, Strauss J, Keller NP.

Mol Microbiol. 2012 Oct;86(2):314-30. doi: 10.1111/j.1365-2958.2012.08195.x. Epub 2012 Aug 27.


Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans.

Sanchez JF, Entwistle R, Corcoran D, Oakley BR, Wang CC.

Medchemcomm. 2012 Aug 1;3(8). doi: 10.1039/C2MD20055D.


Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis.

Yeh HH, Chiang YM, Entwistle R, Ahuja M, Lee KH, Bruno KS, Wu TK, Oakley BR, Wang CC.

Appl Microbiol Biotechnol. 2012 Nov;96(3):739-48. doi: 10.1007/s00253-012-4098-9. Epub 2012 May 25.


Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans.

Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC.

J Am Chem Soc. 2012 May 16;134(19):8212-21. doi: 10.1021/ja3016395. Epub 2012 May 1.


The functions of myosin II and myosin V homologs in tip growth and septation in Aspergillus nidulans.

Taheri-Talesh N, Xiong Y, Oakley BR.

PLoS One. 2012;7(2):e31218. doi: 10.1371/journal.pone.0031218. Epub 2012 Feb 16.


Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.

Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang CC.

J Am Chem Soc. 2012 Mar 14;134(10):4709-20. doi: 10.1021/ja209809t. Epub 2012 Feb 29.


Reengineering an azaphilone biosynthesis pathway in Aspergillus nidulans to create lipoxygenase inhibitors.

Somoza AD, Lee KH, Chiang YM, Oakley BR, Wang CC.

Org Lett. 2012 Feb 17;14(4):972-5. doi: 10.1021/ol203094k. Epub 2012 Feb 1.


Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans.

Liu T, Chiang YM, Somoza AD, Oakley BR, Wang CC.

J Am Chem Soc. 2011 Aug 31;133(34):13314-6. doi: 10.1021/ja205780g. Epub 2011 Aug 10.


Microtubule dynamics in mitosis in Aspergillus nidulans.

Szewczyk E, Oakley BR.

Fungal Genet Biol. 2011 Oct;48(10):998-9. doi: 10.1016/j.fgb.2011.07.003. Epub 2011 Jul 23.


Cryptic Aspergillus nidulans antimicrobials.

Giles SS, Soukup AA, Lauer C, Shaaban M, Lin A, Oakley BR, Wang CC, Keller NP.

Appl Environ Microbiol. 2011 Jun;77(11):3669-75. doi: 10.1128/AEM.02000-10. Epub 2011 Apr 8.


Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.

Sanchez JF, Entwistle R, Hung JH, Yaegashi J, Jain S, Chiang YM, Wang CC, Oakley BR.

J Am Chem Soc. 2011 Mar 23;133(11):4010-7. doi: 10.1021/ja1096682. Epub 2011 Feb 25.


Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms.

Chiang YM, Chang SL, Oakley BR, Wang CC.

Curr Opin Chem Biol. 2011 Feb;15(1):137-43. doi: 10.1016/j.cbpa.2010.10.011. Epub 2010 Nov 24. Review.


Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans.

Palmer JM, Mallaredy S, Perry DW, Sanchez JF, Theisen JM, Szewczyk E, Oakley BR, Wang CC, Keller NP, Mirabito PM.

Microbiology. 2010 Dec;156(Pt 12):3522-31. doi: 10.1099/mic.0.039255-0. Epub 2010 Aug 19.


Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase.

Nayak T, Edgerton-Morgan H, Horio T, Xiong Y, De Souza CP, Osmani SA, Oakley BR.

J Cell Biol. 2010 Aug 9;190(3):317-30. doi: 10.1083/jcb.201002105. Epub 2010 Aug 2.


Unraveling polyketide synthesis in members of the genus Aspergillus.

Chiang YM, Oakley BR, Keller NP, Wang CC.

Appl Microbiol Biotechnol. 2010 May;86(6):1719-36. doi: 10.1007/s00253-010-2525-3. Epub 2010 Apr 2. Review.


Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.

Sanchez JF, Chiang YM, Szewczyk E, Davidson AD, Ahuja M, Elizabeth Oakley C, Woo Bok J, Keller N, Oakley BR, Wang CC.

Mol Biosyst. 2010 Mar;6(3):587-93. doi: 10.1039/b904541d. Epub 2009 Dec 16.


Characterization of the Aspergillus nidulans monodictyphenone gene cluster.

Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang CC, Oakley BR.

Appl Environ Microbiol. 2010 Apr;76(7):2067-74. doi: 10.1128/AEM.02187-09. Epub 2010 Feb 5.


In vivo analysis of the functions of gamma-tubulin-complex proteins.

Xiong Y, Oakley BR.

J Cell Sci. 2009 Nov 15;122(Pt 22):4218-27. doi: 10.1242/jcs.059196. Epub 2009 Oct 27.


Chromatin-level regulation of biosynthetic gene clusters.

Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP.

Nat Chem Biol. 2009 Jul;5(7):462-4. doi: 10.1038/nchembio.177.


Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.

Kim JM, Zeng CJ, Nayak T, Shao R, Huang AC, Oakley BR, Liu B.

Mol Biol Cell. 2009 Jun;20(12):2874-84. doi: 10.1091/mbc.E08-12-1177. Epub 2009 Apr 22.


A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans.

Chiang YM, Szewczyk E, Davidson AD, Keller N, Oakley BR, Wang CC.

J Am Chem Soc. 2009 Mar 4;131(8):2965-70. doi: 10.1021/ja8088185.


The 2008 update of the Aspergillus nidulans genome annotation: a community effort.

Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, Andersen MR, Archer D, Bencina M, Braus G, Coutinho P, von Döhren H, Doonan J, Driessen AJ, Durek P, Espeso E, Fekete E, Flipphi M, Estrada CG, Geysens S, Goldman G, de Groot PW, Hansen K, Harris SD, Heinekamp T, Helmstaedt K, Henrissat B, Hofmann G, Homan T, Horio T, Horiuchi H, James S, Jones M, Karaffa L, Karányi Z, Kato M, Keller N, Kelly DE, Kiel JA, Kim JM, van der Klei IJ, Klis FM, Kovalchuk A, Krasevec N, Kubicek CP, Liu B, Maccabe A, Meyer V, Mirabito P, Miskei M, Mos M, Mullins J, Nelson DR, Nielsen J, Oakley BR, Osmani SA, Pakula T, Paszewski A, Paulsen I, Pilsyk S, Pócsi I, Punt PJ, Ram AF, Ren Q, Robellet X, Robson G, Seiboth B, van Solingen P, Specht T, Sun J, Taheri-Talesh N, Takeshita N, Ussery D, vanKuyk PA, Visser H, van de Vondervoort PJ, de Vries RP, Walton J, Xiang X, Xiong Y, Zeng AP, Brandt BW, Cornell MJ, van den Hondel CA, Visser J, Oliver SG, Turner G.

Fungal Genet Biol. 2009 Mar;46 Suppl 1:S2-13. doi: 10.1016/j.fgb.2008.12.003. Epub 2008 Dec 25.

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