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Items: 22


A rectal cancer organoid platform to study individual responses to chemoradiation.

Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massagué J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ.

Nat Med. 2019 Oct;25(10):1607-1614. doi: 10.1038/s41591-019-0584-2. Epub 2019 Oct 7.


A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation.

Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ.

Mol Biol Cell. 2018 Jul 15;29(13):1682-1692. doi: 10.1091/mbc.E18-02-0141. Epub 2018 May 23.


Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.

O'Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C, Beltran H, Rubin MA, Dow LE, Lowe SW.

Nat Biotechnol. 2017 Jun;35(6):577-582. doi: 10.1038/nbt.3837. Epub 2017 May 1.


Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.

Ptashkin RN, Pagan C, Yaeger R, Middha S, Shia J, O'Rourke KP, Berger MF, Wang L, Cimera R, Wang J, Klimstra DS, Saltz L, Ladanyi M, Zehir A, Hechtman JF.

Mol Cancer Res. 2017 Jun;15(6):708-713. doi: 10.1158/1541-7786.MCR-16-0352. Epub 2017 Feb 9.


Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells.

O'Rourke KP, Ackerman S, Dow LE, Lowe SW.

Bio Protoc. 2016 Feb 20;6(4). pii: e1733.


Immunofluorescent Staining of Mouse Intestinal Stem Cells.

O'Rourke KP, Dow LE, Lowe SW.

Bio Protoc. 2016 Feb 20;6(4). pii: e1732.


Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM.

Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9.


Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.

Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW.

Cell. 2015 Jun 18;161(7):1539-1552. doi: 10.1016/j.cell.2015.05.033.


Inducible in vivo genome editing with CRISPR-Cas9.

Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW.

Nat Biotechnol. 2015 Apr;33(4):390-394. doi: 10.1038/nbt.3155. Epub 2015 Feb 18.


Cytokinesis failure triggers hippo tumor suppressor pathway activation.

Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D.

Cell. 2014 Aug 14;158(4):833-848. doi: 10.1016/j.cell.2014.06.029.


An audit of the frequency of proton pump inhibitor (PPI) prescription in rheumatoid arthritis (RA) patients taking non-steroidal anti-inflammatory drugs (NSAIDs).

Khan S, Mohammad A, O'Rourke KP.

Ir J Med Sci. 2014 Dec;183(4):685-6. doi: 10.1007/s11845-014-1152-x. Epub 2014 Jul 23. No abstract available.


Erosive polyarticular tophaceous gout: an unusually deforming and destructive presentation.

Redmond CE, Babiker A, Redmond PL, O'Rourke KP.

BMJ Case Rep. 2013 Dec 10;2013. pii: bcr2013202335. doi: 10.1136/bcr-2013-202335. No abstract available.


'Sink or swim': an evaluation of the clinical characteristics of individuals with high bone mass.

Gregson CL, Steel SA, O'Rourke KP, Allan K, Ayuk J, Bhalla A, Clunie G, Crabtree N, Fogelman I, Goodby A, Langman CM, Linton S, Marriott E, McCloskey E, Moss KE, Palferman T, Panthakalam S, Poole KE, Stone MD, Turton J, Wallis D, Warburton S, Wass J, Duncan EL, Brown MA, Davey-Smith G, Tobias JH.

Osteoporos Int. 2012 Feb;23(2):643-54. doi: 10.1007/s00198-011-1603-4. Epub 2011 Apr 1.


Malignancy in scleroderma patients from south west England: a population-based cohort study.

Siau K, Laversuch CJ, Creamer P, O'Rourke KP.

Rheumatol Int. 2011 May;31(5):641-5. doi: 10.1007/s00296-009-1348-y. Epub 2010 Jan 8.


Genome-wide characterization of the SloR metalloregulome in Streptococcus mutans.

O'Rourke KP, Shaw JD, Pesesky MW, Cook BT, Roberts SM, Bond JP, Spatafora GA.

J Bacteriol. 2010 Mar;192(5):1433-43. doi: 10.1128/JB.01161-09. Epub 2009 Nov 13.


Bilateral calf chronic compartment syndrome in an elderly male: a case report.

Siau K, O'Rourke KP, Khanna A, Laversuch CJ.

Cases J. 2009 Jun 24;2:8346. doi: 10.4076/1757-1626-2-8346.


High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations.

O'Rourke KP, O'Donoghue G, Adams C, Mulcahy H, Molloy C, Silke C, Molloy M, Shanahan F, O'Gara F.

Rheumatol Int. 2008 Aug;28(10):979-86. doi: 10.1007/s00296-008-0574-z. Epub 2008 Apr 1.


A comparison of paediatric soccer, gaelic football and rugby injuries presenting to an emergency department in Ireland.

O'Rourke KP, Quinn F, Mun S, Browne M, Sheehan J, Cusack S, Molloy M.

Injury. 2007 Jan;38(1):104-11. Epub 2006 Sep 20.


The outcome of direct current cardioversion (DCC) for the treatment of atrial fibrillation (AF) in a district general hospital in Ireland.

O'Rourke KP, Cotter C, Mullane D, Thorpe P, Sullivan P.

Ir J Med Sci. 2006 Apr-Jun;175(2):41-5.


LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection.

Mulcahy H, O'Rourke KP, Adams C, Molloy MG, O'Gara F.

Immunogenetics. 2006 Jan;57(12):893-903. Epub 2005 Dec 17.


A retrospective study of the demographics of sport and exercise injuries in 1143 children presenting to an Irish emergency department over a 6-month period.

O'Rourke KP, Mun S, Browne M, Sheehan J, Cusack S, Molloy M.

Eur J Pediatr. 2005 Jul;164(7):421-6. Epub 2005 Apr 6.


Pneumocystis carinii pneumonia following a second infusion of infliximab.

Tai TL, O'Rourke KP, McWeeney M, Burke CM, Sheehan K, Barry M.

Rheumatology (Oxford). 2002 Aug;41(8):951-2. No abstract available.


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