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Items: 45


Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.

Malouf C, Ottersbach K.

Exp Hematol. 2019 Aug;76:49-59. doi: 10.1016/j.exphem.2019.07.004. Epub 2019 Aug 2.


Endothelial-to-haematopoietic transition: an update on the process of making blood.

Ottersbach K.

Biochem Soc Trans. 2019 Apr 30;47(2):591-601. doi: 10.1042/BST20180320. Epub 2019 Mar 22. Review.


DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation.

Mansell E, Zareian N, Malouf C, Kapeni C, Brown N, Badie C, Baird D, Lane J, Ottersbach K, Blair A, Case CP.

Sci Rep. 2019 Mar 13;9(1):4370. doi: 10.1038/s41598-019-39552-0.


The multi-faceted role of Gata3 in developmental haematopoiesis.

Zaidan N, Ottersbach K.

Open Biol. 2018 Nov 21;8(11). pii: 180152. doi: 10.1098/rsob.180152. Review.


Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.

Crosby A, Toshner MR, Southwood MR, Soon E, Dunmore BJ, Groves E, Moore S, Wright P, Ottersbach K, Bennett C, Guerrero J, Ghevaert C, Morrell NW.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018801642. doi: 10.1177/2045894018801642. Epub 2018 Aug 30.


The fetal liver lymphoid-primed multipotent progenitor provides the prerequisites for the initiation of t(4;11) MLL-AF4 infant leukemia.

Malouf C, Ottersbach K.

Haematologica. 2018 Dec;103(12):e571-e574. doi: 10.3324/haematol.2018.191718. Epub 2018 Jun 14. No abstract available.


PEKK-made indirect temporary crowns and bridges: a clinical pilot study.

Klur T, Hasan I, Ottersbach K, Stark H, Fichte M, Dirk C, Bourauel C.

Clin Oral Investig. 2019 Feb;23(2):771-777. doi: 10.1007/s00784-018-2493-z. Epub 2018 May 30.


Molecular processes involved in B cell acute lymphoblastic leukaemia.

Malouf C, Ottersbach K.

Cell Mol Life Sci. 2018 Feb;75(3):417-446. doi: 10.1007/s00018-017-2620-z. Epub 2017 Aug 17. Review.


Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.

Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SEW, Huntly BJ, Ottersbach K.

Cell Rep. 2016 Jul 26;16(4):1039-1054. doi: 10.1016/j.celrep.2016.06.046. Epub 2016 Jul 7.


Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.

Mascarenhas MI, Bacon WA, Kapeni C, Fitch SR, Kimber G, Cheng SW, Li J, Green AR, Ottersbach K.

Blood. 2016 May 12;127(19):2298-309. doi: 10.1182/blood-2015-08-664631. Epub 2016 Feb 10.


SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.

Marks-Bluth J, Khanna A, Chandrakanthan V, Thoms J, Bee T, Eich C, Kang YC, Knezevic K, Qiao Q, Fitch S, Oxburgh L, Ottersbach K, Dzierzak E, de Bruijn MF, Pimanda JE.

Mol Cell Biol. 2015 Jun;35(12):2165-72. doi: 10.1128/MCB.00239-15. Epub 2015 Apr 13.


High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.

Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ.

Stem Cell Res. 2015 May;14(3):307-22. doi: 10.1016/j.scr.2015.02.001. Epub 2015 Feb 18.


Concise review: From greenhouse to garden: the changing soil of the hematopoietic stem cell microenvironment during development.

Mirshekar-Syahkal B, Fitch SR, Ottersbach K.

Stem Cells. 2014 Jul;32(7):1691-700. doi: 10.1002/stem.1680. Review.


The unconventional embryo: immune-restricted potential precedes multipotentiality.

Malouf C, Ottersbach K.

Cell Stem Cell. 2013 Nov 7;13(5):509-10. doi: 10.1016/j.stem.2013.10.015.


Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.

Diffner E, Beck D, Gudgin E, Thoms JA, Knezevic K, Pridans C, Foster S, Goode D, Lim WK, Boelen L, Metzeler KH, Micklem G, Bohlander SK, Buske C, Burnett A, Ottersbach K, Vassiliou GS, Olivier J, Wong JW, Göttgens B, Huntly BJ, Pimanda JE.

Blood. 2013 Mar 21;121(12):2289-300. doi: 10.1182/blood-2012-07-446120. Epub 2013 Jan 17. Erratum in: Blood. 2014 May 1;123(18):2901.


Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis.

Fitch SR, Kimber GM, Wilson NK, Parker A, Mirshekar-Syahkal B, Göttgens B, Medvinsky A, Dzierzak E, Ottersbach K.

Cell Stem Cell. 2012 Oct 5;11(4):554-66. doi: 10.1016/j.stem.2012.07.002.


Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.

Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MF, Ferguson-Smith AC, Dzierzak E, Ottersbach K.

Haematologica. 2013 Feb;98(2):163-71. doi: 10.3324/haematol.2012.070789. Epub 2012 Jul 16.


Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.

Spensberger D, Kotsopoulou E, Ferreira R, Broccardo C, Scott LM, Fourouclas N, Ottersbach K, Green AR, Göttgens B.

Exp Hematol. 2012 Jul;40(7):588-598.e1. doi: 10.1016/j.exphem.2012.02.006. Epub 2012 Mar 5.


A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.

Knezevic K, Bee T, Wilson NK, Janes ME, Kinston S, Polderdijk S, Kolb-Kokocinski A, Ottersbach K, Pencovich N, Groner Y, de Bruijn M, Göttgens B, Pimanda JE.

Mol Cell Biol. 2011 Jul;31(14):2817-26. doi: 10.1128/MCB.01305-10. Epub 2011 May 16.


Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.

Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, Wang X, Ottersbach K, Stemple DL, Green AR, Ouwehand WH, Göttgens B.

Dev Cell. 2011 May 17;20(5):597-609. doi: 10.1016/j.devcel.2011.04.008.


CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells.

Robin C, Ottersbach K, Boisset JC, Oziemlak A, Dzierzak E.

Blood. 2011 May 12;117(19):5088-91. doi: 10.1182/blood-2011-01-329516. Epub 2011 Mar 17.


cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

Göttgens B, Ferreira R, Sanchez MJ, Ishibashi S, Li J, Spensberger D, Lefevre P, Ottersbach K, Chapman M, Kinston S, Knezevic K, Hoogenkamp M, Follows GA, Bonifer C, Amaya E, Green AR.

Mol Cell Biol. 2010 Dec;30(24):5741-51. doi: 10.1128/MCB.00870-10. Epub 2010 Oct 18.


The placenta as a haematopoietic organ.

Ottersbach K, Dzierzak E.

Int J Dev Biol. 2010;54(6-7):1099-106. doi: 10.1387/ijdb.093057ko. Review.


Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.

Wilson NK, Timms RT, Kinston SJ, Cheng YH, Oram SH, Landry JR, Mullender J, Ottersbach K, Gottgens B.

Mol Cell Biol. 2010 Aug;30(15):3853-63. doi: 10.1128/MCB.00032-10. Epub 2010 Jun 1.


JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.

Li J, Spensberger D, Ahn JS, Anand S, Beer PA, Ghevaert C, Chen E, Forrai A, Scott LM, Ferreira R, Campbell PJ, Watson SP, Liu P, Erber WN, Huntly BJ, Ottersbach K, Green AR.

Blood. 2010 Sep 2;116(9):1528-38. doi: 10.1182/blood-2009-12-259747. Epub 2010 May 20.


Ontogeny of haematopoiesis: recent advances and open questions.

Ottersbach K, Smith A, Wood A, Göttgens B.

Br J Haematol. 2010 Feb;148(3):343-55. doi: 10.1111/j.1365-2141.2009.07953.x. Epub 2009 Oct 22. Review.


Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.

Mascarenhas MI, Parker A, Dzierzak E, Ottersbach K.

Blood. 2009 Nov 19;114(21):4645-53. doi: 10.1182/blood-2009-06-230037. Epub 2009 Sep 30.


Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development.

Peeters M, Ottersbach K, Bollerot K, Orelio C, de Bruijn M, Wijgerde M, Dzierzak E.

Development. 2009 Aug;136(15):2613-21. doi: 10.1242/dev.034728. Epub 2009 Jul 1.


Analysis of the mouse placenta as a hematopoietic stem cell niche.

Ottersbach K, Dzierzak E.

Methods Mol Biol. 2009;538:335-46. doi: 10.1007/978-1-59745-418-6_17.


Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.

Pimanda JE, Chan WY, Wilson NK, Smith AM, Kinston S, Knezevic K, Janes ME, Landry JR, Kolb-Kokocinski A, Frampton J, Tannahill D, Ottersbach K, Follows GA, Lacaud G, Kouskoff V, Göttgens B.

Blood. 2008 Dec 1;112(12):4512-22. doi: 10.1182/blood-2008-05-157560. Epub 2008 Sep 19.


Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.

Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K, Göttgens B.

Blood. 2008 Mar 15;111(6):3005-14. doi: 10.1182/blood-2007-07-098830. Epub 2008 Jan 9.


Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells.

Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20838-43. Epub 2007 Dec 17.


Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.

Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb-Kokocinski A, Green AR, Tannahill D, Lacaud G, Kouskoff V, Göttgens B.

Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17692-7. Epub 2007 Oct 25.


An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells.

Robin C, Ottersbach K, Durand C, Peeters M, Vanes L, Tybulewicz V, Dzierzak E.

Dev Cell. 2006 Aug;11(2):171-80.


A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3).

Ottersbach K, McLean J, Isaacs NW, Graham GJ.

Blood. 2006 Feb 15;107(4):1284-91. Epub 2005 Oct 18.


GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells.

Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E.

J Exp Med. 2004 Oct 4;200(7):871-82.


Developmental origins of hematopoietic stem cells.

Robin C, Ottersbach K, de Bruijn M, Ma X, van der Horn K, Dzierzak E.

Oncol Res. 2003;13(6-10):315-21. Review.


The Ly-6A (Sca-1) GFP transgene is expressed in all adult mouse hematopoietic stem cells.

Ma X, Robin C, Ottersbach K, Dzierzak E.

Stem Cells. 2002;20(6):514-21.


Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.

de Bruijn MF, Ma X, Robin C, Ottersbach K, Sanchez MJ, Dzierzak E.

Immunity. 2002 May;16(5):673-83.


Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis.

Oostendorp RA, Medvinsky AJ, Kusadasi N, Nakayama N, Harvey K, Orelio C, Ottersbach K, Covey T, Ploemacher RE, Saris C, Dzierzak E.

J Cell Sci. 2002 May 15;115(Pt 10):2099-108.


Macrophage inflammatory protein-1alpha uses a novel receptor for primitive hemopoietic cell inhibition.

Ottersbach K, Cook DN, Kuziel WA, Humbles A, Lu B, Gerard C, Proudfoot AE, Graham GJ.

Blood. 2001 Dec 1;98(12):3476-8.


Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin.

James M, Nuttall A, Ilsley JL, Ottersbach K, Tinsley JM, Sudol M, Winder SJ.

J Cell Sci. 2000 May;113 ( Pt 10):1717-26.


ESkine, a novel beta-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms.

Baird JW, Nibbs RJ, Komai-Koma M, Connolly JA, Ottersbach K, Clark-Lewis I, Liew FY, Graham GJ.

J Biol Chem. 1999 Nov 19;274(47):33496-503.

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