Sort by
Items per page

Send to

Choose Destination

Search results

Items: 40


Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.

Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA.

Cancer Res. 2019 Dec 15;79(24):6190-6203. doi: 10.1158/0008-5472.CAN-19-1116. Epub 2019 Oct 31.


Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA.

J Clin Invest. 2019 Aug 1;130:4676-4681. doi: 10.1172/JCI129961.


A Medical Student Inquiry Behavior Assessment Tool: Development and Validity Evidence.

Brondfield S, Boscardin C, Strewler G, Hyland K, Oakes SA, Nishimura H, Crawford J, Hauer KE.

Acad Med. 2019 Apr;94(4):586-594. doi: 10.1097/ACM.0000000000002520.


Bilateral Choroidal Metastases from Pancreatic Adenocarcinoma.

Hiniker A, Oakes SA, Rao RC.

Ophthalmology. 2017 Dec;124(12):1825. doi: 10.1016/j.ophtha.2017.08.020. No abstract available.


CPEB4 links the clock and the UPR to protect the liver.

Moore PC, Oakes SA.

Nat Cell Biol. 2017 Jan 31;19(2):79-81. doi: 10.1038/ncb3460.


Endoplasmic reticulum proteostasis: a key checkpoint in cancer.

Oakes SA.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C93-C102. doi: 10.1152/ajpcell.00266.2016. Epub 2016 Nov 16. Review.


Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.

Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA.

Curr Biol. 2015 Dec 7;25(23):3110-8. doi: 10.1016/j.cub.2015.10.020. Epub 2015 Nov 12.


Erratum: Proteostasis control by the unfolded protein response.

Hetz C, Chevet E, Oakes SA.

Nat Cell Biol. 2015 Aug;17(8):1088. doi: 10.1038/ncb3221. No abstract available.


Proteostasis control by the unfolded protein response.

Hetz C, Chevet E, Oakes SA.

Nat Cell Biol. 2015 Jul;17(7):829-38. doi: 10.1038/ncb3184. Review. Erratum in: Nat Cell Biol. 2015 Aug;17(8):1088.


CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A.

Stem Cell Reports. 2015 Mar 10;4(3):374-89. doi: 10.1016/j.stemcr.2015.01.019. Epub 2015 Feb 26.


Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.

Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, Blelloch R, Wang Y.

Cell Death Differ. 2015 Jul;22(7):1158-69. doi: 10.1038/cdd.2014.205. Epub 2014 Dec 12.


The role of endoplasmic reticulum stress in human pathology.

Oakes SA, Papa FR.

Annu Rev Pathol. 2015;10:173-94. doi: 10.1146/annurev-pathol-012513-104649. Epub 2014 Oct 27. Review.


Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.

Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12823-8. doi: 10.1073/pnas.1413933111. Epub 2014 Aug 18.


Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR.

Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10.


Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.

van Dis V, Kuijpers M, Haasdijk ED, Teuling E, Oakes SA, Hoogenraad CC, Jaarsma D.

Acta Neuropathol Commun. 2014 Apr 7;2:38. doi: 10.1186/2051-5960-2-38.


Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.

Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ.

Nat Chem Biol. 2012 Dec;8(12):982-9. doi: 10.1038/nchembio.1094. Epub 2012 Oct 21.


IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.

Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.


IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR.

Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007.


Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.

Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7. doi: 10.1073/pnas.1202492109. Epub 2012 Jul 16.


The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.

Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA.

Nat Cell Biol. 2011 Dec 18;14(1):87-92. doi: 10.1038/ncb2395.


Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.

Austgen K, Oakes SA, Ganem D.

J Virol. 2012 Feb;86(3):1877-82. doi: 10.1128/JVI.06600-11. Epub 2011 Nov 30.


Signaling cell death from the endoplasmic reticulum stress response.

Shore GC, Papa FR, Oakes SA.

Curr Opin Cell Biol. 2011 Apr;23(2):143-9. doi: 10.1016/ Epub 2010 Dec 9. Review.


Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA.

Sci Signal. 2010 Nov 9;3(147):ra81. doi: 10.1126/scisignal.2001017.


Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.

Reyes NA, Fisher JK, Austgen K, VandenBerg S, Huang EJ, Oakes SA.

J Clin Invest. 2010 Oct;120(10):3673-9. doi: 10.1172/JCI42986. Epub 2010 Sep 20.


IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR.

Cell. 2009 Aug 7;138(3):562-75. doi: 10.1016/j.cell.2009.07.017.


Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.

Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA.

Mol Cell Biol. 2008 Jun;28(12):3943-51. doi: 10.1128/MCB.00013-08. Epub 2008 Apr 21.


A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.

Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR.

Biochem Biophys Res Commun. 2008 Jan 25;365(4):777-83. Epub 2007 Nov 21.


Mitochondria control calcium entry at the immunological synapse.

Oakes SA.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15171-2. Epub 2007 Sep 19. No abstract available.


The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.

Oakes SA, Lin SS, Bassik MC.

Curr Mol Med. 2006 Feb;6(1):99-109. Review.


Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.

Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):105-10. Epub 2004 Dec 21.


Untangling the web: mitochondrial fission and apoptosis.

Oakes SA, Korsmeyer SJ.

Dev Cell. 2004 Oct;7(4):460-2.


Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ.

EMBO J. 2004 Mar 10;23(5):1207-16. Epub 2004 Mar 4.


Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.

Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L.

Biochem Pharmacol. 2003 Oct 15;66(8):1335-40. Review.


BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.

Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ.

Science. 2003 Apr 4;300(5616):135-9. Epub 2003 Mar 6.


A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.

Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA, Korsmeyer SJ.

Dev Cell. 2002 Jan;2(1):55-67.


Structural and functional basis for JAK3-deficient severe combined immunodeficiency.

Candotti F, Oakes SA, Johnston JA, Giliani S, Schumacher RF, Mella P, Fiorini M, Ugazio AG, Badolato R, Notarangelo LD, Bozzi F, Macchi P, Strina D, Vezzoni P, Blaese RM, O'Shea JJ, Villa A.

Blood. 1997 Nov 15;90(10):3996-4003.


Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency.

Taylor N, Candotti F, Smith S, Oakes SA, Jahn T, Isakov J, Puck JM, O'Shea JJ, Weinberg K, Johnston JA.

J Biol Chem. 1997 Mar 14;272(11):7314-9.


Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

Oakes SA, Candotti F, Johnston JA, Chen YQ, Ryan JJ, Taylor N, Liu X, Hennighausen L, Notarangelo LD, Paul WE, Blaese RM, O'Shea JJ.

Immunity. 1996 Dec;5(6):605-15.


In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.

Candotti F, Oakes SA, Johnston JA, Notarangelo LD, O'Shea JJ, Blaese RM.

J Exp Med. 1996 Jun 1;183(6):2687-92.


Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.

Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ.

J Biol Chem. 1995 Dec 1;270(48):28527-30.

Supplemental Content

Loading ...
Support Center