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Transcriptional Signatures of Tau and Amyloid Neuropathology.

Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, Moore K, O'Neill P, Lunnon K, Collier DA, Ahmed Z, O'Neill MJ, Mill J.

Cell Rep. 2020 Feb 11;30(6):2040-2054.e5. doi: 10.1016/j.celrep.2020.01.063.


LC-MS/MS assay coupled with carboxylic acid magnetic bead affinity capture to quantitatively measure cationic host defense peptides (HDPs) in complex matrices with application to preclinical pharmacokinetic studies.

O'Neill MJ, Chan K, Jaynes JM, Knotts Z, Xu X, Abisoye-Ogunniyan A, Guerin T, Schlomer J, Li D, Cary JW, Rajasekaran K, Yates C, Kozlov S, Andresson T, Rudloff U.

J Pharm Biomed Anal. 2020 Mar 20;181:113093. doi: 10.1016/j.jpba.2020.113093. Epub 2020 Jan 2.


The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.

Jang SM, Nathans JF, Fu H, Redon CE, Jenkins LM, Thakur BL, Pongor LS, Baris AM, Gross JM, OʹNeill MJ, Indig FE, Cappell SD, Aladjem MI.

Nat Commun. 2020 Jan 7;11(1):24. doi: 10.1038/s41467-019-13808-9.


Imbalance in the response of pre- and post-synaptic components to amyloidopathy.

Stephen TL, Tamagnini F, Piegsa J, Sung K, Harvey J, Oliver-Evans A, Murray TK, Ahmed Z, Hutton ML, Randall A, O'Neill MJ, Jackson JS.

Sci Rep. 2019 Oct 16;9(1):14837. doi: 10.1038/s41598-019-50781-1.


Correction to: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.

Harrison IF, Whitaker R, Bertelli PM, O'Callaghan JM, Csincsik L, Wells JA, Bocchetta M, Ma D, Fisher A, Ahmed Z, Murray TK, O'Neill MJ, Rohrer JD, Lythgoe MF, Lengyel I.

Acta Neuropathol Commun. 2019 Aug 5;7(1):127. doi: 10.1186/s40478-019-0780-9.


Use of a fluorinated probe to quantitatively monitor amino acid binding preferences of ruthenium(ii) arene complexes.

Biggs GS, O'Neill MJ, Carames Mendez P, Scrase TG, Lin Y, Bin-Maarof AM, Bond AD, Boss SR, Barker PD.

Dalton Trans. 2019 May 21;48(20):6910-6920. doi: 10.1039/c8dt05159c.


Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network.

Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, Morimoto RI.

J Biol Chem. 2019 May 10;294(19):7917-7930. doi: 10.1074/jbc.RA119.007527. Epub 2019 Apr 1.


Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation.

Ma D, Holmes HE, Cardoso MJ, Modat M, Harrison IF, Powell NM, O'Callaghan JM, Ismail O, Johnson RA, O'Neill MJ, Collins EC, Beg MF, Popuri K, Lythgoe MF, Ourselin S.

Front Neurosci. 2019 Jan 24;13:11. doi: 10.3389/fnins.2019.00011. eCollection 2019.


Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.

Harrison IF, Whitaker R, Bertelli PM, O'Callaghan JM, Csincsik L, Bocchetta M, Ma D, Fisher A, Ahmed Z, Murray TK, O'Neill MJ, Rohrer JD, Lythgoe MF, Lengyel I.

Acta Neuropathol Commun. 2019 Jan 7;7(1):4. doi: 10.1186/s40478-018-0654-6. Erratum in: Acta Neuropathol Commun. 2019 Aug 5;7(1):127.


Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.

Wang H, Li Y, Ryder JW, Hole JT, Ebert PJ, Airey DC, Qian HR, Logsdon B, Fisher A, Ahmed Z, Murray TK, Cavallini A, Bose S, Eastwood BJ, Collier DA, Dage JL, Miller BB, Merchant KM, O'Neill MJ, Demattos RB.

Mol Neurodegener. 2018 Dec 17;13(1):65. doi: 10.1186/s13024-018-0296-y.


A Perspective in Catalysis: Development of Efficient Methods in the Age of Sustainability.

O'Neill MJ, Cornella J.

Chimia (Aarau). 2018 Sep 1;72(9):601-605. doi: 10.2533/chimia.2018.601.


Selective Functionalization of Aminoheterocycles by a Pyrylium Salt.

Moser D, Duan Y, Wang F, Ma Y, O'Neill MJ, Cornella J.

Angew Chem Int Ed Engl. 2018 Aug 20;57(34):11035-11039. doi: 10.1002/anie.201806271. Epub 2018 Jul 20.


Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

Carbajosa G, Malki K, Lawless N, Wang H, Ryder JW, Wozniak E, Wood K, Mein CA, Dobson RJB, Collier DA, O'Neill MJ, Hodges AK, Newhouse SJ.

Neurobiol Aging. 2018 Sep;69:151-166. doi: 10.1016/j.neurobiolaging.2018.04.019. Epub 2018 May 17.


GDNF revisited: A novel mammalian cell-derived variant form of GDNF increases dopamine turnover and improves brain biodistribution.

Grondin R, Littrell OM, Zhang Z, Ai Y, Huettl P, Pomerleau F, Quintero JE, Andersen AH, Stenslik MJ, Bradley LH, Lemmon J, O'Neill MJ, Gash DM, Gerhardt GA.

Neuropharmacology. 2019 Mar 15;147:28-36. doi: 10.1016/j.neuropharm.2018.05.014. Epub 2018 May 29. Review.


Thorpe-Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides.

O'Neill MJ, Riesebeck T, Cornella J.

Angew Chem Int Ed Engl. 2018 Jul 16;57(29):9103-9107. doi: 10.1002/anie.201804479. Epub 2018 Jun 19.


Tissue-Specific Transcriptome for Poeciliopsis prolifica Reveals Evidence for Genetic Adaptation Related to the Evolution of a Placental Fish.

Jue NK, Foley RJ, Reznick DN, O'Neill RJ, O'Neill MJ.

G3 (Bethesda). 2018 Jul 2;8(7):2181-2192. doi: 10.1534/g3.118.200270.


Sex chromosome repeats tip the balance towards speciation.

O'Neill MJ, O'Neill RJ.

Mol Ecol. 2018 Oct;27(19):3783-3798. doi: 10.1111/mec.14577. Epub 2018 May 8. Review.


Replication timing kept in LINE.

O'Neill RJ, O'Neill MJ.

J Cell Biol. 2018 Feb 5;217(2):441-443. doi: 10.1083/jcb.201712173. Epub 2018 Jan 18.


In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis.

Colgan N, Ganeshan B, Harrison IF, Ismail O, Holmes HE, Wells JA, Powell NM, O'Callaghan JM, O'Neill MJ, Murray TK, Ahmed Z, Collins EC, Johnson RA, Groves A, Lythgoe MF.

Front Neurosci. 2017 Nov 6;11:599. doi: 10.3389/fnins.2017.00599. eCollection 2017.


Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models.

Latta-Mahieu M, Elmer B, Bretteville A, Wang Y, Lopez-Grancha M, Goniot P, Moindrot N, Ferrari P, Blanc V, Schussler N, Brault E, Roudières V, Blanchard V, Yang ZY, Barneoud P, Bertrand P, Roucourt B, Carmans S, Bottelbergs A, Mertens L, Wintmolders C, Larsen P, Hersley C, McGathey T, Racke MM, Liu L, Lu J, O'Neill MJ, Riddell DR, Ebneth A, Nabel GJ, Pradier L.

Glia. 2018 Mar;66(3):492-504. doi: 10.1002/glia.23260. Epub 2017 Nov 14.


Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders.

Bruns RF, Mitchell SN, Wafford KA, Harper AJ, Shanks EA, Carter G, O'Neill MJ, Murray TK, Eastwood BJ, Schaus JM, Beck JP, Hao J, Witkin JM, Li X, Chernet E, Katner JS, Wang H, Ryder JW, Masquelin ME, Thompson LK, Love PL, Maren DL, Falcone JF, Menezes MM, Zhang L, Yang CR, Svensson KA.

Neuropharmacology. 2018 Jan;128:351-365. doi: 10.1016/j.neuropharm.2017.10.032. Epub 2017 Oct 26.


A high-throughput model for investigating neuronal function and synaptic transmission in cultured neuronal networks.

Virdee JK, Saro G, Fouillet A, Findlay J, Ferreira F, Eversden S, O'Neill MJ, Wolak J, Ursu D.

Sci Rep. 2017 Nov 3;7(1):14498. doi: 10.1038/s41598-017-15171-5.


Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy.

Blackmore T, Meftah S, Murray TK, Craig PJ, Blockeel A, Phillips K, Eastwood B, O'Neill MJ, Marston H, Ahmed Z, Gilmour G, Gastambide F.

Alzheimers Res Ther. 2017 Sep 20;9(1):77. doi: 10.1186/s13195-017-0306-2.


Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA.

Mol Ther. 2017 Oct 4;25(10):2404-2414. doi: 10.1016/j.ymthe.2017.08.017. Epub 2017 Aug 31.


Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.

O'Callaghan J, Holmes H, Powell N, Wells JA, Ismail O, Harrison IF, Siow B, Johnson R, Ahmed Z, Fisher A, Meftah S, O'Neill MJ, Murray TK, Collins EC, Shmueli K, Lythgoe MF.

Neuroimage. 2017 Oct 1;159:334-345. doi: 10.1016/j.neuroimage.2017.08.003. Epub 2017 Aug 4.


The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, Farr TD, Flecknell P, Gallagher L, Gibson CL, Haley MJ, Macleod MR, McColl BW, McCabe C, Morancho A, Moon LD, O'Neill MJ, Pérez de Puig I, Planas A, Ragan CI, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R, Macrae IM.

J Cereb Blood Flow Metab. 2017 Nov;37(11):3488-3517. doi: 10.1177/0271678X17709185. Epub 2017 Aug 11. Review.


Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy.

Holmes HE, Powell NM, Ma D, Ismail O, Harrison IF, Wells JA, Colgan N, O'Callaghan JM, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, O'Neill MJ, Collins EC, Fisher EM, Ourselin S, Lythgoe MF.

Front Neuroinform. 2017 Mar 31;11:20. doi: 10.3389/fninf.2017.00020. eCollection 2017.


Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro.

Johnson NW, Özkan M, Burgess AP, Prokic EJ, Wafford KA, O'Neill MJ, Greenhill SD, Stanford IM, Woodhall GL.

Neuropharmacology. 2017 Jun;119:141-156. doi: 10.1016/j.neuropharm.2017.04.009. Epub 2017 Apr 8.


Altered Synapse Stability in the Early Stages of Tauopathy.

Jackson JS, Witton J, Johnson JD, Ahmed Z, Ward M, Randall AD, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC.

Cell Rep. 2017 Mar 28;18(13):3063-3068. doi: 10.1016/j.celrep.2017.03.013.


Alkyl-(Hetero)Aryl Bond Formation via Decarboxylative Cross-Coupling: A Systematic Analysis.

Sandfort F, O'Neill MJ, Cornella J, Wimmer L, Baran PS.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3319-3323. doi: 10.1002/anie.201612314. Epub 2017 Feb 10.


Nasal neuron PET imaging quantifies neuron generation and degeneration.

Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM.

J Clin Invest. 2017 Feb 1;127(2):681-694. doi: 10.1172/JCI89162. Epub 2017 Jan 23.


Rapid Evolutionary Rates and Unique Genomic Signatures Discovered in the First Reference Genome for the Southern Ocean Salp, Salpa thompsoni (Urochordata, Thaliacea).

Jue NK, Batta-Lona PG, Trusiak S, Obergfell C, Bucklin A, O'Neill MJ, O'Neill RJ.

Genome Biol Evol. 2016 Oct 30;8(10):3171-3186.


Standardizing dose prescriptions: An ASTRO white paper.

Evans SB, Fraass BA, Berner P, Collins KS, Nurushev T, O'Neill MJ, Zeng J, Marks LB.

Pract Radiat Oncol. 2016 Nov - Dec;6(6):e369-e381. doi: 10.1016/j.prro.2016.08.007. Epub 2016 Aug 24.


Respiratory Therapists' Experiences and Attitudes Regarding Terminal Extubations and End-of-Life Care.

Grandhige AP, Timmer M, O'Neill MJ, Binney ZO, Quest TE.

Respir Care. 2016 Jul;61(7):891-6. doi: 10.4187/respcare.04168. Epub 2016 Jun 7.


Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.

Lau DH, Hogseth M, Phillips EC, O'Neill MJ, Pooler AM, Noble W, Hanger DP.

Acta Neuropathol Commun. 2016 May 18;4(1):49. doi: 10.1186/s40478-016-0317-4.


Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.

Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C, O'Neill MJ, Perez-Nievas BG, Hanger DP, Noble W.

Acta Neuropathol Commun. 2016 Mar 31;4:34. doi: 10.1186/s40478-016-0299-2.


Imaging the accumulation and suppression of tau pathology using multiparametric MRI.

Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, Walker-Samuel S, Fisher EM, Ourselin S, O'Neill MJ, Wells JA, Collins EC, Lythgoe MF.

Neurobiol Aging. 2016 Mar;39:184-94. doi: 10.1016/j.neurobiolaging.2015.12.001. Epub 2015 Dec 15.


Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.

Jackson SJ, Kerridge C, Cooper J, Cavallini A, Falcon B, Cella CV, Landi A, Szekeres PG, Murray TK, Ahmed Z, Goedert M, Hutton M, O'Neill MJ, Bose S.

J Neurosci. 2016 Jan 20;36(3):762-72. doi: 10.1523/JNEUROSCI.3542-15.2016.


Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.

Colgan N, Siow B, O'Callaghan JM, Harrison IF, Wells JA, Holmes HE, Ismail O, Richardson S, Alexander DC, Collins EC, Fisher EM, Johnson R, Schwarz AJ, Ahmed Z, O'Neill MJ, Murray TK, Zhang H, Lythgoe MF.

Neuroimage. 2016 Jan 15;125:739-744. doi: 10.1016/j.neuroimage.2015.10.043. Epub 2015 Oct 23.


Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O.

Hum Mol Genet. 2015 Dec 1;24(23):6640-52. doi: 10.1093/hmg/ddv369. Epub 2015 Sep 16.


Selective lability of ruthenium(II) arene amino acid complexes.

Scrase TG, O'Neill MJ, Peel AJ, Senior PW, Matthews PD, Shi H, Boss SR, Barker PD.

Inorg Chem. 2015 Apr 6;54(7):3118-24. doi: 10.1021/ic502051y. Epub 2015 Mar 23.


Increased brain bio-distribution and chemical stability and decreased immunogenicity of an engineered variant of GDNF.

Smith RC, O'Bryan LM, Mitchell PJ, Leung D, Ghanem M, Wilson JM, Hanson JC, Sossick S, Cooper J, Huang L, Merchant KM, Lu J, O'Neill MJ.

Exp Neurol. 2015 May;267:165-76. doi: 10.1016/j.expneurol.2015.03.002. Epub 2015 Mar 12.


In vivo imaging of tau pathology using multi-parametric quantitative MRI.

Wells JA, O'Callaghan JM, Holmes HE, Powell NM, Johnson RA, Siow B, Torrealdea F, Ismail O, Walker-Samuel S, Golay X, Rega M, Richardson S, Modat M, Cardoso MJ, Ourselin S, Schwarz AJ, Ahmed Z, Murray TK, O'Neill MJ, Collins EC, Colgan N, Lythgoe MF.

Neuroimage. 2015 May 1;111:369-78. doi: 10.1016/j.neuroimage.2015.02.023. Epub 2015 Feb 17.


Identification of a recently active mammalian SINE derived from ribosomal RNA.

Longo MS, Brown JD, Zhang C, O'Neill MJ, O'Neill RJ.

Genome Biol Evol. 2015 Jan 29;7(3):775-88. doi: 10.1093/gbe/evv015.


Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease.

Wells JA, Holmes HE, O'Callaghan JM, Colgan N, Ismail O, Fisher EM, Siow B, Murray TK, Schwarz AJ, O'Neill MJ, Collins EC, Lythgoe MF.

J Cereb Blood Flow Metab. 2015 Mar;35(3):359-62. doi: 10.1038/jcbfm.2014.224. Epub 2014 Dec 17.


Conformation determines the seeding potencies of native and recombinant Tau aggregates.

Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S.

J Biol Chem. 2015 Jan 9;290(2):1049-65. doi: 10.1074/jbc.M114.589309. Epub 2014 Nov 18.


Astrocytes and neuroinflammation in Alzheimer's disease.

Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W.

Biochem Soc Trans. 2014 Oct;42(5):1321-5. doi: 10.1042/BST20140155.


Genomics: Something to swing about.

O'Neill MJ, O'Neill RJ.

Nature. 2014 Sep 11;513(7517):174-5. doi: 10.1038/513174a. No abstract available.


Adaptation of iron homeostasis pathways by a Pseudomonas aeruginosa pyoverdine mutant in the cystic fibrosis lung.

Nguyen AT, O'Neill MJ, Watts AM, Robson CL, Lamont IL, Wilks A, Oglesby-Sherrouse AG.

J Bacteriol. 2014 Jun;196(12):2265-76. doi: 10.1128/JB.01491-14. Epub 2014 Apr 11.


A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ.

Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16.

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