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Increasing gender diversity in the STEM research workforce.

Greider CW, Sheltzer JM, Cantalupo NC, Copeland WB, Dasgupta N, Hopkins N, Jansen JM, Joshua-Tor L, McDowell GS, Metcalf JL, McLaughlin B, Olivarius A, O'Shea EK, Raymond JL, Ruebain D, Steitz JA, Stillman B, Tilghman SM, Valian V, Villa-Komaroff L, Wong JY.

Science. 2019 Nov 8;366(6466):692-695. doi: 10.1126/science.aaz0649. No abstract available.


A proposal for the future of scientific publishing in the life sciences.

Stern BM, O'Shea EK.

PLoS Biol. 2019 Feb 12;17(2):e3000116. doi: 10.1371/journal.pbio.3000116. eCollection 2019 Feb. Erratum in: PLoS Biol. 2019 Mar 6;17(3):e3000179.


Looking back and looking forward at Janelia.

Rubin GM, O'Shea EK.

Elife. 2019 Feb 7;8. pii: e44826. doi: 10.7554/eLife.44826.


An RpaA-Dependent Sigma Factor Cascade Sets the Timing of Circadian Transcriptional Rhythms in Synechococcus elongatus.

Fleming KE, O'Shea EK.

Cell Rep. 2018 Dec 11;25(11):2937-2945.e3. doi: 10.1016/j.celrep.2018.11.049.


Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells.

Darnell AM, Subramaniam AR, O'Shea EK.

Mol Cell. 2018 Jul 19;71(2):229-243.e11. doi: 10.1016/j.molcel.2018.06.041.


Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.

Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK.

Elife. 2018 May 10;7. pii: e36620. doi: 10.7554/eLife.36620.


Dynamical localization of a thylakoid membrane binding protein is required for acquisition of photosynthetic competency.

Gutu A, Chang F, O'Shea EK.

Mol Microbiol. 2018 Apr;108(1):16-31. doi: 10.1111/mmi.13912. Epub 2018 Feb 12.


ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus.

Puszynska AM, O'Shea EK.

Cell Rep. 2017 Dec 12;21(11):3155-3165. doi: 10.1016/j.celrep.2017.11.067.


Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria.

Piechura JR, Amarnath K, O'Shea EK.

Elife. 2017 Dec 14;6. pii: e32032. doi: 10.7554/eLife.32032.


An Unstable Singularity Underlies Stochastic Phasing of the Circadian Clock in Individual Cyanobacterial Cells.

Gan S, O'Shea EK.

Mol Cell. 2017 Aug 17;67(4):659-672.e12. doi: 10.1016/j.molcel.2017.07.015. Epub 2017 Aug 10.


Inference and Evolutionary Analysis of Genome-Scale Regulatory Networks in Large Phylogenies.

Koch C, Konieczka J, Delorey T, Lyons A, Socha A, Davis K, Knaack SA, Thompson D, O'Shea EK, Regev A, Roy S.

Cell Syst. 2017 May 24;4(5):543-558.e8. doi: 10.1016/j.cels.2017.04.010.


A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae.

Choi J, Rajagopal A, Xu YF, Rabinowitz JD, O'Shea EK.

PLoS One. 2017 May 17;12(5):e0176085. doi: 10.1371/journal.pone.0176085. eCollection 2017.


Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway.

He BZ, Zhou X, O'Shea EK.

Elife. 2017 May 9;6. pii: e25157. doi: 10.7554/eLife.25157.


Cyanobacteria Maintain Constant Protein Concentration despite Genome Copy-Number Variation.

Zheng XY, O'Shea EK.

Cell Rep. 2017 Apr 18;19(3):497-504. doi: 10.1016/j.celrep.2017.03.067.


A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution.

Zhou X, Blocker AW, Airoldi EM, O'Shea EK.

Elife. 2016 Sep 13;5. pii: e16970. doi: 10.7554/eLife.16970.


The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine.

Chidley C, Trauger SA, Birsoy K, O'Shea EK.

Elife. 2016 Jul 12;5. pii: e14601. doi: 10.7554/eLife.14601.


Encoding four gene expression programs in the activation dynamics of a single transcription factor.

Hansen AS, O'Shea EK.

Curr Biol. 2016 Apr 4;26(7):R269-71. doi: 10.1016/j.cub.2016.02.058.


Correction: Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance.

Mukherji S, O'Shea EK.

Elife. 2015 Nov 24;4:e12522. doi: 10.7554/eLife.12522. No abstract available.


cis Determinants of Promoter Threshold and Activation Timescale.

Hansen AS, O'Shea EK.

Cell Rep. 2015 Aug 25;12(8):1226-33. doi: 10.1016/j.celrep.2015.07.035. Epub 2015 Aug 13.


High-throughput microfluidics to control and measure signaling dynamics in single yeast cells.

Hansen AS, Hao N, O'Shea EK.

Nat Protoc. 2015 Aug;10(8):1181-97. doi: 10.1038/nprot.2015.079. Epub 2015 Jul 9.


An integrated approach reveals regulatory controls on bacterial translation elongation.

Subramaniam AR, Zid BM, O'Shea EK.

Cell. 2014 Nov 20;159(5):1200-1211. doi: 10.1016/j.cell.2014.10.043.


Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast.

Zid BM, O'Shea EK.

Nature. 2014 Oct 2;514(7520):117-21. doi: 10.1038/nature13578. Epub 2014 Aug 3.


Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance.

Mukherji S, O'Shea EK.

Elife. 2014 Jun 10;3:e02678. doi: 10.7554/eLife.02678. Erratum in: Elife. 2015;4:e12522.


Circadian control of global gene expression by the cyanobacterial master regulator RpaA.

Markson JS, Piechura JR, Puszynska AM, O'Shea EK.

Cell. 2013 Dec 5;155(6):1396-408. doi: 10.1016/j.cell.2013.11.005.


Robust circadian oscillations in growing cyanobacteria require transcriptional feedback.

Teng SW, Mukherji S, Moffitt JR, de Buyl S, O'Shea EK.

Science. 2013 May 10;340(6133):737-40. doi: 10.1126/science.1230996.


Two antagonistic clock-regulated histidine kinases time the activation of circadian gene expression.

Gutu A, O'Shea EK.

Mol Cell. 2013 Apr 25;50(2):288-94. doi: 10.1016/j.molcel.2013.02.022. Epub 2013 Mar 28.


Tunable signal processing through modular control of transcription factor translocation.

Hao N, Budnik BA, Gunawardena J, O'Shea EK.

Science. 2013 Jan 25;339(6118):460-4. doi: 10.1126/science.1227299.


Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I, Peel MT, Wykoff DD, O'Shea EK.

BMC Genomics. 2012 Dec 12;13:697. doi: 10.1186/1471-2164-13-697.


Sequence determinants of circadian gene expression phase in cyanobacteria.

Vijayan V, O'Shea EK.

J Bacteriol. 2013 Feb;195(4):665-71. doi: 10.1128/JB.02012-12. Epub 2012 Nov 30.


Hog1 controls global reallocation of RNA Pol II upon osmotic shock in Saccharomyces cerevisiae.

Cook KE, O'Shea EK.

G3 (Bethesda). 2012 Sep;2(9):1129-36. doi: 10.1534/g3.112.003251. Epub 2012 Sep 1.


Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria.

Jain IH, Vijayan V, O'Shea EK.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13638-43. doi: 10.1073/pnas.1211144109. Epub 2012 Aug 6.


The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment.

Grimes CL, Ariyananda Lde Z, Melnyk JE, O'Shea EK.

J Am Chem Soc. 2012 Aug 22;134(33):13535-7. doi: 10.1021/ja303883c. Epub 2012 Aug 13.


Signal-dependent dynamics of transcription factor translocation controls gene expression.

Hao N, O'Shea EK.

Nat Struct Mol Biol. 2011 Dec 18;19(1):31-9. doi: 10.1038/nsmb.2192.


Integrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4.

Zhou X, O'Shea EK.

Mol Cell. 2011 Jun 24;42(6):826-36. doi: 10.1016/j.molcel.2011.05.025.


A high resolution map of a cyanobacterial transcriptome.

Vijayan V, Jain IH, O'Shea EK.

Genome Biol. 2011;12(5):R47. doi: 10.1186/gb-2011-12-5-r47. Epub 2011 May 25.


Light-driven changes in energy metabolism directly entrain the cyanobacterial circadian oscillator.

Rust MJ, Golden SS, O'Shea EK.

Science. 2011 Jan 14;331(6014):220-3. doi: 10.1126/science.1197243.


Synthesis of biologically active biotinylated muramyl dipeptides.

Grimes CL, Podolsky DK, O'Shea EK.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6061-3. doi: 10.1016/j.bmcl.2010.08.056. Epub 2010 Aug 17.


Oscillations in supercoiling drive circadian gene expression in cyanobacteria.

Vijayan V, Zuzow R, O'Shea EK.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22564-8. doi: 10.1073/pnas.0912673106. Epub 2009 Dec 14.


The molecular clockwork of a protein-based circadian oscillator.

Markson JS, O'Shea EK.

FEBS Lett. 2009 Dec 17;583(24):3938-47. doi: 10.1016/j.febslet.2009.11.021. Review.


Transcriptional regulatory circuits: predicting numbers from alphabets.

Kim HD, Shay T, O'Shea EK, Regev A.

Science. 2009 Jul 24;325(5939):429-32. doi: 10.1126/science.1171347. Review.


Structure and function of a transcriptional network activated by the MAPK Hog1.

Capaldi AP, Kaplan T, Liu Y, Habib N, Regev A, Friedman N, O'Shea EK.

Nat Genet. 2008 Nov;40(11):1300-6. doi: 10.1038/ng.235. Epub 2008 Oct 19.


A quantitative model of transcription factor-activated gene expression.

Kim HD, O'Shea EK.

Nat Struct Mol Biol. 2008 Nov;15(11):1192-8. doi: 10.1038/nsmb.1500. Epub 2008 Oct 12.


Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.

Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O'Shea EK.

Comp Funct Genomics. 2005;6(1-2):2-16. doi: 10.1002/cfg.449.


Chromatin decouples promoter threshold from dynamic range.

Lam FH, Steger DJ, O'Shea EK.

Nature. 2008 May 8;453(7192):246-50. doi: 10.1038/nature06867. Epub 2008 Apr 16.


Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate.

Lee YS, Huang K, Quiocho FA, O'Shea EK.

Nat Chem Biol. 2008 Jan;4(1):25-32. Epub 2007 Nov 25.


Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway.

Huang K, Ferrin-O'Connell I, Zhang W, Leonard GA, O'Shea EK, Quiocho FA.

Mol Cell. 2007 Nov 30;28(4):614-23.


Ordered phosphorylation governs oscillation of a three-protein circadian clock.

Rust MJ, Markson JS, Lane WS, Fisher DS, O'Shea EK.

Science. 2007 Nov 2;318(5851):809-12. Epub 2007 Oct 4.

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