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Long-Term Outcomes of Eccentric Rotational Acetabular Osteotomy Combined With Femoral Osteotomy for Hip Dysplasia.

Osawa Y, Hasegawa Y, Seki T.

J Arthroplasty. 2019 Aug 3. pii: S0883-5403(19)30725-9. doi: 10.1016/j.arth.2019.07.041. [Epub ahead of print]


Collagen-derived dipeptide prolyl hydroxyproline directly binds to Foxg1 to change its conformation and inhibit the interaction with Runx2.

Nomura K, Kimira Y, Osawa Y, Shimizu J, Kataoka-Matsushita A, Mano H.

Biosci Biotechnol Biochem. 2019 Jul 19:1-7. doi: 10.1080/09168451.2019.1642099. [Epub ahead of print]


New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report.

Aoyama KI, Kimura M, Yamazaki H, Uchibori M, Kojima R, Osawa Y, Hosomichi K, Ota Y, Tanaka M, Yamada S, Nishimura G.

BMC Med Genet. 2019 Jul 16;20(1):126. doi: 10.1186/s12881-019-0858-z.


Changes in knee extension peak torque and body composition and their relationship with change in gait speed.

Osawa Y, Chiles Shaffer N, Shardell MD, Studenski SA, Ferrucci L.

J Cachexia Sarcopenia Muscle. 2019 Jul 4. doi: 10.1002/jcsm.12458. [Epub ahead of print]


Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab.

Maekawa T, Kato S, Kawamura T, Takada K, Sone T, Ogata H, Saito K, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Horiuchi T, Hikota-Saga R, Endo-Umeda K, Uno S, Osawa Y, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Makishima M, Komatsu N, Kimura F.

Blood. 2019 Sep 5;134(10):814-825. doi: 10.1182/blood.2019000051. Epub 2019 Jul 3.


Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.

Maitra D, Carter EL, Richardson R, Rittié L, Basrur V, Zhang H, Nesvizhskii AI, Osawa Y, Wolf MW, Ragsdale SW, Lehnert N, Herrmann H, Omary MB.

Cell Mol Gastroenterol Hepatol. 2019 Jun 4. pii: S2352-345X(19)30072-4. doi: 10.1016/j.jcmgh.2019.05.010. [Epub ahead of print]


Immune Determinants in the Acquisition and Maintenance of Antibody to Hepatitis B Surface Antigen in Adults After First-Time Hepatitis B Vaccination.

Doi H, Yoshio S, Yoneyama K, Kawai H, Sakamoto Y, Shimagaki T, Aoki Y, Osawa Y, Yoshida H, Kanto T.

Hepatol Commun. 2019 Apr 22;3(6):812-824. doi: 10.1002/hep4.1357. eCollection 2019 Jun.


Liver disease secondary to congenital heart disease in children.

Komatsu H, Inui A, Kishiki K, Kawai H, Yoshio S, Osawa Y, Kanto T, Fujisawa T.

Expert Rev Gastroenterol Hepatol. 2019 Jul;13(7):651-666. doi: 10.1080/17474124.2019.1621746. Epub 2019 May 26.


Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.

Adelnia F, Urbanek J, Osawa Y, Shardell M, Brennan NA, Fishbein KW, Spencer RG, Simonsick EM, Schrack JA, Ferrucci L.

J Am Geriatr Soc. 2019 Aug;67(8):1695-1699. doi: 10.1111/jgs.15991. Epub 2019 May 22.


Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers.

Osawa Y, Kojika E, Nishikawa K, Kimura M, Osakaya S, Miyauchi H, Kanto T, Kawakami Y, Kimura K.

Oncotarget. 2019 Apr 30;10(32):3013-3026. doi: 10.18632/oncotarget.26892. eCollection 2019 Apr 30.


Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma.

Mano Y, Yoshio S, Shoji H, Tomonari S, Aoki Y, Aoyanagi N, Okamoto T, Matsuura Y, Osawa Y, Kimura K, Yugawa K, Wang H, Oda Y, Yoshizumi T, Maehara Y, Kanto T.

J Gastroenterol. 2019 Apr 2. doi: 10.1007/s00535-019-01579-5. [Epub ahead of print]


Measurement of equivalence between the web and paper versions of the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire.

Takegami Y, Seki T, Higuchi Y, Osawa Y, Ishiguro N.

Mod Rheumatol. 2019 Mar 29:1-5. doi: 10.1080/14397595.2019.1592799. [Epub ahead of print]


Failed periacetabular osteotomy leads to acetabular defects during subsequent total hip arthroplasty.

Osawa Y, Seki T, Takegami Y, Kusano T, Ishiguro N, Hasegawa Y.

Arch Orthop Trauma Surg. 2019 May;139(5):729-734. doi: 10.1007/s00402-019-03174-y. Epub 2019 Mar 23.


Stand-up test overestimates the decline of locomotor function in taller people: a cross-sectional analysis of data from the Kameda Health Study.

Miyamoto R, Sawada SS, Gando Y, Matsushita M, Kawakami R, Muranaga S, Osawa Y, Ishii K, Oka K.

J Phys Ther Sci. 2019 Feb;31(2):175-184. doi: 10.1589/jpts.31.175. Epub 2019 Feb 7.


What factors predict ceramic liner malseating after ceramic-on-ceramic total hip arthroplasty?

Higuchi Y, Seki T, Takegami Y, Osawa Y, Kusano T, Ishiguro N.

Orthop Traumatol Surg Res. 2019 May;105(3):453-459. doi: 10.1016/j.otsr.2019.01.009. Epub 2019 Mar 8.


L233P mutation in the bovine leukemia virus Tax protein depresses endothelial cell recruitment and tumorigenesis in athymic nude mice.

Mori H, Tomiyasu T, Nishiyama K, Matsumoto M, Osawa Y, Okazaki K.

Arch Virol. 2019 May;164(5):1343-1351. doi: 10.1007/s00705-019-04191-3. Epub 2019 Mar 8.


Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report.

Aoyama KI, Tamura M, Uchibori M, Nakanishi Y, Arai T, Aoki T, Osawa Y, Kaneko A, Ota Y.

J Med Case Rep. 2019 Jan 29;13(1):26. doi: 10.1186/s13256-018-1833-6.


Whole-liver radiotherapy for diffuse liver metastases improves liver enzymes and related factors.

Ito K, Osawa Y, Shimizuguchi T, Ogawa H, Nihei K, Karasawa K.

Acta Oncol. 2019 Apr;58(4):512-514. doi: 10.1080/0284186X.2018.1548776. Epub 2019 Jan 7. No abstract available.


Postoperative Complications Associated With Spine Surgery in Patients Older Than 90 Years: A Multicenter Retrospective Study.

Kobayashi K, Imagama S, Sato K, Kato F, Kanemura T, Yoshihara H, Sakai Y, Shinjo R, Hachiya Y, Osawa Y, Matsubara Y, Ando K, Nishida Y, Ishiguro N.

Global Spine J. 2018 Dec;8(8):887-891. doi: 10.1177/2192568218767430. Epub 2018 Apr 19. Review.


A Mouse Distraction Osteogenesis Model.

Fujio M, Osawa Y, Matsushita M, Ogisu K, Tsuchiya S, Kitoh H, Hibi H.

J Vis Exp. 2018 Nov 14;(141). doi: 10.3791/57925.


Low mucosal-associated invariant T-cell number in peripheral blood of patients with immune thrombocytopenia and their response to prednisolone.

Maekawa T, Osawa Y, Okada Y, Tachi N, Teramoto M, Kawamura T, Horiuchi T, Kato S, Kobayashi A, Kobayashi S, Sato K, Kimura F.

PLoS One. 2018 Nov 8;13(11):e0207149. doi: 10.1371/journal.pone.0207149. eCollection 2018.


Cytokine and chemokine signatures associated with hepatitis B surface antigen loss in hepatitis B patients.

Yoshio S, Mano Y, Doi H, Shoji H, Shimagaki T, Sakamoto Y, Kawai H, Matsuda M, Mori T, Osawa Y, Korenaga M, Sugiyama M, Mizokami M, Mita E, Katayama K, Tanaka J, Kanto T.

JCI Insight. 2018 Oct 18;3(20). pii: 122268. doi: 10.1172/jci.insight.122268.


Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs.

Nishikawa K, Osawa Y, Kimura K.

Int J Mol Sci. 2018 Oct 10;19(10). pii: E3103. doi: 10.3390/ijms19103103. Review.


Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years or older.

Kobayashi S, Yuan X, Sasaki S, Osawa Y, Hirata T, Abe Y, Takayama M, Arai Y, Masui Y, Ishizaki T.

Public Health Nutr. 2019 Feb;22(2):212-222. doi: 10.1017/S1368980018002331. Epub 2018 Oct 2.


Correction: Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.

Maekawa T, Osawa Y, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Kawamura T, Horiuchi T, Saga R, Kato S, Yamamura T, Watanabe J, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Kimura F.

Leukemia. 2018 Dec;32(12):2729-2730. doi: 10.1038/s41375-018-0237-3.


Knee extension rate of velocity development affects walking performance differently in men and women.

Osawa Y, Studenski SA, Ferrucci L.

Exp Gerontol. 2018 Oct 2;112:63-67. doi: 10.1016/j.exger.2018.09.005. Epub 2018 Sep 12.


Bronchodilator Reversibility Occurring during the Acute Phase of Paragonimiasis westermani Infection.

Harada T, Kawasaki Y, Tsukada A, Osawa Y, Takami H, Yamaguchi K, Kurai J, Yamasaki A, Shimizu E.

Intern Med. 2019 Jan 15;58(2):297-300. doi: 10.2169/internalmedicine.0401-17. Epub 2018 Aug 24.


Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.

Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y.

Mol Pharmacol. 2018 Sep;94(3):984-991. doi: 10.1124/mol.118.112516. Epub 2018 Jun 25.


Cementless total hip arthroplasty for osteonecrosis and osteoarthritis produce similar results at ten years follow-up when matched for age and gender.

Osawa Y, Seki T, Takegami Y, Kusano T, Makida K, Ishiguro N.

Int Orthop. 2018 Jul;42(7):1683-1688. doi: 10.1007/s00264-018-3987-7. Epub 2018 May 24.


Rate of Muscle Contraction Is Associated With Cognition in Women, Not in Men.

Tian Q, Osawa Y, Resnick SM, Ferrucci L, Studenski SA.

J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):714-719. doi: 10.1093/gerona/gly115.


Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice.

Osawa Y, Kojika E, Hayashi Y, Kimura M, Nishikawa K, Yoshio S, Doi H, Kanto T, Kimura K.

Hepatol Commun. 2018 Feb 13;2(4):407-420. doi: 10.1002/hep4.1158. eCollection 2018 Apr.


The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis.

Zhang H, Yokom AL, Cheng S, Su M, Hollenberg PF, Southworth DR, Osawa Y.

J Biol Chem. 2018 May 18;293(20):7727-7736. doi: 10.1074/jbc.RA117.000600. Epub 2018 Apr 4.


CBL mutation and MEFV single-nucleotide variant are important genetic predictors of tumor reduction in glucocorticoid-treated patients with chronic myelomonocytic leukemia.

Watanabe J, Sato K, Osawa Y, Horiuchi T, Kato S, Hikota-Saga R, Maekawa T, Yamamura T, Kobayashi A, Kobayashi S, Kimura F.

Int J Hematol. 2018 Jul;108(1):47-57. doi: 10.1007/s12185-018-2436-0. Epub 2018 Mar 29.


Knee extension rate of torque development and peak torque: associations with lower extremity function.

Osawa Y, Studenski SA, Ferrucci L.

J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):530-539. doi: 10.1002/jcsm.12285. Epub 2018 Mar 23.


Do femoral head collapse and the contralateral condition affect patient-reported quality of life and referral pain in patients with osteonecrosis of the femoral head?

Osawa Y, Seki T, Takegami Y, Kasai T, Higuchi Y, Ishiguro N.

Int Orthop. 2018 Jul;42(7):1463-1468. doi: 10.1007/s00264-018-3867-1. Epub 2018 Mar 9.


Absorption and metabolism of orally administered collagen hydrolysates evaluated by the vascularly perfused rat intestine and liver in situ.

Osawa Y, Mizushige T, Jinno S, Sugihara F, Inoue N, Tanaka H, Kabuyama Y.

Biomed Res. 2018;39(1):1-11. doi: 10.2220/biomedres.39.1.


Preoperative Canal Bone Ratio is Related to High-Degree Stress Shielding: A Minimum 5-Year Follow-Up Study of a Proximally Hydroxyapatite-Coated Straight Tapered Titanium Femoral Component.

Kusano T, Seki T, Higuchi Y, Takegami Y, Osawa Y, Ishiguro N.

J Arthroplasty. 2018 Jun;33(6):1764-1769. doi: 10.1016/j.arth.2017.12.019. Epub 2017 Dec 28.


Functional characterization of the G162R and D216H genetic variants of human CYP17A1.

Capper CP, Liu J, McIntosh LR, Larios JM, Johnson MD, Hollenberg PF, Osawa Y, Auchus RJ, Rae JM.

J Steroid Biochem Mol Biol. 2018 Apr;178:159-166. doi: 10.1016/j.jsbmb.2017.12.002. Epub 2017 Dec 9.


Posterior Reversible Encephalopathy Syndrome after Lenvatinib Therapy in a Patient with Anaplastic Thyroid Carcinoma.

Osawa Y, Gozawa R, Koyama K, Nakayama T, Sagoh T, Sunaga H.

Intern Med. 2018 Apr 1;57(7):1015-1019. doi: 10.2169/internalmedicine.9593-17. Epub 2017 Dec 8.


Patient-reported outcomes in patients who undergo total hip arthroplasty after periacetabular osteotomy.

Osawa Y, Hasegawa Y, Seki T, Takegami Y, Amano T, Ishiguro N.

J Orthop Sci. 2018 Mar;23(2):346-349. doi: 10.1016/j.jos.2017.11.001. Epub 2017 Nov 26.


TAK1 inhibition ameliorates survival from graft-versus-host disease in an allogeneic murine marrow transplantation model.

Kobayashi A, Kobayashi S, Miyai K, Osawa Y, Horiuchi T, Kato S, Maekawa T, Yamamura T, Watanabe J, Sato K, Tsuda H, Kimura F.

Int J Hematol. 2018 Feb;107(2):222-229. doi: 10.1007/s12185-017-2345-7. Epub 2017 Oct 12.


Morphological Analysis of Live Undifferentiated Cells Derived from Induced Pluripotent Stem Cells.

Osawa Y, Miyamoto T, Ohno S, Ohno E.

Stem Cells Dev. 2018 Jan 1;27(1):1-9. doi: 10.1089/scd.2017.0112. Epub 2017 Dec 5.


Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial.

Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M.

EBioMedicine. 2017 Sep;23:79-87. doi: 10.1016/j.ebiom.2017.08.016. Epub 2017 Aug 19.


Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis.

Osawa Y, Matsushita M, Hasegawa S, Esaki R, Fujio M, Ohkawara B, Ishiguro N, Ohno K, Kitoh H.

Bone. 2017 Dec;105:42-49. doi: 10.1016/j.bone.2017.05.016. Epub 2017 Aug 10.


Satisfaction with dietary life affects oral health-related quality of life and subjective well-being in very elderly people.

Iinuma T, Arai Y, Takayama M, Takayama M, Abe Y, Osawa Y, Fukumoto M, Fukui Y, Shioda Y, Hirose N, Komiyama K, Gionhaku N.

J Oral Sci. 2017;59(2):207-213. doi: 10.2334/josnusd.16-0414.


Total Hip Arthroplasty After Transtrochanteric Rotational Osteotomy for Osteonecrosis of the Femoral Head: A Mean 10-Year Follow-Up.

Osawa Y, Seki T, Morita D, Takegami Y, Okura T, Ishiguro N.

J Arthroplasty. 2017 Oct;32(10):3088-3092. doi: 10.1016/j.arth.2017.05.020. Epub 2017 May 18.


Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma.

Shoji H, Yoshio S, Mano Y, Doi H, Sugiyama M, Osawa Y, Kimura K, Arai T, Itokawa N, Atsukawa M, Aoki Y, Fukai M, Taketomi A, Mizokami M, Kanto T.

Int J Cancer. 2017 Sep 1;141(5):1011-1017. doi: 10.1002/ijc.30804. Epub 2017 Jun 8.


Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.

Maekawa T, Osawa Y, Izumi T, Nagao S, Takano K, Okada Y, Tachi N, Teramoto M, Kawamura T, Horiuchi T, Saga R, Kato S, Yamamura T, Watanabe J, Kobayashi A, Kobayashi S, Sato K, Hashimoto M, Suzu S, Kimura F.

Leukemia. 2017 Dec;31(12):2709-2716. doi: 10.1038/leu.2017.112. Epub 2017 Apr 3. Erratum in: Leukemia. 2018 Dec;32(12):2729-2730.


Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model.

Tokunaga Y, Osawa Y, Ohtsuki T, Hayashi Y, Yamaji K, Yamane D, Hara M, Munekata K, Tsukiyama-Kohara K, Hishima T, Kojima S, Kimura K, Kohara M.

Sci Rep. 2017 Mar 23;7(1):325. doi: 10.1038/s41598-017-00282-w.


Identification of dietary patterns and their relationships with general and oral health in the very old.

Osawa Y, Arai Y, Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N.

Asia Pac J Clin Nutr. 2017 Mar;26(2):262-270. doi: 10.6133/apjcn.022016.02.

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