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ELF5 modulates the estrogen receptor cistrome in breast cancer.

Piggin CL, Roden DL, Law AMK, Molloy MP, Krisp C, Swarbrick A, Naylor MJ, Kalyuga M, Kaplan W, Oakes SR, Gallego-Ortega D, Clark SJ, Carroll JS, Bartonicek N, Ormandy CJ.

PLoS Genet. 2020 Jan 2;16(1):e1008531. doi: 10.1371/journal.pgen.1008531. eCollection 2020 Jan.


MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma.

Castillo L, Young AIJ, Mawson A, Schafranek P, Steinmann AM, Nessem D, Parkin A, Johns A, Chou A, Law AMK, Lucas MC, Murphy KJ, Deng N, Gallego-Ortega D, Caldon CE; Australian Pancreatic Cancer Genome Initiative (APGI), Timpson P, Pajic M, Ormandy CJ, Oakes SR.

Oncogene. 2019 Nov 18. doi: 10.1038/s41388-019-1091-0. [Epub ahead of print]


Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.

Wegner KA, Mueller BR, Unterberger CJ, Avila EJ, Ruetten H, Turco AE, Oakes SR, Girardi NM, Halberg RB, Swanson SM, Marker PC, Vezina CM.

J Pathol. 2020 Feb;250(2):231-242. doi: 10.1002/path.5363. Epub 2019 Nov 28.


Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.

Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA.

Cancer Res. 2019 Dec 15;79(24):6190-6203. doi: 10.1158/0008-5472.CAN-19-1116. Epub 2019 Oct 31.


Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA.

J Clin Invest. 2019 Aug 1;130:4676-4681. doi: 10.1172/JCI129961.


A temporal and spatial map of axons in developing mouse prostate.

Turco AE, Cadena MT, Zhang HL, Sandhu JK, Oakes SR, Chathurvedula T, Peterson RE, Keast JR, Vezina CM.

Histochem Cell Biol. 2019 Jul;152(1):35-45. doi: 10.1007/s00418-019-01784-6. Epub 2019 Apr 11.


The Proliferative and Apoptotic Landscape of Basal-like Breast Cancer.

Alexandrou S, George SM, Ormandy CJ, Lim E, Oakes SR, Caldon CE.

Int J Mol Sci. 2019 Feb 4;20(3). pii: E667. doi: 10.3390/ijms20030667. Review.


Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology.

Valdes-Mora F, Handler K, Law AMK, Salomon R, Oakes SR, Ormandy CJ, Gallego-Ortega D.

Front Immunol. 2018 Nov 12;9:2582. doi: 10.3389/fimmu.2018.02582. eCollection 2018. Review.


A Medical Student Inquiry Behavior Assessment Tool: Development and Validity Evidence.

Brondfield S, Boscardin C, Strewler G, Hyland K, Oakes SA, Nishimura H, Crawford J, Hauer KE.

Acad Med. 2019 Apr;94(4):586-594. doi: 10.1097/ACM.0000000000002520.


Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.

Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara WSN, Alamgeer M, Boolell V, Han JZR, Waugh T, Lee HC, Oakes SR, Kumar B, Harrison CA, Hedger MP, Lorensuhewa N, Kita B, Barrow R, Robinson BW, de Kretser DM, Wu J, Ganju V, Sweet-Cordero EA, Burgess A, Martelotto LG, Rossello FJ, Cain JE, Watkins DN.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaat3504. doi: 10.1126/scitranslmed.aat3504.


Void spot assay procedural optimization and software for rapid and objective quantification of rodent voiding function, including overlapping urine spots.

Wegner KA, Abler LL, Oakes SR, Mehta GS, Ritter KE, Hill WG, Zwaans BM, Lamb LE, Wang Z, Bjorling DE, Ricke WA, Macoska J, Marker PC, Southard-Smith EM, Eliceiri KW, Vezina CM.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1067-F1080. doi: 10.1152/ajprenal.00245.2018. Epub 2018 Jul 4.


Biometrics can help protect and safeguard.

Oakes S.

Health Estate. 2017 Jun;71(6):41-3.


Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

Young AI, Timpson P, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Cell Adh Migr. 2018;12(6):513-523. doi: 10.1080/19336918.2017.1393591. Epub 2017 Dec 21. Review.


Bilateral Choroidal Metastases from Pancreatic Adenocarcinoma.

Hiniker A, Oakes SA, Rao RC.

Ophthalmology. 2017 Dec;124(12):1825. doi: 10.1016/j.ophtha.2017.08.020. No abstract available.


Andy's Algorithms: new automated digital image analysis pipelines for FIJI.

Law AMK, Yin JXM, Castillo L, Young AIJ, Piggin C, Rogers S, Caldon CE, Burgess A, Millar EKA, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Sci Rep. 2017 Nov 16;7(1):15717. doi: 10.1038/s41598-017-15885-6.


A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

Oakes SR, Gallego-Ortega D, Stanford PM, Junankar S, Au WWY, Kikhtyak Z, von Korff A, Sergio CM, Law AMK, Castillo LE, Allerdice SL, Young AIJ, Piggin C, Whittle B, Bertram E, Naylor MJ, Roden DL, Donovan J, Korennykh A, Goodnow CC, O'Bryan MK, Ormandy CJ.

PLoS Genet. 2017 Nov 8;13(11):e1007072. doi: 10.1371/journal.pgen.1007072. eCollection 2017 Nov.


Grid therapy using high definition multileaf collimators: realizing benefits of the bystander effect.

Peng V, Suchowerska N, Rogers L, Claridge Mackonis E, Oakes S, McKenzie DR.

Acta Oncol. 2017 Aug;56(8):1048-1059. doi: 10.1080/0284186X.2017.1299939. Epub 2017 Mar 17.


CPEB4 links the clock and the UPR to protect the liver.

Moore PC, Oakes SA.

Nat Cell Biol. 2017 Jan 31;19(2):79-81. doi: 10.1038/ncb3460.


MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.

Young AI, Law AM, Castillo L, Chong S, Cullen HD, Koehler M, Herzog S, Brummer T, Lee EF, Fairlie WD, Lucas MC, Herrmann D, Allam A, Timpson P, Watkins DN, Millar EK, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Breast Cancer Res. 2016 Dec 8;18(1):125.


Endoplasmic reticulum proteostasis: a key checkpoint in cancer.

Oakes SA.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C93-C102. doi: 10.1152/ajpcell.00266.2016. Epub 2016 Nov 16. Review.


Total anticholinergic burden and survival within a cohort of elderly Mexican Americans.

Sarbacker GB, Espino DV, Wood RC, Oakes SL, Anand D, Markides KA.

Geriatr Gerontol Int. 2017 Oct;17(10):1515-1521. doi: 10.1111/ggi.12907. Epub 2016 Oct 10.


Reductions in Medication-Related Hospitalizations in Older Adults with Medication Management by Hospital and Community Pharmacists: A Quasi-Experimental Study.

Pellegrin KL, Krenk L, Oakes SJ, Ciarleglio A, Lynn J, McInnis T, Bairos AW, Gomez L, McCrary MB, Hanlon AL, Miyamura J.

J Am Geriatr Soc. 2017 Jan;65(1):212-219. doi: 10.1111/jgs.14518. Epub 2016 Oct 7.


Prevention of intestinal ischemia-reperfusion injury in humanized mice.

Sheu EG, Wakatsuki K, Oakes S, Carroll MC, Moore FD Jr.

Surgery. 2016 Aug;160(2):436-42. doi: 10.1016/j.surg.2016.03.001. Epub 2016 Apr 15.


ELF5 isoform expression is tissue-specific and significantly altered in cancer.

Piggin CL, Roden DL, Gallego-Ortega D, Lee HJ, Oakes SR, Ormandy CJ.

Breast Cancer Res. 2016 Jan 7;18(1):4. doi: 10.1186/s13058-015-0666-0.


ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.

Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A, Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, Ormandy CJ.

PLoS Biol. 2015 Dec 30;13(12):e1002330. doi: 10.1371/journal.pbio.1002330. eCollection 2015 Dec.


Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.

Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA.

Curr Biol. 2015 Dec 7;25(23):3110-8. doi: 10.1016/j.cub.2015.10.020. Epub 2015 Nov 12.


Erratum: Proteostasis control by the unfolded protein response.

Hetz C, Chevet E, Oakes SA.

Nat Cell Biol. 2015 Aug;17(8):1088. doi: 10.1038/ncb3221. No abstract available.


Proteostasis control by the unfolded protein response.

Hetz C, Chevet E, Oakes SA.

Nat Cell Biol. 2015 Jul;17(7):829-38. doi: 10.1038/ncb3184. Review. Erratum in: Nat Cell Biol. 2015 Aug;17(8):1088.


CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A.

Stem Cell Reports. 2015 Mar 10;4(3):374-89. doi: 10.1016/j.stemcr.2015.01.019. Epub 2015 Feb 26.


Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.

Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, Blelloch R, Wang Y.

Cell Death Differ. 2015 Jul;22(7):1158-69. doi: 10.1038/cdd.2014.205. Epub 2014 Dec 12.


The role of endoplasmic reticulum stress in human pathology.

Oakes SA, Papa FR.

Annu Rev Pathol. 2015;10:173-94. doi: 10.1146/annurev-pathol-012513-104649. Epub 2014 Oct 27. Review.


Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease.

Hilton HN, Doan TB, Graham JD, Oakes SR, Silvestri A, Santucci N, Kantimm S, Huschtscha LI, Ormandy CJ, Funder JW, Simpson ER, Kuczek ES, Leedman PJ, Tilley WD, Fuller PJ, Muscat GE, Clarke CL.

Oncotarget. 2014 Sep 30;5(18):8651-64.


Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients.

Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12823-8. doi: 10.1073/pnas.1413933111. Epub 2014 Aug 18.


The mammary cellular hierarchy and breast cancer.

Oakes SR, Gallego-Ortega D, Ormandy CJ.

Cell Mol Life Sci. 2014 Nov;71(22):4301-24. doi: 10.1007/s00018-014-1674-4. Epub 2014 Jul 31. Review.


Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR.

Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10.


Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.

van Dis V, Kuijpers M, Haasdijk ED, Teuling E, Oakes SA, Hoogenraad CC, Jaarsma D.

Acta Neuropathol Commun. 2014 Apr 7;2:38. doi: 10.1186/2051-5960-2-38.


Therapeutic targets in triple negative breast cancer.

O'Toole SA, Beith JM, Millar EK, West R, McLean A, Cazet A, Swarbrick A, Oakes SR.

J Clin Pathol. 2013 Jun;66(6):530-42. doi: 10.1136/jclinpath-2012-201361. Epub 2013 Feb 22. Review.


ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

Kalyuga M, Gallego-Ortega D, Lee HJ, Roden DL, Cowley MJ, Caldon CE, Stone A, Allerdice SL, Valdes-Mora F, Launchbury R, Statham AL, Armstrong N, Alles MC, Young A, Egger A, Au W, Piggin CL, Evans CJ, Ledger A, Brummer T, Oakes SR, Kaplan W, Gee JM, Nicholson RI, Sutherland RL, Swarbrick A, Naylor MJ, Clark SJ, Carroll JS, Ormandy CJ.

PLoS Biol. 2012;10(12):e1001461. doi: 10.1371/journal.pbio.1001461. Epub 2012 Dec 27.


Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.

Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ.

Nat Chem Biol. 2012 Dec;8(12):982-9. doi: 10.1038/nchembio.1094. Epub 2012 Oct 21.


IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.

Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.


IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR.

Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007.


Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.

Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7. doi: 10.1073/pnas.1202492109. Epub 2012 Jul 16.


The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.

Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA.

Nat Cell Biol. 2011 Dec 18;14(1):87-92. doi: 10.1038/ncb2395.


Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.

Austgen K, Oakes SA, Ganem D.

J Virol. 2012 Feb;86(3):1877-82. doi: 10.1128/JVI.06600-11. Epub 2011 Nov 30.


Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737.

Oakes SR, Vaillant F, Lim E, Lee L, Breslin K, Feleppa F, Deb S, Ritchie ME, Takano E, Ward T, Fox SB, Generali D, Smyth GK, Strasser A, Huang DC, Visvader JE, Lindeman GJ.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2766-71. doi: 10.1073/pnas.1104778108. Epub 2011 Jul 18.


Transitional care of the long-term care patient.

Oakes SL, Gillespie SM, Ye Y, Finley M, Russell M, Patel NK, Espino D.

Clin Geriatr Med. 2011 May;27(2):259-71. doi: 10.1016/j.cger.2011.02.004. Epub 2011 Apr 13.


Signaling cell death from the endoplasmic reticulum stress response.

Shore GC, Papa FR, Oakes SA.

Curr Opin Cell Biol. 2011 Apr;23(2):143-9. doi: 10.1016/ Epub 2010 Dec 9. Review.


Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA.

Sci Signal. 2010 Nov 9;3(147):ra81. doi: 10.1126/scisignal.2001017.


Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.

Reyes NA, Fisher JK, Austgen K, VandenBerg S, Huang EJ, Oakes SA.

J Clin Invest. 2010 Oct;120(10):3673-9. doi: 10.1172/JCI42986. Epub 2010 Sep 20.


Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model.

Bui MR, Hodson V, King T, Leopold D, Dai S, Fiolkoski V, Oakes S, Duke R, Apelian D, Franzusoff A, DeGregori J.

Vaccine. 2010 Aug 23;28(37):6028-35. doi: 10.1016/j.vaccine.2010.06.085. Epub 2010 Jul 7.

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