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Items: 1 to 50 of 340

1.

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ.

Cell Rep. 2019 Oct 1;29(1):151-161.e5. doi: 10.1016/j.celrep.2019.08.072.

2.

Specific Inhibition of the NLRP3 Inflammasome as an Anti-Inflammatory Strategy in Cystic Fibrosis.

McElvaney OJ, Zaslona Z, Becker-Flegler K, Palsson-McDermott EM, Boland F, Gunaratnam C, Gulbins E, O'Neill LA, Reeves EP, McElvaney NG.

Am J Respir Crit Care Med. 2019 Aug 27. doi: 10.1164/rccm.201905-1013OC. [Epub ahead of print]

PMID:
31454256
3.

The Immunomodulatory Potential of the Metabolite Itaconate.

Hooftman A, O'Neill LAJ.

Trends Immunol. 2019 Aug;40(8):687-698. doi: 10.1016/j.it.2019.05.007. Epub 2019 Jun 6. Review.

PMID:
31178405
4.

Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.

Nat Metab. 2019 Jan;1:16-33. doi: 10.1038/s42255-018-0014-7.

5.

Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production.

Geiger SS, Curtis AM, O'Neill LAJ, Siegel RM.

Immunology. 2019 Jun;157(2):122-136. doi: 10.1111/imm.13053. Epub 2019 Apr 16.

PMID:
30773630
6.

Itaconate: the poster child of metabolic reprogramming in macrophage function.

O'Neill LAJ, Artyomov MN.

Nat Rev Immunol. 2019 May;19(5):273-281. doi: 10.1038/s41577-019-0128-5. Review.

PMID:
30705422
7.

Malonylation of GAPDH is an inflammatory signal in macrophages.

Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA.

Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6.

8.

Rocking the world of innate immunity: an interview with Luke O'Neill.

O'Neill LAJ.

Dis Model Mech. 2018 Nov 29;11(12). pii: dmm037838. doi: 10.1242/dmm.037838.

9.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J.

Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092.

10.

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM.

Sci Transl Med. 2018 Oct 31;10(465). pii: eaah4066. doi: 10.1126/scitranslmed.aah4066.

PMID:
30381407
11.

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.

Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK.

Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7.

12.

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8460-E8468. doi: 10.1073/pnas.1800431115. Epub 2018 Aug 20.

13.

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

Murphy MP, O'Neill LAJ.

Cell. 2018 Aug 9;174(4):780-784. doi: 10.1016/j.cell.2018.07.030. Review.

14.

Dimethyl fumarate: targeting glycolysis to treat MS.

Angiari S, O'Neill LA.

Cell Res. 2018 Jun;28(6):613-615. doi: 10.1038/s41422-018-0045-3. No abstract available.

15.

Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.

Johnston DGW, Williams MA, Thaiss CA, Cabrera-Rubio R, Raverdeau M, McEntee C, Cotter PD, Elinav E, O'Neill LAJ, Corr SC.

J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.

PMID:
29608690
16.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

17.

Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3.

O'Neill LAJ, Zaslona Z.

Trends Mol Med. 2018 Apr;24(4):335-337. doi: 10.1016/j.molmed.2018.02.005. Epub 2018 Feb 23.

PMID:
29483038
18.

Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA.

Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7.

19.

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation.

Carroll RG, Zasłona Z, Galván-Peña S, Koppe EL, Sévin DC, Angiari S, Triantafilou M, Triantafilou K, Modis LK, O'Neill LA.

J Biol Chem. 2018 Apr 13;293(15):5509-5521. doi: 10.1074/jbc.RA118.001921. Epub 2018 Feb 20.

20.

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation.

Williams NC, O'Neill LAJ.

Front Immunol. 2018 Feb 5;9:141. doi: 10.3389/fimmu.2018.00141. eCollection 2018. Review.

21.

Canakinumab for Atherosclerotic Disease.

O'Neill LA, Cooper MA.

N Engl J Med. 2018 Jan 11;378(2):198-9. doi: 10.1056/NEJMc1714635. No abstract available.

PMID:
29322757
22.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG.

Sci Rep. 2017 Dec 19;7(1):17832. doi: 10.1038/s41598-017-17861-6.

23.

Metabolic regulation of NLRP3.

Hughes MM, O'Neill LAJ.

Immunol Rev. 2018 Jan;281(1):88-98. doi: 10.1111/imr.12608. Review.

PMID:
29247992
24.

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.

Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, O'Neill LAJ, Mills KHG, Curtis AM.

Nat Commun. 2017 Dec 12;8(1):1923. doi: 10.1038/s41467-017-02111-0.

25.

GOTcha: lncRNA-ACOD1 targets metabolism during viral infection.

Runtsch MC, O'Neill LA.

Cell Res. 2018 Feb;28(2):137-138. doi: 10.1038/cr.2017.153. Epub 2017 Dec 1.

26.

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.

Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KHG, O'Neill LA.

Front Immunol. 2017 Oct 13;8:1300. doi: 10.3389/fimmu.2017.01300. eCollection 2017.

27.

Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays.

Zaric M, Becker PD, Hervouet C, Kalcheva P, Ibarzo Yus B, Cocita C, O'Neill LA, Kwon SY, Klavinskis LS.

J Control Release. 2017 Dec 28;268:166-175. doi: 10.1016/j.jconrel.2017.10.026. Epub 2017 Oct 19.

28.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
29.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24.

30.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

31.

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.

32.

Krebs cycle rewired for macrophage and dendritic cell effector functions.

Ryan DG, O'Neill LAJ.

FEBS Lett. 2017 Oct;591(19):2992-3006. doi: 10.1002/1873-3468.12744. Epub 2017 Jul 26. Review.

33.

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.

Johnston DGW, Kearney J, Zasłona Z, Williams MA, O'Neill LAJ, Corr SC.

Front Cell Infect Microbiol. 2017 May 23;7:201. doi: 10.3389/fcimb.2017.00201. eCollection 2017.

34.

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome.

Domingo-Fernández R, Coll RC, Kearney J, Breit S, O'Neill LAJ.

J Biol Chem. 2017 Jul 21;292(29):12077-12087. doi: 10.1074/jbc.M117.797126. Epub 2017 Jun 2.

35.

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN.

J Exp Med. 2017 Jun 5;214(6):1737-1752. doi: 10.1084/jem.20160462. Epub 2017 May 9.

36.

Mitochondria are the powerhouses of immunity.

Mills EL, Kelly B, O'Neill LAJ.

Nat Immunol. 2017 Apr 18;18(5):488-498. doi: 10.1038/ni.3704. Review.

PMID:
28418387
37.

Macrophage Immunometabolism: Where Are We (Going)?

Van den Bossche J, O'Neill LA, Menon D.

Trends Immunol. 2017 Jun;38(6):395-406. doi: 10.1016/j.it.2017.03.001. Epub 2017 Apr 7. Review.

PMID:
28396078
38.

The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma.

Zasłona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LAJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L855-L860. doi: 10.1152/ajplung.00072.2017. Epub 2017 Mar 23.

39.

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.

Haneklaus M, O'Neil JD, Clark AR, Masters SL, O'Neill LAJ.

J Biol Chem. 2017 Apr 28;292(17):6869-6881. doi: 10.1074/jbc.M116.772947. Epub 2017 Mar 16.

40.

The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.

Zasłona Z, Pålsson-McDermott EM, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran SE, Peters-Golden M, O'Neill LAJ.

J Immunol. 2017 May 1;198(9):3558-3564. doi: 10.4049/jimmunol.1602072. Epub 2017 Mar 15.

41.

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.

PMID:
28252317
42.

The Hunger Games: Salmonella, Anorexia, and NLRP3.

O'Neill LAJ.

Cell Metab. 2017 Feb 7;25(2):225-226. doi: 10.1016/j.cmet.2017.01.015.

43.

Inflammasomes in the lung.

Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O'Neill LAJ, Horvat JC, Hansbro PM.

Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.

PMID:
28129896
44.

Glutathione and Glutathione Transferase Omega 1 as Key Posttranslational Regulators in Macrophages.

Hughes MM, McGettrick AF, O'Neill LAJ.

Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.MCHD-0044-2016. Review.

PMID:
28102119
45.

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA.

Brain Behav Immun. 2017 Mar;61:306-316. doi: 10.1016/j.bbi.2016.12.014. Epub 2016 Dec 18.

PMID:
28003153
46.

Preface.

McGettrick AF, O'Neill LA.

Semin Immunol. 2016 Oct;28(5):395. doi: 10.1016/j.smim.2016.11.001. No abstract available.

PMID:
27938849
47.

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

Brady G, Boggan L, Bowie A, O'Neill LA.

J Biol Chem. 2016 Nov 25;291(48):25278. No abstract available.

48.

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG.

Cell Metab. 2016 Dec 13;24(6):807-819. doi: 10.1016/j.cmet.2016.10.008. Epub 2016 Nov 17.

49.

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA.

J Biol Chem. 2016 Nov 18;291(47):24802. No abstract available.

50.

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion.

Becker CE, Creagh EM, O'Neill LA.

J Biol Chem. 2016 Nov 18;291(47):24800. No abstract available.

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