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Items: 44


Biologicals targeting T helper cell subset differentiating cytokines are effective in the treatment of murine anti-myeloperoxidase glomerulonephritis.

Gan PY, Chan A, Ooi JD, Dick J, Nagai K, O'Sullivan KM, Oudin V, Shim R, Kitching AR, Holdsworth SR.

Kidney Int. 2019 May 27. pii: S0085-2538(19)30531-9. doi: 10.1016/j.kint.2019.05.012. [Epub ahead of print]


A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.

Ooi JD, Jiang JH, Eggenhuizen PJ, Chua LL, van Timmeren M, Loh KL, O'Sullivan KM, Gan PY, Zhong Y, Tsyganov K, Shochet LR, Ryan J, Stegeman CA, Fugger L, Reid HH, Rossjohn J, Heeringa P, Holdsworth SR, Peleg AY, Kitching AR.

Nat Commun. 2019 Jul 29;10(1):3392. doi: 10.1038/s41467-019-11255-0.


Apoptotic Cell-Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN.

Gan PY, Godfrey AS, Ooi JD, O'Sullivan KM, Oudin V, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2019 Aug;30(8):1365-1374. doi: 10.1681/ASN.2018090955. Epub 2019 Jul 23.


Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis.

O'Sullivan KM, Ford SL, Longano A, Kitching AR, Holdsworth SR.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1283-F1294. doi: 10.1152/ajprenal.00040.2018. Epub 2018 Jun 20.


Visualizing Macrophage Extracellular Traps Using Confocal Microscopy.

Sharma R, O'Sullivan KM, Holdsworth SR, Bardin PG, King PT.

J Vis Exp. 2017 Oct 19;(128). doi: 10.3791/56459.


Pathogenic Role for γδ T Cells in Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, Fujita T, Ooi JD, Alikhan MA, Dick J, Shim R, Odobasic D, O'Sullivan KM, Kitching AR, Holdsworth SR.

J Immunol. 2017 Nov 1;199(9):3042-3050. doi: 10.4049/jimmunol.1602025. Epub 2017 Sep 27.


Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung.

King PT, Sharma R, O'Sullivan KM, Callaghan J, Dousha L, Thomas B, Ruwanpura S, Lim S, Farmer MW, Jennings BR, Finsterbusch M, Brooks G, Selemidis S, Anderson GP, Holdsworth SR, Bardin PG.

Sci Rep. 2017 Sep 21;7(1):12128. doi: 10.1038/s41598-017-12474-5.


In Vivo Imaging of Inflamed Glomeruli Reveals Dynamics of Neutrophil Extracellular Trap Formation in Glomerular Capillaries.

Westhorpe CL, Bayard JE, O'Sullivan KM, Hall P, Cheng Q, Kitching AR, Hickey MJ.

Am J Pathol. 2017 Feb;187(2):318-331. doi: 10.1016/j.ajpath.2016.10.008. Epub 2016 Dec 18.


Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis.

Ghali JR, O'Sullivan KM, Eggenhuizen PJ, Holdsworth SR, Kitching AR.

Nephron. 2017;135(3):207-223. doi: 10.1159/000453059. Epub 2016 Dec 10.


CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.

Chang J, Eggenhuizen P, O'Sullivan KM, Alikhan MA, Holdsworth SR, Ooi JD, Kitching AR.

J Am Soc Nephrol. 2017 Jan;28(1):47-55. doi: 10.1681/ASN.2015121356. Epub 2016 Jun 10.


Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 May;27(5):1321-33. doi: 10.1681/ASN.2014090906. Epub 2015 Sep 15.


Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.

O'Sullivan KM, Lo CY, Summers SA, Elgass KD, McMillan PJ, Longano A, Ford SL, Gan PY, Kerr PG, Kitching AR, Holdsworth SR.

Kidney Int. 2015 Nov;88(5):1030-46. doi: 10.1038/ki.2015.202. Epub 2015 Jul 15.


FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis.

Ghali JR, O'Sullivan KM, Eggenhuizen PJ, Holdsworth SR, Kitching AR.

PLoS One. 2015 Apr 7;10(4):e0123118. doi: 10.1371/journal.pone.0123118. eCollection 2015.


Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.

Odobasic D, Muljadi RC, O'Sullivan KM, Kettle AJ, Dickerhof N, Summers SA, Kitching AR, Holdsworth SR.

Arthritis Rheumatol. 2015 Jul;67(7):1868-80. doi: 10.1002/art.39109.


Glomerulonephritis Induced by Heterologous Anti-GBM Globulin as a Planted Foreign Antigen.

Odobasic D, Ghali JR, O'Sullivan KM, Holdsworth SR, Kitching AR.

Curr Protoc Immunol. 2014 Aug 1;106:15.26.1-20. doi: 10.1002/0471142735.im1526s106. Review.


Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis.

Odobasic D, Yang Y, Muljadi RC, O'Sullivan KM, Kao W, Smith M, Morand EF, Holdsworth SR.

Arthritis Rheumatol. 2014 Apr;66(4):907-17. doi: 10.1002/art.38299.


Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function.

Odobasic D, Kitching AR, Yang Y, O'Sullivan KM, Muljadi RC, Edgtton KL, Tan DS, Summers SA, Morand EF, Holdsworth SR.

Blood. 2013 May 16;121(20):4195-204. doi: 10.1182/blood-2012-09-456483. Epub 2013 Mar 18.


The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.

Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR.

J Am Soc Nephrol. 2013 Feb;24(3):419-31. doi: 10.1681/ASN.2012070705. Epub 2013 Feb 14.


Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN.

Tan DS, Gan PY, O'Sullivan KM, Hammett MV, Summers SA, Ooi JD, Lundgren BA, Boyd RL, Scott HS, Kitching AR, Chidgey AP, Holdsworth SR.

J Am Soc Nephrol. 2013 Mar;24(4):573-85. doi: 10.1681/ASN.2012090898. Epub 2013 Feb 7.


Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis.

Gan PY, Summers SA, Ooi JD, O'Sullivan KM, Tan DS, Muljadi RC, Odobasic D, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2012 Dec;23(12):1955-66. doi: 10.1681/ASN.2012060572. Epub 2012 Nov 8.


Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

Summers SA, Gan PY, Dewage L, Ma FT, Ooi JD, O'Sullivan KM, Nikolic-Paterson DJ, Kitching AR, Holdsworth SR.

Kidney Int. 2012 Sep;82(6):676-85. doi: 10.1038/ki.2012.211. Epub 2012 Jun 6.


Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis.

Ooi JD, Snelgrove SL, Engel DR, Hochheiser K, Ludwig-Portugall I, Nozaki Y, O'Sullivan KM, Hickey MJ, Holdsworth SR, Kurts C, Kitching AR.

Kidney Int. 2011 May;79(9):977-86. doi: 10.1038/ki.2010.541. Epub 2011 Jan 19.


Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis.

Summers SA, Steinmetz OM, Ooi JD, Gan PY, O'Sullivan KM, Visvanathan K, Akira S, Kitching AR, Holdsworth SR.

Am J Pathol. 2010 Nov;177(5):2234-44. doi: 10.2353/ajpath.2010.100153. Epub 2010 Sep 16.


Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis.

Summers SA, van der Veen BS, O'Sullivan KM, Gan PY, Ooi JD, Heeringa P, Satchell SC, Mathieson PW, Saleem MA, Visvanathan K, Holdsworth SR, Kitching AR.

Kidney Int. 2010 Dec;78(12):1263-74. doi: 10.1038/ki.2010.327. Epub 2010 Sep 15.


TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.

Summers SA, Hoi A, Steinmetz OM, O'Sullivan KM, Ooi JD, Odobasic D, Akira S, Kitching AR, Holdsworth SR.

J Autoimmun. 2010 Dec;35(4):291-8. doi: 10.1016/j.jaut.2010.05.004.


Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.

Gan PY, Steinmetz OM, Tan DS, O'Sullivan KM, Ooi JD, Iwakura Y, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2010 Jun;21(6):925-31. doi: 10.1681/ASN.2009070763. Epub 2010 Mar 18.


Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis.

Li M, O'Sullivan KM, Jones LK, Lo C, Semple T, Kumanogoh A, Kikutani H, Holdsworth SR, Kitching R.

Immunology. 2009 Sep;128(1):114-22. doi: 10.1111/j.1365-2567.2009.03098.x.


IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis.

Jones LK, O'Sullivan KM, Semple T, Kuligowski MP, Fukami K, Ma FY, Nikolic-Paterson DJ, Holdsworth SR, Kitching AR.

Nephrol Dial Transplant. 2009 Oct;24(10):3024-32. doi: 10.1093/ndt/gfp214. Epub 2009 May 22.


Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice.

Hoi AY, Hickey MJ, Hall P, Yamana J, O'Sullivan KM, Santos LL, James WG, Kitching AR, Morand EF.

J Immunol. 2006 Oct 15;177(8):5687-96.


CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis.

Li M, O'Sullivan KM, Jones LK, Semple T, Kumanogoh A, Kikutani H, Holdsworth SR, Kitching AR.

J Immunol. 2006 Sep 1;177(5):3406-12.


Phospholipase C isozymes are differentially distributed in the rat adrenal medulla.

O'Sullivan KM, Bunn SJ.

Neurosci Lett. 2006 Apr 3;396(3):212-6. Epub 2005 Dec 13.


Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.

Meyer-Olson D, Brady KW, Bartman MT, O'Sullivan KM, Simons BC, Conrad JA, Duncan CB, Lorey S, Siddique A, Draenert R, Addo M, Altfeld M, Rosenberg E, Allen TM, Walker BD, Kalams SA.

Blood. 2006 Mar 15;107(6):2373-83. Epub 2005 Dec 1.


Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.

Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, Brander C, Draenert R, Rockstroh JK, Jessen H, Rosenberg ES, Mallal SA, Walker BD.

J Virol. 2005 Nov;79(21):13239-49.


Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.

Koibuchi T, Allen TM, Lichterfeld M, Mui SK, O'Sullivan KM, Trocha A, Kalams SA, Johnson RP, Walker BD.

J Virol. 2005 Jul;79(13):8171-81.


IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.

Kitching AR, Turner AL, Wilson GR, Semple T, Odobasic D, Timoshanko JR, O'Sullivan KM, Tipping PG, Takeda K, Akira S, Holdsworth SR.

J Am Soc Nephrol. 2005 Jul;16(7):2023-33. Epub 2005 May 11.


Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury.

Dean EG, Wilson GR, Li M, Edgtton KL, O'Sullivan KM, Hudson BG, Holdsworth SR, Kitching AR.

Kidney Int. 2005 Feb;67(2):566-75.


Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.

Allen TM, Altfeld M, Yu XG, O'Sullivan KM, Lichterfeld M, Le Gall S, John M, Mothe BR, Lee PK, Kalife ET, Cohen DE, Freedberg KA, Strick DA, Johnston MN, Sette A, Rosenberg ES, Mallal SA, Goulder PJ, Brander C, Walker BD.

J Virol. 2004 Jul;78(13):7069-78.


Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.

Norris PJ, Moffett HF, Brander C, Allen TM, O'Sullivan KM, Cosimi LA, Kaufmann DE, Walker BD, Rosenberg ES.

AIDS Res Hum Retroviruses. 2004 Mar;20(3):315-25.


Endogenous alpha2-antiplasmin does not enhance glomerular fibrin deposition or injury in glomerulonephritis.

Kitching AR, Turner AL, O'Sullivan KM, Dewerchin M, Lijnen HR.

J Thromb Haemost. 2003 Sep;1(9):1992-9.


A short synthesis of bicyclic dipeptides corresponding to Xxx-L-Pro Xxx-D-Pro having constrained trans-proline amides.

Curran TP, Marcaurelle LA, O'Sullivan KM.

Org Lett. 1999 Oct 21;1(8):1225-8.


Molecular microbial diversity of an agricultural soil in Wisconsin.

Borneman J, Skroch PW, O'Sullivan KM, Palus JA, Rumjanek NG, Jansen JL, Nienhuis J, Triplett EW.

Appl Environ Microbiol. 1996 Jun;62(6):1935-43.


Healthcare workers and hepatitis B.

O'Sullivan KM.

J R Soc Med. 1992 Sep;85(9):587. No abstract available.


Cimetidine in children with peptic esophagitis.

O'sullivan KM.

Ann Saudi Med. 1992 May;12(3):328. No abstract available.


Halofantrine and pruritus.

Hallwood PM, Horton RJ, O'Sullivan KM, Parr SN.

Lancet. 1989 Aug 12;2(8659):397-8. No abstract available.


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