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Janus kinases to jakinibs: from basic insights to clinical practice.

Gadina M, Le MT, Schwartz DM, Silvennoinen O, Nakayamada S, Yamaoka K, O'Shea JJ.

Rheumatology (Oxford). 2019 Feb 1;58(Supplement_1):i4-i16. doi: 10.1093/rheumatology/key432.


No Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over hMT+ on Motion Perception Learning.

Larcombe SJ, Kennard C, O'Shea J, Bridge H.

Front Neurosci. 2019 Jan 17;12:1044. doi: 10.3389/fnins.2018.01044. eCollection 2018.


The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.

Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z, Yin B, Wang J, Jiang K, Li Z, Choi Y, Gong F, Cheng X, O'Shea JJ, Chae JJ, Laurence A, Yang XP.

Autophagy. 2019 Jan 25:1-16. doi: 10.1080/15548627.2019.1569916. [Epub ahead of print]


Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

Schwartz DM, Farley TK, Richoz N, Yao C, Shih HY, Petermann F, Zhang Y, Sun HW, Hayes E, Mikami Y, Jiang K, Davis FP, Kanno Y, Milner JD, Siegel R, Laurence A, Meylan F, O'Shea JJ.

Immunity. 2019 Jan 15;50(1):106-120.e10. doi: 10.1016/j.immuni.2018.12.014.


Selective Janus kinase inhibitors come of age.

O'Shea JJ, Gadina M.

Nat Rev Rheumatol. 2019 Feb;15(2):74-75. doi: 10.1038/s41584-018-0155-9. No abstract available.


Comparison of conventional and videolaryngoscopy blades in neonates.

Kirolos S, O'Shea JE.

Arch Dis Child Fetal Neonatal Ed. 2019 Jan 3. pii: fetalneonatal-2018-315644. doi: 10.1136/archdischild-2018-315644. [Epub ahead of print]


In situ XPS analysis of the atomic layer deposition of aluminium oxide on titanium dioxide.

Temperton RH, Gibson A, O'Shea JN.

Phys Chem Chem Phys. 2019 Jan 21;21(3):1393-1398. doi: 10.1039/c8cp06912c. Epub 2019 Jan 2.


Smaller facemasks for positive pressure ventilation in preterm infants: A randomised trial.

O'Currain E, O'Shea JE, McGrory L, Owen LS, Kamlin O, Dawson JA, Davis PG, Thio M.

Resuscitation. 2019 Jan;134:91-98. doi: 10.1016/j.resuscitation.2018.12.005. Epub 2018 Dec 17.


Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.

Harrison OJ, Linehan JL, Shih HY, Bouladoux N, Han SJ, Smelkinson M, Sen SK, Byrd AL, Enamorado M, Yao C, Tamoutounour S, Van Laethem F, Hurabielle C, Collins N, Paun A, Salcedo R, O'Shea JJ, Belkaid Y.

Science. 2019 Jan 4;363(6422). pii: eaat6280. doi: 10.1126/science.aat6280. Epub 2018 Dec 6.


Neural basis of induced phantom limb pain relief.

Kikkert S, Mezue M, O'Shea J, Henderson Slater D, Johansen-Berg H, Tracey I, Makin TR.

Ann Neurol. 2019 Jan;85(1):59-73. doi: 10.1002/ana.25371. Epub 2019 Jan 7.


Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety: A Randomized Clinical Trial.

Ironside M, Browning M, Ansari TL, Harvey CJ, Sekyi-Djan MN, Bishop SJ, Harmer CJ, O'Shea J.

JAMA Psychiatry. 2018 Oct 17. doi: 10.1001/jamapsychiatry.2018.2172. [Epub ahead of print]


Histone Deacetylase Inhibition Has Targeted Clinical Benefit in ARID1A-Mutated Advanced Urothelial Carcinoma.

Gupta S, Albertson DJ, Parnell TJ, Butterfield A, Weston A, Pappas LM, Dalley B, O'Shea JM, Lowrance WT, Cairns BR, Schiffman JD, Sharma S.

Mol Cancer Ther. 2019 Jan;18(1):185-195. doi: 10.1158/1535-7163.MCT-17-0957. Epub 2018 Oct 9.


Hemolytic Anemia and Gastric Carcinoid in a Russian Seafarer: Highlighting the Role of Diagnostic Technologies in Modern Clinical Practice.

Chaunzwa TL, O'Shea J, Boggs NA, Schwartz JI, Gibson J, Gielissen KA.

Yale J Biol Med. 2018 Sep 21;91(3):243-246. eCollection 2018 Sep.


Translating advice to eat more vegetables into practice: observations from a 12-month weight loss trial.

O'Shea J, Tapsell L, Thorne R, Probst Y.

Eur J Clin Nutr. 2018 Aug 13. doi: 10.1038/s41430-018-0277-9. [Epub ahead of print]


Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing.

Hellwig S, Nix DA, Gligorich KM, O'Shea JM, Thomas A, Fuertes CL, Bhetariya PJ, Marth GT, Bronner MP, Underhill HR.

PLoS One. 2018 Jul 25;13(7):e0197333. doi: 10.1371/journal.pone.0197333. eCollection 2018.


Translational and clinical advances in JAK-STAT biology: The present and future of jakinibs.

Gadina M, Johnson C, Schwartz D, Bonelli M, Hasni S, Kanno Y, Changelian P, Laurence A, O'Shea JJ.

J Leukoc Biol. 2018 Sep;104(3):499-514. doi: 10.1002/JLB.5RI0218-084R. Epub 2018 Jul 12. Review.


Non-classical monocytes as mediators of tissue destruction in arthritis.

Puchner A, Saferding V, Bonelli M, Mikami Y, Hofmann M, Brunner JS, Caldera M, Goncalves-Alves E, Binder NB, Fischer A, Simader E, Steiner CW, Leiss H, Hayer S, Niederreiter B, Karonitsch T, Koenders MI, Podesser BK, O'Shea JJ, Menche J, Smolen JS, Redlich K, Blüml S.

Ann Rheum Dis. 2018 Oct;77(10):1490-1497. doi: 10.1136/annrheumdis-2018-213250. Epub 2018 Jun 29.


Food for thought: formulating away the food effect - a PEARRL review.

O'Shea JP, Holm R, O'Driscoll CM, Griffin BT.

J Pharm Pharmacol. 2019 Apr;71(4):510-535. doi: 10.1111/jphp.12957. Epub 2018 Jun 28. Review.


Ultra-fast intramolecular vibronic coupling revealed by RIXS and RPES maps of an aromatic adsorbate on TiO2(110).

O'Shea JN, Handrup K, Temperton RH, Gibson AJ, Nicolaou A, Jaouen N, Taylor JB, Mayor LC, Swarbrick JC, Schnadt J.

J Chem Phys. 2018 May 28;148(20):204705. doi: 10.1063/1.5024862.


The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review.

Henze LJ, Koehl NJ, O'Shea JP, Kostewicz ES, Holm R, Griffin BT.

J Pharm Pharmacol. 2019 Apr;71(4):581-602. doi: 10.1111/jphp.12912. Epub 2018 Apr 10. Review.


NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.

Mikami Y, Scarno G, Zitti B, Shih HY, Kanno Y, Santoni A, O'Shea JJ, Sciumè G.

Eur J Immunol. 2018 Jul;48(7):1174-1180. doi: 10.1002/eji.201847480. Epub 2018 Apr 16.


Controlling striatal function via anterior frontal cortex stimulation.

van Holstein M, Froböse MI, O'Shea J, Aarts E, Cools R.

Sci Rep. 2018 Feb 19;8(1):3312. doi: 10.1038/s41598-018-21346-5.


Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.

Milewska M, Cremona M, Morgan C, O'Shea J, Carr A, Vellanki SH, Hopkins AM, Toomey S, Madden SF, Hennessy BT, Eustace AJ.

Ther Adv Med Oncol. 2018 Jan 9;10:1758834017746040. doi: 10.1177/1758834017746040. eCollection 2018.


Building a Simulator with Life-like Realism for Teaching Abdominal Operations.

McGreevy JM, O'Shea JM.

J Surg Educ. 2018 Jul - Aug;75(4):1082-1086. doi: 10.1016/j.jsurg.2017.12.008. Epub 2018 Feb 1.


Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.

Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I, Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S, Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ, Belkaid Y.

Cell. 2018 Feb 8;172(4):784-796.e18. doi: 10.1016/j.cell.2017.12.033. Epub 2018 Jan 18.


JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ.

Nat Rev Drug Discov. 2017 Dec 28;17(1):78. doi: 10.1038/nrd.2017.267.


Epigenomic Views of Innate Lymphoid Cells.

Sciumè G, Shih HY, Mikami Y, O'Shea JJ.

Front Immunol. 2017 Nov 13;8:1579. doi: 10.3389/fimmu.2017.01579. eCollection 2017. Review.


Towards a neuro-computational account of prism adaptation.

Petitet P, O'Reilly JX, O'Shea J.

Neuropsychologia. 2018 Jul 1;115:188-203. doi: 10.1016/j.neuropsychologia.2017.12.021. Epub 2017 Dec 14. Review.


IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

Le Saout C, Luckey MA, Villarino AV, Smith M, Hasley RB, Myers TG, Imamichi H, Park JH, O'Shea JJ, Lane HC, Catalfamo M.

JCI Insight. 2017 Nov 16;2(22). pii: 96228. doi: 10.1172/jci.insight.96228. eCollection 2017 Nov 16.


STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.

Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ.

J Immunol. 2018 Jan 1;200(1):110-118. doi: 10.4049/jimmunol.1701133. Epub 2017 Nov 29.


A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib.

O'Shea J, Cremona M, Morgan C, Milewska M, Holmes F, Espina V, Liotta L, O'Shaughnessy J, Toomey S, Madden SF, Carr A, Elster N, Hennessy BT, Eustace AJ.

Oncotarget. 2017 Jul 22;8(49):85120-85135. doi: 10.18632/oncotarget.19461. eCollection 2017 Oct 17.


Analysis of unsuccessful intubations in neonates using videolaryngoscopy recordings.

O'Shea JE, Loganathan P, Thio M, Kamlin COF, Davis PG.

Arch Dis Child Fetal Neonatal Ed. 2018 Sep;103(5):F408-F412. doi: 10.1136/archdischild-2017-313628. Epub 2017 Nov 10.


JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ.

Nat Rev Drug Discov. 2017 Dec;16(12):843-862. doi: 10.1038/nrd.2017.201. Epub 2017 Nov 6. Review. Erratum in: Nat Rev Drug Discov. 2017 Dec 28;17 (1):78.


Devices used for stabilisation of newborn infants at birth.

Roehr CC, O'Shea JE, Dawson JA, Wyllie JP.

Arch Dis Child Fetal Neonatal Ed. 2018 Jan;103(1):F66-F71. doi: 10.1136/archdischild-2016-310797. Epub 2017 Oct 27. Review.


Exploring ultra-fast charge transfer and vibronic coupling with N 1s RIXS maps of an aromatic molecule coupled to a semiconductor.

O'Shea JN, Handrup K, Temperton RH, Gibson AJ, Nicolaou A, Jaouen N.

J Chem Phys. 2017 Oct 7;147(13):134705. doi: 10.1063/1.4999135.


Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O'Shea JJ, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J.

Immunity. 2017 Sep 19;47(3):435-449.e8. doi: 10.1016/j.immuni.2017.08.012.


Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.

Villarino AV, Sciumè G, Davis FP, Iwata S, Zitti B, Robinson GW, Hennighausen L, Kanno Y, O'Shea JJ.

J Exp Med. 2017 Oct 2;214(10):2999-3014. doi: 10.1084/jem.20150907. Epub 2017 Sep 15.


Induced sensorimotor cortex plasticity remediates chronic treatment-resistant visual neglect.

O'Shea J, Revol P, Cousijn H, Near J, Petitet P, Jacquin-Courtois S, Johansen-Berg H, Rode G, Rossetti Y.

Elife. 2017 Sep 12;6. pii: e26602. doi: 10.7554/eLife.26602.


Faradaic processes beyond Nernst's law: density functional theory assisted modelling of partial electron delocalisation and pseudocapacitance in graphene oxides.

Li J, O'Shea J, Hou X, Chen GZ.

Chem Commun (Camb). 2017 Sep 25;53(75):10414-10417. doi: 10.1039/c7cc04344a. Epub 2017 Sep 7.


Adsorption and charge transfer interactions of bi-isonicotinic acid on Ag(111).

Temperton RH, Gibson AJ, Handrup K, O'Shea JN.

J Chem Phys. 2017 Aug 7;147(5):054703. doi: 10.1063/1.4996746.


IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.

Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ.

Sci Immunol. 2016 Oct;1(5). pii: eaaf8612. Epub 2016 Nov 11.


Orotracheal intubation in infants performed with a stylet versus without a stylet.

O'Shea JE, O'Gorman J, Gupta A, Sinhal S, Foster JP, O'Connell LA, Kamlin COF, Davis PG.

Cochrane Database Syst Rev. 2017 Jun 22;6:CD011791. doi: 10.1002/14651858.CD011791.pub2. Review.


Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate.

O'Shea JP, Nagarsekar K, Wieber A, Witt V, Herbert E, O'Driscoll CM, Saal C, Lubda D, Griffin BT, Dressman JB.

J Pharm Pharmacol. 2017 Oct;69(10):1284-1292. doi: 10.1111/jphp.12767. Epub 2017 Jun 20.


The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells.

Iwata S, Mikami Y, Sun HW, Brooks SR, Jankovic D, Hirahara K, Onodera A, Shih HY, Kawabe T, Jiang K, Nakayama T, Sher A, O'Shea JJ, Davis FP, Kanno Y.

Immunity. 2017 Jun 20;46(6):983-991.e4. doi: 10.1016/j.immuni.2017.05.005. Epub 2017 Jun 13.


BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.


A novel perfused porcine simulator for teaching aortic anastomosis increases resident interest in vascular surgery.

Bartline PB, O'Shea J, McGreevy JM, Mueller MT.

J Vasc Surg. 2017 Aug;66(2):642-648.e4. doi: 10.1016/j.jvs.2017.01.049. Epub 2017 May 12.


Extraordinary effects of unnatural pairings.

Villarino A, O'Shea JJ.

Elife. 2017 May 12;6. pii: e27198. doi: 10.7554/eLife.27198.


Letter to the editor regarding the article 'Introducing high-flow nasal cannula to the neonatal transport environment'.

Brunton A, O'Shea J.

Acta Paediatr. 2017 Aug;106(8):1362. doi: 10.1111/apa.13863. Epub 2017 May 10. No abstract available.


Digital disease detection: A systematic review of event-based internet biosurveillance systems.

O'Shea J.

Int J Med Inform. 2017 May;101:15-22. doi: 10.1016/j.ijmedinf.2017.01.019. Epub 2017 Feb 8. Review.


Mechanisms and consequences of Jak-STAT signaling in the immune system.

Villarino AV, Kanno Y, O'Shea JJ.

Nat Immunol. 2017 Mar 22;18(4):374-384. doi: 10.1038/ni.3691. Review.


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