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Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module.

Randall CP, Gupta A, Utley-Drew B, Lee SY, Morrison-Williams G, O'Neill AJ.

mSphere. 2018 Dec 12;3(6). pii: e00633-18. doi: 10.1128/mSphereDirect.00633-18.


Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA.

Yokoyama M, Stevens E, Laabei M, Bacon L, Heesom K, Bayliss S, Ooi N, O'Neill AJ, Murray E, Williams P, Lubben A, Reeksting S, Meric G, Pascoe B, Sheppard SK, Recker M, Hurst LD, Massey RC.

Genome Biol. 2018 Jul 18;19(1):94. doi: 10.1186/s13059-018-1469-2.


Morbidity and mortality resulting from acute inhalation exposures to hydrogen fluoride and carbonyl fluoride in rats.

Januszkiewicz AJ, Bazar MA, Crouse LCB, Chapman MA, Hodges SE, McCormick SJ, O'Neill AJ.

Inhal Toxicol. 2018 Feb;30(3):114-123. doi: 10.1080/08958378.2018.1465494. Epub 2018 May 15.


1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage.

Defraine V, Liebens V, Loos E, Swings T, Weytjens B, Fierro C, Marchal K, Sharkey L, O'Neill AJ, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J.

Front Microbiol. 2018 Feb 8;9:129. doi: 10.3389/fmicb.2018.00129. eCollection 2018.


N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.

Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW.

ACS Med Chem Lett. 2018 Jan 18;9(2):84-88. doi: 10.1021/acsmedchemlett.7b00374. eCollection 2018 Feb 8.


Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight.

Sharkey LKR, O'Neill AJ.

ACS Infect Dis. 2018 Mar 9;4(3):239-246. doi: 10.1021/acsinfecdis.7b00251. Epub 2018 Feb 7. Review.


Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin.

Nass NM, Farooque S, Hind C, Wand ME, Randall CP, Sutton JM, Seipke RF, Rayner CM, O'Neill AJ.

Sci Rep. 2017 Dec 12;7(1):17419. doi: 10.1038/s41598-017-17232-1.


Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens.

Elkrewi E, Randall CP, Ooi N, Cottell JL, O'Neill AJ.

J Antimicrob Chemother. 2017 Nov 1;72(11):3043-3046. doi: 10.1093/jac/dkx258.


Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo.

Renzoni A, Von Dach E, Landelle C, Diene SM, Manzano C, Gonzales R, Abdelhady W, Randall CP, Bonetti EJ, Baud D, O'Neill AJ, Bayer A, Cherkaoui A, Schrenzel J, Harbarth S, François P.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00272-17. doi: 10.1128/AAC.00272-17. Print 2017 Oct.


Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of MSD-819 (6-chloro-2-quinoxalinecarboxylic acid 1,4-dioxide).

Ooi N, O'Neill AJ.

J Antibiot (Tokyo). 2017 Mar;70(3):317-319. doi: 10.1038/ja.2016.140. Epub 2016 Nov 30. No abstract available.


Batumin does not exert its antistaphylococcal effect through inhibition of aminoacyl-tRNA synthetase enzymes.

Lee VE, O'Neill AJ.

Int J Antimicrob Agents. 2017 Jan;49(1):121-122. doi: 10.1016/j.ijantimicag.2016.10.005. Epub 2016 Oct 25. No abstract available.


Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme.

Randall CP, Rasina D, Jirgensons A, O'Neill AJ.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6359-61. doi: 10.1128/AAC.00674-16. Print 2016 Oct.


Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.

Gerits E, Blommaert E, Lippell A, O'Neill AJ, Weytjens B, De Maeyer D, Fierro AC, Marchal K, Marchand A, Chaltin P, Spincemaille P, De Brucker K, Thevissen K, Cammue BP, Swings T, Liebens V, Fauvart M, Verstraeten N, Michiels J.

PLoS One. 2016 May 11;11(5):e0155139. doi: 10.1371/journal.pone.0155139. eCollection 2016.


Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent.

Ooi N, Eady EA, Cove JH, O'Neill AJ.

J Antimicrob Chemother. 2016 Jul;71(7):1841-4. doi: 10.1093/jac/dkw100. Epub 2016 Apr 27.


ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection.

Sharkey LK, Edwards TA, O'Neill AJ.

MBio. 2016 Mar 22;7(2):e01975. doi: 10.1128/mBio.01975-15.


A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus.

Gupta A, Monteferrante C, Rasina D, Leitis G, Randall CP, Tomlinson JH, Jirgensons A, Goessens WH, Hays JP, O'Neill AJ.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21. doi: 10.1128/AAC.02940-15. Print 2016 May.


A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.

Tomlinson JH, Thompson GS, Kalverda AP, Zhuravleva A, O'Neill AJ.

Sci Rep. 2016 Jan 19;6:19524. doi: 10.1038/srep19524.


Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms.

Randall CP, Gupta A, Jackson N, Busse D, O'Neill AJ.

J Antimicrob Chemother. 2015 Apr;70(4):1037-46. doi: 10.1093/jac/dku523. Epub 2015 Jan 6.


Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity.

Liebens V, Gerits E, Knapen WJ, Swings T, Beullens S, Steenackers HP, Robijns S, Lippell A, O'Neill AJ, Veber M, Fröhlich M, Krona A, Lövenklev M, Corbau R, Marchand A, Chaltin P, De Brucker K, Thevissen K, Cammue BP, Fauvart M, Verstraeten N, Michiels J.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5404-8.


Redox-active compounds with a history of human use: antistaphylococcal action and potential for repurposing as topical antibiofilm agents.

Ooi N, Eady EA, Cove JH, O'Neill AJ.

J Antimicrob Chemother. 2015 Feb;70(2):479-88. doi: 10.1093/jac/dku409. Epub 2014 Nov 3.


Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S.

Eur J Med Chem. 2014 Feb 12;73:83-96. doi: 10.1016/j.ejmech.2013.11.031. Epub 2013 Dec 12.


Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

Škedelj V, Perdih A, Brvar M, Kroflič A, Dubbée V, Savage V, O'Neill AJ, Solmajer T, Bešter-Rogač M, Blanot D, Hugonnet JE, Magnet S, Arthur M, Mainardi JL, Stojan J, Zega A.

Eur J Med Chem. 2013 Sep;67:208-20. doi: 10.1016/j.ejmech.2013.06.017. Epub 2013 Jun 28.


Mutagenesis mapping of the protein-protein interaction underlying FusB-type fusidic acid resistance.

Cox G, Edwards TA, O'Neill AJ.

Antimicrob Agents Chemother. 2013 Oct;57(10):4640-4. doi: 10.1128/AAC.00198-13. Epub 2013 Jul 8.


Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S.

Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21.


Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence.

Savage VJ, Chopra I, O'Neill AJ.

PLoS One. 2013 Apr 30;8(4):e62513. doi: 10.1371/journal.pone.0062513. Print 2013.


Antibacterial activity and mode of action of tert-butylhydroquinone (TBHQ) and its oxidation product, tert-butylbenzoquinone (TBBQ).

Ooi N, Chopra I, Eady A, Cove J, Bojar R, O'Neill AJ.

J Antimicrob Chemother. 2013 Jun;68(6):1297-304. doi: 10.1093/jac/dkt030. Epub 2013 Mar 5.


Staphylococcus aureus biofilms promote horizontal transfer of antibiotic resistance.

Savage VJ, Chopra I, O'Neill AJ.

Antimicrob Agents Chemother. 2013 Apr;57(4):1968-70. doi: 10.1128/AAC.02008-12. Epub 2013 Jan 28.


The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens.

Randall CP, Mariner KR, Chopra I, O'Neill AJ.

Antimicrob Agents Chemother. 2013 Jan;57(1):637-9. doi: 10.1128/AAC.02005-12. Epub 2012 Oct 31.


Increased mutability of Staphylococci in biofilms as a consequence of oxidative stress.

Ryder VJ, Chopra I, O'Neill AJ.

PLoS One. 2012;7(10):e47695. doi: 10.1371/journal.pone.0047695. Epub 2012 Oct 24.


Transposon library screening for identification of genetic loci participating in intrinsic susceptibility and acquired resistance to antistaphylococcal agents.

Blake KL, O'Neill AJ.

J Antimicrob Chemother. 2013 Jan;68(1):12-6. doi: 10.1093/jac/dks373. Epub 2012 Oct 7.


The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies.

Randall CP, Oyama LB, Bostock JM, Chopra I, O'Neill AJ.

J Antimicrob Chemother. 2013 Jan;68(1):131-8. doi: 10.1093/jac/dks372. Epub 2012 Sep 25.


6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase.

Škedelj V, Arsovska E, Tomašić T, Kroflič A, Hodnik V, Hrast M, Bešter-Rogač M, Anderluh G, Gobec S, Bostock J, Chopra I, O'Neill AJ, Randall C, Zega A.

PLoS One. 2012;7(8):e39922. doi: 10.1371/journal.pone.0039922. Epub 2012 Aug 2.


"tet(U)" is not a tetracycline resistance determinant.

Caryl JA, Cox G, Trimble S, O'Neill AJ.

Antimicrob Agents Chemother. 2012 Jun;56(6):3378-9. doi: 10.1128/AAC.05957-11. Epub 2012 Apr 9.


Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.

Cox G, Thompson GS, Jenkins HT, Peske F, Savelsbergh A, Rodnina MV, Wintermeyer W, Homans SW, Edwards TA, O'Neill AJ.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2102-7. doi: 10.1073/pnas.1117275109. Epub 2012 Jan 20.


Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

McPhillie MJ, Trowbridge R, Mariner KR, O'Neill AJ, Johnson AP, Chopra I, Fishwick CW.

ACS Med Chem Lett. 2011 Jul 29;2(10):729-34. doi: 10.1021/ml200087m. eCollection 2011 Oct 13.


Loss of function of the gdpP protein leads to joint β-lactam/glycopeptide tolerance in Staphylococcus aureus.

Griffiths JM, O'Neill AJ.

Antimicrob Agents Chemother. 2012 Jan;56(1):579-81. doi: 10.1128/AAC.05148-11. Epub 2011 Oct 10.


Characterisation and manipulation of docetaxel resistant prostate cancer cell lines.

O'Neill AJ, Prencipe M, Dowling C, Fan Y, Mulrane L, Gallagher WM, O'Connor D, O'Connor R, Devery A, Corcoran C, Rani S, O'Driscoll L, Fitzpatrick JM, Watson RW.

Mol Cancer. 2011 Oct 7;10:126. doi: 10.1186/1476-4598-10-126.


Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.

Mariner K, McPhillie M, Trowbridge R, Smith C, O'Neill AJ, Fishwick CW, Chopra I.

Antimicrob Agents Chemother. 2011 May;55(5):2413-6. doi: 10.1128/AAC.01742-10. Epub 2011 Feb 14.


In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance.

Blake KL, Randall CP, O'Neill AJ.

Antimicrob Agents Chemother. 2011 May;55(5):2362-8. doi: 10.1128/AAC.01077-10. Epub 2011 Feb 7.


Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies.

Mariner KR, Ooi N, Roebuck D, O'Neill AJ, Chopra I.

Antimicrob Agents Chemother. 2011 Apr;55(4):1784-6. doi: 10.1128/AAC.01710-10. Epub 2011 Jan 31.


Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

Hurdle JG, O'Neill AJ, Chopra I, Lee RE.

Nat Rev Microbiol. 2011 Jan;9(1):62-75. doi: 10.1038/nrmicro2474. Review.


Distribution of fusidic acid resistance determinants in methicillin-resistant Staphylococcus aureus.

McLaws FB, Larsen AR, Skov RL, Chopra I, O'Neill AJ.

Antimicrob Agents Chemother. 2011 Mar;55(3):1173-6. doi: 10.1128/AAC.00817-10. Epub 2010 Dec 13.


Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase.

Mariner KR, Trowbridge R, Agarwal AK, Miller K, O'Neill AJ, Fishwick CW, Chopra I.

Antimicrob Agents Chemother. 2010 Oct;54(10):4506-9. doi: 10.1128/AAC.00753-10. Epub 2010 Jul 26.


Staphylococcus aureus SH1000 and 8325-4: comparative genome sequences of key laboratory strains in staphylococcal research.

O'Neill AJ.

Lett Appl Microbiol. 2010 Sep;51(3):358-61. doi: 10.1111/j.1472-765X.2010.02885.x. Epub 2010 Jun 10.


Predator control promotes invasive dominated ecological states.

Wallach AD, Johnson CN, Ritchie EG, O'Neill AJ.

Ecol Lett. 2010 Aug 1;13(8):1008-18. doi: 10.1111/j.1461-0248.2010.01492.x. Epub 2010 Jun 10.


More than mere numbers: the impact of lethal control on the social stability of a top-order predator.

Wallach AD, Ritchie EG, Read J, O'Neill AJ.

PLoS One. 2009 Sep 2;4(9):e6861. doi: 10.1371/journal.pone.0006861.


Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation.

Gill C, Dowling C, O'Neill AJ, Watson RW.

Mol Cancer. 2009 Jun 23;8:39. doi: 10.1186/1476-4598-8-39.


Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.

Vickers AA, Potter NJ, Fishwick CW, Chopra I, O'Neill AJ.

J Antimicrob Chemother. 2009 Jun;63(6):1112-7. doi: 10.1093/jac/dkp090. Epub 2009 Apr 21.


Complete nucleotide sequence of pGO1, the prototype conjugative plasmid from the Staphylococci.

Caryl JA, O'Neill AJ.

Plasmid. 2009 Jul;62(1):35-8. doi: 10.1016/j.plasmid.2009.03.001. Epub 2009 Mar 17.


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