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Items: 1 to 50 of 51

1.

Anthropogenic habitat alteration leads to rapid loss of adaptive variation and restoration potential in wild salmon populations.

Thompson TQ, Bellinger MR, O'Rourke SM, Prince DJ, Stevenson AE, Rodrigues AT, Sloat MR, Speller CF, Yang DY, Butler VL, Banks MA, Miller MR.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):177-186. doi: 10.1073/pnas.1811559115. Epub 2018 Dec 4.

PMID:
30514813
2.

Production of a recombinant monoclonal antibody to Herpes Simplex Virus glycoprotein D for immunoaffinity purification of tagged proteins.

O'Rourke SM, Yu B, Morales JF, Didinger CM, Alexander DL, Vollmers C, Berman PW.

J Immunol Methods. 2019 Feb;465:31-38. doi: 10.1016/j.jim.2018.11.015. Epub 2018 Nov 28.

PMID:
30502324
3.

Development of a Stable MGAT1- CHO Cell Line to Produce Clade C gp120 With Improved Binding to Broadly Neutralizing Antibodies.

Doran RC, Yu B, Wright M, O'Rourke SM, Yin L, Richardson JM, Byrne G, Mesa KA, Berman PW.

Front Immunol. 2018 Oct 5;9:2313. doi: 10.3389/fimmu.2018.02313. eCollection 2018.

4.

Structural Simplicity and Mechanistic Complexity in the Hammerhead Ribozyme.

O'Rourke SM, Scott WG.

Prog Mol Biol Transl Sci. 2018;159:177-202. doi: 10.1016/bs.pmbts.2018.07.006. Epub 2018 Sep 17.

PMID:
30340787
5.

Large-effect loci affect survival in Tasmanian devils (Sarcophilus harrisii) infected with a transmissible cancer.

Margres MJ, Jones ME, Epstein B, Kerlin DH, Comte S, Fox S, Fraik AK, Hendricks SA, Huxtable S, Lachish S, Lazenby B, O'Rourke SM, Stahlke AR, Wiench CG, Hamede R, Schönfeld B, McCallum H, Miller MR, Hohenlohe PA, Storfer A.

Mol Ecol. 2018 Nov;27(21):4189-4199. doi: 10.1111/mec.14853. Epub 2018 Oct 5.

PMID:
30171778
6.

CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation.

Byrne G, O'Rourke SM, Alexander DL, Yu B, Doran RC, Wright M, Chen Q, Azadi P, Berman PW.

PLoS Biol. 2018 Aug 29;16(8):e2005817. doi: 10.1371/journal.pbio.2005817. eCollection 2018 Aug.

7.

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

O'Rourke SM, Byrne G, Tatsuno G, Wright M, Yu B, Mesa KA, Doran RC, Alexander D, Berman PW.

PLoS One. 2018 Aug 2;13(8):e0197656. doi: 10.1371/journal.pone.0197656. eCollection 2018.

8.

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies.

Doran RC, Tatsuno GP, O'Rourke SM, Yu B, Alexander DL, Mesa KA, Berman PW.

PLoS One. 2018 Apr 24;13(4):e0196370. doi: 10.1371/journal.pone.0196370. eCollection 2018.

9.

Best available science still supports an ancient common origin of Devils Hole and Devils Hole pupfish.

Sağlam İK, Baumsteiger J, Smith MJ, Linares-Casenave J, Nichols AL, O'Rourke SM, Miller MR.

Mol Ecol. 2018 Feb;27(4):839-842. doi: 10.1111/mec.14502. Epub 2018 Feb 28.

PMID:
29442386
10.

Genomics clarifies taxonomic boundaries in a difficult species complex.

Baumsteiger J, Moyle PB, Aguilar A, O'Rourke SM, Miller MR.

PLoS One. 2017 Dec 12;12(12):e0189417. doi: 10.1371/journal.pone.0189417. eCollection 2017.

11.

The evolutionary basis of premature migration in Pacific salmon highlights the utility of genomics for informing conservation.

Prince DJ, O'Rourke SM, Thompson TQ, Ali OA, Lyman HS, Saglam IK, Hotaling TJ, Spidle AP, Miller MR.

Sci Adv. 2017 Aug 16;3(8):e1603198. doi: 10.1126/sciadv.1603198. eCollection 2017 Aug.

12.

Whole-Genome Sequencing and Concordance Between Antimicrobial Susceptibility Genotypes and Phenotypes of Bacterial Isolates Associated with Bovine Respiratory Disease.

Owen JR, Noyes N, Young AE, Prince DJ, Blanchard PC, Lehenbauer TW, Aly SS, Davis JH, O'Rourke SM, Abdo Z, Belk K, Miller MR, Morley P, Van Eenennaam AL.

G3 (Bethesda). 2017 Sep 7;7(9):3059-3071. doi: 10.1534/g3.117.1137.

13.

Ochratoxin A Concentrations in a Variety of Grain-Based and Non-Grain-Based Foods on the Canadian Retail Market from 2009 to 2014.

Kolakowski B, O'Rourke SM, Bietlot HP, Kurz K, Aweryn B.

J Food Prot. 2016 Dec;79(12):2143-2159. doi: 10.4315/0362-028X.JFP-16-051.

PMID:
28221957
14.

Genome Report: Identification and Validation of Antigenic Proteins from Pajaroellobacter abortibovis Using De Novo Genome Sequence Assembly and Reverse Vaccinology.

Welly BT, Miller MR, Stott JL, Blanchard MT, Islas-Trejo AD, O'Rourke SM, Young AE, Medrano JF, Van Eenennaam AL.

G3 (Bethesda). 2017 Feb 9;7(2):321-331. doi: 10.1534/g3.116.036673.

15.

Phylogenetics support an ancient common origin of two scientific icons: Devils Hole and Devils Hole pupfish.

Sağlam İK, Baumsteiger J, Smith MJ, Linares-Casenave J, Nichols AL, O'Rourke SM, Miller MR.

Mol Ecol. 2016 Aug;25(16):3962-73. doi: 10.1111/mec.13732. Epub 2016 Jul 9.

PMID:
27314880
16.

RAD Capture (Rapture): Flexible and Efficient Sequence-Based Genotyping.

Ali OA, O'Rourke SM, Amish SJ, Meek MH, Luikart G, Jeffres C, Miller MR.

Genetics. 2016 Feb;202(2):389-400. doi: 10.1534/genetics.115.183665. Epub 2015 Dec 29.

17.

Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity.

O'Rourke SM, Estell W, Scott WG.

J Mol Biol. 2015 Jul 17;427(14):2340-7. doi: 10.1016/j.jmb.2015.05.005. Epub 2015 May 14.

18.

Soil organic carbon across scales.

O'Rourke SM, Angers DA, Holden NM, McBratney AB.

Glob Chang Biol. 2015 Oct;21(10):3561-74. doi: 10.1111/gcb.12959. Epub 2015 Jun 30. Review.

PMID:
25918852
19.

Glycans flanking the hypervariable connecting peptide between the A and B strands of the V1/V2 domain of HIV-1 gp120 confer resistance to antibodies that neutralize CRF01_AE viruses.

O'Rourke SM, Sutthent R, Phung P, Mesa KA, Frigon NL, To B, Horthongkham N, Limoli K, Wrin T, Berman PW.

PLoS One. 2015 Mar 20;10(3):e0119608. doi: 10.1371/journal.pone.0119608. eCollection 2015.

20.

RNA catalysis, thermodynamics and the origin of life.

Scott WG, Szöke A, Blaustein J, O'Rourke SM, Robertson MP.

Life (Basel). 2014 Apr 10;4(2):131-41. doi: 10.3390/life4020131.

21.

A semi-dominant mutation in the general splicing factor SF3a66 causes anterior-posterior axis reversal in one-cell stage C. elegans embryos.

Keikhaee MR, Nash EB, O'Rourke SM, Bowerman B.

PLoS One. 2014 Sep 4;9(9):e106484. doi: 10.1371/journal.pone.0106484. eCollection 2014.

22.

Characterization of a monoclonal antibody to a novel glycan-dependent epitope in the V1/V2 domain of the HIV-1 envelope protein, gp120.

Doran RC, Morales JF, To B, Morin TJ, Theolis R Jr, O'Rourke SM, Yu B, Mesa KA, Berman PW.

Mol Immunol. 2014 Nov;62(1):219-226. doi: 10.1016/j.molimm.2014.06.025. Epub 2014 Jul 11.

23.

HIV-1 envelope proteins and V1/V2 domain scaffolds with mannose-5 to improve the magnitude and quality of protective antibody responses to HIV-1.

Morales JF, Morin TJ, Yu B, Tatsuno GP, O'Rourke SM, Theolis R Jr, Mesa KA, Berman PW.

J Biol Chem. 2014 Jul 25;289(30):20526-42.

24.

Spatial and temporal variability of PCBs in Detroit River water assessed using a long term biomonitoring program.

Drouillard KG, Jezdic I, O'Rourke SM, Gewurtz SB, Raeside AA, Leadley TA, Drca P, Haffner GD.

Chemosphere. 2013 Jan;90(1):95-102. doi: 10.1016/j.chemosphere.2012.08.007. Epub 2012 Sep 5.

PMID:
22959602
25.

Sequences in glycoprotein gp41, the CD4 binding site, and the V2 domain regulate sensitivity and resistance of HIV-1 to broadly neutralizing antibodies.

O'Rourke SM, Schweighardt B, Phung P, Mesa KA, Vollrath AL, Tatsuno GP, To B, Sinangil F, Limoli K, Wrin T, Berman PW.

J Virol. 2012 Nov;86(22):12105-14. doi: 10.1128/JVI.01352-12. Epub 2012 Aug 29.

26.

Glycoform and net charge heterogeneity in gp120 immunogens used in HIV vaccine trials.

Yu B, Morales JF, O'Rourke SM, Tatsuno GP, Berman PW.

PLoS One. 2012;7(8):e43903. doi: 10.1371/journal.pone.0043903. Epub 2012 Aug 22.

27.

Monoclonal antibodies to the V2 domain of MN-rgp120: fine mapping of epitopes and inhibition of α4β7 binding.

Nakamura GR, Fonseca DP, O'Rourke SM, Vollrath AL, Berman PW.

PLoS One. 2012;7(6):e39045. doi: 10.1371/journal.pone.0039045. Epub 2012 Jun 13.

28.

Development. Pushing your back into place.

Bowerman B, O'Rourke SM.

Science. 2012 May 25;336(6084):984-5. doi: 10.1126/science.1223141. No abstract available.

29.

Rapid mapping and identification of mutations in Caenorhabditis elegans by restriction site-associated DNA mapping and genomic interval pull-down sequencing.

O'Rourke SM, Yochem J, Connolly AA, Price MH, Carter L, Lowry JB, Turnbull DW, Kamps-Hughes N, Stiffler N, Miller MR, Johnson EA, Bowerman B.

Genetics. 2011 Nov;189(3):767-78. doi: 10.1534/genetics.111.134031. Epub 2011 Sep 6.

30.

A survey of new temperature-sensitive, embryonic-lethal mutations in C. elegans: 24 alleles of thirteen genes.

O'Rourke SM, Carter C, Carter L, Christensen SN, Jones MP, Nash B, Price MH, Turnbull DW, Garner AR, Hamill DR, Osterberg VR, Lyczak R, Madison EE, Nguyen MH, Sandberg NA, Sedghi N, Willis JH, Yochem J, Johnson EA, Bowerman B.

PLoS One. 2011 Mar 1;6(3):e16644. doi: 10.1371/journal.pone.0016644.

31.

Effect of varying the phosphorus content of dairy cow diets on losses of phosphorus in overland flow following surface applications of manure.

O'Rourke SM, Foy RH, Watson CJ, Ferris CP, Gordon A.

J Environ Qual. 2010 Nov-Dec;39(6):2138-46.

PMID:
21284312
32.

Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.

O'Rourke SM, Christensen SN, Bowerman B.

Nat Cell Biol. 2010 Dec;12(12):1235-41. doi: 10.1038/ncb2128. Epub 2010 Nov 14.

33.

Mutation at a single position in the V2 domain of the HIV-1 envelope protein confers neutralization sensitivity to a highly neutralization-resistant virus.

O'Rourke SM, Schweighardt B, Phung P, Fonseca DP, Terry K, Wrin T, Sinangil F, Berman PW.

J Virol. 2010 Nov;84(21):11200-9. doi: 10.1128/JVI.00790-10. Epub 2010 Aug 11.

34.

Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites.

Yu B, Fonseca DP, O'Rourke SM, Berman PW.

J Virol. 2010 Feb;84(3):1513-26. doi: 10.1128/JVI.01765-09. Epub 2009 Nov 25.

35.

Novel ring structure in the gp41 trimer of human immunodeficiency virus type 1 that modulates sensitivity and resistance to broadly neutralizing antibodies.

O'Rourke SM, Schweighardt B, Scott WG, Wrin T, Fonseca DP, Sinangil F, Berman PW.

J Virol. 2009 Aug;83(15):7728-38. doi: 10.1128/JVI.00688-09. Epub 2009 May 27.

37.

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.

Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O'Rourke SM, Bowerman B, McLeod I, Yates JR 3rd, Oegema K, Cheeseman IM, Desai A.

Genes Dev. 2008 Sep 1;22(17):2385-99. doi: 10.1101/gad.1687508.

38.

Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.

O'Rourke SM, Dorfman MD, Carter JC, Bowerman B.

PLoS Genet. 2007 Aug;3(8):e128.

39.

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M.

Nature. 2005 Jun 30;435(7046):1257-61.

PMID:
15988528
40.

Genomics: frontiers of gene function.

O'Rourke SM, Bowerman B.

Nature. 2005 Mar 24;434(7032):444-5. No abstract available.

PMID:
15791235
41.

Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae.

Galgoczy DJ, Cassidy-Stone A, Llinás M, O'Rourke SM, Herskowitz I, DeRisi JL, Johnson AD.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18069-74. Epub 2004 Dec 16.

42.

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.

O'Rourke SM, Herskowitz I.

Mol Biol Cell. 2004 Feb;15(2):532-42. Epub 2003 Oct 31.

43.
44.

Yeast go the whole HOG for the hyperosmotic response.

O'Rourke SM, Herskowitz I, O'Shea EK.

Trends Genet. 2002 Aug;18(8):405-12. Review.

PMID:
12142009
46.

Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo.

Drogen F, O'Rourke SM, Stucke VM, Jaquenoud M, Neiman AM, Peter M.

Curr Biol. 2000 Jun 1;10(11):630-9.

47.

Genetic control of hepatic apoB-100 secretion in human apoB transgenic mouse strains.

Voyiaziakis E, Ko C, O'Rourke SM, Huang LS.

J Lipid Res. 1999 Nov;40(11):2004-12.

48.

Genetic selection of peptide inhibitors of biological pathways.

Norman TC, Smith DL, Sorger PK, Drees BL, O'Rourke SM, Hughes TR, Roberts CJ, Friend SH, Fields S, Murray AW.

Science. 1999 Jul 23;285(5427):591-5.

49.

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