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Items: 47


Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.

Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE.

EMBO J. 2019 Aug 5:e102578. doi: 10.15252/embj.2019102578. [Epub ahead of print]


Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.

Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA.

Nat Commun. 2019 Jul 31;10(1):3436. doi: 10.1038/s41467-019-11373-9.


AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis.

Katwan OJ, Alghamdi F, Almabrouk TA, Mancini SJ, Kennedy S, Oakhill JS, Scott JW, Salt IP.

Biochem J. 2019 Jun 26;476(12):1725-1740. doi: 10.1042/BCJ20180714.


Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs.

de Souza Almeida Matos AL, Oakhill JS, Moreira J, Loh K, Galic S, Scott JW.

Biochem Soc Trans. 2019 Apr 30;47(2):733-741. doi: 10.1042/BST20180625. Epub 2019 Apr 18. Review.


Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death.

Hoque A, Williamson NA, Ameen SS, Ciccotosto GD, Hossain MI, Oakhill JS, Ng DCH, Ang CS, Cheng HC.

Cell Death Dis. 2019 Mar 1;10(3):213. doi: 10.1038/s41419-019-1445-0.


Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling.

Forte GM, Davie E, Lie S, Franz-Wachtel M, Ovens AJ, Wang T, Oakhill JS, Maček B, Hagan IM, Petersen J.

J Cell Sci. 2019 Apr 3;132(7). pii: jcs223925. doi: 10.1242/jcs.223925.


1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

Asquith CRM, Godoi PH, Couñago RM, Laitinen T, Scott JW, Langendorf CG, Oakhill JS, Drewry DH, Zuercher WJ, Koutentis PA, Willson TM, Kalogirou AS.

Molecules. 2018 May 19;23(5). pii: E1221. doi: 10.3390/molecules23051221.


AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.

Dite TA, Langendorf CG, Hoque A, Galic S, Rebello RJ, Ovens AJ, Lindqvist LM, Ngoei KRW, Ling NXY, Furic L, Kemp BE, Scott JW, Oakhill JS.

J Biol Chem. 2018 Jun 8;293(23):8874-8885. doi: 10.1074/jbc.RA118.003547. Epub 2018 Apr 25.


Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

Ngoei KRW, Langendorf CG, Ling NXY, Hoque A, Varghese S, Camerino MA, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB, Oakhill JS.

Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. doi: 10.1016/j.chembiol.2018.03.008. Epub 2018 Apr 12.


Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells.

Hoque A, Sivakumaran P, Bond ST, Ling NXY, Kong AM, Scott JW, Bandara N, Hernández D, Liu GS, Wong RCB, Ryan MT, Hausenloy DJ, Kemp BE, Oakhill JS, Drew BG, Pébay A, Lim SY.

Cell Death Discov. 2018 Mar 5;4:39. doi: 10.1038/s41420-018-0042-9. eCollection 2018 Dec.


Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells.

Oakhill JS, Scott JW, Dite TA.

Methods Mol Biol. 2018;1732:159-169. doi: 10.1007/978-1-4939-7598-3_10.


Visualizing AMPK Drug Binding Sites Through Crystallization of Full-Length Phosphorylated α2β1γ1 Heterotrimer.

Langendorf CG, Oakhill JS, Kemp BE.

Methods Mol Biol. 2018;1732:15-27. doi: 10.1007/978-1-4939-7598-3_2.


Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL.

Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11.


Mdivi-1 Protects Human W8B2+ Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury.

Rosdah AA, Bond ST, Sivakumaran P, Hoque A, Oakhill JS, Drew BG, Delbridge LMD, Lim SY.

Stem Cells Dev. 2017 Dec 15;26(24):1771-1780. doi: 10.1089/scd.2017.0157. Epub 2017 Nov 27.


The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS.

Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y.


Metabolism: Energy sensing through a sugar diphosphate.

Kemp BE, Oakhill JS.

Nature. 2017 Aug 3;548(7665):36-37. doi: 10.1038/nature23099. Epub 2017 Jul 19. No abstract available.


The sweet side of AMPK signaling: regulation of GFAT1.

Scott JW, Oakhill JS.

Biochem J. 2017 Mar 23;474(7):1289-1292. doi: 10.1042/BCJ20170006.


Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation.

O'Brien MT, Oakhill JS, Ling NX, Langendorf CG, Hoque A, Dite TA, Means AR, Kemp BE, Scott JW.

Sci Rep. 2017 Feb 23;7:43264. doi: 10.1038/srep43264.


β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR.

Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417.


Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Langendorf CG, Ngoei KRW, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE.

Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912.


Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration.

Roesley SN, Suryadinata R, Morrish E, Tan AR, Issa SM, Oakhill JS, Bernard O, Welch DR, Šarčević B.

Cell Cycle. 2016;15(1):137-51. doi: 10.1080/15384101.2015.1121328.


Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.

Scott JW, Park E, Rodriguiz RM, Oakhill JS, Issa SM, O'Brien MT, Dite TA, Langendorf CG, Wetsel WC, Means AR, Kemp BE.

Sci Rep. 2015 Sep 23;5:14436. doi: 10.1038/srep14436.


Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS.

Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011.


Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity.

Ford RJ, Fullerton MD, Pinkosky SL, Day EA, Scott JW, Oakhill JS, Bujak AL, Smith BK, Crane JD, Blümer RM, Marcinko K, Kemp BE, Gerstein HC, Steinberg GR.

Biochem J. 2015 May 15;468(1):125-32. doi: 10.1042/BJ20150125.


SnRK1 from Arabidopsis thaliana is an atypical AMPK.

Emanuelle S, Hossain MI, Moller IE, Pedersen HL, van de Meene AM, Doblin MS, Koay A, Oakhill JS, Scott JW, Willats WG, Kemp BE, Bacic A, Gooley PR, Stapleton DI.

Plant J. 2015 Apr;82(2):183-92. doi: 10.1111/tpj.12813.


Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

Scott JW, Ling N, Issa SM, Dite TA, O'Brien MT, Chen ZP, Galic S, Langendorf CG, Steinberg GR, Kemp BE, Oakhill JS.

Chem Biol. 2014 May 22;21(5):619-27. doi: 10.1016/j.chembiol.2014.03.006. Epub 2014 Apr 17.


ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

Scott JW, Oakhill JS, Ling NX, Langendorf CG, Foitzik RC, Kemp BE, Issinger OG.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):435-40. doi: 10.1016/j.bbrc.2013.11.130. Epub 2013 Dec 8.


AMPK functions as an adenylate charge-regulated protein kinase.

Oakhill JS, Scott JW, Kemp BE.

Trends Endocrinol Metab. 2012 Mar;23(3):125-32. doi: 10.1016/j.tem.2011.12.006. Epub 2012 Jan 26. Review.


AMPK is a direct adenylate charge-regulated protein kinase.

Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE.

Science. 2011 Jun 17;332(6036):1433-5. doi: 10.1126/science.1200094.


Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation.

Green MF, Scott JW, Steel R, Oakhill JS, Kemp BE, Means AR.

J Biol Chem. 2011 Aug 12;286(32):28066-79. doi: 10.1074/jbc.M111.251504. Epub 2011 Jun 13.


β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41. doi: 10.1073/pnas.1009705107. Epub 2010 Oct 25.


Adipose tissue as an endocrine organ.

Galic S, Oakhill JS, Steinberg GR.

Mol Cell Endocrinol. 2010 Mar 25;316(2):129-39. doi: 10.1016/j.mce.2009.08.018. Epub 2009 Aug 31. Review.


Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women.

Brown KA, McInnes KJ, Hunger NI, Oakhill JS, Steinberg GR, Simpson ER.

Cancer Res. 2009 Jul 1;69(13):5392-9. doi: 10.1158/0008-5472.CAN-09-0108. Epub 2009 Jun 9.


Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.

Jørgensen SB, Honeyman J, Oakhill JS, Fazakerley D, Stöckli J, Kemp BE, Steinberg GR.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E57-66. doi: 10.1152/ajpendo.90744.2008. Epub 2009 May 12.


AMPK/SNF1 structure: a menage a trois of energy-sensing.

Scott JW, Oakhill JS, van Denderen BJ.

Front Biosci (Landmark Ed). 2009 Jan 1;14:596-610. Review.


Structure and function of AMP-activated protein kinase.

Oakhill JS, Scott JW, Kemp BE.

Acta Physiol (Oxf). 2009 May;196(1):3-14. doi: 10.1111/j.1748-1716.2009.01977.x. Epub 2009 Feb 20. Review.


Are genuine changes in protein expression being overlooked? Reassessing Western blotting.

Mollica JP, Oakhill JS, Lamb GD, Murphy RM.

Anal Biochem. 2009 Mar 15;386(2):270-5. doi: 10.1016/j.ab.2008.12.029. Epub 2009 Jan 4.


Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, Iseli TJ, Koay A, Gooley PR, Stapleton D, Kemp BE.

Chem Biol. 2008 Nov 24;15(11):1220-30. doi: 10.1016/j.chembiol.2008.10.005.


AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.

Dzamko N, Schertzer JD, Ryall JG, Steel R, Macaulay SL, Wee S, Chen ZP, Michell BJ, Oakhill JS, Watt MJ, Jørgensen SB, Lynch GS, Kemp BE, Steinberg GR.

J Physiol. 2008 Dec 1;586(23):5819-31. doi: 10.1113/jphysiol.2008.159814. Epub 2008 Oct 9.


Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism.

Oakhill JS, Marritt SJ, Gareta EG, Cammack R, McKie AT.

Biochim Biophys Acta. 2008 Mar;1777(3):260-8. doi: 10.1016/j.bbabio.2007.12.001. Epub 2007 Dec 23.


AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.

Iseli TJ, Oakhill JS, Bailey MF, Wee S, Walter M, van Denderen BJ, Castelli LA, Katsis F, Witters LA, Stapleton D, Macaulay SL, Michell BJ, Kemp BE.

J Biol Chem. 2008 Feb 22;283(8):4799-807. Epub 2007 Dec 13.


AMPK structure and regulation from three angles.

Kemp BE, Oakhill JS, Scott JW.

Structure. 2007 Oct;15(10):1161-3. No abstract available.


Identification of an intestinal heme transporter.

Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT.

Cell. 2005 Sep 9;122(5):789-801.


Homology modelling of transferrin-binding protein A from Neisseria meningitidis.

Oakhill JS, Sutton BJ, Gorringe AR, Evans RW.

Protein Eng Des Sel. 2005 May;18(5):221-8. Epub 2005 Apr 8.


Meningococcal transferrin-binding proteins A and B show cooperation in their binding kinetics for human transferrin.

Stokes RH, Oakhill JS, Joannou CL, Gorringe AR, Evans RW.

Infect Immun. 2005 Feb;73(2):944-52.


Transferrin-mediated iron acquisition by pathogenic Neisseria.

Evans RW, Oakhill JS.

Biochem Soc Trans. 2002 Aug;30(4):705-7. Review.


Expression and purification of functional recombinant meningococcal transferrin-binding protein A.

Oakhill JS, Joannou CL, Buchanan SK, Gorringe AR, Evans RW.

Biochem J. 2002 Jun 15;364(Pt 3):613-6.

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